BGC0002012 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002012 (Streptomyces afghaniensis 772)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T2PKS	1	35,786	High	julichrome Q3-3/julichrome Q3-5	PKS

BGC0002012 - Region 1 - T2PKS

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Location: 1 - 35,786 nt. (total: 35,786 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 35,787
Label		BGC0002012

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase oxygenase

STAFG_RS30640: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

STAFG_RS30650: Reduction

MITE: MITE0000124Reduction (identity: 86.90%)
smcogs: SMCOG1083: oxidoreductase

STAFG_RS30655: Biaryl bond formation

MITE: MITE0000125Biaryl bond formation (identity: 87.70%)
smcogs: SMCOG1007: cytochrome P450

STAFG_RS30695: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: Acetylation PPTase

STAFG_RS30645: Acetylation

MITE: MITE0000123Acetylation (identity: 84.00%)

STAFG_RS48165: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1012: 4'-phosphopantetheinyl transferase

Hydrolases: phosphatase

STAFG_RS30605: inositol monophosphatase

smcogs: SMCOG1207: inositol monophosphatase

Lyases: cyclase

STAFG_RS30700: cyclase/dehydrase

smcogs: SMCOG1128: cyclase/dehydrase

STAFG_RS56080: Polyketide synthesis cyclase

smcogs: SMCOG1225: Polyketide synthesis cyclase

STAFG_RS56085: Polyketide synthesis cyclase

smcogs: SMCOG1225: Polyketide synthesis cyclase

Ligases: oxygenase synthase

STAFG_RS30655: Biaryl bond formation

MITE: MITE0000125Biaryl bond formation (identity: 87.70%)
smcogs: SMCOG1007: cytochrome P450

STAFG_RS30680: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

STAFG_RS30685: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002012.4	1.00	PKS	julichrome Q3-3, julichrome Q3-5	Streptomyces afghaniensis 772
BGC0002514.3	0.86	PKS	julichrome Q6.6	Streptomyces sampsonii
BGC0000231.5	0.82	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000234.5	0.76	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001723.5	0.67	PKS	oviedomycin	Streptomyces antibioticus
BGC0001895.4	0.63	PKS	huanglongmycin A, huanglongmycin B, huanglongmycin C	Streptomyces sp. CB09001
BGC0002000.4	0.62	PKS	setomimycin	Streptomyces aurantiacus JA 4570
BGC0000197.5	0.57	PKS, saccharide	aranciamycin	Streptomyces echinatus
BGC0001197.5	0.57	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0000221.5	0.57	PKS	erdacin	uncultured soil bacterium V167

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002012.4	1.00	PKS	julichrome Q3-3, julichrome Q3-5	Streptomyces afghaniensis 772
BGC0002514.3	0.86	PKS	julichrome Q6.6	Streptomyces sampsonii
BGC0000231.5	0.82	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000234.5	0.76	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001723.5	0.67	PKS	oviedomycin	Streptomyces antibioticus
BGC0001895.4	0.63	PKS	huanglongmycin A, huanglongmycin B, huanglongmycin C	Streptomyces sp. CB09001
BGC0002000.4	0.62	PKS	setomimycin	Streptomyces aurantiacus JA 4570
BGC0000197.5	0.57	PKS, saccharide	aranciamycin	Streptomyces echinatus
BGC0001197.5	0.57	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0000221.5	0.57	PKS	erdacin	uncultured soil bacterium V167

Similar known clusters from MIBiG 4.0

Detailed domain annotation

Selected features only

Show module domains

Type II PKS

Type II PKS gene cluster prediction details

Cluster section:: 0 to 35786
Starter unit(s):: acetyl-CoA (Score: 0.0; E-value: 0)
Malonyl elongations:: 8|9 (Score: 667.1; E-value: 1.8e-203)
Product class(es):: angucycline
Product molecular weight(s):: acetyl-CoA_8: 349 Da
acetyl-CoA_9: 391 Da

STAFG_RS30640: OXY (Score: 415.4; E-value: 8.1e-127)
STAFG_RS30680: KS (Score: 783.4; E-value: 1.1e-238)
STAFG_RS30685: CLF 8|9 (Score: 667.1; E-value: 1.8e-203)
STAFG_RS30690: ACP (Score: 118.2; E-value: 2.7e-37)
STAFG_RS30695: KR C9 (Score: 453.6; E-value: 4.5e-139)
STAFG_RS30700: CYC C7-C12 (Score: 454.0; E-value: 4.8e-139)
STAFG_RS56085: CYC C4-C17/C2-C19 (Score: 145.8; E-value: 2.9e-45)