LOCUS       BGC0002000             12502 bp    DNA     linear   CON 15-AUG-2021
DEFINITION  Streptomyces aurantiacus JA 4570 Seq74, whole genome shotgun
            sequence.
ACCESSION   BGC0002000
VERSION     BGC0002000
KEYWORDS    .
SOURCE      Streptomyces aurantiacus JA 4570
  ORGANISM  Streptomyces aurantiacus JA 4570
            Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
            Streptomyces; Streptomyces aurantiacus group.
COMMENT     REFSEQ INFORMATION: The reference sequence is identical to
            AOPZ01000074.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-08 05:53:19
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12502
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12502
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[6923:9388]"
                     /cutoff="20000"
                     /detection_rule="(t2ks and t2clf)"
                     /neighbourhood="35000"
                     /product="T2PKS"
                     /protocluster_number="1"
                     /t2pks_malonyl_elongations="8|9 (Score: 676.2; E-value:
                     3e-206)"
                     /t2pks_molecular_weights="acetyl-CoA_8 (Da): 333.357"
                     /t2pks_molecular_weights="acetyl-CoA_9 (Da): 375.393"
                     /t2pks_product_classes="angucycline"
                     /t2pks_starter_units="acetyl-CoA (Score: 0.0; E-value: 0)"
                     /tool="antismash"
     proto_core      6924..9388
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(t2ks and t2clf)"
                     /neighbourhood="35000"
                     /product="T2PKS"
                     /protocluster_number="1"
                     /t2pks_malonyl_elongations="8|9 (Score: 676.2; E-value:
                     3e-206)"
                     /t2pks_molecular_weights="acetyl-CoA_8 (Da): 333.357"
                     /t2pks_molecular_weights="acetyl-CoA_9 (Da): 375.393"
                     /t2pks_product_classes="angucycline"
                     /t2pks_starter_units="acetyl-CoA (Score: 0.0; E-value: 0)"
     cand_cluster    1..12502
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(t2ks and t2clf)"
                     /kind="single"
                     /product="T2PKS"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..12502
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0002000"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..12502
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="T2PKS"
                     /region_number="1"
                     /rules="(t2ks and t2clf)"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            1..1515
                     /locus_tag="STRAU_RS10340"
                     /old_locus_tag="STRAU_2098"
     CDS             1..1515
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005:Drug
                     resistance transporter, EmrB/QacA (Score: 362.3; E-value:
                     4.8e-110)"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009189037.1"
                     /locus_tag="STRAU_RS10340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRAU_2098"
                     /product="DHA2 family efflux MFS transporter permease
                     subunit"
                     /protein_id="WP_016640227.1"
                     /transl_table=11
                     /translation="MEVTATRRWLALGALALAMLTVGLDMTVLNIALPTLARDLGAGTA
                     ALQWFSTAYTLTLAGVMLPAGALGDRFGRKKVVFGALVLFGAASIWCAFAGSSGELISA
                     RVLLGVAAAALMSLSMGMIPVLFPDPAERGRATTVWITAVTLGMPLGPIVGGLLLNHFW
                     WGSVFLVNIPTVVIGALAVGLWMPESRSRVRRPIGPVSVALSAAGLVGLTYGLIRFGDL
                     GWGDGAAWATFIAGLALIAGFVAWERTREHALADLSLFGDRGFRMGTIYQLINAFAMFG
                     LFFTIPLYFQSVLGVDSLGSGLRMLPMIGGLLVASNFLEGLRDKIGLKPTLMIGFALLA
                     VGMGLGALTDIGTSYAFVATWMAIVGLGIGLVLPTSMALAVGALTPERAGAGSALLSAL
                     RQAAGTTGVAVLGTVLSTRYHSELGPLNHKPISDGVGSGVAVADSLGNKAMLHDVQTAF
                     VSGMNLLLVVCAGIAVVGLILAAVTTKSRTTEPGAQLPDSESAPVA"
     gene            1553..2206
                     /locus_tag="STRAU_RS38955"
                     /old_locus_tag="STRAU_2099"
     CDS             1553..2206
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1225:Polyketide synthesis cyclase (Score: 68.4;
                     E-value: 7.9e-21)"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF016551.2"
                     /locus_tag="STRAU_RS38955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRAU_2099"
                     /product="TcmI family type II polyketide cyclase"
                     /protein_id="WP_158692054.1"
                     /transl_table=11
                     /translation="MRSMVTVSKMDHNSIPEVSKLFTEFDSTEIPNLIGLCRRQLFVHD
                     DVQIHLYDFAEQADQSALAKVKGDPRMARLSMDLKPFVAPYDPETWNSPADSAAFCFYD
                     WQDEPIENAGRTDTTVTVTRMDQASIPAVTSIFRESDSTESPRSMGTRRRQLFAYRDLC
                     IHIQDHDGSDGADIAQKAASDIWFGKVVRDLPELADQKPTTDGHASRFYGWVAP"
     gene            2698..3126
                     /locus_tag="STRAU_RS10350"
                     /old_locus_tag="STRAU_2100"
