BGC0002042: anthelvencin A biosynthetic gene cluster from Streptomyces venezuelae
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 1,540 - 27,652 nt. (total: 26,113 nt).
This entry is originally from NCBI GenBank MK483114.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002042
Short description anthelvencin A biosynthetic gene cluster from Streptomyces venezuelae
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
MK483114.1
1540 - 27652
via Knock-out studies
Compounds
  • anthelvencin A
  • anthelvencin B
  • anthelvencin C
Species Streptomyces venezuelae [taxonomy]
References
Chemical products information
anthelvencin A Evidence: NMR, Mass spectrometry
Copy SMILES
C19H25N9O3
anthelvencin B Evidence: Mass spectrometry
Copy SMILES
C18H23N9O3
anthelvencin C Evidence: Mass spectrometry
Copy SMILES
C20H27N9O3
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • QEG98935.1
  • ant22
 1540 - 3081 (-) ant22
  • Activation / processing
copy AA seq
copy Nt seq
  • QEG98936.1
  • ant21
 3065 - 4975 (-) ant21
  • Transport
copy AA seq
copy Nt seq
  • QEG98937.1
  • ant20
 4975 - 6813 (-) ant20
  • Transport
copy AA seq
copy Nt seq
  • QEG98938.1
  • ant1
 7473 - 8099 (+) ant1
  • Regulation
copy AA seq
copy Nt seq
  • QEG98939.1
  • ant2
 8509 - 9930 (+) ant2
  • Scaffold biosynthesis
copy AA seq
copy Nt seq
  • QEG98940.1
  • ant3
 10427 - 11806 (+) ant3
  • Precursor biosynthesis
copy AA seq
copy Nt seq
  • QEG98941.1
  • ant4
 11803 - 12348 (+) ant4
  • Precursor biosynthesis
copy AA seq
copy Nt seq
  • QEG98942.1
  • ant5
 12345 - 13295 (+) ant5
  • Precursor biosynthesis
copy AA seq
copy Nt seq
  • QEG98943.1
  • ant6
 13297 - 14076 (+) ant6
  • Precursor biosynthesis
copy AA seq
copy Nt seq
  • QEG98956.1
  • ant8
 14126 - 15430 (+) ant8
  • Precursor biosynthesis
  • Knock-out
copy AA seq
copy Nt seq
  • QEG98944.1
 15423 - 16415 (+) ant9
  • Precursor biosynthesis
copy AA seq
copy Nt seq
  • QEG98945.1
  • ant10
 16412 - 17494 (+) ant10
  • Precursor biosynthesis
copy AA seq
copy Nt seq
  • QEG98946.1
  • ant11
 17491 - 18255 (+) ant11
  • Precursor biosynthesis
copy AA seq
copy Nt seq
  • QEG98947.1
  • ant12
 18252 - 19403 (+) ant12
  • Precursor biosynthesis
copy AA seq
copy Nt seq
  • QEG98948.1
  • ant13
 19385 - 21286 (+) ant13
  • Precursor biosynthesis
copy AA seq
copy Nt seq
  • QEG98949.1
  • ant14
 21283 - 22185 (+) ant14
  • Scaffold biosynthesis
copy AA seq
copy Nt seq
  • QEG98950.1
  • ant15
 22197 - 23003 (+) ant15
  • Tailoring
copy AA seq
copy Nt seq
  • QEG98951.1
  • ant16
 23000 - 24334 (+) ant16
  • Scaffold biosynthesis
copy AA seq
copy Nt seq
  • QEG98952.1
  • ant17
 24331 - 25377 (+) ant17
  • Precursor biosynthesis
copy AA seq
copy Nt seq
  • QEG98953.1
  • ant19
 25467 - 25808 (+) ant19
  • Scaffold biosynthesis
copy AA seq
copy Nt seq
  • QEG98954.1
  • ant23
 25893 - 27236 (-) ant23
  • Scaffold biosynthesis
  • Knock-out
copy AA seq
copy Nt seq
  • QEG98955.1
  • ant24
 27275 - 27652 (-) ant24
  • Precursor biosynthesis
  • Knock-out Other in vivo study
copy AA seq
copy Nt seq
Biosynthesis information

Biosynthetic modules

Name
Unk01
Type
nrps-type1
Genes
ant22
Substrates
4-acetamidopyrrole-2-carboxylic acid (evidence: Sequence-based prediction)
Integrated Monomers
Domains
adenylation
Annotation changelog

Entry version: 2

Date
Changes
Submitters
Reviewers
2022-10-07
Update chemical activity to schema version 2.11
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
2022-10-07
Changed chemical structures for compounds: anthelvencin C.
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
2022-10-07
Added NPAtlas links to compounds: anthelvencin C.
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

Entry version: 1

Date
Changes
Submitters
Reviewers
2022-09-15
Submitted
  • (ID: P34OM6JOCMMIEQMA65E4OI3N)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
2022-09-15
Corrected NRP module activity
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
2022-09-15
Corrected gene identifiers
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
2022-09-15
Added version to NCBI accession
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
Similar known gene clusters from MIBiG 4.0
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.