BGC0002026: thaxteramide A1 biosynthetic gene cluster from Jahnella sp. MSr9139
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Location: 1 - 57,257 nt. (total: 57,257 nt).
This entry is originally from NCBI GenBank MK551162.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0002026
Short description thaxteramide A1 biosynthetic gene cluster from Jahnella sp. MSr9139
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Unknown)
Loci
MK551162.1
via
Compounds
  • thaxteramide A1
  • thaxteramide A2
  • thaxteramide B1
  • thaxteramide B2
Species Jahnella sp. MSr9139 [taxonomy]
References
Chemical products information
thaxteramide A1 Evidence:
(no structure information available)
thaxteramide A2 Evidence:
(no structure information available)
thaxteramide B1 Evidence:
(no structure information available)
thaxteramide B2 Evidence:
(no structure information available)
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • QDA77054.1
 220 - 1590 (+) PAS/PAC sensor protein
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    • QDA77055.1
    		 1897 - 2754 (+) signal peptide protein
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      • QDA77056.1
      		 2782 - 3441 (-) imidazole glycerol phosphate synthase subunit
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        • QDA77057.1
        		 3443 - 4030 (-) HisB protein
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          • QDA77058.1
          • thxA1
          		 4355 - 13003 (+) polyketide synthase
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            • QDA77059.1
            • thxA2
            		 13014 - 41873 (+) polyketide synthase/nonribosomal peptide synthetase
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              • QDA77060.1
              		 42481 - 43359 (+) secreted protein
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                • QDA77061.1
                		 43429 - 45849 (+) Lon protease 2
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                  • QDA77062.1
                  		 45868 - 48204 (+) hypothetical protein
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                    • QDA77063.1
                    		 48220 - 50769 (+) two-component hybrid sensor and regulator
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                      • QDA77064.1
                      		 50821 - 52578 (-) multi-sensor hybrid histidine kinase
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                        • QDA77065.1
                        		 52697 - 53482 (-) exodeoxyribonuclease III
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                          • QDA77066.1
                          		 53589 - 55292 (-) hypothetical protein
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                            • QDA77067.1
                            		 55289 - 56581 (-) histidyl-tRNA synthetase
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                              • QDA77068.1
                              		 56763 - 57197 (+) Holliday junction resolvase
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                                Biosynthesis information

                                Biosynthetic modules

                                Name
                                Unk01
                                Type
                                nrps-type1
                                Genes
                                thxA2
                                Substrates
                                serine (evidence: Structure-based inference, Sequence-based prediction)
                                Integrated Monomers
                                Domains
                                adenylation
                                Name
                                Unk02
                                Type
                                nrps-type1
                                Genes
                                thxA2
                                Substrates
                                threonine (evidence: Structure-based inference, Sequence-based prediction)
                                Integrated Monomers
                                Domains
                                adenylation
                                Name
                                Unk03
                                Type
                                nrps-type1
                                Genes
                                thxA2
                                Substrates
                                tyrosine (evidence: Structure-based inference, Sequence-based prediction)
                                Integrated Monomers
                                Domains
                                adenylation
                                Name
                                Unk04
                                Type
                                nrps-type1
                                Genes
                                thxA2
                                Substrates
                                glycine (evidence: Structure-based inference, Sequence-based prediction)
                                Integrated Monomers
                                Domains
                                adenylation
                                Name
                                Unk05
                                Type
                                nrps-type1
                                Genes
                                thxA2
                                Substrates
                                beta-alanine, 3R-methylbeta-alanine (evidence: Structure-based inference [1])
                                Integrated Monomers
                                Domains
                                adenylation
                                Name
                                Unk06
                                Type
                                nrps-type1
                                Genes
                                thxA2
                                Substrates
                                tyrosine (evidence: Structure-based inference, Sequence-based prediction)
                                Integrated Monomers
                                Domains
                                adenylation
                                Annotation changelog

                                Entry version: 2

                                Date
                                Changes
                                Submitters
                                Reviewers
                                2022-09-15
                                Added missing polyketide class
                                • (ID: CUSGWVK3I4TVHJH7NHPFAP2L)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                2022-09-15
                                Added NRP substrate specificities
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                Entry version: 1

                                Date
                                Changes
                                Submitters
                                Reviewers
                                2019-10-16
                                Submitted
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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