BGC0002025 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002025 (Jahnella sp. MSr9139)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS,NRPS	1	78,740	thaxteramide C	NRPS:Type I+PKS	100%

BGC0002025 - Region 1 - NRPS,T1PKS

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Location: 1 - 78,740 nt. (total: 78,740 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 78,741
Label		BGC0002025

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002025	1.82	NRP, Polyketide	thaxteramide C	Jahnella sp. MSr9139
BGC0002135	0.67	NRP	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0002518	0.67	NRP	syringafactin A, syringafactin C	Pseudomonas sp. SZ57
BGC0001844	0.67	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454
BGC0001833	0.66	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0001135	0.63	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001128	0.63	NRP	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758	0.63	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0000417	0.62	NRP	rhodochelin	Rhodococcus jostii RHA1
BGC0002286	0.62	NRP	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002025	1.00	NRP, Polyketide	thaxteramide C	Jahnella sp. MSr9139
BGC0002135	0.67	NRP	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0000417	0.67	NRP	rhodochelin	Rhodococcus jostii RHA1
BGC0002518	0.67	NRP	syringafactin A, syringafactin C	Pseudomonas sp. SZ57
BGC0001844	0.67	NRP	holrhizin	Paraburkholderia rhizoxinica HKI 454
BGC0001833	0.66	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0001131	0.65	NRP	ambactin	Xenorhabdus miraniensis
BGC0001135	0.65	NRP	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis
BGC0001128	0.65	NRP	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001185	0.65	NRP	bacillibactin	Bacillus velezensis FZB42

Similar known gene clusters from MIBiG 4.0

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 377 - 78740:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-redmal - Me-redmal) + (mal - Asn - Tyr - Gly - bAla - Tyr)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

thxC1

PKS_AT (626..920): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 66.7%; Isobutyryl-CoA: 62.5%; Malonyl-CoA: 58.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 134.9
Ethylmalonyl-CoA: 115.9
Methoxymalonyl-CoA: 113.1
Isobutyryl-CoA: 104.8
Malonyl-CoA: 82.7
Benzoyl-CoA: 74.0
Propionyl-CoA: 71.4
2-Methylbutyryl-CoA: 70.2
Acetyl-CoA: 68.7
trans-1,2-CPDA: 60.2
3-Methylbutyryl-CoA: 45.2
fatty_acid: 37.1
CHC-CoA: 34.2
inactive: 22.8

PKS_AT (1075..1372): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 211.9
Ethylmalonyl-CoA: 209.2
Methoxymalonyl-CoA: 185.7
trans-1,2-CPDA: 140.2
2-Methylbutyryl-CoA: 136.5
CHC-CoA: 108.4
Propionyl-CoA: 108.0
Isobutyryl-CoA: 102.3
Malonyl-CoA: 96.4
Benzoyl-CoA: 81.7
Acetyl-CoA: 60.1
3-Methylbutyryl-CoA: 48.0
fatty_acid: 29.3
inactive: 24.9

PKS_AT (2625..2922): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 91.7%; Methoxymalonyl-CoA: 87.5%; Ethylmalonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 207.2
Ethylmalonyl-CoA: 202.6
Methoxymalonyl-CoA: 181.1
2-Methylbutyryl-CoA: 138.3
trans-1,2-CPDA: 132.6
Propionyl-CoA: 104.9
CHC-CoA: 103.6
Malonyl-CoA: 98.7
Isobutyryl-CoA: 94.4
Benzoyl-CoA: 71.4
Acetyl-CoA: 55.0
fatty_acid: 52.8
3-Methylbutyryl-CoA: 41.3
inactive: 33.0

PKS_AT (4718..5015): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 213.7
Ethylmalonyl-CoA: 206.4
Methoxymalonyl-CoA: 187.4
trans-1,2-CPDA: 140.2
2-Methylbutyryl-CoA: 138.8
CHC-CoA: 109.2
Propionyl-CoA: 105.6
Isobutyryl-CoA: 105.6
Malonyl-CoA: 101.4
Benzoyl-CoA: 82.9
Acetyl-CoA: 63.8
3-Methylbutyryl-CoA: 49.2
fatty_acid: 33.8
inactive: 25.2

thxC2

Search NORINE for peptide: strict or relaxed

PKS_AT (568..868): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 87.5%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 232.1
inactive: 130.1
Methoxymalonyl-CoA: 65.0
Methylmalonyl-CoA: 50.8
Propionyl-CoA: 32.1
Isobutyryl-CoA: 29.2
Acetyl-CoA: 19.8
2-Methylbutyryl-CoA: 17.9
Benzoyl-CoA: 12.7
Ethylmalonyl-CoA: 9.6
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

AMP-binding (2102..2507): Asn

nrpys: Asn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: asp,asn (Asp, Asn)
Single AA prediction:: asn (Asn)