     CDS             2698..3126
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018383123.1"
                     /locus_tag="STRAU_RS10350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRAU_2100"
                     /product="nuclear transport factor 2 family protein"
                     /protein_id="WP_016640229.1"
                     /transl_table=11
                     /translation="MSINHAQAEVSSLLDRYVLGLDYDKLDDEWAYGLFTNDVLIEFPI
                     SRHTGIEGLVEYHQKALSMWARTHHVNTPSIVSVDGDRATLRANMTAVRVLHEQDGETR
                     PHYSTGTYITGDAVRTERGWRLSRLSFDLIWKTGNPPA"
     gene            3185..3994
                     /locus_tag="STRAU_RS10355"
                     /old_locus_tag="STRAU_2101"
     CDS             3185..3994
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008:response
                     regulator (Score: 185.8; E-value: 1.4e-56)"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010357355.1"
                     /locus_tag="STRAU_RS10355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRAU_2101"
                     /product="response regulator transcription factor"
                     /protein_id="WP_078621122.1"
                     /transl_table=11
                     /translation="MKAIPQQELLESHDGGHGATVRSIFGSRRGAPAATQAPPRNVSDT
                     WRILVVEGNKADRATLTEALARQGHDVGAVNSGGDALASYEAADLVVLDLDLPDLDGLE
                     VCREIRAARDTPVITVTSRGSELDCVLALQAGADDYVVKPYGLRELMARLNAVMRRSRR
                     TACADPGAEGAAVLEHGPLRIDSHSREVEMRGRPVPVTRKEFDLLALLASAPGRVISRE
                     SIMHQVWGESWSRRTVDTHVSSLRNKLGGPEWIVTVRGVGFKLRSMR"
     gene            4095..5315
                     /locus_tag="STRAU_RS10360"
                     /old_locus_tag="STRAU_2102"
     CDS             4095..5315
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007:cytochrome P450 (Score: 424.9; E-value: 5e-129)"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019544765.1"
                     /locus_tag="STRAU_RS10360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRAU_2102"
                     /product="cytochrome P450"
                     /protein_id="WP_052029032.1"
                     /sec_met_domain="p450 (E-value: 3.2e-23, bitscore: 72.1,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MANADIDETNELVSFPIQRTCPFSVPPVYTKFREESPITQVVLPD
                     GGKAWLVTKYDDVRAVMANPKLSSDRRAPDFPVVVPGQNAALAKHAPFMIILDGAEHAA
                     ARRPVISEFSVRRVAAMKPRIQEIVDGFIDDMLKMPKPVDLNQVFSLPVPSLVVSEILG
                     MPYEGHEYFMELAEILLRRTTDEQGRIAVSVELRKYMDKLVEEKIENPGDDLLSRQIEL
                     QRQQGGIDRPQLASLCLLVLLAGHETTANMINLGVFSMLTKPELLAEIKADPSKTPKAV
                     DELLRFYTIPDFGAHRLALDDVEIGGVLIRKGEAVIASTFAANRDPAVFDDPEELDFGR
                     DARHHVAFGYGPHQCLGQNLGRLELQVVFDTLFRRLPELRLAVPEEELSFKSDALVYGL
                     YELPVTW"
     gene            5327..5521
                     /locus_tag="STRAU_RS10365"
                     /old_locus_tag="STRAU_2103"
     CDS             5327..5521
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1265:ferredoxin
                     (Score: 73.9; E-value: 1.4e-22)"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006129797.1"
                     /locus_tag="STRAU_RS10365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRAU_2103"
                     /product="(4Fe-4S)-binding protein"
                     /protein_id="WP_037658546.1"
                     /transl_table=11
                     /translation="MKLEKDHDRCIGAGQCVLTEPRLFDQDDWGLVDILVERPRGADEA
                     AARKAVYICPAKALSLVEE"
     gene            complement(5589..6059)
                     /locus_tag="STRAU_RS10370"
                     /old_locus_tag="STRAU_2104"
     CDS             complement(5589..6059)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024966.2"
                     /locus_tag="STRAU_RS10370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRAU_2104"
                     /product="nuclear transport factor 2 family protein"
                     /protein_id="WP_016640233.1"
                     /transl_table=11
                     /translation="MTNMDTTATDTTAEIRRMEDLFALRALVTRFAHAVDTRDHEALST
                     VFVPDVTMEVVPDIRIDGREKLAGMLRDDRMWATTMHYMSNVLPEPEGDGATIRANVTA
                     VHVSRDGAAKHFDLGARYTFTAVRTADGAWLLSRIEIEPVWSTGDDQGMHDH"
     gene            6277..>6564
                     /locus_tag="STRAU_RS41390"
                     /pseudo=""
     CDS             6277..>6564
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1225:Polyketide synthesis cyclase (Score: 56.1;
                     E-value: 5.5e-17)"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018383120.1"
                     /locus_tag="STRAU_RS41390"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="TcmI family type II polyketide cyclase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MHSSVIVGRLKPGSTEDVVGAFAKLDGAPSGTRKLLRRQLFAYKG
                     VYIHLQDHTEDNLTEVVEHGAGAALAPFVDAYGPAAGTAPSDLVATRFYEW"
     gene            6595..6927
                     /locus_tag="STRAU_RS41395"
     CDS             6595..6927
