BGC0002010: streptophenazine B biosynthetic gene cluster from Streptomyces sp. CNB091
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Location: 101,033 - 137,766 nt. (total: 36,734 nt).
This entry is originally from NCBI GenBank NZ_KB899004.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002010
Short description streptophenazine B biosynthetic gene cluster from Streptomyces sp. CNB091
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide
Loci NCBI GenBank: NZ_KB899004.1
Compounds
  • streptophenazine B
  • streptophenazine C
  • streptophenazine F
  • streptophenazine G
  • streptophenazine H
Species Streptomyces sp. CNB091 [taxonomy]
References
Chemical products information
streptophenazine B
(no structure information available)
streptophenazine C
(no structure information available)
streptophenazine F
(no structure information available)
streptophenazine G
(no structure information available)
streptophenazine H
(no structure information available)
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • D581_RS0125465
  • WP_018960012.1
 101033 - 102022 (-) cytochrome d ubiquinol oxidase subunit II
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  • D581_RS01000000137710
  • WP_018960013.1
 102086 - 103405 (-) cytochrome ubiquinol oxidase subunit I
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  • D581_RS0125475
  • WP_018960014.1
 103464 - 104345 (-) LysR substrate-binding domain-containing protein
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  • D581_RS0125480
  • WP_018960015.1
 104482 - 106284 (-) fatty acyl-AMP ligase
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  • D581_RS0125485
  • WP_018960016.1
  • ccrA
 106281 - 107531 (-) crotonyl-CoA carboxylase/reductase
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  • D581_RS01000000137715
  • WP_018960017.1
 107617 - 110019 (-) type I polyketide synthase
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  • D581_RS0125495
  • WP_018960018.1
 110075 - 111130 (-) aldo/keto reductase
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  • D581_RS01000000137720
  • WP_018960019.1
 111197 - 111991 (-) alpha/beta fold hydrolase
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  • D581_RS01000000137725
  • WP_018960020.1
 111988 - 114729 (-) type I polyketide synthase
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  • D581_RS0125510
  • WP_018960021.1
 114722 - 115051 (-) phosphopantetheine-binding protein
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  • D581_RS0125515
  • WP_018960022.1
 115217 - 116662 (-) aldehyde dehydrogenase family protein
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  • D581_RS0125520
  • WP_018960023.1
 116662 - 117759 (-) hypothetical protein
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  • D581_RS01000000137730
  • WP_199787837.1
 117927 - 118298 (+) hypothetical protein
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  • D581_RS0125530
  • WP_018960025.1
 118305 - 119672 (-) FAD-binding protein
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  • D581_RS01000000137735
  • WP_063738219.1
 119714 - 121351 (-) amino acid adenylation domain-containing protein
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  • D581_RS0125540
  • WP_018960027.1
  • phzG
 121438 - 122100 (-) phenazine biosynthesis FMN-dependent oxidase PhzG
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  • D581_RS0125545
  • WP_018960028.1
 122184 - 123035 (-) PhzF family phenazine biosynthesis isomerase
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  • D581_RS0125550
  • WP_018960029.1
 123103 - 124986 (-) phenazine-specific anthranilate synthase component I
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  • D581_RS0125555
  • WP_018960030.1
 124983 - 125606 (-) isochorismatase family protein
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  • D581_RS0125560
  • WP_018960031.1
 125629 - 126804 (-) 3-deoxy-7-phosphoheptulonate synthase
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  • D581_RS0125565
  • WP_018960032.1
 126857 - 127357 (-) PhzA/PhzB family protein
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  • D581_RS0125570
  • WP_018960033.1
 127692 - 128726 (+) ketoacyl-ACP synthase III family protein
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  • D581_RS01000000137740
  • WP_018960034.1
 128785 - 129078 (+) phosphopantetheine-binding protein
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  • D581_RS0125580
  • WP_018960035.1
 129113 - 131653 (-) LuxR C-terminal-related transcriptional regulator
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  • D581_RS0125585
  • WP_158688635.1
 131739 - 132608 (-) class I SAM-dependent methyltransferase
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  • D581_RS0125590
  • WP_018960037.1
 132789 - 134339 (-) MFS transporter
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  • D581_RS0125595
  • WP_018960038.1
 134459 - 136804 (-) FAD-dependent oxidoreductase
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  • D581_RS0125600
  • WP_018960039.1
 137143 - 137766 (-) TetR/AcrR family transcriptional regulator
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
D581_RS0125520
Module ?
Specificity: phenazine-1,6-dicarboxylic acid / phenazine-1-carboxylic acid
Evidence for specificity:
  • Structure-based inference
D581_RS01000000137735
Module ?
Specificity: N-formylglycine / N-formylalanine
Evidence for specificity:
  • Knock-out studies
  • Mass spectrometry
Annotation changelog
MIBiG version Submitter Notes
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
  • Added NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
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