BGC0002000: setomimycin biosynthetic gene cluster from Streptomyces aurantiacus JA 4570
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Location: 2,057 - 14,558 nt. (total: 12,502 nt).
This entry is originally from NCBI GenBank NZ_AOPZ01000074.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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General
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Biosynthesis
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NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002000
Short description setomimycin biosynthetic gene cluster from Streptomyces aurantiacus JA 4570
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
Loci
NZ_AOPZ01000074.1
2057 - 14558
via
Compounds
  • setomimycin
Species Streptomyces aurantiacus JA 4570 [taxonomy]
References
Chemical products information
setomimycin Evidence:
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C34H28O9
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • STRAU_RS10340
  • WP_016640227.1
 2057 - 3571 (+) DHA2 family efflux MFS transporter permease subunit
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    • STRAU_RS38955
    • WP_158692054.1
    		 3609 - 4262 (+) TcmI family type II polyketide cyclase
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      • STRAU_RS10350
      • WP_016640229.1
      		 4754 - 5182 (+) nuclear transport factor 2 family protein
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        • STRAU_RS10355
        • WP_078621122.1
        		 5241 - 6050 (+) response regulator transcription factor
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          • STRAU_RS10360
          • WP_016640231.1
          		 6223 - 7371 (+) cytochrome P450
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            • STRAU_RS10365
            • WP_037658546.1
            		 7383 - 7577 (+) (4Fe-4S)-binding protein
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              • STRAU_RS10370
              • WP_016640233.1
              		 7645 - 8115 (-) nuclear transport factor 2 family protein
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                • STRAU_RS41390
                		 8333 - >8608 (+) TcmI family type II polyketide cyclase
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                  • STRAU_RS41395
                  • WP_037658559.1
                  		 8651 - 8983 (+) TcmI family type II polyketide cyclase
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                    • STRAU_RS10380
                    • WP_037658548.1
                    		 8980 - 10251 (+) beta-ketoacyl-[acyl-carrier-protein] synthase family protein
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                      • STRAU_RS10385
                      • WP_037658550.1
                      		 10248 - 11444 (+) ketosynthase chain-length factor
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                        • STRAU_RS10390
                        • WP_016640237.1
                        		 11507 - 11773 (+) acyl carrier protein
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                          • STRAU_RS10395
                          • WP_016640238.1
                          • fabG
                          		 11863 - 12648 (+) 3-oxoacyl-ACP reductase FabG
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                            • STRAU_RS10400
                            • WP_016640239.1
                            		 12682 - 13647 (+) aromatase/cyclase
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                              • STRAU_RS10405
                              • WP_016640240.1
                              		 13644 - 14558 (+) alpha/beta fold hydrolase
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                                Biosynthesis information
                                Annotation changelog

                                Entry version: 3

                                Date
                                Changes
                                Submitters
                                Reviewers
                                2022-10-07
                                Update chemical activity to schema version 2.11
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                Entry version: 2

                                Date
                                Changes
                                Submitters
                                Reviewers
                                2022-09-15
                                Cleaned up synonym list
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                2022-09-15
                                Fetch compound properties from PubChem
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                2022-09-15
                                Updated bioactivity data
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                Entry version: 1

                                Date
                                Changes
                                Submitters
                                Reviewers
                                2019-10-16
                                Submitted
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                Detailed domain annotation
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