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1225:Polyketide synthesis cyclase (Score: 137.7;
                     E-value: 2.3e-42)"
                     /gene_functions="biosynthetic-additional (t2pks) CYC
                     C4-C17/C2-C19 (Score: 169.6; E-value: 1.6e-52)"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018383120.1"
                     /locus_tag="STRAU_RS41395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TcmI family type II polyketide cyclase"
                     /protein_id="WP_037658559.1"
                     /transl_table=11
                     /translation="MYSTMIVARLDPADIGTVAKLFGDFDSGTELPHTMGTRRRQLFAY
                     NGLYFHIQDFESDNGGRLIEQAKSDPRFVQIQKDLLPYIHVFDPETWRSPSDAMAQRFY
                     TWQVAA"
     gene            6924..8195
                     /locus_tag="STRAU_RS10380"
                     /old_locus_tag="STRAU_2106"
     CDS             6924..8195
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (5-395). E-value:
                     9e-56. Score: 181.4. Matches aSDomain:
                     nrpspksdomains_STRAU_RS10380_PKS_KS.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) T2PKS:
                     t2ks"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 491.6; E-value:
                     3.2e-149)"
                     /gene_functions="biosynthetic-additional (t2pks) KS (Score:
                     784.1; E-value: 6.6e-239)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019544762.1"
                     /locus_tag="STRAU_RS10380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRAU_2106"
                     /product="beta-ketoacyl-[acyl-carrier-protein] synthase
                     family protein"
                     /protein_id="WP_037658548.1"
                     /sec_met_domain="t2ks (E-value: 1.4e-248, bitscore: 814.7,
                     seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSGRRVVVTGMEVLAPGGVGTDNFWSLLSEGRTATRGITFFDPAQ
                     FRSRVAAEIDFDPYAHGLTPQEVRRMDRAAQFAVVAARGAVADSGLDTDTLDPYRIGVT
                     IGSAVGATMSLDEDYRVVSDAGRLDLVDHTYADPFFYNYFVPSSFATEVARLVGAQGPS
                     SVVSAGCTSGLDSVGYAVELIREGTADVMVAGATDAPISPITMACFDAIKATTPRHDDP
                     EHASRPFDDTRNGFVLGEGTAVFVLEELESARRRGARIYAEIAGYATRSNAYHMTGLRP
                     DGAEMAEAITVALDEARMNPTAIDYINAHGSGTKQNDRHETAAFKRSLGEHAYRTPVSS
                     IKSMVGHSLGAIGSIEIAASILAIQHDVVPPTANLHTPDPQCDLDYVPLNAREQIVDAV
                     LTVGSGFGGFQSAMVLAQPERNAA"
     aSDomain        6939..8108
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_STRAU_RS10380_PKS_KS.1"
                     /domain_subtype="Iterative-KS"
                     /evalue="9.00E-56"
                     /label="STRAU_RS10380_PKS_KS.1"
                     /locus_tag="STRAU_RS10380"
                     /protein_end="395"
                     /protein_start="5"
                     /score="181.4"
                     /tool="antismash"
                     /translation="VVVTGMEVLAPGGVGTDNFWSLLSEGRTATRGITFFDPAQFRSRV
                     AAEIDFDPYAHGLTPQEVRRMDRAAQFAVVAARGAVADSGLDTDTLDPYRIGVTIGSAV
                     GATMSLDEDYRVVSDAGRLDLVDHTYADPFFYNYFVPSSFATEVARLVGAQGPSSVVSA
                     GCTSGLDSVGYAVELIREGTADVMVAGATDAPISPITMACFDAIKATTPRHDDPEHASR
                     PFDDTRNGFVLGEGTAVFVLEELESARRRGARIYAEIAGYATRSNAYHMTGLRPDGAEM
                     AEAITVALDEARMNPTAIDYINAHGSGTKQNDRHETAAFKRSLGEHAYRTPVSSIKSMV
                     GHSLGAIGSIEIAASILAIQHDVVPPTANLHTPDPQCDLDYVPLNAREQI"
     gene            8192..9388
                     /locus_tag="STRAU_RS10385"
                     /old_locus_tag="STRAU_2107"
     CDS             8192..9388
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (69-396). E-value:
                     3.8e-32. Score: 103.5. Matches aSDomain:
                     nrpspksdomains_STRAU_RS10385_PKS_KS.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) T2PKS:
                     t2clf"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1093:Beta-ketoacyl synthase (Score: 642.4; E-value:
                     3.9e-195)"
                     /gene_functions="biosynthetic-additional (t2pks) CLF 8|9
                     (Score: 676.2; E-value: 3e-206)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019544761.1"
                     /locus_tag="STRAU_RS10385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRAU_2107"
                     /product="ketosynthase chain-length factor"
                     /protein_id="WP_037658550.1"
                     /sec_met_domain="t2clf (E-value: 8.8e-202, bitscore: 660.0,
                     seeds: 26, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTASSVVVTGLGVVSPNGLGTQGHWSASRVGKSAIGPLTRFDATP
                     YPAKLAGEISGFAAEEHLPSRLMPQTDQVTRLSLVAADWALADAGVNPAELPAFDMGVI
                     TASSAGGFEFSQNELKSLWSKGGEYVSAYQSFAWFYAVNTGQISIRNGMKGPSGVVVTD
                     QAGGLDAVAQARRQIRKGTSLVVAGAVDALLCSWGWVGLGTSGRLSTEEEPSRAYLPFD
                     DRAAGHVPGEGGALLILESADSAHARGAEVYGEIAGYAATFDGREPGLRKAVELALADA
                     GLAASDVDVVFADGAAEPELDRIEAEALVEVFGERGVPVTAPKTMTGRLYAGGAALDLA
