LOCUS       BGC0002028             33452 bp    DNA     linear   BCT 03-JUL-2019
DEFINITION  Streptomyces griseus strain NTK97 putative methyltransferase gene,
            complete cds; frigocyclinone gene cluster, complete sequence; and
            NAD(P)-dependent oxidoreductase gene, complete cds.
ACCESSION   BGC0002028
VERSION     BGC0002028
KEYWORDS    .
SOURCE      Streptomyces griseus
  ORGANISM  Streptomyces griseus
            Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
            Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-08 06:07:27
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..1134
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MGT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1062:glycosyltransferase, MGT family (Score: 269.2;
                     E-value: 1.2e-81)"
                     /gene_functions="biosynthetic-additional (t2pks) GT (Score:
                     371.8; E-value: 1.2e-113)"
                     /gene_kind="biosynthetic-additional"
                     /note="frig1"
                     /product="glycosyl transferase"
                     /protein_id="QDG00807.1"
                     /sec_met_domain="MGT (E-value: 2.6e-99, bitscore: 323.9,
                     seeds: 193, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKVLFIASGSPATVFGIVPLATAMRGAGHEVFMAGNEAMVPYIAS
                     AGLPALAAAEHEIAHYMDLARAGSGPLDLDNHRQVMEYVGSWFALLGADSFVRLRESLR
                     GWRPDLLVGGTMSYAAPLLAAALDVPYVVQEWTLDDWSGTDAGALRVLEPQLAELGLKG
                     LPEPELRIGICPPAIAHPDAPDVQPMRWRPGNKQGRVEPWMYARPDRPRVCLTAGSRAS
                     HERGFAFLRALHDRIAPLGVEVVIPAPDPVAAELRAAMPGVLTGWIPLDTVMPTCDLVV
                     HHSGGATTMTAADAGVPQLIIPETPVFAPPAQRLADHGAGIMIAEAEATDEAVERACRE
                     ILGDSRFKQRAGEIAAEIAEMPPPPTLVPQLEKVALG"
     misc_feature    1..33452
                     /note="frigocyclinone gene cluster"
     protocluster    1..33452
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[20817:23300]"
                     /cutoff="20000"
                     /detection_rule="(t2ks and t2clf)"
                     /neighbourhood="35000"
                     /product="T2PKS"
                     /protocluster_number="1"
                     /t2pks_malonyl_elongations="8|9 (Score: 687.7; E-value:
                     9.8e-210)"
                     /t2pks_molecular_weights="acetyl-CoA_8 (Da): 531.528"
                     /t2pks_molecular_weights="acetyl-CoA_9 (Da): 573.564"
                     /t2pks_product_classes="angucycline"
                     /t2pks_starter_units="acetyl-CoA (Score: 0.0; E-value: 0)"
                     /tool="antismash"
     proto_core      20818..23300
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(t2ks and t2clf)"
                     /neighbourhood="35000"
                     /product="T2PKS"
                     /protocluster_number="1"
                     /t2pks_malonyl_elongations="8|9 (Score: 687.7; E-value:
                     9.8e-210)"
                     /t2pks_molecular_weights="acetyl-CoA_8 (Da): 531.528"
                     /t2pks_molecular_weights="acetyl-CoA_9 (Da): 573.564"
                     /t2pks_product_classes="angucycline"
                     /t2pks_starter_units="acetyl-CoA (Score: 0.0; E-value: 0)"
     cand_cluster    1..33452
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(t2ks and t2clf)"
                     /kind="single"
                     /product="T2PKS"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..33452
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0002028"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..33452
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="T2PKS"
                     /region_number="1"
                     /rules="(t2ks and t2clf)"
                     /subregion_numbers="1"
                     /tool="antismash"
     CDS             1210..2829
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005:Drug
                     resistance transporter, EmrB/QacA (Score: 332.6; E-value:
                     4.7e-101)"
                     /gene_kind="transport"
                     /note="frig2"
                     /product="drug resistance transporter"
                     /protein_id="QDG00808.1"
                     /transl_table=11
                     /translation="MAQQAPPLAGRREWIGLAVLALPTLLLALSMTSLNLAIPYLSADL
                     NPSGAQLLWITDIYGFLIAGTLITMGTLGDRFGRRRLLLIGAAVFGVASAVGAYSNSPE
                     MLIVMRALLGLSGATLMPSTLSLLSNMFRDPAQRTFAFSTWMATFMGGTAVGPLVGGVF
                     LEHFWWGSVLLLGVPVMLVLLVLGPVLLPENKDPDPGHIDLLSVALSLAGVLSVVYGLK
                     QIAGDSASRLAFAYMAAGIVILVVFLRRQQRLRHPLLDLTMFRNRTFSVPIVALAVGIF
                     MNGGINFFLMQFLQSVLGLTPLQAGLCTLPPTTIGMATSMLAPQLIQRFRPAYIMGPAF
                     LAAAAGHVIVSQVDKDSGAALLVVGLAVMGTGFGLFMAMGTSLALGAVEPEKSGAASAT
                     SETSTELGLSLGIAVLGSVGTAVYQSKFRSLVPEGTPESVVDRAEKTVGAAVLEAEKLP
                     AHLSDQFLDAVGSAFAAGLRTNSVIGAVGLTCVAVFVTVMLRHLPPQPKGSGAHGHGGA
                     EAASDAAAVPSPAQGTEVRHDS"
     CDS             3171..4103
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1248:methyltransferase (Score: 194.3; E-value: 4e-59)"
                     /gene_kind="biosynthetic-additional"
                     /note="frig3"
                     /product="N,N-dimethyltransferase"
                     /protein_id="QDG00809.1"
                     /transl_table=11
                     /translation="MRVLLPGGGVCVAASPRPHGRASPPDPSGRPPVVAPAVRFSPSTV
                     CGALRSALTHSFCLPVGGVMTTVSEEFPAAYSTSHAEIYEFIHSARGRDWAAEADDYVR
                     LVRERNSTASSLLDVASGTGAHLARFAEHFDRAEGLELSEGMRALSRAKLPDVPVHAGD
                     MRDFHLGSTYDAVVCLCFSLSYTRDVDELRAAAFAMSRHLSPGGVLIVEPWWFPEKFID
                     GFVSASLAEQQGRAVSRLSHTVREGRTSRMEVRYTVADQRGIQDFTEYEVLSLFTEQEY
                     AAAFADAGCPVEYHPGGPNGRGLFVGVRQ"
     CDS             4400..5329
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1056:DegT/DnrJ/EryC1/StrS aminotransferase (Score:
                     281.7; E-value: 1.5e-85)"
                     /gene_kind="biosynthetic-additional"
                     /note="frig4"
                     /product="NDP-hexose aminotransferase"
                     /protein_id="QDG00810.1"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 2.6e-72,
                     bitscore: 234.9, seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPSLSFVAAANAVAAAGARPVFCESDVRTLNPTADDIERALTPRT
                     RAVIVLHYGGYPGDIAAIAALCRRRGVTLIEDAACSVASRAGGVACGTFGDLATWSFDS
                     MKVLVTGDGGAFYARSPELARRARQLAYHGLEQASAFDAAKVTDRWWEPNVEHFGRRII
                     GNDVTAAIGSVQLRRLPEFVARRREIAALYDQLLLDVEGVRVPPPLPEGHDSSHYFYWV
                     QMDAAIRSKVASDLLERDIFTTFRYPALHRVPVYSVQDVSLPGAEEAADRTLLLPLHQG
                     LSDAEVHTVVDEFRKSVEFHTQELRSKG"
     CDS             5333..5923
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) dTDP_sugar_isom"
                     /gene_kind="biosynthetic-additional"
                     /note="frig5"
                     /product="NDP-hexose 35-epimerase"
                     /protein_id="QDG00811.1"
                     /sec_met_domain="dTDP_sugar_isom (E-value: 1.6e-49,
                     bitscore: 158.7, seeds: 19, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHVEETTIPGALVVTARRHVDQRGDFYEGLRTDVLEHELGRPFPV
                     RQINYSTSCRNTLRGLHGVAIPPGQVKYVTCVQGALRDIIVDLRIGSPAFGRHHVTELD
                     AESGRSVVVPEGVGHGFLTLTDDARICYVLSTVYVPGTQIDIDPLDRDLALPWGFTQPP
                     LMSDKDAGAPSLAEVTATGRLPRWQAGVAYSNT"
     CDS             6122..7003
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 242; E-value:
                     1.3e-73)"
                     /gene_kind="biosynthetic-additional"
                     /note="frig6"
                     /product="glucose-1-phosphate thymidylyltransferase"
                     /protein_id="QDG00812.1"
                     /transl_table=11
                     /translation="MIGDGARLGAHITYIAQQEPLGLAHCVALARPFLGDDDFVMYLGD
                     NILPDGVMDIAGQFTAHRPDAQVIVHKVPDPRAFGVAELDAEGRVLRLVEKPQDPQSDL
                     ALIGVYFFTPAIHEAVASIEPSPRGELEITDAIQWLVSQGREVRASEYDGYWKDTGRAE
                     DVLECNQRILAGLKPSVAGHVDAYSTLVGTVVLEAGARVVRSAIEGPVIIGAGSVVEDS
                     RLGPGTSVGRDCVVRRSQVADSIILDRAEITDIPSLEGSLIGRGAQVGACTLEPTHHRL
                     VVGDDTRIEVAA"
     CDS             7048..8016
                     /NRPS_PKS="Domain: NAD_binding_4 (58-206). E-value: 5e-15.
                     Score: 47.1. Matches aSDomain:
                     nrpspksdomains_QDG00813.1_NAD_binding_4.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NAD_binding_4"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score:
                     319.1; E-value: 5.3e-97)"
                     /gene_kind="biosynthetic-additional"
                     /note="frig7"
                     /product="dTDP-glucose 46-dehydratase"
                     /protein_id="QDG00813.1"
                     /sec_met_domain="NAD_binding_4 (E-value: 2.6e-15, bitscore:
                     47.1, seeds: 102, tool: rule-based-clusters)"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 2.7e-17,
                     bitscore: 53.7, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="RmlD_sub_bind (E-value: 3.5e-21, bitscore:
                     66.4, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRSLLGGAYPDCADARVTVVDKLSYAGNRDNLPARHPRLAFVEAD
                     ICDLPRMLDVLPGHDAVVHFAAESHVDRSVESAAEFVRTNVGGTQTLLDACLETGVERL
                     VHVSTDEVYGSIAEGSWTEEWPLAPNSPYAATKAASDLVARSHWRTHGLDLSITRCSNN
                     YGPYQHPEKLIPLFVTRLLEGRQVPLYGDGRNVREWLHVDDHCRAIHLVLTRGRAGEIY
                     NVGGGNERSNVQITEEVLRLCGADWSAVRHVADRKGHDLRYALDDSKIREHLGYAPRVP
                     FASGLADTVTWYRDNPHWWKRLGHDGAAVEARTGEGTGVRP"
     aSDomain        7222..7665
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_QDG00813.1_NAD_binding_4.1"
                     /evalue="5.00E-15"
                     /label="QDG00813.1_NAD_binding_4.1"
                     /locus_tag="QDG00813.1"
                     /protein_end="206"
                     /protein_start="58"
                     /score="47.1"
                     /tool="antismash"
                     /translation="HDAVVHFAAESHVDRSVESAAEFVRTNVGGTQTLLDACLETGVER
                     LVHVSTDEVYGSIAEGSWTEEWPLAPNSPYAATKAASDLVARSHWRTHGLDLSITRCSN
                     NYGPYQHPEKLIPLFVTRLLEGRQVPLYGDGRNVREWLHVDDHC"
     CDS             8013..9317
                     /NRPS_PKS="Domain: Aminotran_5 (57-196). E-value: 4.5e-07.
