LOCUS       BGC0002013             11705 bp    DNA     linear   CON 10-APR-2022
DEFINITION  Streptomyces curacoi strain DSM 40107 PRJNA299217_s004, whole genome
            shotgun sequence.
ACCESSION   BGC0002013
VERSION     BGC0002013
KEYWORDS    .
SOURCE      Streptomyces curacoi
  ORGANISM  Streptomyces curacoi
            Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
            Streptomyces.
COMMENT     REFSEQ INFORMATION: The reference sequence is identical to
            KQ947987.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-08 05:59:22
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 11705
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..11705
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[2516:10406]"
                     /cutoff="20000"
                     /detection_rule="((((goadsporin_like or PF00881 or
                     TIGR03605) and (YcaO or TIGR03604)) or TIGR03882 or
                     TIGR03603 or TIGR03602) and not cyanobactin_synth)"
                     /neighbourhood="10000"
                     /product="LAP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      2517..10406
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="((((goadsporin_like or PF00881 or
                     TIGR03605) and (YcaO or TIGR03604)) or TIGR03882 or
                     TIGR03603 or TIGR03602) and not cyanobactin_synth)"
                     /neighbourhood="10000"
                     /product="LAP"
                     /protocluster_number="1"
     cand_cluster    1..11705
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((((goadsporin_like or PF00881 or
                     TIGR03605) and (YcaO or TIGR03604)) or TIGR03882 or
                     TIGR03603 or TIGR03602) and not cyanobactin_synth)"
                     /kind="single"
                     /product="LAP"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..11705
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0002013"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..11705
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="LAP"
                     /region_number="1"
                     /rules="((((goadsporin_like or PF00881 or TIGR03605) and
                     (YcaO or TIGR03604)) or TIGR03882 or TIGR03603 or
                     TIGR03602) and not cyanobactin_synth)"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            1..417
                     /locus_tag="AQI70_RS14560"
                     /old_locus_tag="AQI70_14550"
     CDS             1..417
                     /GO_process="GO:0006355 - regulation of transcription,
                     DNA-templated [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1015:AraC family
                     transcriptional regulator (Score: 71.4; E-value: 1.3e-21)"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003997112.1"
                     /locus_tag="AQI70_RS14560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_14550"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_062148863.1"
                     /transl_table=11
                     /translation="MLLNLEQQTEGRGVGAVRLGVPVHSRRCVLRQQIGAFIEHRLGDP
                     ELTPAAIAEAHHISVRYLYQVFDTHQMTVAAWIRHCRLEHCHRDLADPRLRTRSIRAIA
                     SRWGFSDAAHFSRAFRAAYGMSPSDHRQLALGHG"
     gene            complement(457..1686)
                     /locus_tag="AQI70_RS14565"
                     /old_locus_tag="AQI70_14555"
