BGC0002000: setomimycin biosynthetic gene cluster from Streptomyces aurantiacus JA 4570
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 2,057 - 14,558 nt. (total: 12,502 nt).
This entry is originally from NCBI GenBank NZ_AOPZ01000074.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002000
Short description setomimycin biosynthetic gene cluster from Streptomyces aurantiacus JA 4570
Status Minimal annotation: yes
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide
Loci NCBI GenBank: NZ_AOPZ01000074.1
Compounds
  • setomimycin
Species Streptomyces aurantiacus JA 4570 [taxonomy]
References
Chemical products information
setomimycin
Copy SMILES
C34H28O9
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • STRAU_RS10340
  • WP_016640227.1
 2057 - 3571 (+) DHA2 family efflux MFS transporter permease subunit
copy AA seq
copy Nt seq
  • STRAU_RS38955
  • WP_158692054.1
 3609 - 4262 (+) TcmI family type II polyketide cyclase
copy AA seq
copy Nt seq
  • STRAU_RS10350
  • WP_016640229.1
 4754 - 5182 (+) nuclear transport factor 2 family protein
copy AA seq
copy Nt seq
  • STRAU_RS10355
  • WP_078621122.1
 5241 - 6050 (+) response regulator transcription factor
copy AA seq
copy Nt seq
  • STRAU_RS10360
  • WP_052029032.1
 6151 - 7371 (+) cytochrome P450
copy AA seq
copy Nt seq
  • STRAU_RS10365
  • WP_037658546.1
 7383 - 7577 (+) (4Fe-4S)-binding protein
copy AA seq
copy Nt seq
  • STRAU_RS10370
  • WP_016640233.1
 7645 - 8115 (-) nuclear transport factor 2 family protein
copy AA seq
copy Nt seq
  • STRAU_RS41390
 8333 - >8620 (+) TcmI family type II polyketide cyclase
copy AA seq
copy Nt seq
  • STRAU_RS41395
  • WP_037658559.1
 8651 - 8983 (+) TcmI family type II polyketide cyclase
copy AA seq
copy Nt seq
  • STRAU_RS10380
  • WP_037658548.1
 8980 - 10251 (+) beta-ketoacyl-[acyl-carrier-protein] synthase family protein
copy AA seq
copy Nt seq
  • STRAU_RS10385
  • WP_037658550.1
 10248 - 11444 (+) ketosynthase chain-length factor
copy AA seq
copy Nt seq
  • STRAU_RS10390
  • WP_016640237.1
 11507 - 11773 (+) acyl carrier protein
copy AA seq
copy Nt seq
  • STRAU_RS10395
  • WP_016640238.1
  • fabG
 11863 - 12648 (+) 3-oxoacyl-ACP reductase FabG
copy AA seq
copy Nt seq
  • STRAU_RS10400
  • WP_016640239.1
 12682 - 13647 (+) aromatase/cyclase
copy AA seq
copy Nt seq
  • STRAU_RS10405
  • WP_016640240.1
 13644 - 14558 (+) alpha/beta fold hydrolase
copy AA seq
copy Nt seq
Annotation changelog
MIBiG version Submitter Notes
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Cleaned up synonym list
  • Fetch compound properties from PubChem
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.