                     Score: 20.9. Matches aSDomain:
                     nrpspksdomains_QDG00814.1_Aminotran_5.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1056:DegT/DnrJ/EryC1/StrS aminotransferase (Score:
                     361.9; E-value: 6.7e-110)"
                     /gene_kind="biosynthetic-additional"
                     /note="frig8"
                     /product="NDP-hexose 34-dehydratase"
                     /protein_id="QDG00814.1"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 1.5e-100,
                     bitscore: 327.9, seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNHKAMILDETRKYHADQQPGGPFLPGVTEIWPSGAVLDAEDRA
                     ALVEAALDLNIAAGSRSQRFESRFAKLLGRRKAHLTNSGSSANLLALTALTSHVLGDRR
                     LRPGDEVITVAAGFPTTVNPIVQNGLVPVFIDIDLGIYNTTAERVAEAIGPKTRAIMIA
                     HALGNPFEVAEIAQLAKDNDLFFVEDNCDAVGSTYQGALTGTFGDLTTVSFYPAHHLTM
                     GEGGCVLTSNLKLHRVVESLRDWGRDCWCEPGKNNTCLKRFDHQMGRLPQGYDHKYIFS
                     HVGYNLKATDLQAALGLTQLDKLDGFIAARRRNWRRMREGLEGVPHLRLPEPTRGSDPS
                     WFGFVISVDPGAPFSRAALVDFLEGRKIGTRRLFAGNLTRQPAYLDVPHRVVGSLANSD
                     FVTEHTFWVGVYPGLTDEMIDYVVSSVREFVGGHR"
     aSDomain        8184..8600
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_QDG00814.1_Aminotran_5.1"
                     /evalue="4.50E-07"
                     /label="QDG00814.1_Aminotran_5.1"
                     /locus_tag="QDG00814.1"
                     /protein_end="196"
                     /protein_start="57"
                     /score="20.9"
                     /tool="antismash"
                     /translation="AGSRSQRFESRFAKLLGRRKAHLTNSGSSANLLALTALTSHVLGD
                     RRLRPGDEVITVAAGFPTTVNPIVQNGLVPVFIDIDLGIYNTTAERVAEAIGPKTRAIM
                     IAHALGNPFEVAEIAQLAKDNDLFFVEDNCDAVGS"
     CDS             9314..10696
                     /codon_start=1
                     /note="frig9"
                     /product="NDP-hexose 23-dehydratase"
                     /protein_id="QDG00815.1"
                     /transl_table=11
                     /translation="MTTTVGLLQPRRDGGRPGVLSRSRACRDEGVQLSTAQFAPWLTWR
                     GEMNRFAVERIAFSSLEGWSFARDTGNLGHRSGRFFTVEGLEVRTHDGSVAPWRQPTIK
                     QPEVGILGILAKEFDGVLHFLMQAKMEPGNPNLLQLSPTVQATRSNYTKVHRGADVKYI
                     EYFTQPGRNRVLADVLQSEHGSWFYRKSNRNMLVQTDEDVPVDDEFCWLTLGQLGELLL
                     RDNVVNMDARTVLASIPGCCQDSRAVHSDIELRSWFTGERARHEITVERTPLREVSRWQ
                     RDDWSISHEEGRYFRVVALAVEASNREVGGWTQPLFEPVAKGVTAFLTRHFDGVLHVLA
                     HARVEGGFLDTVELGPTVQYTPENYAHLDAADRPPFLDLVLGADPSRIRYEAVHSEEGG
                     RFLNAESRYLFVAADDIGADLPAGYAWVTPGQLNSLAQHGHYVNVQARTLLACLNAGAV
                     AY"
     CDS             10762..11655
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1079:oxidoreductase (Score: 243.9; E-value: 4.8e-74)"
                     /gene_kind="biosynthetic-additional"
                     /note="frig10"
                     /product="dNDP-hexose 3-ketoreductase"
                     /protein_id="QDG00816.1"
                     /transl_table=11
                     /translation="MAACAGTEISVVASRDLIRAQETARAYGCRAVQGYESVLGDPMVD
                     AVYVPVPAALHADWAEAALRAGKHVLVEKPLATEYGRTAELIGFARERSLALMENVMFV
                     HHGQHEAVRKLVADGTVGGLRAFRAEFTVPGRPDDDIRYRPELAGGALWDTGVYPLRAA
                     LHFLGPQLSVAGAALSNGAGRQVDTAGAALLRTPEGVTAQLSFGLDHGYRSLYELVGSH
                     GRITVDHAFTPPAGHSPVVRLENGDGTRELTLPADDQVAATVRAFVAAARAGAAPDSST
                     VRRQAELLASIRQAAR"
     CDS             11714..12937
                     /codon_start=1
                     /note="frig11"
                     /product="putative methyltransferase"
                     /protein_id="QDG00817.1"
                     /transl_table=11
                     /translation="MTSRLFTSESVTEGHPDKIADQISDTVLDALLRADPASRVAVETL
                     ITTGQVHIAGEVTTKAYAPIAQLVRDKILEIGYDSSAKGFDGASCGVSVSIGAQSPDIA
                     QGVNTSYEKRVGDAVTDTEGDELDLQGAGDQGLMFGYACDETPELMPLPIHLAHRLSRR
                     LSEVRKDGTLPYLRPDGKTQVTIEYRGSRPVRLDTVVVSSQHAPEISLETLLTRDVREH
                     VVDHVLARLAADGIKLETEGYRLLVNPTGRFEIGGPMGDAGLTGRKIIIDTYGGMARHG
                     GGAFSGKDPSKVDRSAAYAMRWVAKNVVAARLATRCEVQVAYAIGKAEPVGLFVETFGT
                     AVVPQRAIEKAITEVFDLRPAAIIRDLDLLRPIYAQTAAYGHFGRELPDFTWERTDRAE
                     ALARAAGV"
     CDS             13053..13922
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1276:PfkB domain protein (Score: 75; E-value: 1e-22)"
                     /gene_kind="biosynthetic-additional"
                     /note="frig12"
                     /product="putative adenosine kinase"
                     /protein_id="QDG00818.1"
                     /transl_table=11
                     /translation="MDGMDVRRGGVAANIAYGLGVLGQGPVLVGGAGADFGDYRLRLKE
                     HGVDTEAVLVSATRQTARFLCLTDQDMNQIAAFYPGAMSEAADIRLRAVAESVGGLDLV
                     LVSPNDPGAMVTHTEECRELGIPFAADPSQQLASLSGQQTRGLVEGAAWLFTNEYEAAL
                     VRERTGWSEQQVLERVGAWVITLGAQGVRVARRGAEPEVVPAVPCAAPVDPTGVGDAFR
                     AGFLAGLAQQLSTGAAARLGCALATTALGFTGPQEYAITSERLSQALASAYGGAAVVEA
                     APVLERMR"
     CDS             13919..14788
                     /codon_start=1
                     /note="frig13"
                     /product="methylenetetrahydrofolate reductase"
                     /protein_id="QDG00819.1"
                     /transl_table=11
                     /translation="MTTYSFEFFPPKTGKGAAALWRTVRRVEALRPDFVSVTYGAGGSS
                     RDHTVEVTHRIATETTLRPVAHLTAVGHSVAELRRIIGQYADAGIRDVLVLRGDPPGDP
                     MGPWVSHPDGFTHAYQLVELVRSLGDFTIGVAAFPERHPRSPDWDSDIRHFVAKCRAGA
                     DYAITQMFFRVEDYLRLRDQVASAGCDTPIIPEIMPATDVRQIRRFAELSGATFPQDLA
                     RRLEAARENAADGYRIGVEHATAMADRLLAEEAPGLHYITLNRCAAALEVHHNVVASHS
                     ASVRSVRT"
     CDS             complement(15167..16159)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /note="frig14"
                     /product="thioesterase"
                     /protein_id="QDG00820.1"
                     /sec_met_domain="Abhydrolase_6 (E-value: 2.7e-13, bitscore:
                     41.9, seeds: 455, tool: rule-based-clusters)"
                     /sec_met_domain="PF00561 (E-value: 4.7e-07, bitscore: 20.5,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPAGTPARPPLHSAPSPTDGPRRPTIHPGETRMAEPTRRTPPQTR
                     GITLDADGLRLSALLALPQQLPPRAVVVAVHGGGMRAGYFDSRARPGHSLLTLGAELGY
                     AVLAVDRPGYGASAAQLPQGQSLADQSATLRAALTDFARNQERGAGYFVVAHSNGGKLA
                     LALAAGHEPGTDLVGLDISGLGTHLAVEPHDLPGPDRPGTWRRHWGPLRLYPPEAFGQC
                     RDVVAPVPALEAQEAARWPQIYQDIAARVRVPVRFTFAEQEQWWHQDEQALRALRAPLA
                     APHVVIDRQPDAGHNISLGWASRTYHLQALAFLEKCLLARETAAVTAPR"
     CDS             complement(16286..18622)
                     /NRPS_PKS="Domain: PKS_KR (532-711). E-value: 6.6e-09.
                     Score: 27.7. Matches aSDomain:
                     nrpspksdomains_QDG00821.1_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1050:monooxygenase FAD-binding (Score: 539.3; E-value:
                     1.7e-163)"
                     /gene_functions="biosynthetic-additional (t2pks) KR C15
                     (Score: 494.8; E-value: 1.1e-151)"
                     /gene_kind="biosynthetic-additional"
                     /note="frig15"
                     /product="oxygenase-reductase"
                     /protein_id="QDG00821.1"
                     /transl_table=11
                     /translation="MTADRLDTQVIVVGAGPVGLLLAGELRLGGADTLVLERRRSPTTE
                     SRASTLHARTMEILETRGLLAPLGDLPNEPTGHFGGIPLDLSLPSRYPGQWKVPQTRVE
                     ELLGQWATGLGADIRRGHELTGLTMTTDGAEAQVRLGDGRTTRLRAKCIVGCDGENSTV
                     RRLGGFDFPGTDAQRHLLRADIDGIDIPNRRFERLPHGLAIAARRGDGVTRVMVHQYGT
                     RPRTAPAEFTDVVDAWKRVTGEDISGGRPLWVNTFGDASRHASRYRDHRLFLAGDAAHQ
                     QMPIGGQALNLGLQDAANLGWKLAAQLLERGPDGLLDSYHSERHAVGRRVLDNIRAQAL
                     LLLGTAEVDAARQVLAELLRHEGVRRHLAGMISGLDTRYDVGPGTHPLLGARLPHWELT
                     TNTPGPTTAAELMHDGRGVLLVPPGDAARQKTLRTAALPWTGLVHTAAASPPADAADPG
                     APALLVRPDGHVAWAGSDPTHLTTALHRWFGTATSPAAPPTVQASAPGPMTPVKSPAKP
                     PRKKRSTDMGRLSGKTALVTGASRGMGRATALRLAQEGALVAVHYASSEEAATDVLELI
                     EKDGGRGFTVRAELGPAGDVHELFLGLENGLRERTGSTDLDILVNNAGVMGNVKPQDTT
                     PETFDRIFAINAKAPFFLIQRALKNMPDGGRIINISTGLTRFANPDEIAYAMSKGAVEQ
                     LALHYAKLLGPRGITINSVAPGITRNDNPVFGIPEAVEQMAQLSTFNRVGEPEDVADVV
                     AFLATDEARWITGSFVDATGGTLLG"
     aSDomain        complement(16490..17026)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_QDG00821.1_PKS_KR.1"
                     /evalue="6.60E-09"
                     /label="QDG00821.1_PKS_KR.1"
                     /locus_tag="QDG00821.1"
                     /protein_end="711"
                     /protein_start="532"
                     /score="27.7"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="TALVTGASRGMGRATALRLAQEGALVAVHYASSEEAATDVLELIE
                     KDGGRGFTVRAELGPAGDVHELFLGLENGLRERTGSTDLDILVNNAGVMGNVKPQDTTP
                     ETFDRIFAINAKAPFFLIQRALKNMPDGGRIINISTGLTRFANPDEIAYAMSKGAVEQL
                     ALHYAKLLGPRGITIN"
     CDS_motif       complement(16955..17020)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_QDG00821.1_0002"
                     /evalue="4.60E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="QDG00821.1"
                     /protein_end="556"
                     /protein_start="534"
                     /score="12.9"
                     /tool="antismash"
                     /translation="LVTGASRGMGRATALRLAQEGA"
     CDS_motif       complement(18515..18592)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_QDG00821.1_0001"
                     /evalue="9.40E+00"
                     /label="PKSI-KR_m1"
                     /locus_tag="QDG00821.1"
                     /protein_end="36"
                     /protein_start="10"
                     /score="-0.9"
                     /tool="antismash"
                     /translation="IVVGAGPVGLLLAGELRLGGADTLVL"
     CDS             complement(18625..19581)
                     /NRPS_PKS="Domain: Polyketide_cyc2 (10-153). E-value:
                     4.2e-19. Score: 61.2. Matches aSDomain:
                     nrpspksdomains_QDG00822.1_Polyketide_cyc2.1"
                     /NRPS_PKS="Domain: Polyketide_cyc2 (162-300). E-value:
                     2.6e-08. Score: 26.2. Matches aSDomain:
                     nrpspksdomains_QDG00822.1_Polyketide_cyc2.2"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1128:cyclase/dehydrase (Score: 472.5; E-value:
                     1e-143)"
                     /gene_functions="biosynthetic-additional (t2pks) CYC C7-C12
                     (Score: 508.7; E-value: 1e-155)"
                     /gene_kind="biosynthetic-additional"
                     /note="frig16"
                     /product="aromatase/cyclase"
                     /protein_id="QDG00822.1"
                     /transl_table=11
                     /translation="MTPRRFTMTTHEVEHEITVAAPPPTVYRLLADVQNWPRIFPPTIH
                     VDQVERNGDDERIRIWATANGAAKNWTSHRTLDPEGLRIDFRQEVSTPPVASMGGAWVI
                     EPLPEAGCRVRLLHDYRAIDDDPAGLQWIDEAVDRNSRSELAALKQNVELAHAAEALTF
                     SFEDSVQVHGSAKDVYDFINEAGLWSQRLPHVATVRLTEDEPGLQTLEMDTRAKDGSVH
                     TTKSYRVCLPHEKIAYKQVTLPALMTLHTGYWTFVEDNNGVTTASSQHTVVINAANIAR
                     ILGADATVTDAREYVQGALSANSRITLGHAKDYAEKR"
     aSDomain        complement(18682..19095)
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_QDG00822.1_Polyketide_cyc2.2"
                     /domain_subtype="Polyketide_cyc2"
                     /evalue="2.60E-08"
                     /label="QDG00822.1_Polyketide_cyc2.2"
                     /locus_tag="QDG00822.1"
                     /protein_end="300"
                     /protein_start="162"
                     /score="26.2"
                     /tool="antismash"
                     /translation="FSFEDSVQVHGSAKDVYDFINEAGLWSQRLPHVATVRLTEDEPGL
                     QTLEMDTRAKDGSVHTTKSYRVCLPHEKIAYKQVTLPALMTLHTGYWTFVEDNNGVTTA
                     SSQHTVVINAANIARILGADATVTDAREYVQGAL"
     aSModule        18682..19551
                     /domains="nrpspksdomains_QDG00822.1_Polyketide_cyc2.1"
                     /domains="nrpspksdomains_QDG00822.1_Polyketide_cyc2.2"
                     /incomplete
                     /locus_tags="QDG00822.1"
                     /tool="antismash"
                     /type="unknown"
     aSDomain        complement(19123..19551)
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_QDG00822.1_Polyketide_cyc2.1"