     CDS             complement(457..1686)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1053:beta-lactamase (Score: 236.2; E-value: 7.8e-72)"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003963620.1"
                     /locus_tag="AQI70_RS14565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_14555"
                     /product="serine hydrolase"
                     /protein_id="WP_062148866.1"
                     /transl_table=11
                     /translation="MGTGKGGFSAAGLRRVRDVLARHVESGRIPGLVALVDRGGETHVE
                     ALGTMRHDGGAPMRRDTIFRMASTSKPVAMAPVMALLDECRLRLDDPVEPWLPELADRR
                     VLTRIDGPLDDTVPAQRPVTVRDLVTSTFGIGIDLTAPSSPIMSAIFERGVYTQGAEPT
                     PEPDEWMRRLGTLPLMRQPGEHWQYHVSHDVLAVLVARVTGRPFETFLRERVLAPLGMK
                     DTGFHVPADDIDRLPPSYAPDPKTGEFLVWDEAAGGRYSRPPAFPSGGGGLVSTVDDYH
                     AYFRMLLRHGMHGTERILSRPAVQLMTTNRLTPEQQAARDALARNNVHVSFGQGLHGGW
                     GLGMAVRTHRGDYASVGQFGWDGGTGTTAYADPDKQLTGILLTQVGMSTPDSARLIHDF
                     WTTVYQAIDD"
     misc_feature    complement(1546..1548)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(<1897..2394)
                     /locus_tag="AQI70_RS14570"
                     /old_locus_tag="AQI70_14560"
                     /pseudo=""
     CDS             complement(<1897..2394)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010070691.1"
                     /locus_tag="AQI70_RS14570"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_14560"
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="VAHDVAALAEVLKAMAASDQRSSVHANSDDPAEQLAWRRLTARHG
                     DRLGEIMDEYGWPTAELVGEEAARSAWLIAQHADRQLHIQRRALQLMQQAVSAGAPGAR
                     ELAFLRDRTLVNEGRKQIYGTQIAGVKDGAPVPWPCEEPERMDELRAEVGIEPFDEYVA
                     KFA"
     gene            complement(2517..3914)
                     /locus_tag="AQI70_RS37415"
                     /old_locus_tag="AQI70_14565"
     CDS             complement(2517..3914)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) LAP:
                     PF00881"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF013077.2"
                     /locus_tag="AQI70_RS37415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_14565"
                     /product="SagB family peptide dehydrogenase"
                     /protein_id="WP_062148869.1"
                     /sec_met_domain="PF00881 (E-value: 1.9e-25, bitscore: 79.4,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTASYTLVGFDPLGLAPADRPGLGPFTGTASPVLTTLDALRDRL
                     ADLAAAGRTGCVVAVLDADRAPEAVRLRQELNETVLAAGSPLVPCVVTDDRTLRIGPWV
                     RPHTTPCLACFARDLLPAPDGFRLDALPRPAVTDDRNEPTTKPDDLVAAGLQEALGTLR
                     TGLRDSPDRSVWGRVLSVRVQADGRLLRESWRAPRDPDCPSCGAPSGLPRLSRILHENS
                     KLHEHFRERDAIDSAHATAEPADQRPSPVHRLPDVQGIRSLPLEEAITRRRSRRRFGPS
                     ALDPADLSALLHYSSGVTGWGRTTDGGRIPLRAAPSGGALYPIDVYTYLRRVSGLPRGL
                     FRYDPLAHALVATGRPADAGERLSAHSAHREVLDDAAAIVLLAASFGRTQAKYLERGYR
                     ITLMEAGHIAQNLQLVATARRLRVCGVTGFVDDTVNDVLGLPAQGETQALYLLAVGRPL
                     TPAGSGA"
     gene            complement(3911..4999)
                     /locus_tag="AQI70_RS14580"
                     /old_locus_tag="AQI70_14570"
     CDS             complement(3911..4999)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AQI70_RS14580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="AQI70_14570"
                     /product="hypothetical protein"
                     /protein_id="WP_062148872.1"
                     /transl_table=11
