BGC0002019: tiancilactone A biosynthetic gene cluster from Streptomyces sp. CB03234
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Location: 1 - 24,752 nt. (total: 24,752 nt).
This entry is originally from NCBI GenBank BK010469.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002019
Short description tiancilactone A biosynthetic gene cluster from Streptomyces sp. CB03234
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • terpene (Unknown)
Loci
BK010469.1
via
Compounds
  • tiancilactone A
  • tiancilactone B
  • tiancilactone C
  • tiancilactone D
  • tiancilactone E
  • tiancilactone F
  • tiancilactone G
  • tiancilactone H
Species Streptomyces sp. CB03234 [taxonomy]
References
Chemical products information
tiancilactone A Evidence:
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C32H44Cl1N1O8
Chemical database entries
PubCHEM
tiancilactone B Evidence:
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C32H45N1O8
Chemical database entries
PubCHEM
tiancilactone C Evidence:
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C32H44Cl1N1O8
Chemical database entries
PubCHEM
tiancilactone D Evidence:
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C34H49Cl1N2O8
Chemical database entries
PubCHEM
tiancilactone E Evidence:
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C35H51Cl1N2O8
Chemical database entries
PubCHEM
tiancilactone F Evidence:
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C31H44Cl1N1O6
Chemical database entries
PubCHEM
tiancilactone G Evidence:
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C30H46Cl1N1O5
Chemical database entries
PubCHEM
tiancilactone H Evidence:
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C22H34O4
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • DAC74128.1
 1 - 1296 (+) Na/H exchanger
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    • DAC74129.1
    		 1387 - 1605 (+) LuxR family regulator
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      • DAC74131.1
      		 1676 - 2542 (-) alpha-ketoglutarate-dependent dioxygenase
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        • DAC74130.1
        		 2568 - 3830 (-) FAD-dependent GGPP epoxidase
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          • DAC74132.1
          		 3857 - 5671 (-) type II diterpene synthase
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            • DAC74133.1
            		 5691 - 6710 (-) UbiA-type prenyltransferase
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              • DAC74134.1
              		 6712 - 7743 (-) GGPP synthase
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                • DAC74135.1
                		 7747 - 8598 (-) fumarylacetoacetate-like hydrolase
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                  • DAC74136.1
                  		 8644 - 9786 (-) cytochrome P450
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                    • DAC74137.1
                    		 10342 - 11841 (+) AMP-dependent synthetase
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                      • DAC74138.1
                      		 11828 - 12103 (+) peptide carrier protein
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                        • DAC74139.1
                        		 12281 - 13426 (+) cytochrome P450
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                          • DAC74140.1
                          		 13459 - 14307 (+) alpha beta hydrolase
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                            • DAC74141.1
                            		 14342 - 15055 (+) tryptophan dioxygenase
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                              • DAC74150.1
                              		 15112 - 16581 (+) tryptophan halogenase
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                                • DAC74142.1
                                		 16629 - 17222 (-) TetR family regulator
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                                  • DAC74143.1
                                  		 17367 - 18527 (+) cytochrome P450
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                                    • DAC74144.1
                                    		 18649 - 19473 (+) methyltransferase
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                                      • DAC74145.1
                                      		 19588 - 20397 (+) methyltransferase
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                                        • DAC74146.1
                                        		 20456 - 21451 (+) NAD-dependent epimerase/dehydratase
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                                          • DAC74147.1
                                          		 21456 - 22277 (+) methyltransferase
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                                            • DAC74148.1
                                            		 22341 - 23480 (-) alpha beta hydrolase
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                                              • DAC74149.1
                                              		 23541 - 24752 (-) pyridoxal-dependent decarboxylase
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                                                Biosynthesis information
                                                Annotation changelog

                                                Entry version: next

                                                Date
                                                Changes
                                                Submitters
                                                Reviewers
                                                2024-08-09
                                                MIBiG v4 annotathon
                                                • (ID: 4CEPXXFDQQ46VQJXBT4B4AUO)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                Entry version: 2

                                                Date
                                                Changes
                                                Submitters
                                                Reviewers
                                                2022-09-15
                                                Add compound details
                                                • (ID: SJG3CBEHSM6A3I74YXLH6GLA)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                2022-09-15
                                                Added AMP-binding domain substrate specificities
                                                • (ID: SJG3CBEHSM6A3I74YXLH6GLA)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                Entry version: 1

                                                Date
                                                Changes
                                                Submitters
                                                Reviewers
                                                2019-10-16
                                                Submitted
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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