                     /domain_subtype="Polyketide_cyc2"
                     /evalue="4.20E-19"
                     /label="QDG00822.1_Polyketide_cyc2.1"
                     /locus_tag="QDG00822.1"
                     /protein_end="153"
                     /protein_start="10"
                     /score="61.2"
                     /tool="antismash"
                     /translation="HEVEHEITVAAPPPTVYRLLADVQNWPRIFPPTIHVDQVERNGDD
                     ERIRIWATANGAAKNWTSHRTLDPEGLRIDFRQEVSTPPVASMGGAWVIEPLPEAGCRV
                     RLLHDYRAIDDDPAGLQWIDEAVDRNSRSELAALKQNVE"
     CDS             complement(19581..20363)
                     /NRPS_PKS="Domain: PKS_KR (6-159). E-value: 2.6e-13. Score:
                     42.1. Matches aSDomain: nrpspksdomains_QDG00823.1_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     267; E-value: 2.6e-81)"
                     /gene_functions="biosynthetic-additional (t2pks) KR C9
                     (Score: 482.0; E-value: 9.6e-148)"
                     /gene_kind="biosynthetic-additional"
                     /note="frig17"
                     /product="polyketide ketoreductase"
                     /protein_id="QDG00823.1"
                     /sec_met_domain="adh_short (E-value: 2.3e-40, bitscore:
                     129.4, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQQDQPVAVVTGATSGIGLAVARLLAEQGHRVFLGARTQENVAAT
                     VKQLREEGLEVDGTAVDVRSGEAVEAFVRAAVDRFGTIDVLVNNAGRSGGGVTADLTDE
                     LWDDVIDTNLNSVFRVTRAVLNTGGMRAKDRGRIINIASTAGKQGVILGAPYSASKHGV
                     VGFTKALGNELAPTGVTVNAVCPGYVETPMAQRVREGYATAYQTSEAAILEKFQAKIPL
                     GRYSTPQEVAGLVGYLVSDTAASITAQALNVCGGLGNF"
     aSDomain        complement(19887..20345)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_QDG00823.1_PKS_KR.1"
                     /evalue="2.60E-13"
                     /label="QDG00823.1_PKS_KR.1"
                     /locus_tag="QDG00823.1"
                     /protein_end="159"
                     /protein_start="6"
                     /score="42.1"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="VAVVTGATSGIGLAVARLLAEQGHRVFLGARTQENVAATVKQLRE
                     EGLEVDGTAVDVRSGEAVEAFVRAAVDRFGTIDVLVNNAGRSGGGVTADLTDELWDDVI
                     DTNLNSVFRVTRAVLNTGGMRAKDRGRIINIASTAGKQGVILGAPYSAS"
     CDS_motif       complement(20268..20339)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_QDG00823.1_0001"
                     /evalue="2.80E-07"
                     /label="PKSI-KR_m1"
                     /locus_tag="QDG00823.1"
                     /protein_end="32"
                     /protein_start="8"
                     /score="23.2"
                     /tool="antismash"
                     /translation="VVTGATSGIGLAVARLLAEQGHRV"
     CDS             complement(20437..20733)
                     /NRPS_PKS="Domain: ACP (21-91). E-value: 3.4e-18. Score:
                     57.6. Matches aSDomain: nrpspksdomains_QDG00824.1_ACP.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1129:acyl carrier protein (Score: 110.1; E-value:
                     6.7e-34)"
                     /gene_functions="biosynthetic-additional (t2pks) ACP
                     (Score: 121.8; E-value: 2.1e-38)"
                     /gene_kind="biosynthetic-additional"
                     /note="frig18"
                     /product="acyl carrier protein"
                     /protein_id="QDG00824.1"
                     /sec_met_domain="PP-binding (E-value: 4.9e-13, bitscore:
                     40.4, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRQTYERHVMPKKEFTLDDLTRILLEGAGADEDVVLDEDILDKQF
                     GDLGYESLALLETASRIEREYGISLDDDIFTEHPTPRALIETINTALAKLISA"
     aSDomain        complement(20461..20670)
                     /aSDomain="ACP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_QDG00824.1_ACP.1"
                     /evalue="3.40E-18"
                     /label="QDG00824.1_ACP.1"
                     /locus_tag="QDG00824.1"
                     /protein_end="91"
                     /protein_start="21"
                     /score="57.6"
                     /tool="antismash"
                     /translation="RILLEGAGADEDVVLDEDILDKQFGDLGYESLALLETASRIEREY
                     GISLDDDIFTEHPTPRALIETINTA"
     CDS             complement(20818..22035)
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (62-402). E-value:
                     1e-28. Score: 92.2. Matches aSDomain:
                     nrpspksdomains_QDG00825.1_PKS_KS.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) T2PKS:
                     t2clf"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1093:Beta-ketoacyl synthase (Score: 650.9; E-value:
                     1e-197)"
                     /gene_functions="biosynthetic-additional (t2pks) CLF 8|9
                     (Score: 687.7; E-value: 9.8e-210)"
                     /gene_kind="biosynthetic"
                     /note="frig19"
                     /product="chain length factor"
                     /protein_id="QDG00825.1"
                     /sec_met_domain="t2clf (E-value: 5.2e-207, bitscore: 678.1,
                     seeds: 26, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSAKAVVTGIGIFTPHGLGVDDFWSATRIGKNAIGQVTRFDATPY
                     PAQLAGEIRSFAAAQHLPSRLIPQTDRMTRMALVAADCAFGDADVQPGEFAEYDMGVVT
                     ASTSGGFEFGQNELQKLWSQGSHYVSAYQSFAWFYAVNSGQISIRNGMRGPSSVVVSDH
                     AGGLDAIAQARRLIRKGSRLILSGGFDASICTWGWVAQLASDRLSTSTDPERAYLPFDE
                     AADGYVPGEGGALLTLESAESARARGARRIYGEIAGYGSTFDPRPDSGREPGLRRAIET
                     ALTDAHVPAAEIDVVFADGAGTPRLDREEAEAITAVFGPAGVPVTVPKASTGRLYSGAA
                     PVDVVTALLTIREGLIPPTINVLPSPDYDLDLVTGQARVTPVNTALVLARGYGGFNSAM
                     VLRAPH"
     aSDomain        complement(20830..21849)
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_QDG00825.1_PKS_KS.1"
                     /domain_subtype="Iterative-KS"
                     /evalue="1.00E-28"
                     /label="QDG00825.1_PKS_KS.1"
                     /locus_tag="QDG00825.1"
                     /protein_end="402"
                     /protein_start="62"
                     /score="92.2"
                     /tool="antismash"
                     /translation="PSRLIPQTDRMTRMALVAADCAFGDADVQPGEFAEYDMGVVTAST
                     SGGFEFGQNELQKLWSQGSHYVSAYQSFAWFYAVNSGQISIRNGMRGPSSVVVSDHAGG
                     LDAIAQARRLIRKGSRLILSGGFDASICTWGWVAQLASDRLSTSTDPERAYLPFDEAAD
                     GYVPGEGGALLTLESAESARARGARRIYGEIAGYGSTFDPRPDSGREPGLRRAIETALT
                     DAHVPAAEIDVVFADGAGTPRLDREEAEAITAVFGPAGVPVTVPKASTGRLYSGAAPVD
                     VVTALLTIREGLIPPTINVLPSPDYDLDLVTGQARVTPVNTALVLARGYGGFNSAMVLR
                     "
     CDS_motif       complement(21340..21378)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_QDG00825.1_0001"
                     /evalue="8.10E-05"
                     /label="PKSI-KS_m4"
                     /locus_tag="QDG00825.1"
                     /protein_end="232"
                     /protein_start="219"
                     /score="15.5"
                     /tool="antismash"
                     /translation="FDEAADGYVPGEG"
     CDS             complement(22032..23300)
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (4-396). E-value:
                     2.8e-57. Score: 186.3. Matches aSDomain:
                     nrpspksdomains_QDG00826.1_PKS_KS.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) T2PKS:
                     t2ks"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 502.4; E-value:
                     1.8e-152)"
                     /gene_functions="biosynthetic-additional (t2pks) KS (Score:
                     797.6; E-value: 5.3e-243)"
                     /gene_kind="biosynthetic"
                     /note="frig20"
                     /product="beta-ketoacyl synthase"
                     /protein_id="QDG00826.1"
                     /sec_met_domain="t2ks (E-value: 5.7e-253, bitscore: 830.1,
                     seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGRRVAITGVGVLAPGGIGVKNFWSLLSEGRTATRGITFFDPAPF
                     RSRVAAEIDFDAAQHGLRPQELRRMDRAAQFAVVTAREALADSQLAVADFDPHRTGVTI
                     GSAVGATTGLDDEYRVVSDDGRLDLVDHTYAPRHLYNYFVPSSFSAEVAWAVGAEGPAT
                     VISTGCTSGIDSVGHAVELIREGTADVMIAGATDAPISPITLACFDAIKATTARNDDPE
                     HASRPFDGTRNGFVLGEGSAVFVLEELESAQRRGAHIYAEIAGYASRCNAFHMTGLRPD
                     GREMAEAIRVAMTEARMNPEDIDYINAHGSGTKQNDRHETAAFKLSLGEHAYRTPVSSI
                     KSMVGHSLGAIGSIEIAASVLAMEHNVVPPTANLRTPDPECDLDYVPLTAREQRTDTVL
                     TVGSGFGGFQSAMVLARPERKAA"
     aSDomain        complement(22113..23288)
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_QDG00826.1_PKS_KS.1"
                     /domain_subtype="Iterative-KS"
                     /evalue="2.80E-57"
                     /label="QDG00826.1_PKS_KS.1"
                     /locus_tag="QDG00826.1"
                     /protein_end="396"
                     /protein_start="4"
                     /score="186.3"
                     /tool="antismash"
                     /translation="VAITGVGVLAPGGIGVKNFWSLLSEGRTATRGITFFDPAPFRSRV
                     AAEIDFDAAQHGLRPQELRRMDRAAQFAVVTAREALADSQLAVADFDPHRTGVTIGSAV
                     GATTGLDDEYRVVSDDGRLDLVDHTYAPRHLYNYFVPSSFSAEVAWAVGAEGPATVIST
                     GCTSGIDSVGHAVELIREGTADVMIAGATDAPISPITLACFDAIKATTARNDDPEHASR
                     PFDGTRNGFVLGEGSAVFVLEELESAQRRGAHIYAEIAGYASRCNAFHMTGLRPDGREM
                     AEAIRVAMTEARMNPEDIDYINAHGSGTKQNDRHETAAFKLSLGEHAYRTPVSSIKSMV
                     GHSLGAIGSIEIAASVLAMEHNVVPPTANLRTPDPECDLDYVPLTAREQRTD"
     CDS             complement(23338..23901)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1225:Polyketide synthesis cyclase (Score: 153.5;
                     E-value: 2.9e-47)"
                     /gene_functions="biosynthetic-additional (t2pks) CYC
                     C4-C17/C2-C19 (Score: 199.3; E-value: 1.4e-61)"
                     /gene_kind="biosynthetic-additional"
                     /note="frig21"
                     /product="polyketide cyclase"
                     /protein_id="QDG00827.1"
                     /transl_table=11
                     /translation="MVRTAGGGLNRRHALLPDTDRHIEERCTARPRPVHARPRTPCRVH
                     SGRGCRPRSTREQSAPHRPSDSPPNADPRKREDMHSNLIVARMDAASGTQVARLFEAFD
                     NTDMPHRMGTRRRQLFQYRGLYFHLQDFDADNGGELIEEAKSDPRFLQISDDLKPHIEA
                     YDPATWRSPADAMAKRFYDWTATR"
     CDS             complement(23874..25406)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1050:monooxygenase FAD-binding (Score: 577.9; E-value:
                     3.4e-175)"
                     /gene_functions="biosynthetic-additional (t2pks) OXY
                     (Score: 607.8; E-value: 3.4e-185)"
                     /gene_kind="biosynthetic-additional"
                     /note="frig22"
                     /product="FAD-binding protein"
                     /protein_id="QDG00828.1"
                     /transl_table=11
                     /translation="MGDVPDHPEEALALIEERYMDAAVIVVGAGPAGMMLAGELRLAGV
                     DVIVLERLAKRSGESRGLGFTARTMEVFDQRGILPRFGEVETSNVGHFGGLPIDFGVLE
                     GALQAAKSVPQSVTETHLEEWASSLGVDIRRSHEFLDLRDLGTQVEVDVRGPDGTHTLR
                     ADYLVGCDGGRSAVRKATGFDFPGTAATLEMFLADVKGIELEPRMIGETLPGGMVMVGP
                     LPGGITRLIVCERGTPPQRRTAPPSFDEVADAWKRLTGDDISHAEPVWVSAFGDASRQV
                     TEYRRGRVLLAGDSAHIHLPAGGQGMNTSIQDSVNLGWKLAAEVKGSAPAGLLDSYHSE
                     RHAVGKRLLMNTRAQGLLFLSGPEVQPLRDVLGELITYKDVARHLAGMVSGLEITYDVG
                     TGTHPLLGKRMPHLVLDSARRRTSTTELLHSARGVLLDFEANERLRKRAYGWADRVDIV
                     TTAPPSFSPDSQLADTSAVLVRPDGHVVWAAPGSHHDLQMALERWFGQPAAG"
     misc_feature    complement(25119..25121)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     CDS             complement(25830..26636)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008:response
                     regulator (Score: 173.2; E-value: 9.9e-53)"
                     /gene_kind="regulatory"
                     /note="frig23"
                     /product="two-component system response regulator"
                     /protein_id="QDG00829.1"
                     /transl_table=11
                     /translation="MKRQFTDLREPRPAKRPHGGSCGEALPDPAHTPQTEAEAVRATGR
                     EPLSVLVVEGDERAAECLVVGLRRHGYHAQSVGTGAKALRVHSHADLVLLDLDLPDLDG
                     LEVCRSIRAACDTPVIAVTARDTELDRVLGLQAGSDDYMIKPYGFRELMARMEAVMRRV
                     RSHHSSAEEQVVEHGPLRIYAGIREIRLDGRLITATRKEFDLLHLLASRPEYVFSRKEL
                     MVQVWDDAWSRSGRTIDTHVSNLRSKLGSCSWIVTLRGVGFRFGHP"
     CDS             complement(27749..28729)
                     /NRPS_PKS="Domain: PKS_ER (11-320). E-value: 7.2e-44.