                     /translation="MTDVGHLAELRGLERTVLTVTTPHHPTWLPVFPVAHLAEHLLGRE
                     LGRLPGLSALTGHLRRDLITVRFLTATAGPAAFDVRQLVDLRETARQDFEQERRVLAVE
                     DAILPPPLRTAGRLPASLAEFLDAWRRTEPRPRLERQPYLTDRLRELVDPAAPPHPYGT
                     TAPDPGPADPRQEHAEALAAVRRRTCGTPPELFLDGGPLEQYCGAGSVFLAGLSAYRSP
                     LFRGLREGPRPLYTLKLFDFPWRRRTFIACVTQPAIGPAEFAATLGARTVGLIAGLDDA
                     DLRTVLAEGRVAVLDDLAAVLDFPPRRAWLPVLARLNGFSARPADLARPVLDCTVDDLA
                     RYRDTFLDAYARHIHRTAREAV"
     gene            complement(4996..5859)
                     /locus_tag="AQI70_RS14585"
                     /old_locus_tag="AQI70_14575"
     CDS             complement(4996..5859)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="AQI70_RS14585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="AQI70_14575"
                     /product="hypothetical protein"
                     /protein_id="WP_062148875.1"
                     /transl_table=11
                     /translation="MSAPAGHDRHAAATALHWLHRHPIDRRDAPALPLADEAWFHAMLL
                     ERFSTLCPADVPAWEGTLNALLDTARQPAPPAARQHPAAEADDLLGTAMLAHLLHVRAP
                     GDKAARHLVERLAPRLRTASLPPLHALCLAHNLHELGEHDLAGALRPPRDADQAAAGLT
                     GAERLLTQAYFHTHVVLFAFGTFRRPDADPAPLAGSVRFLRRHAPAFARYGWADLCAEA
                     ALSLSLCAARDEDFRLLIAALHGSQRPEGDWTHPRVDARQARHATMMASLALLESARHS
                     TAAARG"
     gene            complement(5856..6641)
                     /locus_tag="AQI70_RS14590"
                     /old_locus_tag="AQI70_14580"
     CDS             complement(5856..6641)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF040270.1"
                     /locus_tag="AQI70_RS14590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_14580"
                     /product="hypothetical protein"
                     /protein_id="WP_062148878.1"
                     /transl_table=11
                     /translation="MRHATTALVAGLMRKEEFSGRTLEEAMARYVISPTLAARTAAVHC
                     SVTGRLAAPGVVELRCTTRLDGLTEPFALKHTYTFPLLDEVRESGLVLRPETPAGTSEI
                     LVALKDGAKSYVNVAVHDDEGYMLYSSVLTYDRRGEVRPYVPVIPDKFTSPLSLGKAEL
                     GEAVDERGHRVLRLVLELEELTGPAVVKVGYNTLGIQEVRRFEAGPADPVVVSDLLLEN
                     NPELLPGEWVIGATDAEDRMLVNGIVRVAPMGGPRGATA"
     gene            complement(6638..8047)
                     /locus_tag="AQI70_RS14595"
                     /old_locus_tag="AQI70_14585"
     CDS             complement(6638..8047)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034:cytochrome P450 (Score: 304.5; E-value: 2.2e-92)"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012296.2"
                     /locus_tag="AQI70_RS14595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_14585"
                     /product="cytochrome P450"
                     /protein_id="WP_062148882.1"
                     /sec_met_domain="p450 (E-value: 6.5e-61, bitscore: 195.9,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNWKAIPLVSGAAACPAHPPGRPAGPGPGPGPGDEPPGRHLRELR
                     TAPLDLLRRAAHEGTHGLARLDAGPGACLVVNDPAAIDVVLADRDAVFFKPKMELWKRV
                     LGENVLTSEGPDWASSRRRSVRITGARYVRRAARIVAGAADERLRHWTGTDPLDIHEEM
                     RSLTLAATLRQLCGTDADFDLRAFSHHLRTVMECIHALESAPAAPAEHDDVRREFSRAA
                     TELRTSVLNLVAHHPGGRDDLIGLLTDAPGEPLTVRQVCDEVLAHLIAGHESTATSLAW
                     ALLLLAGDPAVTERVRTEIDTAVGDRAPEDADLARMPLLRAVFLEALRLYPPAWTIMRA
                     TGRPSVVGGVRIPAGAVLLVSPYGVQRSERWFEGPDEFRPERWLGGGRNGDPKYTFFPF
