BGC0002038 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002038 (Streptomyces sp. DASNCL29)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	95,046	nigericin	PKS	100%

BGC0002038 - Region 1 - T1PKS

Download region GenBank file

Download region SVG

Location: 1 - 95,046 nt. (total: 95,046 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 95,047
Label		BGC0002038

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002038	1.00	Polyketide	nigericin	Streptomyces sp. DASNCL29
BGC0000114	0.49	Polyketide	nigericin	Streptomyces violaceusniger
BGC0000353	0.38	NRP	tacrolimus	Streptomyces sp. MA6548
BGC0000041	0.37	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0002227	0.36	NRP	AKML B, AKML D, AKML A, AKML C	Aspergillus luchuensis IFO 4308
BGC0000068	0.36	Polyketide	geldanamycin	Streptomyces hygroscopicus
BGC0001164	0.36	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0002729	0.36	Polyketide	sordarial	Neurospora crassa OR74A
BGC0002228	0.36	NRP	CIML B, CIML A, CIML D, CIML C	Colletotrichum incanum
BGC0001276	0.36	Polyketide	6-methylsalicyclic acid	Aspergillus terreus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002038	1.00	Polyketide	nigericin	Streptomyces sp. DASNCL29
BGC0000114	0.78	Polyketide	nigericin	Streptomyces violaceusniger
BGC0000353	0.70	NRP	tacrolimus	Streptomyces sp. MA6548
BGC0000041	0.70	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0002227	0.69	NRP	AKML B, AKML D, AKML A, AKML C	Aspergillus luchuensis IFO 4308
BGC0000068	0.69	Polyketide	geldanamycin	Streptomyces hygroscopicus
BGC0001164	0.69	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0002729	0.69	Polyketide	sordarial	Neurospora crassa OR74A
BGC0002228	0.69	NRP	CIML B, CIML A, CIML D, CIML C	Colletotrichum incanum
BGC0001276	0.69	Polyketide	6-methylsalicyclic acid	Aspergillus terreus

Similar known gene clusters from MIBiG 4.0

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 95046:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal - Me-mal) + (Me-redmal) + (ccmal - Me-redmal) + (Me-ccmal - redmal) + (Me-ccmal - Me-redmal) + (pk) + (Me-redmal) + (Me-ccmal)
Non-colinear ordering:: FGK60_03865 + FGK60_03860 + FGK60_03855 + FGK60_03850 + FGK60_03845 + FGK60_03840 + FGK60_03785 + FGK60_03790

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

FGK60_03740

PKS_AT (1362..1559): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 110.3
Methoxymalonyl-CoA: 43.8
Methylmalonyl-CoA: 39.8
inactive: 38.4
fatty_acid: 32.1
Ethylmalonyl-CoA: 25.2
Isobutyryl-CoA: 24.2
Benzoyl-CoA: 17.7
CHC-CoA: 16.2
2-Methylbutyryl-CoA: 14.8
Propionyl-CoA: 14.5
Acetyl-CoA: 13.1
trans-1,2-CPDA: 12.9
3-Methylbutyryl-CoA: 0.0

FGK60_03775

PKS_AT (0..268): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 66.7%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 137.1
Methoxymalonyl-CoA: 53.9
Methylmalonyl-CoA: 49.2
inactive: 47.4
fatty_acid: 39.4
Ethylmalonyl-CoA: 25.4
Propionyl-CoA: 24.9
Isobutyryl-CoA: 19.7
2-Methylbutyryl-CoA: 17.1
trans-1,2-CPDA: 17.0
Benzoyl-CoA: 16.1
CHC-CoA: 15.3
Acetyl-CoA: 13.4
3-Methylbutyryl-CoA: 0.0

FGK60_03785

PKS_AT (575..875): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 211.0
Ethylmalonyl-CoA: 195.2
Methoxymalonyl-CoA: 176.1
2-Methylbutyryl-CoA: 150.2
trans-1,2-CPDA: 132.3
Propionyl-CoA: 125.8
Malonyl-CoA: 108.2
CHC-CoA: 91.7
Isobutyryl-CoA: 74.4
fatty_acid: 50.7
Benzoyl-CoA: 48.5
Acetyl-CoA: 44.3
3-Methylbutyryl-CoA: 37.6
inactive: 19.4

FGK60_03790

PKS_AT (575..875): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 211.0
Ethylmalonyl-CoA: 195.2
Methoxymalonyl-CoA: 176.1
2-Methylbutyryl-CoA: 150.2
trans-1,2-CPDA: 132.3
Propionyl-CoA: 125.8
Malonyl-CoA: 108.2
CHC-CoA: 91.7
Isobutyryl-CoA: 74.4
fatty_acid: 50.7
Benzoyl-CoA: 48.5
Acetyl-CoA: 44.3
3-Methylbutyryl-CoA: 37.6
inactive: 19.4

FGK60_03840

PKS_AT (582..882): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 211.1
Methylmalonyl-CoA: 210.3
Methoxymalonyl-CoA: 175.0
2-Methylbutyryl-CoA: 135.0
trans-1,2-CPDA: 127.9
Propionyl-CoA: 114.8
Malonyl-CoA: 106.2
CHC-CoA: 96.3
Isobutyryl-CoA: 64.5
Benzoyl-CoA: 44.4
Acetyl-CoA: 41.4
fatty_acid: 39.6
3-Methylbutyryl-CoA: 27.7
inactive: 20.9