                     Score: 142.0. Matches aSDomain:
                     nrpspksdomains_QDG00830.1_PKS_ER.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028:crotonyl-CoA reductase / alcohol dehydrogenase
                     (Score: 225.7; E-value: 1.3e-68)"
                     /gene_kind="biosynthetic-additional"
                     /note="frig25"
                     /product="quinone oxidoreductase protein"
                     /protein_id="QDG00830.1"
                     /sec_met_domain="ADH_N (E-value: 1.4e-10, bitscore: 32.0,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 2.7e-19, bitscore:
                     60.4, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHAVVLHEFGPAENLRYETVPDPVPGPGEVRVLVAAAGVHQIETA
                     MREGLKTGPPLPELPAVFGGEVSGVVESVGPGVDGAWIGARVVTAHGSPGGYAELAVAG
                     VSSLHRIPAGLGDEAAVAMVVTGATAIGLLDIAELTPDDVVLVTSAAGGIGRLVVQFAH
                     RLGATVIGAAGGPAKTAAVRELGADIAVDYNLPQWADTVRGALGGRGVTVVLDGVEGDK
                     GLAAFGLLAEGGRYITIGAASRQEFRPGKAELKERGVRFTDALALLLEGQDAAADEARA
                     LAEAAEAGLVPSFQAFPLSQAAEAHAALEARATTGKVILVPDGRG"
     aSDomain        complement(27770..28696)
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_QDG00830.1_PKS_ER.1"
                     /evalue="7.20E-44"
                     /label="QDG00830.1_PKS_ER.1"
                     /locus_tag="QDG00830.1"
                     /protein_end="320"
                     /protein_start="11"
                     /score="142.0"
                     /tool="antismash"
                     /translation="AENLRYETVPDPVPGPGEVRVLVAAAGVHQIETAMREGLKTGPPL
                     PELPAVFGGEVSGVVESVGPGVDGAWIGARVVTAHGSPGGYAELAVAGVSSLHRIPAGL
                     GDEAAVAMVVTGATAIGLLDIAELTPDDVVLVTSAAGGIGRLVVQFAHRLGATVIGAAG
                     GPAKTAAVRELGADIAVDYNLPQWADTVRGALGGRGVTVVLDGVEGDKGLAAFGLLAEG
                     GRYITIGAASRQEFRPGKAELKERGVRFTDALALLLEGQDAAADEARALAEAAEAGLVP
                     SFQAFPLSQAAEAHAALEARATTGKVIL"
     CDS_motif       complement(28244..28303)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_QDG00830.1_0002"
                     /evalue="6.20E-04"
                     /label="PKSI-ER_m5"
                     /locus_tag="QDG00830.1"
                     /protein_end="162"
                     /protein_start="142"
                     /score="12.5"
                     /tool="antismash"
                     /translation="DVVLVTSAAGGIGRLVVQFA"
     CDS_motif       complement(28505..28543)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_QDG00830.1_0001"
                     /evalue="2.90E-02"
                     /label="PKSI-ER_m2"
                     /locus_tag="QDG00830.1"
                     /protein_end="75"
                     /protein_start="62"
                     /score="7.6"
                     /tool="antismash"
                     /translation="FGGEVSGVVESVG"
     CDS             complement(28782..29360)
                     /codon_start=1
                     /note="frig26"
                     /product="hypothetical protein"
                     /protein_id="QDG00831.1"
                     /transl_table=11
                     /translation="MDFKHPHVTSRRAGSGVVRFACFSSVTVRVPFHRAVRRHRSGGAR
                     TALPSFSPVFTRRCLLGEGVRERHRAWTEGRHLGGHLRGWAADAEGCCPAAVDPPGRLV
                     PHGVWGPAAGPPGFTFRPAATTEIWNGRSTPGARRPGNASAAVSLSRPGLATAPACRKR
                     LAGLTVRGILRASGRGAAQGSGVCGLTSS"
     CDS             29684..30382
                     /codon_start=1
                     /note="frig27"
                     /product="hypothetical protein"
                     /protein_id="QDG00832.1"
                     /transl_table=11
                     /translation="MPFNTAALEARSSIVSVLSSWSALVAEERRVPAPQRTAGRLAAFL
                     LRHADWLASHEASGDLSREVARLAGAARQVIDPGPGRRIPIGTCVEAGCPGMLTATVRA
                     DRPALPAEIVCDASAGHRWIGHQWLQLSRRLNSPTGLPTPGVVLPGGRTEPGRRTERAG
                     ARTNRHVEAEQERTRWIGATDIARLWKIPSGTVYRHASHQQWRRRSEHGRTYYNGADVE
                     RTLSALRRTA"
     CDS             complement(30694..31227)
                     /codon_start=1
                     /note="frig28"
                     /product="hypothetical protein"
                     /protein_id="QDG00833.1"
                     /transl_table=11
                     /translation="MVVRVREGPAPAPPGSGHAVTRSSPAAASWRSRPRPRRRARLHGP
                     PRAFRAGPHPRAPPGRRLVVPLRRTPGRDLAGPAVAHPSSARPGQDRGKRRPITLLIRA
                     GVHRRSSRPCTAGPLAGSASGWADCFSLGLGSDAGPRDRKPAGRPRPPSGATAARSGRW
                     PADPWRSPSSPRPG"
     CDS             complement(31527..32513)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008:response
                     regulator (Score: 186.2; E-value: 1.1e-56)"
                     /gene_kind="regulatory"
                     /note="frig29"
                     /product="two-component system response regulator"
                     /protein_id="QDG00834.1"
                     /transl_table=11
                     /translation="MRRAPAVRGGRAVSRAPLPAPGRAPAREGGRGADQAWGFDKPTRR
                     FVWWRGHIHGGCAVCADTGGERMERQSTDVLMSRAPRRTLSEPPADPGGYRPVVQPGPR
                     FRREELRVLVVENEPRAADSLVQSLRRHGYLVESVATGVKALQVHRSADLILLDLDLPD
                     LDGLEVCRSIRVTCDTPVIAVTARDSELDRVLGLQAGADDYMVKPYGFRELMARMEAIM
                     RRVRPVQPLKQVIARGTLWIDAGAREIRVDGTPVEMTRKEFDLLHLLASQPETVILRKQ
                     LMTQVWDDSWSRSERTIDTHVSSLRSKLGATSWIITVRGVGFRLGHP"
     misc_feature    complement(32259..32261)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     CDS             32643..33452
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057:TetR family
                     transcriptional regulator (Score: 60.9; E-value: 3.7e-18)"
                     /gene_kind="regulatory"
                     /note="frig30"
                     /product="tetr family transcriptional regulator"
                     /protein_id="QDG00835.1"
                     /transl_table=11
                     /translation="MSKQERAARTRNALIRSAAELFEQCGYTKASLYEISSGAGVSRGA
                     LHFHFVNKADLADAVEGAAARSLHRAARRAEQGQTNALQALTNLSHTFAQLLSWDVVVR
                     AGFRINCDAGLHTGRDLRRQWQSCVRELVSRAGEEEALARDVPQEPLVMTVVGATTGFE
                     VLGRANGHWLSHYSLTSFWQLLLPVVAAPRVLATLDPAGSGPVTGALPGQFRHTGDIPP
                     RARRSGSGPRPAAPACRSCAAPDGPGAPGPKQQVSRPCSSEPGGTSS"
ORIGIN
        1 atgaaggtcc tgttcatcgc ctcgggcagc ccggccaccg tcttcggaat cgtgccgctc
       61 gccactgcca tgcgtggcgc cggtcacgag gtcttcatgg ccggcaacga ggccatggtg
      121 ccgtacatcg cgagcgcggg tctgcctgcg ctggcggcgg ccgagcatga gatagcccac
      181 tacatggacc tcgcgcgggc cggcagcggt ccgctcgatc tcgacaatca ccgccaggtg
      241 atggagtacg tcggcagctg gttcgcgttg ctcggtgccg acagcttcgt ccggctgcgg
      301 gagtcgctgc gcggctggcg ccctgatctt ctggtgggcg gcacgatgag ctatgcggcg
      361 ccgctgctcg cggcagcgct cgacgtgccg tacgtggtgc aggagtggac gctggacgac
      421 tggtcgggca cggacgcggg ggcgctgcgc gtcctggagc cgcagctggc cgagctgggc
      481 ctgaaggggc tgccggagcc ggagttgagg atcgggatct gtccgccggc catcgcgcat
      541 cccgacgccc ccgacgtcca gccgatgcgc tggcggcctg gtaacaagca gggccgcgtc
      601 gagccgtgga tgtatgcgcg gcccgaccgt ccgcgggtgt gcctgaccgc ggggagccgg
      661 gccagccacg aacggggctt cgcctttctg cgcgcgctcc acgaccggat cgcgccgctg
      721 ggtgtcgagg tggtcatccc cgcgcccgat ccggtcgccg ccgagttgcg tgcggccatg
      781 cccggagtgc tcacgggatg gatccccctc gacacggtca tgccgacctg tgacctggtc
      841 gtgcaccact cgggcggcgc cacgacgatg acggccgccg acgcgggggt gccgcagctg
      901 atcatccctg agacgccggt gttcgctccg cccgcccagc ggctcgccga tcacggcgcg
      961 ggcatcatga tcgccgaggc cgaagcgacg gacgaggcgg tggagcgcgc ctgccgggag
     1021 atcctcggcg actcccgatt caagcagcgg gccggtgaga tcgctgcgga gatcgctgag
     1081 atgcctccgc cgccgacgct cgtgccccag ctggaaaagg tcgcgctcgg ctgaacttct
     1141 ccgcccgcgg ggcccttctc ggtgttccgc gctgtccacc accgcaccac agtttgaagg
     1201 agaacgatca tggctcagca agcgccccct ctcgccggtc ggcgggaatg gatcggcctt
     1261 gccgtcctgg ccttgcccac cctgctcctg gcgctgagca tgacctcgct caacctggcg
     1321 atcccctacc tgagtgcgga cctcaacccc agtggcgccc agctgctgtg gatcactgac
     1381 atctacgggt tcctcatagc cgggaccctg atcaccatgg gcaccctcgg cgacaggttc
     1441 ggccgccggc ggctgctgtt gatcggtgcg gcggtcttcg gcgtggcgtc ggcggtcgga
     1501 gcgtactcga acagccccga gatgctgatc gtgatgcggg ccctgctcgg cctgtcgggc
     1561 gcaaccctga tgccgtcgac gctgtccctg ctgtccaaca tgttccggga tccggcgcag
     1621 cggacgttcg cgttctccac ctggatggcc acgttcatgg gcggcaccgc ggtgggaccg
     1681 ctggtcggcg gggtgttcct ggagcacttc tggtgggggt cggtgctgct gctcggtgtt
     1741 cccgtgatgc tggtgctgct cgtgctcgga ccggtcctgc tgccggagaa caaggacccc
     1801 gacccgggac acatcgacct gttgagtgtg gcgctgtccc tcgcgggagt cctgagtgtg
     1861 gtctacgggc tgaagcagat cgccggtgac agcgcgagcc ggctcgcgtt cgcgtacatg
     1921 gcggcgggga tcgtgatcct ggtggtgttc ctgcggcggc agcagcggct gcgccatccg
     1981 ctgctggatc tcacgatgtt ccgcaaccgc acgttcagcg tgcccatcgt ggccctggcc
     2041 gtgggtatct tcatgaacgg cggcatcaac ttcttcctga tgcagttcct gcagagtgtc
     2101 ctgggcctga cgccgctgca ggcggggctg tgcactttgc ccccgaccac catcggtatg
     2161 gccacctcga tgctggcgcc ccagctgatc cagcggttcc ggcccgcgta catcatggga
     2221 ccggccttct tggcggcagc tgccggtcac gtcatcgtct cccaggtcga caaggacagt
     2281 ggggccgccc tgctcgtggt cgggctcgcg gtgatgggca ccggtttcgg tctgttcatg
     2341 gccatgggca cgtctctcgc cctcggcgcg gtcgaacccg agaagtccgg tgcggcgtcg
     2401 gcgacttcgg agaccagcac cgagctcggc ctctcgttgg gcatcgcggt gctcggcagt
     2461 gtggggaccg ccgtgtatca gagcaagttc cgttccctgg tgcccgaggg gacaccggag
     2521 tctgtggtgg acagggccga gaagaccgtg ggtgccgccg tcctggaggc cgagaagctg
     2581 ccggcgcacc tgtccgatca gttcctcgac gcggtcggca gcgccttcgc ggcggggctg
