BGC0002015 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002015 (Streptomyces sp. ZS0098)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	lassopeptide	1	12,018	aborycin	ribosomal:RiPP	100%

BGC0002015 - Region 1 - lassopeptide

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Location: 1 - 12,018 nt. (total: 12,018 nt) Show pHMM detection rules used

Region on contig edge.

lassopeptide: (PF13471 and Asn_synthase or micJ25 or mcjC)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

MIBiG comparison

KnownClusterBlast

Lasso peptides

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 12,019
Label		BGC0002015

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002015	0.94	RiPP	aborycin	Streptomyces sp. ZS0098
BGC0002307	0.58	RiPP	humidimycin	Streptomyces humidus
BGC0001674	0.57	RiPP	MS-271	Streptomyces mirabilis
BGC0001920	0.57	RiPP	siamycin I	Streptomyces sp.
BGC0001779	0.54	RiPP	siamycin	Streptomyces nodosus
BGC0002064	0.33	RiPP	felipeptin A2, felipeptin A1	Amycolatopsis sp. YIM 10
BGC0002006	0.32	RiPP	albusnodin	Streptomyces albus
BGC0001176	0.31	RiPP	streptomonomicin	Streptomonospora alba
BGC0002289	0.31	RiPP	LP2	Streptomyces leeuwenhoekii
BGC0001549	0.30	RiPP	citrulassin B	Streptomyces aurantiacus JA 4570

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002015	0.98	RiPP	aborycin	Streptomyces sp. ZS0098
BGC0002307	0.83	RiPP	humidimycin	Streptomyces humidus
BGC0001674	0.82	RiPP	MS-271	Streptomyces mirabilis
BGC0001920	0.82	RiPP	siamycin I	Streptomyces sp.
BGC0001779	0.81	RiPP	siamycin	Streptomyces nodosus
BGC0002064	0.66	RiPP	felipeptin A2, felipeptin A1	Amycolatopsis sp. YIM 10
BGC0002006	0.66	RiPP	albusnodin	Streptomyces albus
BGC0001176	0.65	RiPP	streptomonomicin	Streptomonospora alba
BGC0002289	0.64	RiPP	LP2	Streptomyces leeuwenhoekii
BGC0001549	0.64	RiPP	citrulassin B	Streptomyces aurantiacus JA 4570

Similar known gene clusters from MIBiG 4.0

Lasso peptide predictions

Lassopeptide(s) for BIU87_RS24185

BIU87_RS24185

Leader:

MTAIYEPPALQEIGDFDELTK

Full core:

CLGIGSCNDFAGCGYAVVCFW

Putative macrolactam:

CLGIGSCND

antiSMASH-DB 4.0 matches for BIU87_RS24185

100.0% NZ_BMTZ01000002.1and 7 others:

NZ_CP075343.1 Lassopeptides: KIH30_RS18120_lassopeptideNZ_CP094918.1 Lassopeptides: MTR79_RS01420_lassopeptideNZ_CP104864.1 Lassopeptides: N7E53_RS18640_lassopeptideNZ_JAGPYC010000023.1 Lassopeptides: KBZ00_RS26815_lassopeptideNZ_JAHLXF010000008.1 Lassopeptides: KQY13_RS13475_lassopeptideNZ_KL503830.1 Lassopeptides: DJ64_RS36290_lassopeptideNZ_RAII01000001.1 Lassopeptides: EBH12_RS13875_lassopeptide

Lassopeptides: IE148_RS05685_lassopeptide

CLGIGSCNDFAGCGYAVVCFW

95.2% NZ_FKJH01000010.1: Lassopeptides: STEPF7_RS33500_lassopeptide

CLGIGSCNDFAGCGYAVVCFW

CLGIGSCNDFAGCGYA+VCFW

CLGIGSCNDFAGCGYAIVCFW

90.5% NZ_BMUQ01000008.1and 14 others:

NZ_CP009313.1 Lassopeptides: SNOD_RS36345_lassopeptideNZ_CP032427.1 Lassopeptides: DWG14_RS11510_lassopeptideNZ_CP041604.2 Lassopeptides: FNV64_RS26100_lassopeptideNZ_CP041610.2 Lassopeptides: FNV62_RS23380_lassopeptideNZ_CP041611.1 Lassopeptides: FNV63_RS24615_lassopeptideNZ_CP041613.2 Lassopeptides: FNV68_RS25480_lassopeptideNZ_CP041650.2 Lassopeptides: FNV59_RS25255_lassopeptideNZ_CP051010.1 Lassopeptides: HEP87_RS24130_lassopeptideNZ_CP063808.1 Lassopeptides: IOD14_RS09840_lassopeptideNZ_FONR01000003.1 Lassopeptides: BM303_RS11340_lassopeptideNZ_KQ948177.1 Lassopeptides: AQI84_RS43500_lassopeptideNZ_KQ948458.1 Lassopeptides: AQJ27_RS55690_lassopeptideNZ_KQ948736.1 Lassopeptides: AQJ54_RS45005_lassopeptideNZ_SLYY01000004.1 Lassopeptides: EV578_RS15180_lassopeptide

Lassopeptides: IE289_RS20825_lassopeptide

CLGIGSCNDFAGCGYAVVCFW

CLG+GSCNDFAGCGYA+VCFW

CLGVGSCNDFAGCGYAIVCFW

with 10 more sequence matches

85.7% NZ_CP110539.1and 1 other:

NZ_CP112880.1 Lassopeptides: N7925_RS31855_lassopeptide

Lassopeptides: OH133_RS33845_lassopeptide

CLGIGSCNDFAGCGYAVVCFW

CLG+GSC DF GCGYAVVCFW

CLGVGSCTDFVGCGYAVVCFW

85.7% NZ_CP119143.1: Lassopeptides: PYR72_RS21585_lassopeptide

CLGIGSCNDFAGCGYAVVCFW

CLG+GSC+DFAGCGYA+VCFW

CLGVGSCDDFAGCGYAIVCFW

85.7% NZ_LIPD01000011.1: Lassopeptides: AMK13_RS28885_lassopeptide

CLGIGSCNDFAGCGYAVVCFW

CLGIGSC DF GCGYAVVCF+

CLGIGSCQDFVGCGYAVVCFF

52.4% NZ_BBQG01000021.1and 3 others:

NZ_CP048875.1 Lassopeptides: G3260_RS22950_lassopeptideNZ_CP103060.1 Lassopeptides: NR995_RS11105_lassopeptideNZ_KE150472.1 Lassopeptides: HMPREF1486_RS35370_lassopeptide

Lassopeptides: TU22_RS34200_lassopeptide

CLGIGSCNDFAGCGYAVVCF

CL G C DF GCG A+ C

CLPSGDCPDFLGCGRAIWCI

52.4% NZ_CP050693.1: Lassopeptides: HC362_RS11085_lassopeptide

CLGIGSCNDFAGCGYAVVCF

CL G C DF GCG A+ C

CLPSGDCPDFLGCGRALWCI

47.6% NZ_CM000951.1: Lassopeptides: SSEG_RS44950_lassopeptide

CLGIGSCNDFAGCGYAVVC

C+ G C DF GCG A +C

CVWGGDCTDFLGCGTAWIC

47.6% NZ_SGWQ01000010.1: Lassopeptides: EV193_RS25540_lassopeptide

CLGIGSCNDFAGCGYAVVC

C G C DF GCG A +C

CTPWGDCRDFLGCGRAPIC

38.1% NZ_CP084585.1: Lanthipeptides: LFM56_RS02720_lanthipeptide

IGSCNDFAGCGYAVVCFW

IGS A CG + FW

IGSTISIALCGSTISAFW

24.1% NZ_KB235922.1and 1 other:

NZ_KB235922.1 Lanthipeptides: PLEUR7319_RS34845_lanthipeptide

Lanthipeptides: PLEUR7319_RS34845_lanthipeptide

IGSCNDFAGCGYAVVC

IG C GCG ++C

IGDCVHTQGCGNTMIC

12.5% NZ_JADMQJ010000021.1: Lanthipeptides: I2H29_RS15610_lanthipeptide

LGIGSCNDFAGCGYAVVCFW

LG+ C + G GY+ + W

LGVRGCAENLGIGYSTLTKW

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Lasso peptides

Core peptide predictions

BIU87_RS24185 - Class I: Cleavage pHMM score: 12.50; RODEO score: 20; Monoisotopic mass: 2169.9 Da; Molecular weight: 2171.5 Da; Number of bridges: 2