BGC0002010: streptophenazine B biosynthetic gene cluster from Streptomyces sp. CNB091
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Location: 87,617 - 148,726 nt. (total: 61,110 nt).
This entry is originally from NCBI GenBank NZ_KB899004.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0002010
Short description streptophenazine B biosynthetic gene cluster from Streptomyces sp. CNB091
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Unknown)
Loci
NZ_KB899004.1
101033 - 137766
via
Compounds
  • streptophenazine B
  • streptophenazine C
  • streptophenazine F
  • streptophenazine G
  • streptophenazine H
Species Streptomyces sp. CNB091 [taxonomy]
References
Chemical products information
streptophenazine B Evidence:
(no structure information available)
streptophenazine C Evidence:
(no structure information available)
streptophenazine F Evidence:
(no structure information available)
streptophenazine G Evidence:
(no structure information available)
streptophenazine H Evidence:
(no structure information available)
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • D581_RS0125465
  • WP_018960012.1
 101033 - 102022 (-) cytochrome d ubiquinol oxidase subunit II
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    • D581_RS01000000137710
    • WP_018960013.1
    		 102086 - 103405 (-) cytochrome ubiquinol oxidase subunit I
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      • D581_RS0125475
      • WP_018960014.1
      		 103464 - 104345 (-) LysR substrate-binding domain-containing protein
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        • D581_RS0125480
        • WP_018960015.1
        		 104482 - 106284 (-) fatty acyl-AMP ligase
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          • D581_RS0125485
          • WP_018960016.1
          • ccrA
          		 106281 - 107531 (-) crotonyl-CoA carboxylase/reductase
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            • D581_RS01000000137715
            • WP_018960017.1
            		 107617 - 110019 (-) type I polyketide synthase
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              • D581_RS0125495
              • WP_018960018.1
              		 110075 - 111130 (-) aldo/keto reductase
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                • D581_RS01000000137720
                • WP_018960019.1
                		 111197 - 111991 (-) alpha/beta fold hydrolase
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                  • D581_RS01000000137725
                  • WP_018960020.1
                  		 111988 - 114729 (-) type I polyketide synthase
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                    • D581_RS0125510
                    • WP_018960021.1
                    		 114722 - 115051 (-) phosphopantetheine-binding protein
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                      • D581_RS0125515
                      • WP_018960022.1
                      		 115217 - 116662 (-) aldehyde dehydrogenase family protein
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                        • D581_RS0125520
                        • WP_018960023.1
                        		 116662 - 117759 (-) hypothetical protein
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                          • D581_RS01000000137730
                          • WP_199787837.1
                          		 117927 - 118298 (+) hypothetical protein
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                            • D581_RS0125530
                            • WP_018960025.1
                            		 118305 - 119672 (-) FAD-binding protein
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                              • D581_RS01000000137735
                              • WP_063738219.1
                              		 119714 - 121351 (-) amino acid adenylation domain-containing protein
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                                • D581_RS0125540
                                • WP_018960027.1
                                • phzG
                                		 121438 - 122100 (-) phenazine biosynthesis FMN-dependent oxidase PhzG
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                                  • D581_RS0125545
                                  • WP_018960028.1
                                  		 122184 - 123035 (-) PhzF family phenazine biosynthesis isomerase
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                                    • D581_RS0125550
                                    • WP_018960029.1
                                    		 123103 - 124986 (-) phenazine-specific anthranilate synthase component I
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                                      • D581_RS0125555
                                      • WP_018960030.1
                                      		 124983 - 125606 (-) isochorismatase family protein
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                                        • D581_RS0125560
                                        • WP_018960031.1
                                        		 125629 - 126804 (-) 3-deoxy-7-phosphoheptulonate synthase
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                                          • D581_RS0125565
                                          • WP_018960032.1
                                          		 126857 - 127357 (-) PhzA/PhzB family protein
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                                            • D581_RS0125570
                                            • WP_018960033.1
                                            		 127692 - 128726 (+) ketoacyl-ACP synthase III family protein
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                                              • D581_RS01000000137740
                                              • WP_018960034.1
                                              		 128785 - 129078 (+) phosphopantetheine-binding protein
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                                                • D581_RS0125580
                                                • WP_018960035.1
                                                		 129113 - 131653 (-) LuxR C-terminal-related transcriptional regulator
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                                                  • D581_RS0125585
                                                  • WP_158688635.1
                                                  		 131739 - 132608 (-) class I SAM-dependent methyltransferase
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                                                    • D581_RS0125590
                                                    • WP_018960037.1
                                                    		 132789 - 134339 (-) MFS transporter
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                                                      • D581_RS0125595
                                                      • WP_018960038.1
                                                      		 134459 - 136804 (-) FAD-dependent oxidoreductase
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                                                        • D581_RS0125600
                                                        • WP_018960039.1
                                                        		 137143 - 137766 (-) TetR/AcrR family transcriptional regulator
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                                                          Biosynthesis information

                                                          Biosynthetic modules

                                                          Name
                                                          Unk01
                                                          Type
                                                          nrps-type1
                                                          Genes
                                                          D581_RS0125520
                                                          Substrates
                                                          phenazine-1,6-dicarboxylic acid, phenazine-1-carboxylic acid (evidence: Structure-based inference)
                                                          Integrated Monomers
                                                          Domains
                                                          adenylation
                                                          Name
                                                          Unk02
                                                          Type
                                                          nrps-type1
                                                          Genes
                                                          D581_RS01000000137735
                                                          Substrates
                                                          N-formylglycine, N-formylalanine (evidence: Knock-out studies, Mass spectrometry)
                                                          Integrated Monomers
                                                          Domains
                                                          adenylation
                                                          Annotation changelog

                                                          Entry version: 3

                                                          Date
                                                          Changes
                                                          Submitters
                                                          Reviewers
                                                          2022-10-07
                                                          Update chemical activity to schema version 2.11
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                          Entry version: 2

                                                          Date
                                                          Changes
                                                          Submitters
                                                          Reviewers
                                                          2022-09-15
                                                          Updated bioactivity data
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          2022-09-15
                                                          Added NRP substrate specificities
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                          Entry version: 1

                                                          Date
                                                          Changes
                                                          Submitters
                                                          Reviewers
                                                          2019-10-16
                                                          Submitted
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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