     2641 cgcaccaact ccgtcatcgg cgctgtgggg ctgacgtgtg tggccgtctt cgtcacggtg
     2701 atgcttcgtc atctgccgcc ccagcccaag gggtcgggcg cacatgggca cggcggcgcc
     2761 gaagcggcgt ccgacgcggc tgccgtcccc tctccggctc agggcacgga agtgagacac
     2821 gattcctgat gcggggaccc tttcgtgggg tcacgcgctt gtgtacgcaa tctcccggtg
     2881 tgcggcctga aaggccgggg gtcgcacttc cccgttcgct gatgcagctg cgtcggcgaa
     2941 cggggaagtg ctgtgtgtgt ccggcactct gcggccggcg gcctgtccgg cgtcactgac
     3001 tgcggcggtt gggcgccggc ttgcgtggct ccggtcggaa tctcgtgccg ggccggcggc
     3061 gccgacggcc gagtgccaac ggcgcctcag gtacctacag gcctacgtca acttcgttgc
     3121 ttcggccgtc ctggcccgat gagaatcctt ggtgtagagg cggatcggtt gtgcgggtcc
     3181 tcctcccggg gggaggcgtg tgcgtcgcgg cttctcctcg ccctcacggc cgagcatctc
     3241 cacccgaccc gtccgggcgg ccacctgtag tggctcccgc cgtcaggttc agtccctcca
     3301 ccgtctgcgg agcccttcgg tccgcactca ctcattcctt ttgtctgcct gttggaggcg
     3361 tcatgaccac cgtttcggaa gagttccccg cggcctacag cacgagccac gccgagatct
     3421 acgagttcat ccactcggcc cgcggccggg actgggcggc cgaggccgac gactatgtgc
     3481 ggctggtccg ggagcggaac tccacggcct cctccctgct cgacgtcgcc agtggcaccg
     3541 gtgctcatct cgcgcggttc gccgagcact tcgaccgtgc cgagggtctt gagctgtcgg
     3601 agggcatgcg cgcgctgtcc agggcgaagc tgcccgatgt gcctgtgcat gccggcgaca
     3661 tgcgggactt ccacctgggc agtacgtacg acgctgtcgt gtgcctgtgc ttctcgctgt
     3721 cgtacacccg tgacgtggat gagctgcgcg ccgccgcttt tgcgatgtcc cggcacctct
     3781 ccccgggtgg ggtgctgatc gtcgaaccct ggtggttccc ggagaagttc atcgacgggt
     3841 tcgtctccgc cagcctggcc gagcagcagg ggcgggcggt cagccgtctc tcccacaccg
     3901 ttcgtgaggg gcgcaccagc cggatggaag tgcgttacac ggtggccgac cagcgtggca
     3961 tccaggattt cacggagtac gaggtcctct ccctgttcac cgagcaggag tacgcggcgg
     4021 ccttcgcgga cgccgggtgc ccggtggagt accaccccgg cggtcccaat ggccgtggtc
     4081 tgttcgtcgg ggttcgtcag tagccgaccg gtcttcgtgg cccggtcgcg gggcatccgg
     4141 caagtcctca tgtggtccaa ggagacacga cgtgatcaat gttttccagc ccagcctggg
     4201 cgacgaggag gccgccgcgg tcgcggaggt cttcgccacc aactggacgg ggcgcgggcc
     4261 tcggaccaag gccttcgaag cggagttcgc ccagcacctc ggggtcgacc cgagccatgt
     4321 gctgctcatc aactcctgta cctcaggcct gtttctcgcc accgagctcc ttgggctcgg
     4381 ccctggtgac gacgtggtga tgccgtcgct gagctttgtg gccgccgcca acgccgtcgc
     4441 ggcggccgga gcgcgcccgg tgttctgcga gtccgacgtc cgcacgctca acccgacggc
     4501 cgacgacatc gagcgggcac tcacgccgcg caccagggcg gtcatcgtgc tgcactacgg
     4561 cggctatccc ggcgacatcg ccgcgatcgc cgcgttgtgc cgtcggcgtg gtgtcacgct
     4621 catcgaggat gccgcctgct ccgtggcgtc gcgtgccggc ggtgtcgcgt gcggcacgtt
     4681 cggtgatctg gccacgtgga gcttcgactc catgaaggtc ctggtcaccg gtgacggcgg
     4741 tgccttctat gcccgtagtc ctgaactggc gcgccgggcg cgccagttgg cgtatcacgg
     4801 tcttgagcag gccagtgcgt tcgatgccgc gaaggtgacc gatcgctggt gggagccgaa
     4861 tgtcgaacac ttcggccgca ggatcatcgg caatgacgtg acggcggcca tcgggagcgt
     4921 gcagttgcgc aggctgcccg agttcgtcgc caggcggcgc gagatagccg cgctctacga
     4981 ccagcttctc ctggacgtgg agggggtgcg ggtgccgccg ccgctgcccg aagggcacga
     5041 cagctcgcac tacttctact gggtacagat ggacgcggcc atccgcagca aggtcgcctc
     5101 ggatctgctg gagcgtgaca tcttcaccac gttccgctat cccgccctgc accgggtccc
     5161 cgtctacagc gtgcaggacg tgtcgctgcc cggcgccgag gaagctgcgg acaggactct
     5221 gctgctgccc ctgcaccagg ggctgagcga cgcggaagtc cacaccgtgg tcgacgagtt
     5281 ccgcaagtcg gtcgaatttc atacgcagga gctgcggagc aaggggtgag ggatgcacgt
     5341 cgaggagacc accattcccg gcgcgctggt cgtcactgcc cgacgccacg tggaccaacg
     5401 cggtgacttc tacgagggtc tgcgcaccga cgttctggag cacgagctgg gccgcccctt
     5461 ccctgtgcgc cagatcaact actccacttc gtgccggaac acccttcgtg gtctgcacgg
     5521 tgtagcgatt ccgccgggcc aggtcaagta cgtcacctgc gtccagggcg cgttgcgcga
     5581 catcatcgtc gacctgcgga tcggctcgcc cgcgttcggc cgccaccacg tcaccgagct
     5641 ggatgccgaa tccgggcgga gcgtcgtcgt ccccgaaggc gtcgggcacg gctttctgac
     5701 gctcaccgac gacgcccgca tctgctacgt gctgtccacc gtctacgtac ccggcaccca
     5761 gatcgacatc gatccgctgg atcgcgatct cgccctcccc tgggggttca cccagccacc
     5821 gctgatgtcc gacaaggacg ccggggcccc ttccctggcc gaggtcaccg ccaccgggcg
     5881 gctgccccgg tggcaggccg gtgtcgccta ctccaacacg tgaggagaga acgcgatgaa
     5941 ggcattggta ctttccggcg ggtccggtac ccgtctgcgc ccattcagct actccatgcc
     6001 caagcagctc atccccgtag ccaacaagcc ggtcctggag cacgtcctgg aaaacatccg
     6061 ggacctcggc atcaccgaca tcggcatcat cgtcggcgac cggggcgagc agatcgcgga
     6121 ggtgatcggc gacggcgcac ggctcggggc ccacatcacc tacatcgccc agcaggagcc
     6181 tctggggctg gcgcactgcg tggcgctcgc ccggccgttt ttgggcgacg acgacttcgt
     6241 catgtacctc ggggacaaca tcctgcccga cggggtcatg gacatcgccg gccagttcac
     6301 cgcgcaccgt cccgatgcac aggtcatcgt gcacaaggtg cccgaccccc gtgccttcgg
     6361 cgtggcggaa ctggacgccg agggccgggt cctgcggctg gtggagaagc cgcaggaccc
     6421 gcagagcgat ctcgctctga tcggcgtcta cttcttcacc ccggccatcc acgaggccgt
     6481 cgcgtcgatc gagcccagcc cccgcggcga gctggagatc accgatgcca tccagtggct
     6541 ggtgtcccag ggccgcgagg tacgggccag tgagtacgac ggctactgga aggacaccgg
     6601 ccgggccgag gatgtcctgg agtgcaacca gcggattctc gcgggcctga agccgagcgt
     6661 cgccggtcac gtggacgcgt acagcacact ggtgggcacg gtcgtgctcg aggcgggtgc
     6721 cagggtggtg cgctccgcga tcgagggccc ggtgatcatc ggcgcgggct cggtcgtgga
     6781 ggacagccgc ctcgggccgg gcacatcggt gggacgggac tgcgtggtgc gacggtccca
     6841 ggtggccgac tcgatcattc tcgaccgggc tgagatcacc gacatcccct cgctcgaagg
     6901 ctccctgatc gggcgcggcg cccaggtggg cgcctgcacg ctggagccga cccaccaccg
     6961 gctcgtcgtc ggcgacgaca cccggataga ggtggcggcg tgagaatcct ggtgaccggc
     7021 ggagccgggt tcatcggctc gcattatgtg cgctccctgc tggggggcgc gtacccggac
     7081 tgtgcggacg cccgggtgac cgtggtggac aagctcagct atgcgggcaa ccgggacaac
     7141 cttcctgcgc ggcatccacg ccttgcgttc gtcgaggcgg acatctgcga cctgccgcgg
     7201 atgctcgacg tgctgcccgg acatgacgcc gtggtgcact tcgctgcgga gtcccacgtc
     7261 gaccggtccg tcgagtccgc ggccgagttc gtacggacga acgtgggcgg gacgcagaca
     7321 ctgctcgacg cctgcctgga gaccggcgtc gagcggttgg tgcacgtatc gaccgacgag
     7381 gtctacgggt ccatcgccga ggggtcctgg acggaggaat ggccgctcgc ccccaactcc
     7441 ccctatgccg cgaccaaggc ggcgtcggat ctggtggcgc ggtcccactg gcgtacgcac
     7501 ggcctcgacc tgtcgatcac ccgctgctcc aacaactacg ggccctacca gcacccggag
     7561 aagctgatcc cgctgttcgt cacgcgtctt ctggagggcc ggcaggtgcc cctctacggt
     7621 gacggacgca acgtgcggga gtggctgcat gtggacgacc actgccgggc gatccacctg
     7681 gtgctcaccc ggggcagggc tggcgagatc tacaacgtgg gcgggggcaa cgaacggtcc
     7741 aacgtgcaga tcaccgagga ggtcctgcgg ctgtgcgggg ccgactggtc ggcggtccgt
     7801 catgtcgccg accgcaaggg ccatgacctg cgctacgcgc tcgacgacag caagatccgc
     7861 gagcacctcg gctatgcgcc acgggtcccc ttcgcatcgg gtctcgcgga caccgtcacc
     7921 tggtaccgcg acaacccgca ctggtggaag cgcctggggc acgacggcgc cgctgtggag
     7981 gcccggaccg gagaaggcac aggagtgagg ccatgaacaa ccacaaagcc atgatccttg
     8041 acgagacccg taagtaccat gccgaccagc aaccgggcgg tcccttcctg cccggcgtca
     8101 ccgagatctg gccctcgggc gccgtcctgg acgccgagga ccgcgcggcg ctcgtcgaag
     8161 cggccctcga tctgaacatc gcggcgggct cccgctcgca gcggttcgaa tcgcggttcg
     8221 ccaagctgct ggggcgccgg aaggcccatc tgacgaactc cggttcgtcg gccaacctgc
     8281 tcgcgctgac cgcgctcacc tcgcatgtcc tgggcgaccg gcgactccgt ccgggcgacg
     8341 aggtgatcac ggtcgcggcg ggctttccca ccacggtgaa cccgatcgtg cagaacgggc
     8401 tcgtacccgt cttcatcgat atcgacctgg gtatctacaa caccacggct gaacgggtcg
     8461 ccgaggcgat cggtccgaag acccgcgcca tcatgatcgc gcacgccctc ggcaatccct
     8521 tcgaggtcgc ggagatcgcc cagctcgcca aggacaacga tctgttcttc gtggaggaca
     8581 actgtgatgc cgtgggctcc acctatcagg gtgcgctcac cggcaccttc ggtgacctga
     8641 ccacggtgag cttctatccg gcgcaccatc tgacgatggg tgagggcggc tgtgtgctga
     8701 cctcgaacct gaagttgcac cgggtggtgg agtcgctgcg cgactggggt cgcgactgct
     8761 ggtgcgagcc gggcaagaac aacacgtgtc tcaagcggtt cgaccaccag atgggccggc
     8821 tgccacaggg ctacgaccac aagtacatct tctcccacgt cggttacaac ctgaaggcca
     8881 ccgatctgca ggcggcactc ggcctgaccc agctggacaa gctggacggc ttcatcgcgg
     8941 cgcggcggcg taactggcgg cggatgcggg aggggctcga gggggtgccg cacctgcggc
     9001 tgccggagcc gacgcggggc agcgatccca gctggttcgg gttcgtcatc agtgtggatc
     9061 ccggggcgcc gttcagccgg gccgcgctgg tggacttcct cgaaggccgc aagatcggca
     9121 cccggcggct gttcgcgggc aatctgaccc ggcagcccgc ctatctggac gtgccgcacc
     9181 gggtggtggg gtccctggcc aacagtgact tcgtcaccga gcacaccttc tgggtcgggg
     9241 tctatccggg cctcaccgac gagatgatcg actacgtcgt gtcatcggta cgcgagttcg
     9301 tcggagggca ccgatgacga ccacggtcgg gctgctccag ccacgccggg acggcgggcg
     9361 tcccggcgtg ctctcccggt cgcgcgcctg ccgcgacgag ggcgtccagc tgagcacggc
     9421 gcaattcgct ccctggctca cctggcgcgg agagatgaat cggttcgcgg tcgagcggat
     9481 tgcgttctcg tcgctcgaag gctggtcgtt cgcgcgtgac acggggaacc tggggcaccg
     9541 cagcgggcgg ttcttcaccg tggaagggct ggaggtgcgg acgcacgacg ggtcggtggc
     9601 cccgtggcgg cagcccacga tcaagcagcc cgaggtgggc atcctcggca tcctcgccaa
     9661 agagttcgac ggggtgctgc acttcctcat gcaggccaag atggagcccg gcaacccgaa
     9721 cctgctgcag ctctcgccga cggtgcaggc gacccggagc aactacacca aggtgcaccg
     9781 gggcgcggac gtgaagtaca tcgagtactt cacgcagccc ggcaggaatc gggtactcgc
     9841 cgatgtcctg cagtccgaac acggctcctg gttctaccgg aagtccaatc ggaacatgct
     9901 cgtccagacg gatgaggacg tccccgtgga cgacgagttc tgctggctga ccctggggca
     9961 gctcggcgaa ctgctgttgc gggacaacgt ggtcaacatg gacgcacgta ccgttctggc
    10021 ctccataccc ggctgctgtc aggacagccg ggccgtgcac tcggacatcg agctgcggtc
    10081 ctggttcacc ggcgagcggg cacggcacga gatcaccgtg gagcggaccc ccttgcgcga
    10141 ggtgagccgc tggcagcgcg acgactggag catcagccac gaagaaggcc gctacttccg
    10201 cgtcgtggcc ctggcggtgg aggccagcaa ccgggaggtg ggcggctgga cccagccgct
    10261 gttcgagccg gtcgccaaag gcgtcaccgc gttcctgacc cggcacttcg acggcgtcct
    10321 gcacgtgctg gcgcacgccc gtgtcgaagg cggattcctg gacacagtgg agctggggcc
