BGC0002025: thaxteramide C biosynthetic gene cluster from Jahnella sp. MSr9139
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Location: 1 - 78,740 nt. (total: 78,740 nt).
This entry is originally from NCBI GenBank MK551161.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002025
Short description thaxteramide C biosynthetic gene cluster from Jahnella sp. MSr9139
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Unknown)
Loci
MK551161.1
via
Compounds
  • thaxteramide C
Species Jahnella sp. MSr9139 [taxonomy]
References
Chemical products information
thaxteramide C Evidence:
(no structure information available)
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • QDA77028.1
 148 - 2136 (-) hypothetical protein
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    • QDA77029.1
    		 2140 - 2943 (-) membrane protein TerC family
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      • QDA77030.1
      		 3188 - 4642 (+) acylating methylmalonate-semialdehyde dehydrogenase
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        • QDA77031.1
        		 4642 - 5514 (+) beta-ureidopropionase
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          • QDA77032.1
          		 5582 - 6985 (+) dihydropyrimidinase
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            • QDA77033.1
            		 7021 - 8403 (+) dihydropyrimidine dehydrogenase subunit
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              • QDA77034.1
              		 8407 - 9801 (+) dihydropyrimidine dehydrogenase subunit
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                • QDA77035.1
                		 9832 - 11298 (+) allantoin transporter
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                  • QDA77036.1
                  		 11325 - 11717 (-) hypothetical protein
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                    • QDA77037.1
                    		 11714 - 12016 (-) hypothetical protein
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                      • QDA77038.1
                      		 12009 - 12590 (-) ECF subfamily RNA polymerase sigma-24 subunit
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                        • QDA77039.1
                        		 12790 - 13584 (+) short-chain dehydrogenase/reductase SDR
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                          • QDA77040.1
                          		 13589 - 15760 (-) PAS/PAC sensor signal transduction histidine kinase
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                            • QDA77041.1
                            		 15846 - 17273 (-) hypothetical protein
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                              • QDA77042.1
                              		 17469 - 18998 (+) sigma-54 dependent transcriptional regulator
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                                • QDA77043.1
                                		 19010 - 19729 (+) hypothetical protein
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                                  • QDA77044.1
                                  • thxC1
                                  		 20378 - 39373 (+) polyketide synthase
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                                    • QDA77045.1
                                    • thxC2
                                    		 39363 - 61112 (+) polyketide synthase/nonribosomal peptide synthetase
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                                      • QDA77046.1
                                      		 61771 - 66924 (+) protein kinase
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                                        • QDA77047.1
                                        		 66965 - 68251 (-) major facilitator superfamily protein
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                                          • QDA77048.1
                                          		 68416 - 69966 (+) hypothetical protein
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                                            • QDA77049.1
                                            		 69994 - 71097 (-) membrane protease subunit stomatin/prohibitin-like protein
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                                              • QDA77050.1
                                              		 71429 - 72109 (-) hypothetical protein
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                                                • QDA77051.1
                                                		 72165 - 73895 (-) ABC-type siderophore export system
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                                                  • QDA77052.1
                                                  		 74015 - 75349 (-) hypothetical protein
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                                                    • QDA77053.1
                                                    		 75613 - 78549 (-) protein kinase
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                                                      Biosynthesis information

                                                      Biosynthetic modules

                                                      Name
                                                      Unk01
                                                      Type
                                                      nrps-type1
                                                      Genes
                                                      thxC2
                                                      Substrates
                                                      asparagine (evidence: Structure-based inference, Sequence-based prediction)
                                                      Integrated Monomers
                                                      Domains
                                                      adenylation
                                                      Name
                                                      Unk02
                                                      Type
                                                      nrps-type1
                                                      Genes
                                                      thxC2
                                                      Substrates
                                                      tyrosine (evidence: Structure-based inference, Sequence-based prediction)
                                                      Integrated Monomers
                                                      Domains
                                                      adenylation
                                                      Name
                                                      Unk03
                                                      Type
                                                      nrps-type1
                                                      Genes
                                                      thxC2
                                                      Substrates
                                                      glycine (evidence: Structure-based inference, Sequence-based prediction)
                                                      Integrated Monomers
                                                      Domains
                                                      adenylation
                                                      Name
                                                      Unk04
                                                      Type
                                                      nrps-type1
                                                      Genes
                                                      thxC2
                                                      Substrates
                                                      beta-alanine (evidence: Structure-based inference [1])
                                                      Integrated Monomers
                                                      Domains
                                                      adenylation
                                                      Name
                                                      Unk05
                                                      Type
                                                      nrps-type1
                                                      Genes
                                                      thxC2
                                                      Substrates
                                                      tyrosine (evidence: Structure-based inference, Sequence-based prediction)
                                                      Integrated Monomers
                                                      Domains
                                                      adenylation
                                                      Annotation changelog

                                                      Entry version: 3

                                                      Date
                                                      Changes
                                                      Submitters
                                                      Reviewers
                                                      2022-10-07
                                                      Update chemical activity to schema version 2.11
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                      Entry version: 2

                                                      Date
                                                      Changes
                                                      Submitters
                                                      Reviewers
                                                      2022-09-15
                                                      Added missing polyketide class
                                                      • (ID: CUSGWVK3I4TVHJH7NHPFAP2L)
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                      2022-09-15
                                                      Updated bioactivity data
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                      2022-09-15
                                                      Added NRP substrate specificities
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                      Entry version: 1

                                                      Date
                                                      Changes
                                                      Submitters
                                                      Reviewers
                                                      2019-10-16
                                                      Submitted
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                      Detailed domain annotation
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