                     TAFLAMEEGLIPPTVHTEPAERYGLDLVVSQPRAADVRTALVLARGHGGFNSAMVVRS"
     aSDomain        8399..9379
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_STRAU_RS10385_PKS_KS.1"
                     /domain_subtype="Iterative-KS"
                     /evalue="3.80E-32"
                     /label="STRAU_RS10385_PKS_KS.1"
                     /locus_tag="STRAU_RS10385"
                     /protein_end="396"
                     /protein_start="69"
                     /score="103.5"
                     /tool="antismash"
                     /translation="QTDQVTRLSLVAADWALADAGVNPAELPAFDMGVITASSAGGFEF
                     SQNELKSLWSKGGEYVSAYQSFAWFYAVNTGQISIRNGMKGPSGVVVTDQAGGLDAVAQ
                     ARRQIRKGTSLVVAGAVDALLCSWGWVGLGTSGRLSTEEEPSRAYLPFDDRAAGHVPGE
                     GGALLILESADSAHARGAEVYGEIAGYAATFDGREPGLRKAVELALADAGLAASDVDVV
                     FADGAAEPELDRIEAEALVEVFGERGVPVTAPKTMTGRLYAGGAALDLATAFLAMEEGL
                     IPPTVHTEPAERYGLDLVVSQPRAADVRTALVLARGHGGFNSAMVV"
     gene            9451..9717
                     /locus_tag="STRAU_RS10390"
                     /old_locus_tag="STRAU_2108"
     CDS             9451..9717
                     /NRPS_PKS="Domain: ACP (26-82). E-value: 1.2e-15. Score:
                     49.4. Matches aSDomain: nrpspksdomains_STRAU_RS10390_ACP.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1129:acyl carrier protein (Score: 106.6; E-value:
                     8.6e-33)"
                     /gene_functions="biosynthetic-additional (t2pks) ACP
                     (Score: 118.9; E-value: 1.7e-37)"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015037163.1"
                     /locus_tag="STRAU_RS10390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRAU_2108"
                     /product="acyl carrier protein"
                     /protein_id="WP_016640237.1"
                     /sec_met_domain="PP-binding (E-value: 4e-12, bitscore:
                     36.6, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRSTFTLDDLKRILLEGSGAPEGDGLDGDVLDTEFTDIGYDSLA
                     LLETSSRIEREYGIELDESVVGEATTPRAFIAAVTGHLTVAAA"
     aSDomain        9529..9696
                     /aSDomain="ACP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_STRAU_RS10390_ACP.1"
                     /evalue="1.20E-15"
                     /label="STRAU_RS10390_ACP.1"
                     /locus_tag="STRAU_RS10390"
                     /protein_end="82"
                     /protein_start="26"
                     /score="49.4"
                     /tool="antismash"
                     /translation="LDGDVLDTEFTDIGYDSLALLETSSRIEREYGIELDESVVGEATT
                     PRAFIAAVTGH"
     gene            9807..10592
                     /gene="fabG"
                     /locus_tag="STRAU_RS10395"
                     /old_locus_tag="STRAU_2109"
     CDS             9807..10592
                     /EC_number="1.1.1.100"
                     /NRPS_PKS="Domain: PKS_KR (7-162). E-value: 1.9e-10. Score:
                     32.8. Matches aSDomain:
                     nrpspksdomains_STRAU_RS10395_PKS_KR.1"
                     /codon_start=1
                     /gene="fabG"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     262.3; E-value: 7e-80)"
                     /gene_functions="biosynthetic-additional (t2pks) KR C9
                     (Score: 470.8; E-value: 2.6e-144)"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018103042.1"
                     /locus_tag="STRAU_RS10395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRAU_2109"
                     /product="3-oxoacyl-ACP reductase FabG"
                     /protein_id="WP_016640238.1"
                     /sec_met_domain="adh_short (E-value: 6.4e-37, bitscore:
                     117.2, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQQEQRVALVTGATSGIGLAVARLLAGQGHRVFIGSRTEDKVLT
                     TVKQLQEEQLDVDGTVLDVRSTDSIRAYVQAAVDRFGRVDILVNNAGISGGGVTADIAD
                     DLWNDIIDTNLNSVFRLTREVLTTGGLRERSWGRVINIASTAGKQGVVLGAPYSASKHG
                     VVGFTKALGNELAPTGITVNAVCPGYVETPMAERVRQNYSRLSGAPESAILEKFQAKIP
                     LGRYSTPEEVAGLVGYLASDTAASITSQALNVCGGLGNF"
     aSDomain        9828..10292
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_STRAU_RS10395_PKS_KR.1"
                     /evalue="1.90E-10"
                     /label="STRAU_RS10395_PKS_KR.1"
                     /locus_tag="STRAU_RS10395"
                     /protein_end="162"
                     /protein_start="7"
                     /score="32.8"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="VALVTGATSGIGLAVARLLAGQGHRVFIGSRTEDKVLTTVKQLQE
                     EQLDVDGTVLDVRSTDSIRAYVQAAVDRFGRVDILVNNAGISGGGVTADIADDLWNDII
                     DTNLNSVFRLTREVLTTGGLRERSWGRVINIASTAGKQGVVLGAPYSASKH"
     CDS_motif       9834..9902
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_STRAU_RS10395_0001"
                     /evalue="2.10E-06"
                     /label="PKSI-KR_m1"
                     /locus_tag="STRAU_RS10395"
                     /protein_end="32"
                     /protein_start="9"
