BGC0002009: kanglemycin A biosynthetic gene cluster from Amycolatopsis vancoresmycina
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 420,871 - 534,653 nt. (total: 113,783 nt).
This entry is originally from NCBI GenBank NZ_JNYY01000005.1.

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC

MIBiG accession | BGC0002009
Short description | kanglemycin A biosynthetic gene cluster from Amycolatopsis vancoresmycina
Status | Quality: questionable The quality level of this entry. Status: active The status of this entry. Completeness: unknown Whether the entry covers everything needed for the pathway producing the compound(s)

Biosynthetic class(es)

- PKS (Unknown)

Loci
NZ_JNYY01000005.1
420871 - 518113
via
Compounds

- kanglemycin A
- kanglemycin V1
- kanglemycin V2

Species Amycolatopsis vancoresmycina [taxonomy]
References

- [1] Mode of Action of Kanglemycin A, an Ansamycin Natural Product that Is Active against Rifampicin-Resistant Mycobacterium tuberculosis. Mosaei, H et al., Molecular Cell (2018) DOI:10.1016/j.molcel.2018.08.028
- [2] Rifamycin congeners kanglemycins are active against rifampicin-resistant bacteria via a distinct mechanism. Peek J et al., Nat Commun (2018) PMID:30297823

Chemical products information
kanglemycin A Evidence:
(no structure information available)
kanglemycin V1 Evidence:
(no structure information available)
kanglemycin V2 Evidence:
(no structure information available)
List of genes involved in compound(s) production

