BGC0002037: azetidomonamide A biosynthetic gene cluster from Pseudomonas aeruginosa PAO1
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 3,729,471 - 3,746,067 nt. (total: 16,597 nt).
This entry is originally from NCBI GenBank AE004091.2.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002037
Short description azetidomonamide A biosynthetic gene cluster from Pseudomonas aeruginosa PAO1
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
AE004091.2
3729471 - 3746067
via Knock-out studies
Compounds
  • azetidomonamide A
  • azetidomonamide B
Species Pseudomonas aeruginosa PAO1 [taxonomy]
References
Chemical products information
azetidomonamide A Evidence:
Copy SMILES
Chemical database entries
NPAtlas
azetidomonamide B Evidence:
Copy SMILES
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • PA3326
  • AAG06714.1
 3729471 - 3730076 (-) probable Clp-family ATP-dependent protease
    copy AA seq
    copy Nt seq
    • PA3327
    • AAG06715.1
    		 3730557 - 3737615 (+) probable non-ribosomal peptide synthetase
      copy AA seq
      copy Nt seq
      • PA3328
      • AAG06716.1
      		 3737612 - 3738778 (+) probable FAD-dependent monooxygenase
        copy AA seq
        copy Nt seq
        • PA3329
        • AAG06717.1
        		 3738775 - 3740103 (+) hypothetical protein
          copy AA seq
          copy Nt seq
          • PA3330
          • AAG06718.1
          		 3740105 - 3741019 (+) probable short chain dehydrogenase
            copy AA seq
            copy Nt seq
            • PA3331
            • AAG06719.1
            		 3741012 - 3742268 (+) cytochrome P450
              copy AA seq
              copy Nt seq
              • PA3332
              • AAG06720.1
              		 3742265 - 3742690 (+) conserved hypothetical protein
                copy AA seq
                copy Nt seq
                • PA3333
                • AAG06721.1
                • fabH2
                		 3742694 - 3743686 (+) 3-oxoacyl-[acyl-carrier-protein] synthase III
                  copy AA seq
                  copy Nt seq
                  • PA3334
                  • AAG06722.1
                  		 3743700 - 3743939 (+) probable acyl carrier protein
                    copy AA seq
                    copy Nt seq
                    • PA3335
                    • AAG06723.1
                    		 3744057 - 3744809 (+) hypothetical protein
                      copy AA seq
                      copy Nt seq
                      • PA3336
                      • AAG06724.1
                      		 3744901 - 3746067 (+) probable major facilitator superfamily (MFS) transporter
                        copy AA seq
                        copy Nt seq
                        Biosynthesis information

                        Biosynthetic modules

                        Name
                        Unk01
                        Type
                        nrps-type1
                        Genes
                        PA3327
                        Substrates
                        serine (evidence: Structure-based inference [2])
                        Integrated Monomers
                        Domains
                        adenylation
                        Name
                        Unk02
                        Type
                        nrps-type1
                        Genes
                        PA3327
                        Substrates
                        azetidine-2-carboxylic acid (evidence: Structure-based inference [2])
                        Integrated Monomers
                        Domains
                        adenylation
                        Name
                        Unk03
                        Type
                        nrps-type1
                        Genes
                        PA3327
                        Substrates
                        serine (evidence: Structure-based inference, Mass spectrometry, ATP-PPi exchange assay)
                        Integrated Monomers
                        Domains
                        adenylation
                        Name
                        Unk04
                        Type
                        nrps-type1
                        Genes
                        PA3327
                        Substrates
                        azetidine-2-carboxylic acid, proline (evidence: Structure-based inference, Mass spectrometry, ATP-PPi exchange assay)
                        Integrated Monomers
                        Domains
                        adenylation
                        Annotation changelog

                        Entry version: 2

                        Date
                        Changes
                        Submitters
                        Reviewers
                        2022-10-07
                        Added chemical structures for compounds: azetidomonamide A, azetidomonamide B.
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        2022-10-07
                        Added NPAtlas links to compounds: azetidomonamide A, azetidomonamide B.
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                        Entry version: 1

                        Date
                        Changes
                        Submitters
                        Reviewers
                        2022-09-15
                        Entry added
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        2022-09-15
                        Added NRP substrate specificities
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        Detailed domain annotation
                        Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
                        A domain glossary is available here, and an explanation of the visualisation is available here.
                        Selected features only
                        Show module domains
                        Similar known gene clusters from MIBiG 4.0
                        Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
                        Click on reference genes to show details of similarities to genes within the current region.
                        Click on an accession to open that entry in the MiBIG database.