                     GGGRRSCPGRQLALVTGGVVLTRVLQGFSLAPVGDPLRAAVDIILRPRPGTRLRATPRQ
                     PEPAGHRKESR"
     gene            complement(9006..10406)
                     /locus_tag="AQI70_RS14600"
                     /old_locus_tag="AQI70_14590"
     CDS             complement(9006..10406)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) LAP:
                     YcaO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF014661.2"
                     /locus_tag="AQI70_RS14600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_14590"
                     /product="YcaO-like family protein"
                     /protein_id="WP_159042661.1"
                     /sec_met_domain="YcaO (E-value: 2.2e-60, bitscore: 194.6,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGSTLPGTGQRDPRQGPPQGADGASGSASMSPLPEAHPLLDRII
                     RRERVFAAVPRVRRVPGDPAVYSHTCLPGPAVERLGRFGRYTKCGGAGFDPADSWIAAA
                     AEGLERFYAITYSTTAPYRRGRWSEHPDDFADPAKWAPFAPEQYAEPGFAFRPLTAESD
                     IRWYEGQDLLTGRQRWLPGPAVCFPYLRSRDEERVLPAVTTGLAFGLGPEHAARSALWE
                     VIERDALVLAWHWQLPVRRIDTTAGLPRELARTAELDDRCTVDAYDITSDLGVPACLVI
                     LRVADATGPILAAGSACRGSLQAALRKAFLEALQGVPYVRHLRATLAEGWTFGGDFAEV
                     SSFERSAAFYSLFPDQLKACLTARPEFLDVVGAPVRVEAHPEPTATLGLDETLKALDER
                     GHRAYAVDMSPQALRADGCAVVRVVVPGLYGLEGAHRFRSAHRARAEAVAALSGTTPDP
                     HPFPHPLP"
     gene            complement(10473..10607)
                     /locus_tag="AQI70_RS38515"
     CDS             complement(10473..10607)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003997107.1"
                     /locus_tag="AQI70_RS38515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="YM-216391 family RiPP peptide"
                     /protein_id="WP_107116988.1"
                     /transl_table=11
                     /translation="MFENTTAEIEEVDIEVGFIIGSTCCSLEMEEDDLDVAAEETEAV"
     gene            complement(10737..11564)
                     /locus_tag="AQI70_RS14605"
                     /old_locus_tag="AQI70_14595"
     CDS             complement(10737..11564)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003997106.1"
                     /locus_tag="AQI70_RS14605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="AQI70_14595"
                     /product="cupin domain-containing protein"
                     /protein_id="WP_244181632.1"
                     /transl_table=11
                     /translation="MKDSVAFEARALVQRHPHGVRLHLTRSADRYRADIVVDGGQGAAF
                     FDDGVSVNLEEFDRVCPAAGLWLDALAEELGVPRRFLGCSAFVSPVGSGLPLHFDDKDV
                     VVVQVSGVKRWRLADNTGLRYPTANYAAGSRYVSRELAGYYRPGSPGTEPPRHLDTVDL
                     RPGDALFLPRGHWHGTEAHEHTPSVSLSFGIATPSWSAVFLERLRLRLLTADHWRAPAV
                     RLDASHGRFAPADLVRRMDGAISDLMSGELDRALAGEITAGRAPDPAADVSGR"
ORIGIN
        1 atgttgttga atctggaaca gcaaaccgaa ggccgcggcg tcggcgccgt ccggctggga
       61 gtgccggtcc actcccgtcg gtgcgtcctg cgccaacaga tcggcgcctt catcgaacac
      121 cggctggggg acccggagct gaccccggcg gcgatcgccg aggcccacca catctcggtg
      181 cgctatctgt accaggtctt cgacacccac cagatgaccg tcgccgcctg gatccggcac
      241 tgccgactgg agcactgcca ccgcgatctg gcggatccac ggctgcgtac gcggtccatc
      301 cgggcgatcg cctcccgctg gggcttctcg gatgcggcgc acttcagccg ggccttcagg
      361 gccgcgtacg ggatgtctcc cagcgaccat cgccaactgg ccctcgggca cggttagggg
      421 cgtgggtcca gggtctacgg gggcgcccgg ccggtgtcag tcgtcgatcg cctggtagac