FGK60_03845

PKS_AT (567..870): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 212.0
Ethylmalonyl-CoA: 201.4
Methoxymalonyl-CoA: 173.6
trans-1,2-CPDA: 142.3
2-Methylbutyryl-CoA: 137.2
Propionyl-CoA: 111.4
Malonyl-CoA: 103.9
CHC-CoA: 100.4
Isobutyryl-CoA: 75.5
Benzoyl-CoA: 66.0
fatty_acid: 40.9
Acetyl-CoA: 38.3
3-Methylbutyryl-CoA: 37.9
inactive: 22.9

PKS_AT (2374..2677): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 209.5
Ethylmalonyl-CoA: 206.3
Methoxymalonyl-CoA: 175.2
trans-1,2-CPDA: 144.7
2-Methylbutyryl-CoA: 135.7
Propionyl-CoA: 116.6
Malonyl-CoA: 105.9
CHC-CoA: 104.8
Isobutyryl-CoA: 76.2
Benzoyl-CoA: 68.4
fatty_acid: 48.0
Acetyl-CoA: 45.1
3-Methylbutyryl-CoA: 33.4
inactive: 20.4

FGK60_03850

PKS_AT (566..869): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 212.5
Ethylmalonyl-CoA: 206.5
Methoxymalonyl-CoA: 173.9
2-Methylbutyryl-CoA: 136.9
trans-1,2-CPDA: 132.3
Propionyl-CoA: 116.0
Malonyl-CoA: 109.4
CHC-CoA: 104.4
Isobutyryl-CoA: 78.1
Benzoyl-CoA: 77.0
Acetyl-CoA: 56.8
3-Methylbutyryl-CoA: 48.2
fatty_acid: 44.1
inactive: 25.8

PKS_AT (2368..2655): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 75.0%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 190.0
inactive: 95.4
Methylmalonyl-CoA: 69.0
Methoxymalonyl-CoA: 68.8
Propionyl-CoA: 41.0
fatty_acid: 40.5
Isobutyryl-CoA: 35.4
Ethylmalonyl-CoA: 33.3
2-Methylbutyryl-CoA: 31.3
Acetyl-CoA: 20.7
trans-1,2-CPDA: 12.6
CHC-CoA: 11.6
Benzoyl-CoA: 10.9
3-Methylbutyryl-CoA: 0.0

FGK60_03855

PKS_AT (573..870): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 83.3%; Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 228.0
inactive: 121.9
Methoxymalonyl-CoA: 54.6
Methylmalonyl-CoA: 45.5
Propionyl-CoA: 29.8
Isobutyryl-CoA: 28.9
Acetyl-CoA: 19.4
Benzoyl-CoA: 17.5
Ethylmalonyl-CoA: 13.3
2-Methylbutyryl-CoA: 10.4
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (2368..2672): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 210.6
Ethylmalonyl-CoA: 206.0
Methoxymalonyl-CoA: 177.3
trans-1,2-CPDA: 145.1
2-Methylbutyryl-CoA: 140.1
Propionyl-CoA: 120.6
Malonyl-CoA: 108.6
CHC-CoA: 102.1
Isobutyryl-CoA: 70.8
Benzoyl-CoA: 61.9
fatty_acid: 54.0
Acetyl-CoA: 49.5
3-Methylbutyryl-CoA: 31.9
inactive: 24.1

FGK60_03860

PKS_AT (579..882): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 210.4
Ethylmalonyl-CoA: 203.4
Methoxymalonyl-CoA: 173.6
trans-1,2-CPDA: 135.8
2-Methylbutyryl-CoA: 130.0
Propionyl-CoA: 111.1
Malonyl-CoA: 104.0
CHC-CoA: 103.9
Isobutyryl-CoA: 78.9
Benzoyl-CoA: 77.3
Acetyl-CoA: 56.3
fatty_acid: 52.0
3-Methylbutyryl-CoA: 45.1
inactive: 30.3

FGK60_03865

PKS_AT (558..864): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 87.5%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 205.3
inactive: 99.6
Methoxymalonyl-CoA: 77.6
Methylmalonyl-CoA: 64.3
Isobutyryl-CoA: 48.1
Benzoyl-CoA: 32.7
Propionyl-CoA: 32.1
Ethylmalonyl-CoA: 27.7
CHC-CoA: 23.1
Acetyl-CoA: 22.7
3-Methylbutyryl-CoA: 14.5
2-Methylbutyryl-CoA: 14.1
fatty_acid: 13.9
trans-1,2-CPDA: 0.5

PKS_AT (1585..1889): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 207.7
Ethylmalonyl-CoA: 201.9
Methoxymalonyl-CoA: 176.2
trans-1,2-CPDA: 144.1
2-Methylbutyryl-CoA: 129.3
Propionyl-CoA: 118.0
Malonyl-CoA: 108.5
CHC-CoA: 94.3
Isobutyryl-CoA: 68.4
Benzoyl-CoA: 56.2
Acetyl-CoA: 47.3
fatty_acid: 46.5
3-Methylbutyryl-CoA: 26.7
inactive: 25.7