                     /score="20.4"
                     /tool="antismash"
                     /translation="LVTGATSGIGLAVARLLAGQGHR"
     gene            10626..11591
                     /locus_tag="STRAU_RS10400"
                     /old_locus_tag="STRAU_2110"
     CDS             10626..11591
                     /NRPS_PKS="Domain: Polyketide_cyc2 (7-146). E-value:
                     1.6e-14. Score: 46.3. Matches aSDomain:
                     nrpspksdomains_STRAU_RS10400_Polyketide_cyc2.1"
                     /NRPS_PKS="Domain: Polyketide_cyc2 (159-280). E-value:
                     8.3e-10. Score: 31.1. Matches aSDomain:
                     nrpspksdomains_STRAU_RS10400_Polyketide_cyc2.2"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1128:cyclase/dehydrase (Score: 415.8; E-value:
                     1.9e-126)"
                     /gene_functions="biosynthetic-additional (t2pks) CYC C7-C12
                     (Score: 443.0; E-value: 1e-135)"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019544758.1"
                     /locus_tag="STRAU_RS10400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRAU_2110"
                     /product="aromatase/cyclase"
                     /protein_id="WP_016640239.1"
                     /transl_table=11
                     /translation="MPSELRTSEHEIKIAAPAESVYRLLAHAENWPQLFPPNIYVDHVE
                     RTGREERIRIWATAGDTVKNWTSRRTLDPDRLRIDFRQEVSTPPVAAMGGTWQVEALPS
                     GETLLRLGHDFRATDDEGLTWLEEVVDRNSRSELDSLKALAESRDGDGDGATDELTCSF
                     EDTVQIKGAAQDVYDFIWEADLWSERLPHVMTVRLDEPVPGLQTLEMDTLSKDGSTHTT
                     KSHRVGLAPHRIAYKQTTLPALITLHTGYWTFTPNDDGVAASSQHTFTVDTGNIAKVLG
                     ADATVQDAIAYVRTALSTNSMATLGIAKTYAEGLAGAGRS"
     aSDomain        10647..11063
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_STRAU_RS10400_Polyketide_cyc2.1"
                     /domain_subtype="Polyketide_cyc2"
                     /evalue="1.60E-14"
                     /label="STRAU_RS10400_Polyketide_cyc2.1"
                     /locus_tag="STRAU_RS10400"
                     /protein_end="146"
                     /protein_start="7"
                     /score="46.3"
                     /tool="antismash"
                     /translation="SEHEIKIAAPAESVYRLLAHAENWPQLFPPNIYVDHVERTGREER
                     IRIWATAGDTVKNWTSRRTLDPDRLRIDFRQEVSTPPVAAMGGTWQVEALPSGETLLRL
                     GHDFRATDDEGLTWLEEVVDRNSRSELDSLKALAE"
     aSModule        10647..11465
                     /domains="nrpspksdomains_STRAU_RS10400_Polyketide_cyc2.1"
                     /domains="nrpspksdomains_STRAU_RS10400_Polyketide_cyc2.2"
                     /incomplete
                     /locus_tags="STRAU_RS10400"
                     /tool="antismash"
                     /type="unknown"
     aSDomain        11103..11465
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_STRAU_RS10400_Polyketide_cyc2.2"
                     /domain_subtype="Polyketide_cyc2"
                     /evalue="8.30E-10"
                     /label="STRAU_RS10400_Polyketide_cyc2.2"
                     /locus_tag="STRAU_RS10400"
                     /protein_end="280"
                     /protein_start="159"
                     /score="31.1"
                     /tool="antismash"
                     /translation="TCSFEDTVQIKGAAQDVYDFIWEADLWSERLPHVMTVRLDEPVPG
                     LQTLEMDTLSKDGSTHTTKSHRVGLAPHRIAYKQTTLPALITLHTGYWTFTPNDDGVAA
                     SSQHTFTVDTGNIAKVL"
     gene            11588..12502
                     /locus_tag="STRAU_RS10405"
                     /old_locus_tag="STRAU_2111"
     CDS             11588..12502
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010038840.1"
                     /locus_tag="STRAU_RS10405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="STRAU_2111"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_016640240.1"
                     /sec_met_domain="Abhydrolase_6 (E-value: 3.6e-12, bitscore:
                     37.3, seeds: 455, tool: rule-based-clusters)"
                     /sec_met_domain="PF00561 (E-value: 1.7e-07, bitscore: 21.1,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTAPVAPFTGRSADPRIDRRHLTLDADGVTLSARLARPAHVPPR
                     ATVVALHGAGMSAGYFDGPAHPETSLLTLAAELGFTAVAVDRPGYGDSAGRLPHGQGVA
                     AQADTLAAALRGLLARHETGAGIFLMGHSFGCKPALRIAADGTVPGLLGLDLSGCGAEY
                     LAAPGAPATRAGSWKLNWGPLRLYPPGTFQSSIDVVAPAPVRELADAAHWPTVFPALAE
                     RVRVPVRFTFAEHEAWWRRDHEALTRLRNRLAAAPRVLIDHQPDAGHNISLGWAARAYH
                     LRALGFAEECLRRYAADGKVVHP"
ORIGIN
        1 atggaagtga cggccacgcg ccgctggctg gccctcggtg cgctcgctct cgcgatgctc
       61 accgtcgggc tcgacatgac cgtgctcaac atcgccctgc cgaccctcgc ccgcgacctg
      121 ggcgccggca ccgcggccct gcagtggttc agcaccgcct acacgctgac gctggccggc
      181 gtgatgctgc ccgccggcgc gctgggcgac cggttcgggc ggaagaaggt cgtgttcggc
      241 gccctggtgc tgttcggcgc ggcttcgatc tggtgcgcgt tcgccgggtc gtcgggcgag
      301 ctgatctcgg cccgcgtgct cctgggcgtc gcggcggcag cgctgatgtc cctgtcgatg
      361 ggcatgatcc cggtgctgtt ccccgacccg gcggaacgcg gccgggccac caccgtgtgg