      481 cgtggtccag aagtcgtgga tgagccgcgc cgaatccggc gtggacatcc cgacctgggt
      541 cagcaggatg ccggtgagct gcttgtccgg gtcggcgtag gccgtggtgc cggttccgcc
      601 gtcccagccg aactggccta cggacgcgta gtcaccgcga tgggtgcgca ccgccatccc
      661 gaggccccag ccgccgtgca gcccctggcc gaacgacaca tggacgttgt tgcgggccag
      721 ggcgtcccgg gcggcctgct gctcgggcgt gaggcggttg gtggtcatca gctggacggc
      781 gggccgggac aggatccgtt cggtcccgtg catcccgtga cgcagcaaca tccggaaata
      841 ggcgtggtag tcgtcgacgg tggagaccag cccaccgccg cctgacggga acgccggagg
      901 ccggctgtac cgtccgcctg ccgcctcgtc ccacacgagg aactctccgg tcttcgggtc
      961 cggggcgtag ctgggcggca gccggtcgat gtcgtcggcg ggcacgtgga agccggtgtc
     1021 cttcatcccc aagggagcga ggacgcgctc gcgcaggaac gtctcgaacg gccggcccgt
     1081 gaccctcgcg acgagcacgg cgagcacatc gtggctgacg tggtactgcc agtgctctcc
     1141 gggctgccgc atcagcggaa gcgtgcccag gcggcgcatc cactcgtccg gctcgggcgt
     1201 cggctccgcc ccctgggtgt agacgccccg ctcgaagatc gcggacatga tcggagagct
     1261 cggcgcggtc agatctatgc cgatcccgaa cgtggaggtc accaggtccc gtacggtgac
     1321 cggccgctgt gccggcacgg tgtcgtccag cgggccgtcg atccgcgtca gcacccggcg
     1381 gtcggcgagt tcgggcagcc acggctccac cgggtcgtcc agccgcagcc tgcactcgtc
     1441 gagaagggcc atcaccggcg ccatcgcgac cggcttggac gtggacgcca tccggaagat
     1501 cgtgtcccgg cgcatcggcg cgccaccgtc atggcgcatc gtccctaatg cttcgacgtg
     1561 cgtctcaccg ccgcggtcga ccagcgcgac gagtccggga atcctcccgg actcgacgtg
     1621 ccgtgccagt acgtcgcgca ctctgcgcag gcctgccgcg gagaagccgc ccttgcccgt
     1681 tcccatcatg agtctccctg catgcaatgt ttgggaattg ctgaacgctc acgacgctat
     1741 attgcgttca gtgattcgtc aacgatgggt tgggggcgca atttgcttgt tggtgagcca
     1801 ggttgggtgg gtgcgttgca atgagtgtga cgctgaacgc aatgggtggc ctggggcggg
     1861 tattgcgatg gagtctgcct tactcctggg gggcggtgcg aacttggcga cgtactcgtc
     1921 gaagggctcg atgccgactt ccgcgcgcag ttcgtccatg cgctcgggct cttcgcaggg
     1981 ccacggaacc ggtgctccgt ccttcacgcc ggcgatctgc gtgccgtaga tctgcttgcg
     2041 gccctcgttg acgagcgtac ggtcgcgcag gaaggcgagt tcgcgtgcgc cgggcgcgcc
     2101 tgccgatacc gcctgctgca tcagttgcag ggcgcgtcgc tggatgtgga gctgtcggtc
     2161 ggcgtgttgg gcgatcagcc acgcggagcg agcggcctcc tcgccgacga gttccgccgt
     2221 gggccagccg tactcgtcca tgatctcgcc gagccggtcg ccgtgccgtg cggtcagccg
     2281 gcgccacgcc agctgttcgg ccgggtcgtc gctgttcgcg tgaacggagg accgctggtc
     2341 gctcgcggcc atggccttga gtacctccgc cagtgcggca acgtcgtgcg ccactctcaa
     2401 ctcccaggat cggtcgacgt gttgtgtgcg tcatcggcaa ccctaggggg catatcgggc
     2461 gtaaagatca ttccggggaa cggtgacagg cacctcggcg agcggcgata atggatctac
     2521 gccccggagc cggccggcgt gagcgggcgg ccgacggcca gcagatacag ggcctgggtc
     2581 tcgccctggg ccgggagtcc cagtacgtcg ttgacggtgt cgtcgacgaa gccggtcacc
     2641 ccgcacaccc gcaagcgccg ggcggtcgcg acgagttgca ggttctgcgc gatgtgcccg
     2701 gcctccatca gcgtgatccg gtagccccgt tcgaggtatt tcgcctgtgt ccggccgaag
     2761 gacgcggcga gcagcacgat cgccgcggcg tcgtcgagta cctcacgatg cgccgagtgg
     2821 gccgacagcc gctcgccggc atcagccgga cgcccggtcg cgacgagggc gtgcgcgagg
     2881 gggtcgtacc ggaagaggcc ccgcggcagg cccgacaccc ggcgcagata cgtgtacacg
     2941 tcgatcgggt acagcgcacc gcccgacggc gccgcgcgca gcgggatccg gccgccgtcc
     3001 gtggtcctgc cccagccggt gacgccggag gagtagtgca gcagggcgga gaggtcggcc
     3061 gggtccaggg cggacggtcc gaaacggcgg cgggaacggc ggcgggtgat cgcctcctcc
     3121 agcggcagcg accgtatgcc ctggacgtcg ggcaggcgat gcaccgggga cggtcgctga
     3181 tcggcgggct cggcggtggc gtgggcgctg tcgatcgcgt cccgttcccg gaagtgctcg
