BGC0002033: spiramycin biosynthetic gene cluster from Streptomyces ambofaciens ATCC 23877
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Location: 5,967,886 - 6,057,980 nt. (total: 90,095 nt).
This entry is originally from NCBI GenBank NZ_CP012382.1.

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core biosynthetic genes
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002033
Short description spiramycin biosynthetic gene cluster from Streptomyces ambofaciens ATCC 23877
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
Loci
NZ_CP012382.1
5967886 - 6057980
via
Compounds
  • spiramycin
Species Streptomyces ambofaciens ATCC 23877 [taxonomy]
References
Chemical products information
spiramycin Evidence:
Copy SMILES
C43H74N2O14
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • SAM23877_RS26565
  • WP_053138380.1
 5967886 - 5969310 (+) non-reducing end alpha-L-arabinofuranosidase family hydrolase
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    • SAM23877_RS26570
    • WP_079030442.1
    		 5969372 - 5969647 (-) DUF3253 domain-containing protein
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      • SAM23877_RS26575
      • WP_053138398.1
      		 5969721 - 5971232 (+) PLP-dependent aminotransferase family protein
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        • SAM23877_RS26580
        • WP_053138404.1
        		 5971481 - 5972455 (-) aldo/keto reductase
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          • SAM23877_RS26585
          • WP_063796824.1
          		 5972675 - 5973523 (+) NAD(P)H-binding protein
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            • SAM23877_RS26590
            • WP_079030445.1
            		 5973546 - 5974553 (-) glycosyl hydrolase
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              • SAM23877_RS26595
              • WP_053138412.1
              		 5975242 - 5976405 (+) transposase
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                • SAM23877_RS26600
                • WP_053138415.1
                		 5976669 - 5977289 (-) dTDP-4-dehydrorhamnose 3,5-epimerase family protein
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                  • SAM23877_RS26605
                  • WP_063483317.1
                  		 5977339 - 5978556 (-) glycosyltransferase
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                    • SAM23877_RS26610
                    • WP_053138421.1
                    		 5978806 - 5979672 (+) 3-hydroxyacyl-CoA dehydrogenase family protein
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                      • SAM23877_RS26615
                      • WP_053138424.1
                      		 5979669 - 5979980 (+) acyl carrier protein
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                        • SAM23877_RS26620
                        • WP_053138427.1
                        		 5979973 - 5981094 (+) acyl-CoA dehydrogenase family protein
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                          • SAM23877_RS26625
                          • WP_053138430.1
                          		 5981183 - 5982298 (+) HAD-IIIC family phosphatase
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                            • SAM23877_RS26630
                            • WP_053138433.1
                            		 5982295 - 5983527 (+) class I SAM-dependent methyltransferase
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                              • SAM23877_RS26635
                              • WP_053138436.1
                              		 5983570 - 5984577 (-) aldo/keto reductase
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                                • SAM23877_RS26640
                                • WP_235614616.1
                                		 5984574 - 5985566 (-) NAD(P)-dependent oxidoreductase
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                                  • SAM23877_RS26645
                                  • WP_053138443.1
                                  		 5985568 - 5986746 (-) DUF1205 domain-containing protein
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                                    • SAM23877_RS26650
                                    • WP_053138447.1
                                    		 5986863 - 5988134 (-) activator-dependent family glycosyltransferase
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                                      • SAM23877_RS26655
                                      • WP_053138450.1
                                      		 5988191 - 5989429 (-) P450-derived glycosyltransferase activator
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                                        • SAM23877_RS26660
                                        • WP_079030446.1
                                        		 5989742 - 5990782 (+) Gfo/Idh/MocA family oxidoreductase
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                                          • SAM23877_RS26665
                                          • WP_053138455.1
                                          		 5990891 - 5991934 (-) hypothetical protein
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                                            • SAM23877_RS26670
                                            • WP_079030798.1
                                            • hflX
                                            		 5992254 - 5993651 (+) GTPase HflX
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                                              • SAM23877_RS26675
                                              • WP_053138458.1
                                              • rfbH
                                              		 5993715 - 5995016 (-) lipopolysaccharide biosynthesis protein RfbH
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                                                • SAM23877_RS26680
                                                • WP_053138477.1
                                                		 5995360 - 5997012 (+) ABC-F type ribosomal protection protein Srm(B)
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                                                  • SAM23877_RS26685
                                                  • WP_053138480.1
                                                  		 5997123 - 5999090 (-) helix-turn-helix domain-containing protein
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                                                    • SAM23877_RS26690
                                                    • WP_053138489.1
                                                    		 5999665 - 6000384 (+) class I SAM-dependent methyltransferase
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                                                      • SAM23877_RS26695
                                                      • WP_053138492.1
                                                      		 6000512 - 6001660 (-) DegT/DnrJ/EryC1/StrS family aminotransferase
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                                                        • SAM23877_RS26700
                                                        • WP_053142891.1
                                                        		 6002065 - 6003474 (-) NDP-hexose 2,3-dehydratase family protein
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                                                          • SAM23877_RS26705
                                                          • WP_053142893.1
                                                          		 6003476 - 6004279 (-) alpha/beta fold hydrolase
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                                                            • SAM23877_RS26710
                                                            • WP_053142895.1
                                                            • rfbB
                                                            		 6004276 - 6005247 (-) dTDP-glucose 4,6-dehydratase
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                                                              • SAM23877_RS26715
                                                              • WP_053138495.1
                                                              • rfbA
                                                              		 6005297 - 6006175 (-) glucose-1-phosphate thymidylyltransferase RfbA