      421 atcacggcgg tgacactcgg aatgccgctg ggccccatcg tcggcggcct gctgctcaac
      481 cacttctggt ggggctcggt gttcctggtg aacatcccga ccgtcgtcat cggcgcgctc
      541 gcggtgggcc tgtggatgcc ggagtcccgc agccgggtcc gccggcccat cggcccggtc
      601 agcgtggcgc tctcggcggc cggcctcgtc ggtctcacct acggcctgat ccggttcggc
      661 gacctgggct ggggtgacgg cgcggcctgg gcgaccttca tcgcgggcct cgccctgatc
      721 gcgggcttcg tcgcctggga acggacccgg gagcacgccc tggcggatct cagcctcttc
      781 ggagaccgcg gattccgcat gggcacgatc taccaactga tcaacgcctt cgcgatgttc
      841 ggcctgttct tcaccatccc gctgtacttc cagtcggtgc tcggcgtcga ctcgctcggc
      901 agtggcctgc gcatgctccc gatgatcggc ggcctgctgg tggcctcgaa cttcctggag
      961 ggcctgcgcg acaagatcgg cctcaagccg accctgatga tcggcttcgc cctcctcgcg
     1021 gtcgggatgg gactcggcgc cctgaccgac atcggcacct cgtacgcgtt cgtcgccacc
     1081 tggatggcca tcgtcggcct cggcatcggc cttgtgctgc ccacctccat ggcgctggcc
     1141 gtgggcgcgc tcacccccga gcgggcgggt gccggatcgg ccctgctctc ggccctgcgc
     1201 caggcggccg gcaccaccgg cgtggcggtg ctcggcacgg tgctgtccac ccgctaccac
     1261 tccgaactcg gcccgctcaa ccacaagccg atctccgacg gcgtcggctc cggcgtggcc
     1321 gtcgccgatt cactcggcaa caaggcgatg ctccacgacg tccagacggc cttcgtgagc
     1381 ggcatgaacc tgctcctggt cgtctgcgcc ggaatcgccg tcgtcggtct catccttgcg
     1441 gcggtcacca ccaagagccg caccaccgaa cccggggcac agctgcccga ttcggaatcc
     1501 gcgccggtcg cgtaaccacc tatcgatatt ttcccacgag gaagtgatga acatgcgcag
     1561 catggttacc gtctcgaaga tggatcacaa ttccatcccc gaggtctcga agttgttcac
     1621 cgaattcgac agcacggaga tcccgaacct gatcgggctg tgccgccgtc agctgtttgt
     1681 gcacgacgat gtccagatcc acctttacga tttcgccgag caggccgacc agtccgcgct
     1741 cgccaaggtc aagggtgatc cgcggatggc ccgcctctcg atggacctga agccgttcgt
     1801 cgcaccctac gacccggaga catggaattc tccggccgat tccgcggcct tctgtttcta
     1861 cgactggcag gacgagccga tcgagaacgc gggccggacg gacaccaccg tcaccgtcac
     1921 ccggatggac caggcttcga ttcccgccgt cacgagcatc ttccgggagt ccgactccac
     1981 cgaatcccct cgctcgatgg gcacccggcg gcgccagctg ttcgcctacc gggatctgtg
     2041 cattcacatt caggaccacg acggcagcga tggtgcggac atcgcgcaga aggccgcgtc
     2101 ggacatctgg ttcggcaagg tggtccggga ccttccggaa ctcgccgacc agaagcccac
     2161 gacggacggc cacgcgagcc gcttctacgg ctgggtggcg ccgtgacgcg gtgacccgcg
     2221 ggtagtgacg ggtcgtgacg ctgagtaaga gattccggtc tccttacgca gcgtcacaga
     2281 tcgctgctgg tgacagctcc gccgcggagc gaagcgggga aaataacata gcgactacga
     2341 ttacgatgcg actccgattc gtgtacggtg gggcgcgagc gcgtacggca ccgaccggtc
     2401 ggcccgagca aggggggcgc ggacgcggcg gacacacccc gccggaacgc cgctccaccg
     2461 ggggcgccat tgtcggtaat acggcggccc tctgttcgca tattcacgga acgtcgtacc
     2521 accacagtcg gccgcactct gcgattacct cctcaacgta tacggattga aaagacctga
     2581 caaaaaaccg gcggtaaccc ctcctggttc gtgcaagtcg aaactactcg gtctacggtg
     2641 atggtcatca cgcaccctat agttgcgtga acgggaaggg gactgcagga tgtaataatg
     2701 agcattaacc acgcacaggc tgaggtaagt tcgcttctcg accgctatgt tctcgggctc
     2761 gactacgaca aactcgatga cgagtgggcg tacggtcttt tcacgaatga tgtgctcatc
     2821 gaattcccca tcagtcggca cacgggaatc gaaggactcg tcgaatacca ccagaaggct
     2881 ctttcgatgt gggccaggac tcatcatgtg aacacgccgt cgatcgtgag cgtcgacggc
     2941 gaccgtgcga cgctccgggc caatatgacg gcggtgcgcg tgctgcacga gcaggacggc
     3001 gagacgcgtc cgcactactc gaccggtacc tacatcaccg gcgacgcggt gcgtaccgag
     3061 cgcggctggc gcctttcacg tctttcgttc gatctgatat ggaagacggg taacccgccg
     3121 gcctagcggg gtgggcattc atggcccagc agggaaaagc tgagaacggg ggaggccaac
     3181 aaaaatgaaa gcgattcctc aacaggagct actcgaaagc cacgacggtg ggcacggcgc
     3241 gacggtccgg tcgatcttcg gcagcagacg cggcgcccct gcggcgacgc aggcgccgcc
     3301 ccggaacgtg tcggacacct ggcggatcct cgtcgtcgag ggcaacaagg ccgatcgcgc
     3361 gaccctcacc gaagcgctcg cgcgccaggg ccacgatgtc ggtgccgtca actcgggcgg
     3421 ggacgcgctc gcgtcgtacg aggccgcgga cctcgtcgta ctggacctcg atctcccgga
     3481 tctggacggc ctggaggtgt gccgcgagat ccgggcggcc cgcgacaccc cggtcatcac
     3541 cgtcacctca cgcgggtccg agctcgactg cgtgctcgcg ttgcaggccg gagcggacga
     3601 ctacgtcgtc aagccctatg ggctcaggga actcatggcc cggctgaacg ccgtgatgcg
     3661 gcgttcgcgc cgcaccgcgt gcgcggaccc gggcgccgag ggcgccgccg tgctcgagca
     3721 cggcccgctg cggatcgaca gccactcgcg cgaggtcgag atgcgcggcc ggccggttcc
     3781 ggtgacgcgc aaggaattcg atctgctcgc cctgctggcc agcgccccgg gacgggtgat
     3841 ctcgcgggaa tccatcatgc atcaggtgtg gggcgaatcc tggtcccgcc gtaccgtcga
     3901 cacacacgtc agcagcctcc gcaacaagct gggcggaccc gaatggatcg tcactgtccg
     3961 tggggtgggc ttcaaactcc gcagtatgcg ctgacacttc atttgcagcg aattgacatt
     4021 cgttgaacct ggccgtgtaa ctgccccggc tatcgtgagt tcgcaggaag tgcaaactcc
     4081 gatcgagggg cctcatggcg aacgccgaca tcgacgaaac caacgagctc gtcagtttcc
     4141 caattcaacg cacctgccct ttctcggtgc cgcctgtcta caccaagttc cgggaggagt
     4201 caccgatcac ccaggtggtc ctcccggacg gcggaaaagc ctggctggtc accaagtacg
     4261 acgacgtgcg ggccgtgatg gccaatccca agctcagctc ggaccggcgc gcacctgatt
     4321 tcccggtcgt ggtgcccggc cagaacgcgg cactggccaa gcacgccccc ttcatgatta
     4381 ttctcgacgg cgcggagcac gcggcggcgc gacggcccgt catcagtgaa ttctcggtgc