    10381 gacggtccag tacacaccgg agaactacgc ccatctcgac gcggccgacc ggccgccctt
    10441 tctggacctg gtgctcggtg cggacccgtc ccggatccgg tacgaggccg tgcactccga
    10501 ggagggcggc cgcttcctca acgccgagtc ccgctacctc ttcgtggcgg ccgacgacat
    10561 cggcgcggat ctgccggccg gctacgcctg ggtgacccct ggccagctca actcccttgc
    10621 ccagcacgga cattatgtga acgtgcaggc ccgtacgctg ctcgcctgcc tcaacgccgg
    10681 tgcggtggcg tactgatggc gccgctccgg atcgggatcc tgggctgtgc cgagatcgcc
    10741 cggcggcgga tgctgccggc catggcggcc tgcgccggga ccgagatctc cgtcgtggcc
    10801 agccgcgacc tgatccgggc ccaggagacc gcccgcgcct acgggtgccg cgccgtccag
    10861 gggtacgaga gtgtcctcgg cgaccccatg gtcgacgctg tgtacgtccc ggtacccgcg
    10921 gccctgcacg ccgactgggc cgaggcagcc ctgcgtgcgg gcaagcacgt cctggtggag
    10981 aagccgctgg ccaccgagta cggccggacc gccgaactga tcggcttcgc acgggagcgg
    11041 tccctggccc tgatggagaa cgtcatgttc gtgcatcacg gccagcacga agcggtccgc
    11101 aaactcgttg ccgacggcac cgtcggcggg ctgcgggcgt tccgcgccga gttcaccgtg
    11161 ccgggcaggc ccgacgacga catccgctac cgccccgagc tggccggcgg tgccctgtgg
    11221 gacaccggcg tctacccgct gcgcgcggcc ctgcacttcc tcgggccgca gctgtccgtt
    11281 gccggggccg ctctgtccaa cggcgccgga cggcaggtcg acacggcggg cgccgcgttg
    11341 ctgcggacgc cggagggcgt caccgcccag ctctccttcg gccttgatca tggctaccgc
    11401 tccctgtacg agctcgtcgg cagccacggc cgcatcacgg tcgaccacgc cttcacaccg
    11461 cccgccggcc actcccccgt cgtacgtctg gagaacggcg acggaacgag ggaactcacc
    11521 ctgcccgcgg acgaccaggt cgccgcgacc gtccgcgcct tcgttgctgc tgcccgtgcc
    11581 ggggccgctc cggacagctc cacggtccga cgccaggcgg aactgctggc gagcatccgg
    11641 caagccgctc ggtgaaggca gccgctgcct cgtcaccgct gccccgccca cacctgacga
    11701 caggaccctt ctcatgacga gccgtctgtt cacctcggaa tccgtgaccg aggggcaccc
    11761 cgacaagatc gccgaccaga tcagtgacac cgttctcgac gcactgctcc gtgcggaccc
    11821 cgcctcccgg gtcgcggtgg agacgctcat caccaccggg caggtgcaca tcgccggaga
    11881 ggtgaccacg aaggcgtacg ctccgatcgc gcagctggtg cgggacaaga tcctcgagat
    11941 cggctacgac tcgtccgcca agggcttcga cggcgcctcc tgcggtgtct cggtgtcgat
    12001 cggcgcgcag tccccggaca tcgcgcaggg cgtgaacacc tcgtacgaga agcgtgtcgg
    12061 ggacgccgtc acggacacgg agggcgatga gctcgacctg cagggcgccg gcgatcaggg
    12121 cctgatgttc ggctacgcct gcgatgagac gcccgagctg atgccgctgc ccatccacct
    12181 cgcgcaccgg ctctcgcgcc gtctgtccga ggtgcgcaag gacggcacgc ttccctatct
    12241 gcgcccggac gggaagaccc aggtcaccat cgagtaccgg ggcagtcgtc cggttcggct
    12301 cgacacggtc gtggtctcct cgcagcacgc ccccgagatc agcctggaga ccctgctcac
    12361 cagggacgta cgggagcatg tggtcgacca tgtactggcc cggctggccg ccgacggcat
    12421 caagttggag accgagggct accggctcct ggtcaacccg accggccggt tcgagatcgg
    12481 cggcccgatg ggtgacgcgg ggctcaccgg ccgcaagatc atcatcgaca cctacggcgg
    12541 catggcccgc cacggaggcg gcgccttctc gggcaaggac ccctccaagg tggaccgctc
    12601 ggcggcctac gcgatgcgct gggtcgccaa gaacgtggtg gccgcccgcc tcgccacccg
    12661 ctgcgaggtc caggtcgcct acgcgatcgg caaggccgag ccggtcggcc tgttcgtgga
    12721 gaccttcggc accgcggtgg tgccccagcg ggcgatcgag aaggcgataa ccgaggtctt
    12781 cgacctccgc ccggccgcga tcatccgcga cctcgacctg ctgcggccca tctacgcgca
    12841 gaccgccgcg tacgggcact tcggccgcga actcccggac ttcacctggg agcgcaccga
    12901 tcgggccgag gccctcgcgc gggcggccgg agtctgagat gcggatcgcc gtcaccggtt
    12961 ccatcgccat cgaccatctg atgaccttcc ccggcaggtt caccgaccag ttgctcgccg
    13021 atcagctcga caaggtctcg ctgtccttcc tggtggacgg gatggacgta cgccggggtg
    13081 gggtcgcggc caacatcgcc tacggactgg gggtgttggg ccagggcccg gtgctcgtcg
    13141 gaggggcggg cgccgacttc ggtgactacc gcctccggct gaaggagcac ggtgtcgata
    13201 ccgaggcggt gctggtgtcc gccacacgcc agacggcccg gttcctgtgt ctcaccgacc
    13261 aggacatgaa ccagatcgcc gccttctacc caggggcgat gtcggaggct gcagacatcc
    13321 ggctgcgtgc cgtcgccgag tccgtcggcg ggctcgacct ggtgctggtc tcccccaacg
    13381 acccgggagc gatggtgacg cacacggagg agtgccgcga gctgggcatc cccttcgccg
    13441 cggacccctc ccagcagctc gcctcgctgt ccgggcagca gacgcgcggc ttggtggagg
    13501 gtgcggcgtg gctgttcacc aacgagtacg aggcggctct ggtgcgcgaa cgcaccggct
    13561 ggagcgagca gcaggtcctg gagcgggtcg gggcctgggt catcaccctc ggcgcgcagg
    13621 gcgtgcgtgt tgcccgcagg ggcgccgaac ccgaggtcgt gcccgccgtc ccgtgcgcgg
    13681 ctccggtcga tccgaccgga gtcggtgacg ctttccgtgc cggtttcctc gcgggcctcg
    13741 cccagcagct cagcacgggc gccgcagccc ggctcggctg cgcgctggcg acgacagcgc
    13801 tcggtttcac cggtccgcag gagtacgcga taacgtcgga gcggctttcg caggccctcg
    13861 cgtccgcgta cggcggtgcg gccgtggtgg aggccgcccc tgtgctggag cggatgcgat
    13921 gacgacgtat tccttcgagt tcttcccgcc caagaccggc aagggtgccg ccgccctgtg
    13981 gaggaccgtc cggcgtgtcg aggccctgcg gcccgatttc gtctccgtca cgtatggtgc
    14041 gggcggctcc tcacgggacc acaccgtcga ggtcacccac cgtatcgcca ccgagaccac
    14101 gctgcggccg gtcgcccacc tgacagcggt gggccactcc gtcgccgagc ttcgtcgcat
    14161 catcggccag tacgccgacg ccggtatccg ggatgtcctg gtgctgcgcg gggacccgcc
    14221 cggcgacccc atggggccgt gggtgtcaca cccggacggc ttcacgcacg cctaccagct
    14281 tgtggaactc gtgcgctctc tcggcgattt caccatcggg gtggccgctt tccccgaacg
    14341 gcacccgcgc tcgcccgact gggacagcga catccggcac ttcgtggcca agtgccgggc
    14401 aggtgcggac tacgccatca cgcagatgtt cttccgtgtg gaggactatc tgcggctgcg
    14461 cgaccaggtg gcctcggcgg gttgcgacac tccgatcatc cccgagatca tgcctgccac
    14521 cgacgtccgc cagatccgcc gcttcgccga gctgtccggc gcgactttcc cgcaggacct
    14581 cgcccgccgg ctggaggcgg cccgggagaa tgccgccgac ggctatcgca tcggggtcga
    14641 gcacgccacg gccatggccg accggctcct tgccgaggag gcaccgggcc tgcattacat
    14701 cactctgaac cgctgcgcgg cggctctgga ggtacaccac aacgtggtcg cttcgcacag
    14761 tgcttccgtc cgttccgtcc gcacctagaa actgccgtcg tcgcccgaag ggcggccgcg
    14821 cggcgtctgg tgcgtgcgat cgcaaggcgc cggaatggtc tcggatgggg cctcccctgc
    14881 tcgaacgaag ccgagagcca ggggaaggag ctacttggcc atttcggcaa cgccgcgagc
    14941 gtgcgtgcca ggcgtcgcgc ggcaggcggc agtttgacga caggccctag cgggtcgggt
    15001 gcccaggcgg gtgcggtcgg cgggccgggc ggcacctgct gacccgtagg tatcagtcct
    15061 ggttctcgtc ggggtgcccg gcacaacgcg gtgcccgtgg agctgaccgg ttggggccgg
    15121 gcggcgttga cgtgccgcag tcgctgcatg ctgggggcgg tgtgtcctac cgtggcgcgg
    15181 tgaccgccgc ggtctcccgc gcgagaaggc acttctccag gaaggccagt gcctggaggt
    15241 ggtaagtacg ggaggcccac cccaggctga tgttgtgccc ggcgtcgggc tgccggtcga
    15301 tcaccacgtg gggggcggcc agcggtgcgc gcagcgctcg gagcgcctgt tcgtcctggt
    15361 gccaccactg ttcctgctcg gcgaaggtga accggacggg aactctcacc ctggcggcga
    15421 tgtcctggta gatctgcggc cagcgtgccg cttcctgggc ttcgagtgcg ggcacggggg
    15481 cgacgacgtc gcggcactgg ccgaaggcct ccggcgggta caggcgcagt gggccccagt
    15541 gccggcgcca ggtacccggc cggtcggggc cgggcaggtc gtgcggttcg acggcgaggt
    15601 gggtgccgag tccggagatg tccagaccca cgaggtccgt gccgggttcg tggcccgcgg
    15661 cgagtgccag tgcgagtttg ccgccgttgg agtgcgccac gacgaagtat ccggcgcccc
    15721 gttcctggtt gcgggcgaag tcggtgagcg ccgcccgcag ggtcgccgac tggtcggcca
    15781 ggctctgtcc ctgaggcagc tgggcggcgg acgctccgta gccgggccgg tccaccgcca
    15841 ggacggcgta gccgagttcg gcgcccaggg tcagcaggga gtggccgggc ctggcccggc
    15901 tgtcgaagta gcctgcgcgc attccgccgc cgtgcaccgc gaccaccacg gcgcgcggtg
    15961 gcagttgctg aggcagtgcg agcagtgccg acaggcgcag cccgtctgcg tcgagggtga
    16021 tgccgcgggt ctgcggcggt gtgcggcgtg tcggctcggc catgcgcgtc tctccagggt
    16081 ggatcgtcgg acgccgggga ccgtccgtgg gtgaaggggc cgagtggagc gggggtcgtg
    16141 ccggggtgcc ggcgggcacg gtgcccggtc tgtcacgccg ctgggcgggg tcgggtgccg
    16201 ttgaccgggc ggccggccgg gcgggtgccg tggcggggcc atgagcggcg gcgggggtcg
    16261 tccggccgcc cggtgggggc gggcatcagc cgagcagtgt tcctccggtg gcgtcgacga
    16321 acgagccggt gatccagcgt gcttcgtcgg tggcgaggaa ggccacgacg tcggcgacgt
    16381 cctcgggttc gccgacgcgg ttgaaggtgg acagctgtgc catctgctcc acggcttcgg
    16441 ggatgccgaa gaccgggttg tcgttacggg tgatgcccgg tgccacggag ttgatggtga
    16501 tgccgcgtgg gccgaggagt ttggcgtagt gcagtgccag ttgttcgacg gcgcccttgc
    16561 tcatcgcgta ggcgatctcg tcggggttcg cgaagcgggt gaggccggtg gagatgttga
    16621 tgatgcggcc gccgtcgggc atgttcttca gcgcgcgctg gatgaggaag aacggggcct
    16681 tggcgttgat cgcgaagatc cggtcgaacg tttcgggcgt ggtgtcctgg ggcttcacgt
    16741 tgcccatgac gccggcgttg ttgacgagga tgtccaggtc agtgctgccc gtgcgctcgc
    16801 gcaggccgtt ctccaggccc aggaagagct cgtggacatc gccggccggg ccgagttccg
    16861 cccgtacggt gaagccgcgg ccaccgtcct tctcgatcag ttcgaggacg tccgtggccg
    16921 cctcctcgct cgacgcgtag tgcaccgcga cgagtgctcc ttcctgagcc agccggagtg
    16981 ccgttgcccg gcccatccct cggctggcgc cggtgacgag cgcggtcttt ccgctgagcc
    17041 tgcccatgtc tgtactccgc ttcttccgtg gtggctttgc tggggacttc accggtgtca
    17101 tgggccccgg tgccgaggcc tgcacggtgg gtggggcggc gggtgaggtg gctgttccga
    17161 accagcggtg cagggcagtt gtgaggtggg tggggtcgct tcccgcccag gcgacgtgtc
    17221 cgtcgggccg caccagcagg gccggggcgc cggggtcggc ggcatcggcg ggcggggagg
    17281 cggcggccgt gtgcaccagg ccggtccagg ggagggcggc ggtgcgcagc gtcttctggc
    17341 gtgctgcgtc gccgggtggt acgagcagga cgccgcggcc gtcgtgcatc agttcggctg
    17401 cggtggtggg tcccggggtg ttcgtggtca gctcccagtg cggcagccgg gcgccgagca
    17461 ggggatgtgt gccgggcccg acgtcgtagc gggtgtccag gccggagatc attcctgcca
    17521 ggtggcggcg tacgccttcg tgccgtagca gttcggcgag aacctggcgt gcggcgtcga
    17581 cttcagcggt tcccagcagc aggagtgcct gggcccggat gttgtcgagg actctgcggc
    17641 cgaccgcgtg ccgttcgctg tggtagctgt ccagcagccc gtcggggccg cgctccagga
    17701 gttgcgcggc gagcttccat ccgaggttgg cggcatcctg caggcccagg ttgagggcct
    17761 gtcctccgat gggcatctgc tggtgcgcgg cgtccccggc gaggaacagg cggtggtcgc
    17821 ggtagcgcga ggcgtgccgg gaggcgtcac cgaacgtgtt gacccagagg ggacggccgc
    17881 cgctgatgtc ctctccggtc acgcgcttcc acgcatcgac gacatcggtg aactcggccg
    17941 gtgcggtgcg cggccgggtt ccgtattggt ggaccatcac ccgggtgacg ccgtctccgc
    18001 ggcgtgcggc gatggccagg ccgtgcggca gcctctcgaa gcgccggttg gggatgtcga