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                                                                • SAM23877_RS26720
                                                                • WP_053138498.1
                                                                		 6006202 - 6007368 (-) DegT/DnrJ/EryC1/StrS family aminotransferase
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                                                                  • SAM23877_RS41815
                                                                  • WP_256359409.1
                                                                  		 6007365 - 6007910 (-) FdtA/QdtA family cupin domain-containing protein
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                                                                    • SAM23877_RS26730
                                                                    • WP_053138501.1
                                                                    		 6007901 - 6009112 (-) cytochrome P450
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                                                                      • SAM23877_RS39245
                                                                      • WP_053138504.1
                                                                      		 6009659 - 6023317 (+) type I polyketide synthase
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                                                                        • SAM23877_RS37920
                                                                        • WP_079030450.1
                                                                        		 6023361 - 6029351 (+) type I polyketide synthase
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                                                                          • SAM23877_RS26760
                                                                          • WP_159041997.1
                                                                          		 6029425 - 6040599 (+) type I polyketide synthase
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                                                                            • SAM23877_RS26765
                                                                            • WP_053138519.1
                                                                            		 6040644 - 6045386 (+) type I polyketide synthase
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                                                                              • SAM23877_RS26770
                                                                              • WP_053138522.1
                                                                              		 6045482 - 6051145 (+) type I polyketide synthase
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                                                                                • SAM23877_RS26775
                                                                                • WP_053138527.1
                                                                                		 6051145 - 6051855 (+) class I SAM-dependent methyltransferase
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                                                                                  • SAM23877_RS26780
                                                                                  • WP_053138530.1
                                                                                  		 6051975 - 6053246 (+) P450-derived glycosyltransferase activator
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                                                                                    • SAM23877_RS26785
                                                                                    • WP_053138533.1
                                                                                    		 6053286 - 6054551 (+) activator-dependent family glycosyltransferase
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                                                                                      • SAM23877_RS26790
                                                                                      • WP_053138536.1
                                                                                      • ccrA
                                                                                      		 6054578 - 6055927 (+) crotonyl-CoA carboxylase/reductase
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                                                                                        • SAM23877_RS26795
                                                                                        • WP_053142901.1
                                                                                        		 6056065 - 6056730 (-) class I SAM-dependent methyltransferase
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                                                                                          • SAM23877_RS26800
                                                                                          • WP_053138539.1
                                                                                          		 6056736 - 6057980 (-) acyltransferase
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                                                                                            Biosynthesis information
                                                                                            Annotation changelog

                                                                                            Entry version: 3

                                                                                            Date
                                                                                            Changes
                                                                                            Submitters
                                                                                            Reviewers
                                                                                            2022-10-07
                                                                                            Update chemical activity to schema version 2.11
                                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                            Entry version: 2

                                                                                            Date
                                                                                            Changes
                                                                                            Submitters
                                                                                            Reviewers
                                                                                            2022-09-15
                                                                                            Cleaned up synonym list
                                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                            2022-09-15
                                                                                            Fetch compound properties from PubChem
                                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                            2022-09-15
                                                                                            Updated bioactivity data
                                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                            Entry version: 1

                                                                                            Date
                                                                                            Changes
                                                                                            Submitters
                                                                                            Reviewers
                                                                                            2019-10-16
                                                                                            Submitted
                                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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