     4441 ggcgggtcgc cgcgatgaag ccgcggatcc aggagatcgt cgacggattc atcgacgaca
     4501 tgctgaagat gccgaagccc gtcgacctga atcaggtctt ctccctgccg gttccttcgc
     4561 tcgtcgtctc cgagatcctc ggcatgccct acgagggcca cgagtacttc atggagctgg
     4621 ccgagatcct gctgcgccgc accaccgacg aacagggccg tatcgccgtc tcggtcgagc
     4681 tgcgcaagta catggacaag ctggtcgagg agaagatcga gaaccccggc gacgacctgc
     4741 tcagccggca gatcgaactg cagcggcagc agggcggcat cgaccgcccg cagctcgcca
     4801 gcctctgcct gctggtgctc ctcgccgggc acgagaccac cgcgaacatg atcaacctcg
     4861 gtgtgttctc gatgctgacg aagccggaac tgctcgcgga gatcaaggcg gatccctcga
     4921 agaccccgaa ggccgtcgac gagctgctgc gcttctacac gattccggac ttcggcgcgc
     4981 accgcctcgc gctggacgac gtggagatcg gcggcgtcct catccgcaag ggcgaggccg
     5041 tcatcgcctc caccttcgcg gcgaaccgcg accccgcggt gttcgacgac ccggaggagc
     5101 tcgacttcgg cagggacgca cggcatcacg tggccttcgg ctacgggccg caccagtgtc
     5161 tgggccagaa cctcggccgc ctggagctcc aggtcgtgtt cgacacgctg ttccggcgcc
     5221 tgccggagct gcgcctcgcc gtgccggaag aggaactgtc gttcaagagc gacgcgttgg
     5281 tctacggcct ctacgaactg cccgtgacgt ggtgaaggag atggccatga aacttgagaa
     5341 ggaccatgac cgctgcatcg gcgcgggtca gtgtgtgctg accgagccga ggctcttcga
     5401 ccaggacgac tggggcctgg tggacatcct ggtcgagcgg ccgcgcggcg ccgacgaggc
     5461 cgccgcccgc aaagcggtct acatctgccc ggcgaaggcg ctgtccctcg tggaggagtg
     5521 aaccgtacga aaaccgcgct ggggcctttc cctgaaagga aaggccccag cgcggttttc
     5581 acttgttctc agtggtcgtg cattccctgg tcgtcacccg tgctccagac gggttcgatc
     5641 tcgatccggg acagcagcca cgccccgtcg gcggtccgca cggcggtgaa ggtgtagcgg
     5701 gcgcccaggt cgaaatgctt ggccgccccg tcccggctca catgcaccgc ggtgacgttc
     5761 gcgcgaatgg tcgcgccatc accctccggt tcgggcagca cattgctcat gtagtgcatg
     5821 gtggtcgccc acatccggtc gtcacgcagc atgccggcca atttctcacg gccgtcgatc
     5881 cggatgtccg gcaccacttc catcgtcacg tccggaacga ataccgtgga cagcgcctcg
     5941 tggtcacggg tgtcgacggc gtgcgcgaat cgcgtcacca gcgcccgcaa tgcgaagaga
     6001 tcttccatgc gcctgatctc ggcggtcgta tccgtggcgg tcgtatccat gttggtcatg
     6061 ccagcgattc tgcgccgcgc ggcaccggcc ctgccccggc ttcaaggtct tctgacgaag
     6121 atctgacgaa gatttacctc tgtgcacatc gctgaatctc ccgcgccgaa ataccacaca
     6181 gtcctgaagt tgcccgtatt gaaacctgta ttgggtgccg gaagactcgt ttctcgtcac
     6241 cggctcgatc agtgcggaag tgcggagaaa agaagcatgc acagcagtgt catcgtgggc
     6301 aggctgaaac ctggatccac cgaggatgtc gtcggcgcct tcgcgaagct ggacggcgcg
     6361 ccgtccggca ccaggaagct cctgcgccgc cagctcttcg cgtacaaagg cgtctacatc
     6421 cacctccagg accacaccga ggacaacctc accgaggtcg tggagcacgg cgccggcgcc
     6481 gcgttggccc cgttcgtcga cgcctacggc ccggccgccg gcaccgcgcc ttcggacctg
     6541 gtcgcgacgc ggttctacga gtggcacgga cagccggtga ccgacgagca ccggatgtac
     6601 agcaccatga tcgtggcccg cctcgacccc gccgacatcg gcaccgtcgc caagctgttc
     6661 ggggacttcg acagcggcac cgagctgccg cacaccatgg gcacccggcg ccgccagctg
     6721 ttcgcgtaca acgggctcta cttccacatc caggacttcg agtccgacaa cggcggccgg
     6781 ctgatcgagc aggcgaagtc cgacccgcgc ttcgtgcaga tccagaagga cctgctgccc
     6841 tacatccacg tcttcgaccc ggagacgtgg cgctcgccct ccgacgccat ggcgcagcgc
     6901 ttctacacct ggcaggtcgc cgcatgagcg gccgtcgcgt ggtcgtcacc gggatggagg
     6961 tgctggcccc cggcggtgtg ggcaccgaca acttctggtc cctgctgagc gaaggccgca
     7021 cggccacccg gggcatcacc ttcttcgacc ccgcccagtt ccgctcgcgc gtggccgcgg
     7081 agatcgactt cgatccgtac gcgcacggcc tcaccccgca ggaagtgcgg cgcatggacc
     7141 gtgccgcgca gttcgcggtg gtcgcggcgc gcggtgccgt cgcggacagc ggcctcgaca
     7201 cggacaccct ggacccctac cggatcggtg tcaccatcgg cagcgcggtc ggcgccacga
     7261 tgagcctcga cgaggactac cgcgtcgtca gcgacgcggg ccggctcgat ctggtcgacc
     7321 acacctacgc cgaccccttc ttctacaact acttcgtgcc gagctccttc gccaccgagg
     7381 tcgcccggct cgtgggcgcg caggggccga gcagcgtggt gtcggcgggg tgcacgtccg
     7441 gcctcgactc ggtcgggtac gccgtcgagc tgatcaggga aggcacggcg gacgtcatgg
     7501 tcgccggcgc caccgacgcg ccgatctcgc cgatcacgat ggcctgcttc gacgcgatca
     7561 aggcgaccac gcctcgtcac gacgacccgg agcacgcctc ccggccgttc gacgacaccc
     7621 gcaacggctt cgtactcggt gagggcacgg cggtgttcgt cctcgaggag ctggagagcg
     7681 cgcgccgccg gggcgcgcgg atctacgcgg agatcgcggg ctacgcgaca cgcagcaacg
     7741 cgtaccacat gacgggattg cgccccgacg gcgccgagat ggccgaggcc atcacggtgg
     7801 cgctcgacga ggcccggatg aacccgaccg cgatcgacta catcaacgcg cacggctcgg
     7861 gcaccaagca gaacgaccgg cacgagaccg ccgccttcaa gcgcagcctc ggcgagcacg
     7921 cgtaccgcac ccccgtgagc tccatcaagt ccatggtggg ccactcactc ggcgcgatcg
     7981 gctcgatcga gatcgcggcg tcgatcctgg cgatccagca cgacgtggtc ccgccgacgg
     8041 cgaatctgca cacccccgac ccccagtgcg acctcgacta cgtccccctg aacgcacgcg
     8101 agcagatcgt cgacgccgtc ctcacggtcg gcagcggctt cggcgggttc cagagcgcga
     8161 tggtgctggc ccaacccgaa aggaacgcgg catgacggcc tcctctgtgg tggtgaccgg
     8221 actgggcgtc gtctcgccca acgggctcgg tacgcagggc cattggagcg cgagccgggt
     8281 cggcaagagc gccatcggcc cgctcacccg cttcgacgcg acgccgtacc cggcgaagct
     8341 ggccggggag atcagcggct tcgcggccga ggagcatctg cccagccgcc tgatgccgca
     8401 gaccgaccag gtcacccggc tctcgctggt cgcggcagac tgggcgctcg ccgacgccgg