    18061 tgccgtcgat gtccgcgcgc agcaggtggc gctgtgcgtc ggtaccgggg aagtcgaagc
    18121 cgcccagccg tcgcacggtg ctgttctcgc cgtcgcagcc gacgatgcac ttggcccgca
    18181 ggcgggtggt ccgcccgtcg ccgaggcgta cctgtgcctc ggcgccgtcc gtggtcatgg
    18241 tcaggccggt gagctcgtgg ccgcgccgga tgtccgcgcc gaggcctgtt gcccattgtc
    18301 cgagaagctc ctcgacgcgg gtctggggga ctttccactg ccccggatag cggctgggca
    18361 gggacaggtc gagggggatg cccccgaagt ggcccgtcgg ctcgttcggc aggtcaccga
    18421 gcggagcgag caggccgcgg gtttcgagga tctccatggt gcgggcgtgc agcgtcgagg
    18481 ccctcgactc cgtcgtgggg ctccggcgcc tctccagcac gagggtgtca gccccgccga
    18541 ggcgcagttc accggcgagc agcagcccga cggggcctgc gcccacgacg atgacctgtg
    18601 tgtccagtcg gtcggccgtc atcgtcagcg cttctcggcg tagtccttgg cgtggcccag
    18661 ggtgatgcgg ctgttggccg acagtgcgcc ctgtacgtac tcgcgggcgt ccgtgacggt
    18721 ggcgtcggcg cccaggatcc gtgcgatgtt cgctgcgttg atgaccacgg tgtgctgcga
    18781 ggaggcggtg gtgacgccgt tgttgtcctc cacgaaggtc cagtagccgg tgtgcagggt
    18841 catcagggcg ggcagtgtca cttgtttgta ggcgatcttc tcgtgcggga gacacacgcg
    18901 gtatgacttg gtggtgtgca cggagccgtc cttggcgcgg gtgtccatct ccagggtctg
    18961 caggcccggt tcgtcctcgg tcaggcgcac ggtcgccacg tgggggagcc gttgggacca
    19021 caggccggct tcgttgatga agtcgtagac gtccttggcg ctgccgtgga cctggacact
    19081 gtcctcgaag gagaaggtca gtgcctctgc ggcgtgggcc agttccacgt tctgtttgag
    19141 ggcggcgagt tcggagcgtg aattgcggtc gacggcctcg tcgatccact gcagaccggc
    19201 cgggtcgtcg tcgatcgccc ggtagtcgtg cagcagccgc acccggcagc cggcctcggg
    19261 cagcggttcg atcacccagg cgcctcccat cgaggcgacc ggcggcgtgg agacctcctg
    19321 ccggaagtcg atgcgcaggc cctcggggtc gagagtgcgg tgcgaggtcc agttcttggc
    19381 ggcgccgttg gcggtcgccc agatgcggat gcgctcgtcg tcgccgttgc gctcgacctg
    19441 gtcgacgtgg atggtcggcg ggaagatgcg gggccagttc tgcacgtcgg cgaggagccg
    19501 gtagacggtg gggggcgggg ccgccaccgt gatctcgtgc tcgacctcgt gagtcgtcat
    19561 ggtgaacctc cttggggtca tcagaagttg cccaggccgc cgcagacgtt cagggcctgt
    19621 gcggtgatgg acgcggcggt gtccgagacg aggtagccga ccagtcctgc gacctcctgc
    19681 ggggtggagt agcggccgag cgggatcttc gcctggaatt tctccaggat cgcggcctcc
    19741 gaggtctggt acgccgtcgc gtacccttcg cgtacgcgct gcgccatggg cgtttccacg
    19801 tagccggggc agacggcgtt caccgtgacc ccggtcggcg ccagctcgtt gcccagggct
    19861 ttggtgaacc cgacgacacc gtgtttggag gcggagtagg gggcgccgag gatcacgccc
    19921 tgcttgcctg cggtcgaggc tatgttgatg atccggccgc ggtccttggc ccgcattccg
    19981 ccggtgttga gcacggcccg ggtcaccctg aagacgctgt tgaggttggt gtcgatgacg
    20041 tcgtcccaca gttcgtcggt gaggtccgcg gtcaccccgc caccgctgcg gcccgcgttg
    20101 ttgaccagta cgtcgatcgt cccgaagcgg tccacggcgg cacggacgaa cgcttccacc
    20161 gcttcgccgg accgtacgtc cacggccgtt ccgtccacct ccagcccttc ttcccgcagc
    20221 tgcttgacgg tggcggccac gttctcctgg gtgcgggcgc cgaggaagac ccggtggccc
    20281 tgctcggcaa gcagtcgggc gactgccaga ccgattccgc tggtcgcgcc ggtgacgacc
    20341 gcgacaggct ggtcctgctg catgatggtt actccaaaca gggcggtggg gtgggcggcc
    20401 gctgcgctcg gcgcagcggc cgcggtggtg cacggatcag gcgctgatga gctttgccag
    20461 cgcggtgttg atggtctcga tcaacgcgcg cggtgtcggg tgttccgtga agatgtcgtc
    20521 gtcgagcgat atgccgtatt cgcgctcgat tcggctcgct gtctccagca gggccagtga
    20581 ctcgtagccg aggtccccga actgcttgtc gaggatgtct tcgtcgagga cgacgtcttc
    20641 gtcggcgccc gctccctcca gcaagatccg tgtgaggtcg tcgagggtga attccttctt
    20701 gggcatgacg tgcctttcgt aggtctgccg cacgcggtgc accgtgcggg aggggtgggg
    20761 ctgggcgccc gccggcgagc gccgggggga gaagcggtgg gagcggcttc tggggggtca
    20821 gtgcggggcc cggagcacca tcgcggagtt gaagccgccg tagccgcggg caaggacgag
    20881 tgcggtgttc accggcgtga cgcgcgcctg gccggtgacc aggtcaaggt cgtagtcggg
    20941 cgagggcagt acgttgatgg tgggcgggat caggccttcg cggatggtga gcagggcggt
    21001 gaccacatcc accggtgcgg ctccggagta gaggcggccg gtcgatgcct tgggtacggt
    21061 gaccggcacg ccggcgggcc cgaagaccgc ggtgatcgcc tcggcttcct cacggtcgag
    21121 gcgcggtgta cccgcgccgt ccgcgaagac cacgtcgatc tcggcggccg ggacgtgcgc
    21181 gtcggtgagt gcggtctcga tggcccggcg caggccgggt tcgcggccgc tgtccggccg
    21241 ggggtcgaac gtggagccgt agcctgcgat ctcgccgtag atccggcgtg cgccgcgggc
    21301 acgggccgac tctgcgcttt ccagggtcag cagtgcgcct ccttcgccgg gcacgtagcc
    21361 gtcggccgct tcgtcgaagg ggaggtaggc ccgttcgggg tcggtgctgg tggacagccg
    21421 gtcgctggcc agttgcgcca cccatcccca ggtgcagatg gaggcgtcga agccgcccga
    21481 gaggatcagc cggctgccct tgcggatcag ccgccgggcc tgggcgatcg cgtccaggcc
    21541 gccggcgtgg tcgctgacga ccacgctgct ggggccgcgc atgccgttgc gtatcgagat
    21601 ctgtccgctg ttgacggcgt agaaccaggc gaacgactgg taggcgctga cgtagtggct
    21661 gccttggctc cacagcttct gcagctcgtt ctgtccgaac tcgaagccgc cggaggtgga
    21721 ggcggtgacc acacccatgt cgtactcggc gaactcgccg ggctggacgt ccgcgtcccc
    21781 gaaggcgcag tccgccgcga ccagggccat ccgggtcatc cggtcggtct gcgggatgag
    21841 tctgctgggg aggtgttgtg cggctgcgaa gctgcggatc tcgccggcga gctgggcggg
    21901 gtagggggtc gcgtcgaagc gggtgacttg gccgatcgcg ttctttccga tacgggtcgc
    21961 gctccagaag tcgtccaccc ccagtccgtg cggggtgaag attcctatgc cggtgacgac
    22021 cgccttggcg ctcatgccgc cttcctttcg ggccgtgcaa ggaccatcgc gctctggaac
    22081 ccgccgaatc cactgccgac cgtgagtacg gtgtcggttc gctgctcgcg ggcggtgagc
    22141 ggcacgtagt ccaggtcgca ctcggggtca ggggtgcgca ggttggcggt ggggggcacc
    22201 acgttgtgct ccatggccag gacggacgcg gcgatctcga tggaaccgat ggcgccgagt
    22261 gagtgcccga ccatcgactt gatggagctg accggggtcc ggtaggcgtg ttcgcccagg
    22321 ctcagtttga atgcggcggt ctcgtggcgg tcgttctgct tggtgccgga gccgtgtgcg
    22381 ttgatgtagt cgatgtcttc ggggttcatc cgcgcctctg tcatggcgac gcggatcgcc
    22441 tccgccatct cgcgcccgtc ggggcgcagg ccggtcatgt ggaaggcgtt gcaccgggag
    22501 gcgtatccgg cgatctccgc gtatatgtgg gcgccgcggc gctgcgcgct ctccagttcc
    22561 tccaggacga agacggcgct gccttctccg agcacgaacc cgttacgggt gccgtcgaag
    22621 gggcgggagg cgtgctcagg gtcgtcgttg cgggccgtgg tggccttgat cgcgtcgaag
    22681 caggccagag tgatcgggga gatcggggcg tcggtggcgc cggcgatcat cacgtcggcg
    22741 gtgccctcgc ggatcagctc gacggcgtgg ccgaccgagt cgatgcccga ggtgcagccg
    22801 gtggagatca cggtggcggg tccttcggcg ccgacggccc acgccacttc ggccgagaag
    22861 gagctcggta cgaagtagtt gtacaggtgc cgcggtgcgt aggtgtggtc gacgagatcg
    22921 aggcggccgt cgtcgctcac cacgcggtac tcgtcgtcga gtccggtggt ggcgccgacg
    22981 gcgctgccga tggtgacgcc ggtgcggtgc gggtcgaagt cggcgacggc gagttggctg
    23041 tcggcgagtg cctcgcgtgc ggtgaccacg gcgaactggg cggcgcggtc catgcggcgg
    23101 agttcctggg ggcgcagccc gtgctgtgcc gcatcgaagt cgatctctgc ggcgaccctg
    23161 gagcggaagg gcgcggggtc gaagaaggtg atgccccggg tcgctgtgcg tccttcgctc
    23221 agcagactcc agaagttttt gacgcctatc ccgcccggcg ccaggactcc gactcctgtg
    23281 attgctacgc ggcggcccac tagtggccgc ctcccctcgt gtctgtgtgg cggagtttca
    23341 ccgggtcgcc gtccagtcgt agaagcgctt ggccatcgcg tcggcgggtg agcgccaggt
    23401 cgccgggtcg taggcttcga tgtgtggctt gaggtcgtcg ctgatctgga ggaaccgggg
    23461 gtccgacttg gcctcctcga tgagttcgcc gccgttgtct gcgtcgaagt cctgcaggtg
    23521 gaagtacaag ccccggtact ggaacagctg gcgccgccgt gtgcccatcc ggtgcggcat
    23581 gtcggtgttg tcgaatgctt cgaacaggcg cgccacttgg gtgccggagg cggcatccat
    23641 tcgggccacg atcaggttgc tgtgcatgtc ttctctcttc cgtgggtcag cgttcggcgg
    23701 cgagtccgaa gggcggtggg gggcggactg ttcgcgggtg gatcgcggtc ggcagcctcg
    23761 gccggagtgg acacggcatg gtgtccgggg tcttgcgtgc acgggccggg gccgggcggt
    23821 gcaacgttcc tcgatgtgcc ggtcggtgtc cgggagaagg gcgtggcgcc ggttcagccc
    23881 gccgccggct gtccgaacca tcgttccagc gccatctgca ggtcgtggtg gctgccgggt
    23941 gccgcccata cgacgtgtcc gtcgggtcgg accagcacgg cggatgtgtc ggcgagttgg
    24001 ctgtcgggcg agaaggaggg tggtgcggtg gtgacgatgt cgacgcggtc ggcccatccg
    24061 taggcccgct tccgcagccg ctcgttggcc tcgaagtcga ggagcacgcc gcgggcggag
    24121 tgcagcagtt cggtggtcga ggtccggcgc cgtgcgctgt ccagtaccag gtgcggcatg
    24181 cgtttgccga gaagcgggtg cgtgccggtg ccgacgtcat aggtgatctc gaggccgctc
    24241 accatgccgg cgagatggcg cgcgacgtcc ttgtaggtga tgagctcgcc cagtacgtca
    24301 cgcaacggct gtacttcggg tccgctgagg aagagcaggc cctgggcccg ggtgttcatc
    24361 aacaggcgct tgccgaccgc gtgtcgctcg ctgtggtacg aatccagcag gcccgcaggg
    24421 gccgatccct tgacctcggc agcgagtttc cagcccaggt tcaccgagtc ctggatgctg
    24481 gtgttcatgc cctgcccgcc ggcgggcagg tgaatgtgcg cggagtcccc ggccaggagg
    24541 acccggccgc gccggtactc ggtgacctga cggctcgcgt cgccgaatgc gctgacccac
    24601 accggttctg cgtgtgatat gtcgtctccg gtcaggcgct tccaggcgtc ggcgacttca
    24661 tcgaaggagg ggggtgcggt acgccgctgg ggcggggtgc cgcgctcgca gacgatcagg
    24721 cgtgtgatgc caccgggcag cggaccgacc atgaccattc cgccgggcag tgtctcgccg
    24781 atcatgcgcg gttcgagttc gatgcccttc acatcggcga ggaacatctc caaagtcgcc
    24841 gcggtgcccg ggaagtcgaa gcccgtggcc ttccgtacgg cgctccgccc tccgtcacag
    24901 cccaccaggt agtccgcgcg cagtgtgtgg gttccgtcgg ggccgcggac atcgacctcg
    24961 acctgcgtac cgaggtcccg cagatcgagg aactcgtggc tgcgccggat gtcgacgccg
    25021 aggctgctgg cccattcctc caggtgcgtc tcggtgacgg attgcggcac gctcttcgcc
    25081 gcctgcaatg cgccttcgag caccccgaaa tcaatgggta aaccgccgaa gtgaccgacg
    25141 ttactggtct ccacttcgcc gaaccgcggc aggattccac gctgatcgaa gacttccatg
    25201 gtgcgcgcgg tgaatccgag accgcgtgat tcgccggagc gcttcgcgag gcgctccaga
    25261 acgatgacgt caactcctgc gagcctgagt tcgccggcca gcatcattcc cgccggacct
    25321 gcgcccacga caatcactgc agcgtccatg tacctctcct cgatcagcgc aagggcttct
    25381 tcagggtgat ccggcacgtc gcccatgagc gaagaatgcg cacctcaggt ccgagcaacg
    25441 acaactacta gtgagattcc cagcccgggg cggcaacttc aagacgatcc ttctcagatc
    25501 tccgtgatgt ttcttcagag atcgacacgt tcggaacggg gaggtcaagc aagcgtcaag
    25561 gaaacttaaa ccgaacacac cgttccacct acgccgcacc gggtcggcgc tctttccccg
    25621 cccatggcgt aatccgaaat tttcagggac tcagggcctg gtaaattcgt cgtctgcaag
    25681 tacataattg gcgaacaaga cctttacggg cccccggccc tccccctccc cctccacctg