     3241 tgcagcttgc tgttctcgtg caggatccgg gagaggcggg gcaggccgct cggcgcgccg
     3301 caggacgggc agtccgggtc cctgggcgcc cgccacgact cccgtagcag ccgtccgtcg
     3361 gcctggacgc gcaccgacag gacacggccc cacaccgacc ggtcggggct gtcccgcagc
     3421 ccggtgcgca gggtgccgag cgcctcttgg agaccggccg cgaccaggtc gtccggtttg
     3481 gtcgtcggct cgttgcggtc gtcggtgacg gcgggccggg gcagcgcgtc gagtcggaag
     3541 ccgtccgggg cggggagcag gtcccgggcg aaacaggcca ggcagggtgt ggtgtgcggc
     3601 cggacccagg ggccgatgcg cagggtgcgg tcatcggtca cgacacaggg cacgaggggg
     3661 gagcccgcgg cgagcacggt ctcgttgagt tcctgccgca gccgtaccgc ctccggcgcg
     3721 cggtcggcgt ccaggacggc cacgacacag ccggtccggc ccgccgccgc gaggtccgcg
     3781 aggcggtcgc gcagtgcgtc gagggtcgtc aggacggggc tcgcggtgcc ggtgaagggg
     3841 ccgagcccgg ggcggtcggc gggggccagg cccagcgggt cgaagccgac gagggtgtac
     3901 gaggcggtgg tcatacggcc tcccgggcgg tgcggtggat gtgccgggcg tacgcgtcga
     3961 ggaaggtgtc gcggtaccgg gcgaggtcgt cgacggtgca gtcgagcacc gggcgggcga
     4021 gatcggcggg ccgcgcgctg aagccgttga gacgcgccag caccggcagc caggcccgcc
     4081 ggggcgggaa gtccagtacg gcggccaggt cgtcgagtac ggcgactcgg ccctcggcga
     4141 gcaccgtgcg caggtcggcg tcgtcgaggc cggcgatcag gccgaccgtg cgggcgccga
     4201 gcgtggcggc gaactcggcc gggccgatgg cgggttgggt gacgcaggcg atgaacgtgc
     4261 gccgccgcca cgggaagtcg aacagcttca gggtgtagag gggacgcggg ccttcccgca
     4321 gcccgcggaa gaggggggag cggtaggcgg agagtcccgc gaggaagacc gagcccgccc
     4381 cgcagtactg ctccaacggg ccgccgtcca ggaacagttc cggtggggtg ccacaggtcc
     4441 tgcggcgtac ggcggccagc gcctcggcgt gctcctggcg ggggtccgcg gggccggggt
     4501 cgggagccgt cgtaccgtac gggtgcggtg gtgcggcggg gtcgacgagt tccctcagcc
     4561 ggtccgtgag gtagggctgc cgctccagcc ggggccgggg ttccgtccga cgccatgcgt
     4621 ccaggaactc ggcgagcgac gccgggagcc gtcccgcggt gcgcagcggg ggcggcagga
     4681 tcgcgtcctc cacggcgagg acgcgccgct cctgctcgaa gtcctgccgg gccgtctccc
     4741 gcaggtccac cagctgccgg acgtcgaacg cggccggtcc ggccgtggcg gtgaggaagc
     4801 gtacggtgat caggtcccgg cgcagatgac cggtcagggc gctcaggccg gggagccggc
     4861 ccagctcccg tccgaggagg tgctcggcga ggtgggcgac ggggaagacg ggcagccagg
     4921 tcggatggtg cggggtggtg accgtcagga ccgtccgctc caggccgcgc agctcggcga
     4981 ggtgccccac gtcggtcatc cccgtgccgc cgccgtcgag tgccgcgccg actccagcag
     5041 ggccagggac gccatcatgg tggcgtgccg ggcctggcgg gcgtcgacgc gcgggtgcgt
     5101 ccagtcgccc tccgggcgct gcgagccgtg cagcgccgcg atgagcaggc ggaagtcctc
     5161 gtcgcgtgcc gcgcacaggg agagggacag cgccgcctcg gcgcacaggt ccgcccagcc
     5221 gtaccgggcg aaggcggggg cgtgccggcg caggaagcga acgctgcccg cgagcggcgc
     5281 ggggtccgcg tcgggcctgc ggaaggtgcc gaaggcgaac agcaccacat gggtgtggaa
     5341 gtaggcctgg gtcagcagcc gttcggcacc ggtgaggccc gctgccgcct gatcggcgtc
     5401 ccgcggcggg cgcagggcgc cggccaggtc gtgttcgccg agctcgtgca ggttgtgcgc
     5461 caggcacagg gcgtgcaagg gcggcaggga ggccgtcctc aggcgcgggg cgagccgctc
     5521 gaccaggtgc cgggcggcct tgtcgccggg agcccggacg tgcagcaggt gggcgagcat
     5581 cgcggtgccc agcaggtcgt ccgcctcggc ggcggggtgc tgccgggcgg cgggcggagc
     5641 cggctgccgc gccgtgtcca gcagggcgtt cagagtgcct tcccaggccg gtacgtcggc
     5701 gggacagagg gtggagaaac gttcgagcag catggcgtgg aaccacgcct cgtcggcgag
     5761 cggcagggcg ggcgcgtccc gccggtcgat cgggtgccgg tgcaaccagt gcagcgccgt
     5821 ggccgccgcg tgccggtcgt gcccggcggg tgcgctcatg ccgtcgctcc gcgcggtccg
     5881 cccatggggg ccacccggac gatgccgttg acgagcatgc ggtcctcggc gtcggtcgct
     5941 ccgatcaccc actcgcccgg cagcagctcg gggttgttct ccagcagcag gtccgagacg
     6001 accaccggat cggcgggacc ggcctcgaaa cggcgtacct cctggatgcc cagggtgttg