     8461 tgtgaacccc gccgagctgc ccgccttcga catgggcgtg atcaccgcca gctcggccgg
     8521 cggattcgag ttcagccaga acgagctcaa gagcctgtgg agcaagggcg gggagtacgt
     8581 cagcgcgtac cagtcgttcg cctggttcta cgcggtcaac accggccaga tctccatccg
     8641 caacgggatg aagggcccca gcggcgtcgt cgtcaccgac caggccggcg gcctcgacgc
     8701 ggtggcgcag gcccgccgtc agatccgcaa gggcacctcc ctggtggtgg cgggcgccgt
     8761 ggacgcgctg ctgtgctcct ggggctgggt gggtctgggc accagcggcc ggctgagcac
     8821 cgaggaggaa cccagccgcg cctacctccc cttcgacgac cgcgcggccg gccatgtgcc
     8881 cggtgagggc ggcgccctgc tcatcctgga gtccgccgac tccgcccacg cccgcggagc
     8941 cgaggtgtac ggcgagatcg ccggatacgc cgccacgttc gacgggcgcg agccgggcct
     9001 ccgcaaggcc gtcgaactcg ccctcgccga cgccggcctg gcggcatcgg acgtggacgt
     9061 ggtcttcgcg gacggcgcgg ccgagcccga gctcgaccgg atcgaggccg aggccctcgt
     9121 cgaggtgttc ggcgagcggg gcgtcccggt caccgcgccc aagacgatga ccggccgcct
     9181 gtacgcgggc ggggccgccc tcgacctcgc caccgccttc ctcgcgatgg aggagggcct
     9241 gatcccgccg accgtccaca cggagcccgc cgaacggtac ggcctcgacc tggtggtctc
     9301 gcagccgcgc gccgccgacg tgcgcacggc gctcgtcctc gcccgcggcc acggcggctt
     9361 caactcggcg atggtcgtac gttcctgagc ccgccgctcc cggcacgaac cccgcacccc
     9421 gaccccacct ccatgaaagg caggaccctc atgtcccgct ccaccttcac cctcgacgac
     9481 ctcaagcgga tcctcctcga aggctccggc gcccccgagg gcgacggtct cgacggcgac
     9541 gtcctcgaca ccgagttcac cgacatcggc tacgactcgc tcgcgctcct ggagacctcc
     9601 agccggatcg agcgcgagta cggcatcgag ctggacgagt ccgtcgtcgg cgaggccacg
     9661 acgccgcgcg ccttcatcgc cgccgtcacc gggcacctca cggtcgcggc cgcctgagca
     9721 cggccgcacc cggccgcacc cggccacacc cggccaccac ccagccgcac aagatccgaa
     9781 gacagcagga cccgagaagg ggagacatga cacagcagga gcagcgcgtc gctctggtga
     9841 ccggcgccac cagcggaatc ggcctggccg tggcccggct gctggccggg cagggccacc
     9901 gggtgttcat cggttcgcgt accgaggaca aggtgctgac cacggtcaag cagcttcagg
     9961 aggagcagct cgacgtggac ggcacggtcc tcgacgtgcg gtcgacggac tcgatacgcg
    10021 cctacgtcca ggccgccgtc gaccggttcg gcagggtcga catcctcgtc aacaacgcgg
    10081 gcatcagcgg cggcggcgtg acggccgaca tcgccgacga cctgtggaac gacatcatcg
    10141 acaccaacct caacagcgtg ttccggctga cccgggaggt cctcaccacg ggcggcctgc
    10201 gggagcggag ctggggccgc gtcatcaaca tcgcctccac cgccggcaag cagggcgtgg
    10261 tgctcggggc gccgtactcc gcctccaagc acggcgtcgt cggcttcacc aaggcgctgg
    10321 gcaacgagct ggcgcccacc ggcatcaccg tcaacgccgt ctgccccggc tatgtcgaga
    10381 cgccgatggc cgagcgcgta cggcagaact actcccgcct ctccggcgcc cccgagagcg
    10441 ccattctgga gaagttccag gccaagatcc cgctgggccg ctactcgacc cccgaggaag
    10501 tggccgggct cgtgggctat ctggcctccg acacggcggc gtccatcacc tcccaggccc
    10561 tgaacgtctg tggtggcctc ggcaacttct gaccgcacca cgcccgttcc tacccgagga
    10621 tccccatgcc gtccgaactg cgtacatccg agcacgagat caagatcgcg gcaccggccg
    10681 agagcgtcta ccggctgctg gcgcacgcgg agaactggcc ccagctgttt cctccgaaca
    10741 tctacgtcga ccatgtggag cgcaccgggc gcgaggagcg catccgcatc tgggcgacgg
    10801 ccggcgacac cgtcaagaac tggacctcgc gccgcaccct ggacccggac cggctccgca
    10861 tcgacttccg gcaggaggtc agcacgcccc ccgtcgccgc catgggggga acctggcagg
    10921 tcgaggcgct cccctcggga gagaccctgc tgcgccttgg ccacgacttc cgggcgaccg
    10981 acgacgaggg cctgacctgg ctcgaagagg tcgtggaccg caactcccgc tccgaactcg
    11041 actctttgaa ggcactcgcc gagtcgcggg acggggacgg ggacggggcc accgacgaac
    11101 tgacgtgctc cttcgaggac acggtgcaga tcaagggggc cgcccaggac gtgtacgact
    11161 tcatctggga agccgacctg tggtccgagc ggctgcccca cgtgatgacg gtgcgcctgg
    11221 acgagccggt gccggggctg cagaccctgg agatggacac gctgtccaag gacggcagca
    11281 cccacaccac gaagtcgcac cgggttggcc tcgccccgca ccggatcgcg tacaagcaga
    11341 cgacgctgcc cgcgctgatc acgctgcaca cggggtactg gacgttcacg ccgaacgacg
    11401 acggtgtcgc ggcctcctcg cagcacacct tcacggtcga caccggcaac atcgccaagg
    11461 tgctcggcgc ggacgcgacg gtgcaggacg cgatcgcgta cgtacgcacc gcgctcagca
    11521 ccaacagcat ggcgacgctc ggcatcgcga agacgtacgc ggaagggctc gccggggcag
    11581 gccggtcatg accacggcac ccgttgcccc cttcacgggg cggtcggccg acccccggat
    11641 cgaccgacgc cacctcacgc tggacgcgga cggcgtcacg ctgtccgccc ggctcgcccg
    11701 cccggcgcac gtcccgccga gggccacggt cgtcgcgctg cacggggcgg ggatgagcgc
    11761 cgggtacttc gacgggcccg cgcacccgga gacctcgctc ctgacgctcg ccgcggaact
    11821 gggcttcacg gccgtggccg tcgaccgccc cggatacggc gattcggcgg gccggctccc
    11881 ccacggccag ggggtcgcgg cgcaggccga caccctggcg gcggcgctgc gcgggctgct
    11941 cgcgcggcac gagacaggcg cggggatctt cctgatgggg cactccttcg gctgcaagcc
    12001 cgcgttgcgg atcgcggccg acggcacggt ccccggcctc ctcggcctcg acctgtccgg
    12061 ctgcggggcc gagtacctgg ccgcccccgg cgcaccggcc acccgcgccg gcagctggaa
    12121 gctcaactgg ggccccctgc ggctgtatcc gccggggacg ttccagtcca gcatcgatgt
    12181 cgtcgccccg gccccggtgc gcgagctggc ggacgccgcc cactggccga cggtgttccc
    12241 cgcgctcgcg gagcgggtac gcgttccggt ccggttcacc ttcgccgagc acgaggcgtg
    12301 gtggcgccgc gaccacgagg cactcacgcg gctgcggaac cggctggccg cggcgccccg
    12361 ggtcctgatc gaccaccagc ccgacgcggg ccacaacatc agcctcggct gggcggcacg
    12421 cgcctaccac ctgcgggcgc tcggcttcgc ggaggagtgt ctgcgccggt acgcggccga
    12481 cggcaaggtc gtgcacccct ga
//
