BGC0002037 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002037 (Pseudomonas aeruginosa PAO1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	16,597	azetidomonamide A/azetidomonamide B	NRPS:Type I	100%

BGC0002037 - Region 1 - NRPS

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Location: 1 - 16,597 nt. (total: 16,597 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 16,598
Label		BGC0002037

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002037	1.00	NRP	azetidomonamide A, azetidomonamide B	Pseudomonas aeruginosa PAO1
BGC0001873	0.42	NRP	pyrrolizixenamide A	Xenorhabdus szentirmaii DSM 16338
BGC0002084	0.32	RiPP	biarylitide YYH, biarylitide YFH	Planomonospora sp. ID82291
BGC0002075	0.32	NRP, Alkaloid	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0002099	0.32	RiPP	biarylite-YFH	Planomonospora sp. ID107089
BGC0000457	0.31	NRP	vicibactin	Rhizobium etli CFN 42
BGC0000417	0.30	NRP	rhodochelin	Rhodococcus jostii RHA1
BGC0002554	0.29	Alkaloid	carquinostatin A, carquinostatin B	Streptomyces exfoliatus
BGC0002528	0.28	NRP	aminochelin, azotochelin, protochelin	Azotobacter vinelandii CA
BGC0001185	0.28	NRP	bacillibactin	Bacillus velezensis FZB42

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002037	1.00	NRP	azetidomonamide A, azetidomonamide B	Pseudomonas aeruginosa PAO1
BGC0001873	0.73	NRP	pyrrolizixenamide A	Xenorhabdus szentirmaii DSM 16338
BGC0002084	0.66	RiPP	biarylitide YYH, biarylitide YFH	Planomonospora sp. ID82291
BGC0002075	0.65	NRP, Alkaloid	pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E	Pseudomonas fluorescens
BGC0002099	0.65	RiPP	biarylite-YFH	Planomonospora sp. ID107089
BGC0000457	0.64	NRP	vicibactin	Rhizobium etli CFN 42
BGC0000417	0.64	NRP	rhodochelin	Rhodococcus jostii RHA1
BGC0002554	0.63	Alkaloid	carquinostatin A, carquinostatin B	Streptomyces exfoliatus
BGC0002528	0.62	NRP	aminochelin, azotochelin, protochelin	Azotobacter vinelandii CA
BGC0001185	0.62	NRP	bacillibactin	Bacillus velezensis FZB42

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 16597:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Ser - X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

PA3327

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AMP-binding (450..852): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: DVWHFSLVDK
Nearest Stachelhaus code(s):: Ser DVWHFSLVDK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1480..1877): X

nrpys: Aze

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
Small clusters prediction:: pro (Pro)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DMQLVSQQVK
Nearest Stachelhaus code(s):: Aze DMQLVSQQVK (100% 8Å match)
Stachelhaus code match:: 100% (strong)