     6061 tagccgacct tcaccacggc cggaccggtc agctcctcca gctccagcac gagccgcagc
     6121 acccggtggc cccgctcgtc gaccgcctcg cccagctcgg ccttgcccag ggacagcggg
     6181 gaggtgaact tgtccgggat caccggcaca taggggcgga cctcgccgcg gcggtcgtag
     6241 gtgagcaccg aggagtagag catgtagccc tcgtcgtcgt gcacggcgac gttgacgtag
     6301 ctcttggccc cgtccttgag cgcgaccagg atctcgctgg tgccggcggg cgtctcgggg
     6361 cgcagcacca gccccgactc ccgcacctcg tccagcagcg ggaaggtgta cgtgtgcttg
     6421 agcgcgaagg gctcggtgag cccgtccagc cgggtggtgc agcgcagctc caccacgccc
     6481 ggcgcggcga gccggccggt gaccgagcag tgcacggcgg ccgtacgggc ggccagggtg
     6541 ggcgagatga cgtaccgcgc catggcctcc tccagcgtcc ggccggagaa ctcctccttg
     6601 cgcatcagcc ccgcgaccag cgcggtcgtc gcatgcctca tcgtgattcc tttcggtgtc
     6661 cggcgggttc cggttgcctg ggggtcgccc gcagccgggt gccgggacgg ggacgcagga
     6721 tgatgtccac ggcggcccgg agcgggtcgc cgacgggtgc cagggagaag ccctgcagca
     6781 cccgggtgag caccacgccc ccggtgacca gggccagttg acggccgggg caggagcggc
     6841 ggccgccccc gaaggggaag aacgtgtact tcggatcacc gtttcgcccg ccgcccagcc
     6901 agcgctccgg ccggaactcg tcgggcccct cgaaccagcg ctccgagcgc tgcacgccgt
     6961 agggagagac cagcaggacc gccccggccg ggatgcgtac gccgccgacc acgctgggcc
     7021 ggccggtggc ccgcatgatc gtccaggcgg gcgggtacag ccgcagcgcc tccaggaaga
     7081 ccgcccgcag cagcggcata cgggccaggt ccgcgtcctc gggggcccgg tcgccgacgg
     7141 ccgtgtcgat ctccgtgcgc acccgctcgg tcaccgccgg atcaccggcg agcagcagca
     7201 gcgcccaggc gagcgaggtg gccgtggact cgtgcccggc gatgaggtgg gcgaggacct
     7261 cgtcgcacac ctgccgcact gtcagcggct ccccgggggc gtcggtgagc aggccgatca
     7321 agtcgtcccg gccgccggga tgatgggcca cgagattcag tacggaggtc ctgagctcgg
     7381 ttgcggcacg gctgaactcc ctgcggacgt cgtcgtgttc ggccggggcg gcgggcgcgg
     7441 actccagggc gtggatgcac tccatcaccg tgcgcagatg gtgcgagaaa gcgcgcaggt
     7501 cgaagtcggc gtcggtgccg cacagctggc gcagggtcgc cgcgagggtg agcgaccgca
     7561 tctcctcgtg gatgtcgagc gggtccgtgc ccgtccagtg gcgcagccgc tcgtcggcgg
     7621 ccccggcgac gatccgggcg gcgcgccgga cgtaccgcgc cccggtgatg cggacgctcc
     7681 ggcgccgtga actcgcccag tcggggccct cgctggtgag cacgttctcg ccgagcacgc
     7741 gcttccacag ctccatcttc ggtttgaaga agacggcgtc gcggtcggcg agcacgacgt
     7801 cgatggccgc cgggtcgttc accacgagac aggcgccggg gcccgcgtcc agccgggcca
     7861 gaccgtgcgt gccctcgtgt gccgcgcggc gcagcaggtc cagcggtgcg gtgcgcagct
     7921 cgcgcagatg gcggcccggc ggctcgtcgc cgggaccggg gcccgggccg gggccggcgg
     7981 gccggccggg tggatgtgcc gggcaggccg ccgcgccgct caccagggga atggccttcc
     8041 agttcatcgc gggcacctcg gggcgtcggt cacggcaggg cgcggtcggg gcgggcgtgc
     8101 ggatcggggt cgtggtcggg gcggggggtg cggatcgggg tcgtggtcgg ggcgggggnn
     8161 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     8221 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     8281 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     8341 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     8401 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     8461 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     8521 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     8581 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     8641 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     8701 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     8761 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     8821 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     8881 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nggccgggtc
