BGC0002021 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002021 (Actinoplanes missouriensis 431)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T2PKS,PKS-like	1	95,974	High	fogacin/fogacin B/fogacin C	PKS

BGC0002021 - Region 1 - PKS-like,T2PKS

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Location: 1 - 95,974 nt. (total: 95,974 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)
PKS-like: (t2pks2 or ksIII)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 95,975
Label		BGC0002021

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase oxygenase

AMIS_50460: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

AMIS_50470: oxidoreductase

smcogs: SMCOG1083: oxidoreductase

AMIS_50490: acyl-CoA dehydrogenase type 2

smcogs: SMCOG1191: acyl-CoA dehydrogenase type 2

AMIS_50550: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

AMIS_50680: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: acyltransferase aminotransferase glycosyltransferase methyltransferase transferase

AMIS_50540: acyltransferase 3

smcogs: SMCOG1088: acyltransferase 3

AMIS_50560: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

AMIS_50590: DegT/DnrJ/EryC1/StrS aminotransferase

smcogs: SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase

AMIS_50600: methyltransferase

smcogs: SMCOG1248: methyltransferase

AMIS_50630: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

AMIS_50710: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs: SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

Hydrolases: hydrolase

AMIS_50570: beta-lactamase

smcogs: SMCOG1053: beta-lactamase

AMIS_50670: beta-lactamase

smcogs: SMCOG1053: beta-lactamase

Lyases: cyclase dehydratase hydratase

AMIS_50360: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

AMIS_50370: enoyl-CoA hydratase

smcogs: SMCOG1023: enoyl-CoA hydratase

AMIS_50620: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

AMIS_50660: cyclase/dehydrase

smcogs: SMCOG1128: cyclase/dehydrase

AMIS_50700: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: synthase

AMIS_50350: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

AMIS_50380: hydroxymethylglutaryl-CoA synthase

smcogs: SMCOG1043: hydroxymethylglutaryl-CoA synthase

AMIS_50420: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

AMIS_50430: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

AMIS_50450: 3-oxoacyl-(acyl carrier protein) synthase III

smcogs: SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III

AMIS_50640: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

AMIS_50650: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002021.3	2.72	PKS	fogacin, fogacin B, fogacin C	Actinoplanes missouriensis 431
BGC0001273.3	0.93	PKS	asperlactone	Aspergillus ochraceus
BGC0001276.3	0.91	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001817.5	0.91	other (other)	vancosamine	Streptomyces sp. WAC2288
BGC0001275.3	0.91	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244.3	0.90	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001284.4	0.89	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001254.3	0.88	PKS	ACT-Toxin II	Alternaria alternata
BGC0002192.3	0.87	PKS	FR901512	fungal sp. No.14919
BGC0001160.5	0.84	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002021.3	1.00	PKS	fogacin, fogacin B, fogacin C	Actinoplanes missouriensis 431
BGC0001273.3	0.64	PKS	asperlactone	Aspergillus ochraceus
BGC0001276.3	0.64	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001817.5	0.64	other (other)	vancosamine	Streptomyces sp. WAC2288
BGC0001275.3	0.64	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001244.3	0.64	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001284.4	0.63	PKS	alternariol	Parastagonospora nodorum SN15
BGC0002276.2	0.63	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0001254.3	0.63	PKS	ACT-Toxin II	Alternaria alternata
BGC0002192.3	0.62	PKS	FR901512	fungal sp. No.14919

Similar known clusters from MIBiG 4.0

Detailed domain annotation

Selected features only

Show module domains

Type II PKS

Type II PKS gene cluster prediction details

Cluster section:: 0 to 72477
Starter unit(s):: acetyl-CoA (Score: 0.0; E-value: 0)
Malonyl elongations:: 7 (Score: 1290.0; E-value: 1.3e-198)
Product class(es):: benzoisochromanequinone
Product molecular weight(s):: acetyl-CoA_7: 669 Da

AMIS_50420: CLF 7 (Score: 638.8; E-value: 7.1e-195)
AMIS_50430: KS (Score: 726.1; E-value: 2.6e-221)
AMIS_50440: ACP (Score: 110.7; E-value: 6.1e-35)
AMIS_50460: KR (Score: 168.4; E-value: 5.4e-52)
AMIS_50510: CYC C5-C14 (Score: 445.7; E-value: 1.6e-136)
AMIS_50560: GT (Score: 300.9; E-value: 4.1e-92)
AMIS_50630: GT (Score: 356.6; E-value: 5.3e-109)
AMIS_50640: KS (Score: 755.3; E-value: 3.6e-230)
AMIS_50650: CLF 7 (Score: 651.2; E-value: 1.3e-198)
AMIS_50660: CYC C7-C12 (Score: 405.9; E-value: 2e-124)
AMIS_50680: KR C9 (Score: 433.4; E-value: 6.2e-133)

Cluster section:: 23512 to 95974
Starter unit(s):: acetyl-CoA (Score: 0.0; E-value: 0)
Malonyl elongations:: 7 (Score: 1290.0; E-value: 1.3e-198)
Product class(es):: benzoisochromanequinone
Product molecular weight(s):: acetyl-CoA_7: 669 Da

AMIS_50420: CLF 7 (Score: 638.8; E-value: 7.1e-195)
AMIS_50430: KS (Score: 726.1; E-value: 2.6e-221)
AMIS_50440: ACP (Score: 110.7; E-value: 6.1e-35)
AMIS_50460: KR (Score: 168.4; E-value: 5.4e-52)
AMIS_50510: CYC C5-C14 (Score: 445.7; E-value: 1.6e-136)
AMIS_50560: GT (Score: 300.9; E-value: 4.1e-92)
AMIS_50630: GT (Score: 356.6; E-value: 5.3e-109)
AMIS_50640: KS (Score: 755.3; E-value: 3.6e-230)
AMIS_50650: CLF 7 (Score: 651.2; E-value: 1.3e-198)
AMIS_50660: CYC C7-C12 (Score: 405.9; E-value: 2e-124)
AMIS_50680: KR C9 (Score: 433.4; E-value: 6.2e-133)