BGC0002014: pepticinnamin E biosynthetic gene cluster from Actinobacteria bacterium OK006
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Location: 101,713 - 146,406 nt. (total: 44,694 nt).
This entry is originally from NCBI GenBank NZ_LJCU01000236.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002014
Short description pepticinnamin E biosynthetic gene cluster from Actinobacteria bacterium OK006
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide
Loci NCBI GenBank: NZ_LJCU01000236.1
Compounds
  • pepticinnamin E
Species Actinobacteria bacterium OK006 [taxonomy]
References
Chemical products information
pepticinnamin E [synonyms: Pepticinnamine E]
Copy SMILES
C49H54Cl1N5O10
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • OK006_RS36460
  • WP_082417547.1
 101713 - 103281 (-) tryptophan 7-halogenase
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  • OK006_RS36465
  • WP_054234617.1
 103289 - 110821 (-) non-ribosomal peptide synthetase
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  • OK006_RS36470
  • WP_054234618.1
 110864 - 111067 (-) MbtH family protein
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  • OK006_RS36475
  • WP_054234619.1
 111378 - 111821 (+) enediyne antibiotic chromoprotein
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  • OK006_RS36480
  • WP_054234620.1
 111950 - 112753 (-) ABC transporter permease
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  • OK006_RS36485
  • WP_054234621.1
 112750 - 113736 (-) ATP-binding cassette domain-containing protein
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  • OK006_RS36490
  • WP_054234622.1
 113902 - 115143 (+) beta-ketoacyl-[acyl-carrier-protein] synthase family protein
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  • OK006_RS36495
  • WP_054234623.1
 115140 - 116216 (+) hypothetical protein
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  • OK006_RS36500
  • WP_054234624.1
 116213 - 117925 (+) NAD(P)/FAD-dependent oxidoreductase
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  • OK006_RS36505
  • WP_054234625.1
 117948 - 118610 (-) class I SAM-dependent methyltransferase
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  • OK006_RS36510
  • WP_054234626.1
 118648 - 119406 (-) hypothetical protein
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  • OK006_RS36515
  • WP_054234627.1
 119679 - 119936 (+) acyl carrier protein
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  • OK006_RS36520
  • WP_054234628.1
 119967 - 121193 (+) beta-ketoacyl-[acyl-carrier-protein] synthase family protein
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  • OK006_RS36525
  • WP_054234629.1
 121190 - 122332 (+) 3-oxoacyl-ACP synthase
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  • OK006_RS36530
  • WP_054234630.1
 122329 - 123327 (+) hypothetical protein
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  • OK006_RS36535
  • WP_082417543.1
 123324 - 124211 (+) alpha/beta hydrolase
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  • OK006_RS36540
  • WP_054234632.1
 124211 - 125221 (+) hypothetical protein
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  • OK006_RS36545
  • WP_054234633.1
 125218 - 126261 (+) hypothetical protein
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  • OK006_RS36550
  • WP_054234634.1
 126346 - 127092 (+) 3-oxoacyl-ACP reductase FabG
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  • OK006_RS36555
  • WP_054234635.1
 127120 - 127836 (+) DsbA family protein
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  • OK006_RS36560
  • WP_054234636.1
 127878 - 128135 (+) acyl carrier protein
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  • OK006_RS36565
  • WP_054234637.1
 128132 - 128467 (+) hypothetical protein
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  • OK006_RS36570
  • WP_054234638.1
 128470 - 128883 (+) DsrE family protein
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  • OK006_RS58490
  • WP_054234639.1
 128884 - 129267 (+) DsrE family protein
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  • OK006_RS58495
  • WP_054234640.1
 129264 - 129713 (+) hypothetical protein
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  • OK006_RS36585
  • WP_067733580.1
 129710 - 130249 (+) hypothetical protein
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  • OK006_RS36590
  • WP_054234641.1
 130267 - 131589 (-) NB-ARC domain-containing protein
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  • OK006_RS36595
  • WP_097286309.1
 131730 - 132224 (-) DUF3995 domain-containing protein
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  • OK006_RS36600
  • WP_159055335.1
 132542 - 132943 (-) DUF6191 domain-containing protein
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  • OK006_RS36605
  • WP_054234643.1
 133375 - 144807 (+) non-ribosomal peptide synthetase
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  • OK006_RS36610
  • WP_054234644.1
 145063 - 146406 (+) cation:proton antiporter
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NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
OK006_RS36465
Module ?
Specificity: tyrosine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: tyrosine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
OK006_RS36605
Module ?
Specificity: phenylalanine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: serine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Module ?
Specificity: glycine
Evidence for specificity:
  • Structure-based inference
  • Sequence-based prediction
Annotation changelog
MIBiG version Submitter Notes
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Cleaned up synonym list
  • Fetch compound properties from PubChem
  • Added NRP substrate specificities
Detailed domain annotation
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