     8941 gtggtcaggg ccgggggtgc gggccgggtc gtggtcaggg cagggggtgc gggcctggta
     9001 cgtagtcagg gcagggggtg cgggaagggg tgggggtcgg gcgtggtgcc cgacagcgcg
     9061 gccacggcct cggcgcgggc gcgatgggcg ctgcggaagc ggtgggcgcc ttcgaggccg
     9121 tacaggccgg gcacgacgac ccggacgacg gcacagccgt cggcacgcag ggcctgcgga
     9181 ctcatgtcga cggcgtaggc gcggtgcccc cgctcgtcga gcgccttcag ggtctcgtcg
     9241 aggccgaggg tcgccgtcgg ctcggggtgg gcctcgacgc ggacgggcgc tccgacgacg
     9301 tcgaggaact ccgggcgggc cgtgaggcag gccttcagct ggtccgggaa caacgagtag
     9361 aaggccgcgc tgcgttcgaa ggagctcacc tcggcgaagt ccccgccgaa ggtccacccc
     9421 tcggcgaggg tggcgcgcag atgccgtacg tagggcaccc cttgcagggc ctccaggaaa
     9481 gccttgcgca gggcggcctg gaggctgccc cggcaggccg agcccgcggc caggatcggg
     9541 ccggtggcgt cggccacccg caggatcacc aggcaggcgg ggacgccgag gtcggaggtg
     9601 atgtcgtagg cgtcgacggt gcagcggtcg tcgagttcgg cggtccgggc cagctcgcgg
     9661 gggagaccgg cggtggtgtc gatcctgcgc acgggcagct gccagtgcca ggcgagcacc
     9721 agggcgtccc gctcgatcac ctcccacagc gccgagcggg cggcgtgctc gggaccgagc
     9781 ccgaaggcga ggcccgtggt gacggccggc aggacgcgct cctcgtcccg ggaccggagg
     9841 tagggaaagc acacggccgg gccggggagc caccgctgcc gtccggtcaa caggtcctgg
     9901 ccctcgtacc acctgatgtc gctctcggcg gtcaacggcc ggaaggcaaa gccgggttcg
     9961 gcgtactgct ccggcgcgaa cggagcccac tttgccgggt cggcgaagtc gtcggggtgc
    10021 tcgctccagc gcccccgccg gtagggcgcg gtcgtgctgt aggtgatggc gtaaaagcgc
    10081 tccagcccct cggccgccgc cgcgatccag ctgtcggcgg ggtcgaagcc cgcgccgccg
    10141 cacttggtgt accggccgaa gcggccgagc cgttccacgg ccgggccggg caggcaggtg
    10201 tggctgtaca cagccggatc gcccgggacg cggcgcaccc ggggcaccgc ggcgaagacc
    10261 cgctcgcggc ggatgatccg gtcgagcaga gggtgcgcct cgggcagcgg tgacatcgac
    10321 gcgctgcccg aggcgccgtc cgcgccctgc ggaggtcctt gacgggggtc gcgctgtccg
    10381 gttccgggca atgtgctccc cgtcatgcgg gactccattc catgggtgcg gtggtgtgcc
    10441 ggagaattac cgaggactta ccggttcacc ggtcagacgg cctcggtctc ctcggcggcg
    10501 acgtccaggt cgtcctcttc catctccagg gaacagcagg tcgacccgat gatgaatccg
    10561 acctcgatgt cgacttcctc gatctcggcg gtcgtgttct cgaacatttc tgtctcccgt
    10621 ctccggtcat cactgaccgg tcaattggct cggtcctcaa ctgccggtga ttccccgggt
    10681 cttcgacgac tggcaatctc gaccagcccg caggaccggg ggatttcctc cggccttcaa
    10741 cgaccgctga catcggcggc cgggtccggt gcccggcccg ccgtgatttc cccggccagt
    10801 gcccggtcga gttcaccgga catcaggtcc gagatcgccc cgtccatccg ccggaccaga
    10861 tccgcgggcg cgaaccgccc gtggctcgcg tccagccgga cggccggggc ccgccagtgg
    10921 tcggcggtca gcagccggag cctgagccgc tccaggaaga ccgccgacca tgacggagtc
    10981 gcgataccga acgacagcga cacggagggc gtgtgctcgt gggcctcggt gccgtgccag
    11041 tggccgcggg gcaggaacag ggcgtccccg ggccgcagat cgacggtgtc gagatgccgc
    11101 ggcggctcgg tcccggggga accgggccgg tagtagccgg ccagctcccg ggacacataa
    11161 cggctgccgg cggcgtagtt ggcggtggga tagcgcagcc cggtgttgtc ggcgagccgc
    11221 caccgcttga cgccgctgac ctggacgacc accacgtcct tgtcgtcgaa gtgcagcggc
    11281 agcccgctgc cgaccggcga cacgaacgcc gagcagccca ggaaccgccg cgggacgccc
    11341 aactcctcgg ccagcgcgtc cagccagagg ccggccgccg ggcagacccg gtcgaactcc
    11401 tccaggttca ccgagacccc gtcgtcgaag aaggcggcgc cctgcccgcc gtcgacgacg
    11461 atgtcggccc ggtaccggtc cgccgaacgc gtcagatgca gccgtacgcc gtgcggatgg
    11521 cgctgaacca gggcgcgggc ctcgaaggcc acagaatcct tcattccgtc gaggatttcc
    11581 ggtccgccgc tcccggtgat ccgccggcct tccgcaaagg ccttccggac ttcctccgcc
    11641 ccggccccgg gaaagagaac ggagagtgcc ccgcccttga ccgcgcgtgc ttcctcctcg
    11701 gccat
//