    25741 ccgtctccgg tccggcgctt gcacccgccg cgggcctgac ggtgcgccgg cacaccaccg
    25801 gaagtcccct ggccctgggc gacgagttct caggggtgcc cgaagcggaa gccgacaccg
    25861 cgaagtgtga cgatccagct gcaggaaccg agcttgctgc gcaggttgct gacgtgtgtg
    25921 tcgatcgtgc gtcccgatct ggaccacgcg tcgtcccaca cctgcaccat cagctccttg
    25981 cgcgagaaga catactccgg acgggatgcc agcaggtgca ggaggtcgaa ctccttccgg
    26041 gtggcggtga tgagcctgcc gtcgagccgg atctcccgga tgcccgcgta gatgcgcagc
    26101 ggaccatgct cgacgacttg ttcctccgcc gaggaatggt gcgatctcac tctgcgcatg
    26161 acggcttcca tacgggccat cagctcacgg aatccgtacg gcttgatcat gtagtcgtcc
    26221 gagcccgcct gcagaccgag gacccggtcg agctcggtgt cacgtgccgt gacggcgatg
    26281 accggggtgt cgcaggcggc ccggatgctc cggcagacct cgagaccgtc caggtcgggg
    26341 aggtccaggt caaggagaac aaggtccgcg tggctgtgaa cgcgcagcgc cttggcgccg
    26401 gttcccacgc tctgggcgtg gtagccgtgt cgccgcagcc ctacgaccag gcactcggcg
    26461 gcacgttcgt cgccctccac cacaagcacg ctcaggggct cccgccccgt cgcgcggacc
    26521 gcttcggcct cggtctgagg ggtgtgggcg gggtcgggga gtgcctctcc gcaggagccg
    26581 ccatgggggc gcttcgccgg gcggggctcg cgtaggtccg tgaactgccg tttcattagc
    26641 tgctcctacc gtgcgatgag gctcctcagg agtgaccctt cggcaggaac tttacaaacc
    26701 ggtacgccgg tttggcaatg acttaactcc ctgcaacaag tgatgaccac tcccccgtcc
    26761 ggccccgtcg ccgagcggtg cgaaccgggt tgaaaagtca ttgtttttca gacattcgag
    26821 gcgctcgtcc gtggtcaacg gccggtgggt gaacagctcg acggctgatc ccgttccgtc
    26881 taaaaccagg acgatggttc tgtatttccg tcgcggtcca tcacaccccc gcagtgggcc
    26941 ggcggccccc ccgcagtggg ccggcggcca cccccaccgg cggaaagggc cggaccggcc
    27001 ggggccggcc ggttgccgga ggccccggac aggggtacga cgtcctggcg gcgatccgtc
    27061 gcaccgcggg tccgggcagg caggcggccc ggcagcccgc gttccgggcg gacgccgatc
    27121 gggacgggcc ggtccacgat caccgggacc gtgccgaacc tcgcggccgg cctgccgcag
    27181 gggggcccgc gacttcggtt cgcggccggg cagttcgccg aagtccttcc tgcccgccgg
    27241 ggccggtccg tggccgtgat gggcctctgg ccggcgcccg tgccaggagg acgcccgcat
    27301 ccgcagtgcc ggacgccgcg ccctgacagg tggccggcct tgccggcctc ggcggtggga
    27361 ccgtgctcgc gcatccacgc tgcgcaggcc tgccgcccgc gaactgcccg gtgcggtgcc
    27421 ggcctcggtc acctccggcc ggcaggccgt gctgaagatc gagcccgtgc ctcaagagct
    27481 cttcggcgtg accgccttcc tgatcacgct ggtgccggta gccggtgtgg acgtatctcc
    27541 tggccggtgc accagcgggc tcacccgaag cgtccgttca gtacctgtcg ccgggcatct
    27601 tggtgacgcc gtcgtccggg tcggccgtga tgtccacggg catcgcggcc gacagcgaca
    27661 cgggcaaggg cgtcctcggc cgcttacgca cgatgcccct ccggcggcct gcggtggtgg
    27721 tcgcgccgtt ccttccgccg gccgtacctc acccccggcc gtcggggacg agaatgacct
    27781 tgcctgtcgt ggcccgtgcc tcgagcgcgg cgtgcgcctc agccgcctgc gacagaggga
    27841 aggcctggaa ggagggcacc agaccggctt cggcggcctc cgcgagcgcg cgggcttcgt
    27901 cagcagcggc gtcctggccc tccaacagca gggccagcgc gtcggtgaag cgcacgccgc
    27961 gctccttcag ctccgccttc ccggggcgga actcctgccg cgaggccgcg ccgatggtga
    28021 tgtagcgccc gccttcggcc agcagcccga acgcggccag ccccttgtcg ccctcgacac
    28081 cgtccaggac gaccgtgaca ccgcgaccgc ccagggcgcc gcggacggtg tccgcccact
    28141 gcggcaggtt gtagtcgacg gcgatgtcgg cccccagctc ccgcacggcc gccgtcttgg
    28201 ccggtccgcc ggccgcaccg atgaccgtgg cgccgaggcg gtgggcgaac tggacgacca
    28261 gacggccgat gccgccggcc gcggaggtga ccaggaccac gtcatcgggg gtgagctccg
    28321 cgatgtcgag caggccgatg gcagtggcgc ctgtgacgac catggcgacc gctgcctcgt
    28381 caccgagccc ggccggaatc cggtgcaggg acgagacgcc ggcgacggcg agctcggcgt
    28441 aaccccccgg gctgccgtgc gcggtcacga ctctggcgcc gatccacgcc ccgtccacgc
    28501 ccggcccgac cgactcgacc acgccggaca cctctccccc gaagaccgcc gggagctcgg
    28561 gaagcggcgg accggtcttc agcccttccc gcatcgccgt ctcgatctga tggactcctg
    28621 cggccgccac caggacacgg acctcccccg gccccggtac gggatcgggc acggtctcat
    28681 agcggaggtt ctcagcgggg ccgaactcgt gcagcacgac agcgtgcatg accgttcctt
    28741 ccggtggatc tgcaggacga cacccactct gcaagctcaa ctcaacttga tgtcaaaccg
    28801 cacacgccgg agccctgcgc agcaccccgg cccgatgccc ggaggatgcc ccgtacggtg
    28861 agtccggcga gcctcttgcg gcaggccgga gctgtggcga ggccggggcg ggaaagggaa
    28921 acggccgcgc tcgcgttccc gggacggcga gcccccggag tcgaacggcc gttccatatt
    28981 tccgtggtgg cggccggacg gaacgtgaac cccggggggc cggccgccgg cccccacacc
    29041 ccgtgcggca cgagccggcc gggcggatcg acagccgcgg gacagcaccc ttccgcatcg
    29101 gcggcccacc ccctgagatg ccctccgagg tgtcgcccct ctgtccaggc cctgtgacgt
    29161 tccctcacac cttcgcccag gagacagcga cgggtgaaga cgggtgaaaa ggacggcagg
    29221 gctgtgcggg caccgccgga ccgatgccgc cgtacagccc gatggaaggg aacccgtacc
    29281 gtcacagagg agaaacaggc gaaacgcacg actccagagc cagctctgcg tgatgtcacg
    29341 tgcggatgct tgaaatccat gtcaaaggtt ccacagggat ctccacacgg cttgtccccc
    29401 gccgaacgcc agaactagct tggccgttcc tgcaagcaac catcgatggg gtgttgcggt
    29461 gacccgcgga acaatccgta cggccacggt gaccacggct tgcgtggtca cggaatgccc
    29521 gcgccgggcc gtcaccggga cccgactgtg ccggtcctgc cggcggcagc tcgtagcgga
    29581 actgacacga ctgcccaccc tgtacgagga gtgcgccctg cagctcgtcg gcggcccgga
    29641 gccggggcgg cgggaaagga cgtcgggcgg cgcactgccc ggcatgccct tcaacacggc
    29701 tgcgctggag gcccgttcgt cgatcgtctc ggtgctctcg tcctggtccg ccctggtcgc
    29761 cgaggagcgc cgggtccccg caccgcagcg cacggccggg cggctggccg cgtttctgct
    29821 gcggcatgcg gactggctcg cctcgcacga ggcgtcgggt gatctgtccc gggaggtcgc
    29881 ccgtctggcc ggcgcggccc gacaggtgat cgaccccgga ccgggacgcc ggataccgat
    29941 cggcacctgt gtggaggccg gctgcccggg catgctgacc gccaccgtcc gtgccgatcg
    30001 gccggcgctg ccggccgaga tcgtgtgtga cgcctccgcc gggcaccgct ggatcggcca
    30061 ccagtggctc cagctgagcc gtcggctcaa ctcgccgacc ggcctcccga cgcccggcgt
    30121 ggtcctgccc ggcggccgca cggagcccgg gcgccgcacg gagagagccg gagcgcggac
    30181 gaaccggcac gtcgaggccg agcaggagag gacccgctgg atcggcgcga ccgacatcgc
    30241 ccggctgtgg aagatcccgt caggcacggt ctaccggcat gccagccacc agcagtggcg
    30301 ccgccgcagc gagcacggcc gcacctacta caacggcgcc gacgtggagc ggacactcag
    30361 cgccctgcgc cgcacggcct gagaccggcc acccgtatcg acggggggcc gaccgcgtac
    30421 gtcaagcacg gatacgcgag agcggacttg tgccacccgc ggcaatccgc atcccggtcc
    30481 tgtggccgaa cgcggtatga ggccccgtca cgaccctgtg ggggctggtg gagagctcgt
    30541 tgccgggtac cgcggctgaa ctcgtggtgc cgtagggacc ggcggcccct tcacccctgc
    30601 gatgccaccg gggcatgcgg tgtccgggga gccggccggc cggcgaacgg ctgcagttcc
    30661 gcgaggagtt gcggcggaag gcggccggga ggttcacccg gggcgaggcg agctcggtga
    30721 ccgccaggga tctgcgggcc agcgtccgct ccgcgcagcg gtggcgccgg atgggggacg
    30781 agggcggccc gcgggcttgc ggtcacgggg gccggcgtca ctgccgaggc cgagcgagaa
    30841 gcagtccgcc cagccggagg cggagccggc caaggggccg gccgtgcacg gccgggagga
    30901 ccggcggtgg acgccggcac ggatgaggag ggtgatcggc cggcgtttcc ccctgtcctg
    30961 cccagggcgt gcggaagacg ggtgcgcaac ggctggtcct gccaggtccc ggcccggcgt
    31021 gcgacggagc gggacgacga ggcggcggcc gggcggggca cgcgggtgcg gccctgcgcg
    31081 gaaggctcgc ggcggcccgt ggagcctggc tcgtcttcga ggacgaggcc ggcttctcca
    31141 tgacgccgca gcgggcgagg acctggtcac agcgtggccg gaccccggtg gtgcgggtgc
    31201 ggggccctcc cgcacccgca ccaccatcgc ggcctcggcc tgctgcggac ccggccaccg
    31261 gtcgcggccg gtctgccggc cgtgccggga cgacgggcgc cgtgagggcc gcaggagctt
    31321 gtcctggcgc ggctaccggg acccgctgat ccgccgcccg ggccgggcgg gtcccgtcgg
    31381 gggaatccgg ccgctgccgg ggttcccctc ccgcccgcgg gacagccggc agggctccgg
    31441 tgggcgggcg gtgttctcgg cggtgggtac gtgccggccg gcgggtgcgc ctgtgcggcg
    31501 ccttccgccg gtgttcaggg tcgagctcac ggatgcccga gccggaaacc caccccgcgt
    31561 acggtgatga tccagctggt ggcccccagc ttgctgcgca ggctgctgac gtgcgtgtcg
    31621 atggtgcgct ccgaccgcga ccaggagtcg tcccacacct gggtcatcag ctgtttgcgc
    31681 aagatgaccg tttcgggctg cgaggccagc agatgcagca ggtcgaactc cttgcgggtc
    31741 atctcgaccg gcgtgccgtc gacccggatc tcacgtgcgc ccgcatcgat ccacaacgtg
    31801 ccgcgtgcga tgacctgctt gaggggctgc accggcctga ccctgcgcat gatcgcttcc
    31861 atccgggcca tgagttcacg gaaaccgtag ggcttgacca tgtagtcgtc cgcgccggcc
    31921 tgcaggccca gtacccggtc gagttcggag tcccgggcgg tgacggcgat gaccggggtg
    31981 tcacaggtga cgcggatgct gcggcagacc tcaaggccgt ccagatccgg caggtcgagg
    32041 tccagcagga tcagatctgc gcttcggtgc acctgcagtg ccttgacccc ggtcgcgacg
    32101 ctctccacca ggtagccgtg ccggcgcagg ctctgcacca gtgaatccgc cgcgcgcggc
    32161 tcgttctcca cgacgagaac ccgcagctcc tcccggcgga aacggggccc cggctgcacc
    32221 acgggccggt agccccccgg gtcggccggg ggctccgata aggtgcgcct cggcgccctc
    32281 gacatcagta catcggtcga ctgccgttcc atccgctctc ccccggtgtc cgcgcacacg
    32341 gcacatcccc catgaatgtg ccccctccac catacaaacc ggcgcgtcgg tttgtcaaag
    32401 ccccaggcct gatccgcacc ccggccgccc tcccgcgcag gcgcccgccc cggggccgga
    32461 aggggggccc gcgagacggc ccgcccgcct cgtacggccg gcgcacgccg cactcacctc
    32521 cgccgggcgg ggcggcgaca atcggccatt cgcgaagcat ctgatctccc gctagatatc
    32581 aaaccggcat cctggtttga taattcaccg cagggaaaca cttccgcaac gggaggcagt
    32641 aggtgagcaa acaggaacgg gctgcccgca cccgcaacgc actgatccgt tcggcggccg
    32701 agctgttcga gcagtgcggc tatacgaagg ccagcctgta cgagatcagt tcgggtgcgg
    32761 gagtgagccg cggcgccctg cacttccact tcgtcaacaa ggcggacctg gccgatgccg
    32821 tggaaggcgc cgctgcccgt tccctgcacc gcgcggcccg gagggcggag cagggacaga
    32881 cgaacgccct gcaggcgctg acgaacctgt cgcacacctt cgcgcaactg ctgagctggg
    32941 acgtggtggt gcgggcgggg ttccggatca actgtgacgc gggcctgcac accggacgcg
    33001 acctgcgccg gcaatggcag agctgtgtac gcgagctcgt ctcccgggcc ggggaggagg
    33061 aggcactggc gcgtgacgtg ccgcaggagc ccctggtcat gaccgtggtg ggcgcgacga
    33121 ccggtttcga ggtgctcggc agagccaacg gtcactggct gtcgcactac tcactcacca
    33181 gcttctggca gctgctgctg cccgtggtgg ccgccccacg ggtgctggcc acgctcgacc
    33241 ccgccggcag cggcccggtg accggcgctc tgccggggca gttcaggcac accggggaca
    33301 tcccgccccg cgcacgccgc tccggctcgg gcccccgccc ggccgcaccg gcgtgccgct
    33361 cttgcgccgc ccccgacggg ccgggcgctc cgggcccgaa gcagcaggtg agccgcccct
    33421 gttcgtccga gcccggcggg acctcgtcgt ga
//