Identifiers | Position | Product | Functions | Evidence | Extra
--- | --- | --- | --- | --- | ---
OO60_RS14025 WP_003071771.1 | 420872 - 422086 (-) | helix-turn-helix transcriptional regulator |  |  | copy AA seq copy Nt seq
OO60_RS14030 WP_003071773.1 | 422651 - 423100 (-) | type II 3-dehydroquinate dehydratase |  |  | copy AA seq copy Nt seq
OO60_RS14035 WP_003071775.1 | 423344 - 424603 (+) | cytochrome P450 |  |  | copy AA seq copy Nt seq
OO60_RS14040 WP_003071776.1 | 424672 - 425583 (-) | transketolase |  |  | copy AA seq copy Nt seq
OO60_RS14045 WP_003071778.1 | 425580 - 426275 (-) | thiamine pyrophosphate-dependent enzyme |  |  | copy AA seq copy Nt seq
OO60_RS14050 WP_003071780.1 | 426474 - 427742 (+) | cytochrome P450 |  |  | copy AA seq copy Nt seq
OO60_RS14055 WP_003071782.1 | 427786 - 428523 (+) | alpha/beta fold hydrolase |  |  | copy AA seq copy Nt seq
OO60_RS14060 WP_033261516.1 | 428541 - 429746 (+) | acyltransferase |  |  | copy AA seq copy Nt seq
OO60_RS14065 WP_003071786.1 | 429743 - 431197 (+) | bifunctional 3-(3-hydroxy-phenyl)propionate/3-hydroxycinnamic acid hydroxylase |  |  | copy AA seq copy Nt seq
OO60_RS14070 WP_003071788.1 | 431194 - 432228 (-) | CoA transferase |  |  | copy AA seq copy Nt seq
OO60_RS14075 WP_003071791.1 | 432225 - 432620 (-) | cobalamin B12-binding domain-containing protein |  |  | copy AA seq copy Nt seq
OO60_RS14080 WP_033261449.1 | 432620 - 434197 (-) | methylmalonyl-CoA mutase family protein |  |  | copy AA seq copy Nt seq
OO60_RS14085 WP_003071800.1 | 434267 - 436051 (-) | ABC transporter ATP-binding protein |  |  | copy AA seq copy Nt seq
OO60_RS14090 WP_051767685.1 | 436051 - 437820 (-) | ABC transporter ATP-binding protein |  |  | copy AA seq copy Nt seq
OO60_RS14095 WP_244885523.1 | 438046 - 440025 (+) | multicopper oxidase domain-containing protein |  |  | copy AA seq copy Nt seq
OO60_RS14100 WP_004562633.1 | 440095 - 441690 (-) | acyl-CoA carboxylase subunit beta |  |  | copy AA seq copy Nt seq
OO60_RS14105 WP_004562634.1 | 441797 - 443062 (-) | cytochrome P450 |  |  | copy AA seq copy Nt seq
OO60_RS14110 WP_004562636.1 | 443253 - 444419 (-) | cytochrome P450 |  |  | copy AA seq copy Nt seq
OO60_RS14115 WP_004562638.1 | 444652 - 446076 (+) | NDP-hexose 2,3-dehydratase family protein |  |  | copy AA seq copy Nt seq
OO60_RS14120 WP_004562640.1 | 446120 - 447271 (+) | glycosyltransferase |  |  | copy AA seq copy Nt seq
OO60_RS14125 WP_004562641.1 | 447297 - 448277 (+) | 5'/3'-nucleotidase SurE |  |  | copy AA seq copy Nt seq
OO60_RS14130 WP_004562642.1 | 448338 - 449105 (-) | TylF/MycF/NovP-related O-methyltransferase |  |  | copy AA seq copy Nt seq
OO60_RS14135 WP_004562643.1 | 449124 - 450185 (-) | aldo/keto reductase |  |  | copy AA seq copy Nt seq
OO60_RS14140 WP_004562644.1 | 450215 - 450976 (-) | NAD-dependent epimerase/dehydratase family protein |  |  | copy AA seq copy Nt seq
OO60_RS14145 WP_156081305.1 | 450976 - 454188 (-) | S41 family peptidase |  |  | copy AA seq copy Nt seq
OO60_RS14150 WP_003062297.1 | 454346 - 455542 (+) | cytochrome P450 |  |  | copy AA seq copy Nt seq
OO60_RS14155 WP_003062299.1 | 455532 - 456416 (-) | ROK family protein |  |  | copy AA seq copy Nt seq
OO60_RS14160 WP_003062302.1 | 456422 - 457120 (-) | HAD-IA family hydrolase |  |  | copy AA seq copy Nt seq
OO60_RS14165 WP_033261451.1 | 457133 - 458206 (-) | Gfo/Idh/MocA family oxidoreductase |  |  | copy AA seq copy Nt seq
OO60_RS14170 WP_003062304.1 rifK | 458280 - 459440 (-) | 3-amino-5-hydroxybenzoate synthase |  |  | copy AA seq copy Nt seq
OO60_RS46435 WP_155848838.1 | 459483 - 459689 (-) | hypothetical protein |  |  | copy AA seq copy Nt seq
OO60_RS14175 WP_033261524.1 | 459774 - 460562 (-) | shikimate dehydrogenase |  |  | copy AA seq copy Nt seq
OO60_RS14180 WP_004559804.1 | 460559 - 461815 (-) | 3-deoxy-7-phosphoheptulonate synthase |  |  | copy AA seq copy Nt seq
OO60_RS14185 WP_004559805.1 | 461812 - 462867 (-) | 3-dehydroquinate synthase family protein |  |  | copy AA seq copy Nt seq
OO60_RS14190 WP_004559806.1 | 462864 - 463052 (-) | hypothetical protein |  |  | copy AA seq copy Nt seq
OO60_RS14195 WP_004559807.1 | 463071 - 463847 (-) | arylamine N-acetyltransferase |  |  | copy AA seq copy Nt seq
OO60_RS14200 WP_033261452.1 | 463865 - 474211 (-) | type I polyketide synthase |  |  | copy AA seq copy Nt seq
OO60_RS14205 WP_240490790.1 | 474264 - 479618 (-) | type I polyketide synthase |  |  | copy AA seq copy Nt seq
OO60_RS14210 WP_033261453.1 | 479767 - 485190 (-) | type I polyketide synthase |  |  | copy AA seq copy Nt seq
OO60_RS14215 WP_033261454.1 | 485200 - 500367 (-) | type I polyketide synthase |  |  | copy AA seq copy Nt seq
OO60_RS14220 WP_003060229.1 | 500401 - 514653 (-) | type I polyketide synthase |  |  | copy AA seq copy Nt seq
OO60_RS14225 WP_003060232.1 | 514695 - 515885 (-) | cytochrome P450 |  |  | copy AA seq copy Nt seq
OO60_RS14230 WP_033261526.1 | 515919 - 516134 (-) | DUF5988 family protein |  |  | copy AA seq copy Nt seq
OO60_RS14235 WP_003060236.1 | 516321 - 517088 (-) | Gfo/Idh/MocA family oxidoreductase |  |  | copy AA seq copy Nt seq
OO60_RS14240 WP_240490590.1 | 517085 - 518077 (-) | Gfo/Idh/MocA family oxidoreductase |  |  | copy AA seq copy Nt seq

Biosynthesis information

No biosynthesis information available for this record.

Annotation changelog

#### Entry version: 3

Date
Changes
Submitters
Reviewers
2022-10-07
Update chemical activity to schema version 2.11

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

#### Entry version: 2

Date
Changes
Submitters
Reviewers
2022-09-15
Added chemical activity and supporting publication

- (ID: SJG3CBEHSM6A3I74YXLH6GLA)

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

2022-09-15
Refined reference coordinates

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

#### Entry version: 1

Date
Changes
Submitters
Reviewers
2019-10-16
Submitted

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains