BGC0002044 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002044 (Massilia sp. YMA4)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS	1	65,291	empedopeptin	NRPS:Type I	100%

BGC0002044 - Region 1 - NRPS

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Location: 1 - 65,291 nt. (total: 65,291 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 65,292
Label		BGC0002044

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002044	1.00	NRP	empedopeptin	Massilia sp. YMA4
BGC0002071	0.51	NRP	virginiafactin A, virginiafactin B, virginiafactin C, virginiafactin D	Pseudomonas sp. QS1027
BGC0001629	0.43	NRP	jessenipeptin	Pseudomonas sp. QS1027
BGC0001833	0.39	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0001050	0.38	NRP, Polyketide	thalassospiramide A	Tistrella bauzanensis
BGC0001758	0.38	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0002518	0.38	NRP	syringafactin A, syringafactin C	Pseudomonas sp. SZ57
BGC0002135	0.38	NRP	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0000426	0.37	NRP	sevadicin	Paenibacillus larvae
BGC0001131	0.37	NRP	ambactin	Xenorhabdus miraniensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002044	1.00	NRP	empedopeptin	Massilia sp. YMA4
BGC0002071	0.79	NRP	virginiafactin A, virginiafactin B, virginiafactin C, virginiafactin D	Pseudomonas sp. QS1027
BGC0001629	0.74	NRP	jessenipeptin	Pseudomonas sp. QS1027
BGC0001833	0.71	NRP	icosalide A, icosalide B	Burkholderia gladioli
BGC0001050	0.71	NRP, Polyketide	thalassospiramide A	Tistrella bauzanensis
BGC0001758	0.71	NRP	rhizomide A, rhizomide B, rhizomide C	Paraburkholderia rhizoxinica HKI 454
BGC0002518	0.71	NRP	syringafactin A, syringafactin C	Pseudomonas sp. SZ57
BGC0002135	0.71	NRP	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0000426	0.70	NRP	sevadicin	Paenibacillus larvae
BGC0001131	0.70	NRP	ambactin	Xenorhabdus miraniensis

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 65291:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Pro - Ser - Pro - Arg - Asp) + (Ser) + (Pro - Asp)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

DPH57_09140

Search NORINE for peptide: strict or relaxed

AMP-binding (562..964): Pro

nrpys: Pro

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
Small clusters prediction:: pro (Pro)
Single AA prediction:: pro (Pro)

Stachelhaus prediction details:

Stachelhaus sequence:: DVQYIAHVVK
Nearest Stachelhaus code(s):: Pro DVQYIAHVVK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1619..2024): Asp

nrpys: Asp

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: asp,asn (Asp, Asn)
Single AA prediction:: asp (Asp)

Stachelhaus prediction details:

Stachelhaus sequence:: DMKELGMVDK
Nearest Stachelhaus code(s):: Asp DMKELGMVDK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

DPH57_09145

Search NORINE for peptide: strict or relaxed

AMP-binding (517..916): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: DVWHMSLVDK
Nearest Stachelhaus code(s):: Ser DVWHMSLVDK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

DPH57_09150

Search NORINE for peptide: strict or relaxed

AMP-binding (468..870): Pro

nrpys: Pro

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
Small clusters prediction:: pro (Pro)
Single AA prediction:: pro (Pro)

Stachelhaus prediction details:

Stachelhaus sequence:: DVQYIAHVVK
Nearest Stachelhaus code(s):: Pro DVQYIAHVVK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1553..1952): Ser

nrpys: Ser

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: ser (Ser)
Single AA prediction:: ser (Ser)

Stachelhaus prediction details:

Stachelhaus sequence:: DVWHMSLVDK
Nearest Stachelhaus code(s):: Ser DVWHMSLVDK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2630..3032): Pro

nrpys: Pro

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
Small clusters prediction:: pro (Pro)
Single AA prediction:: pro (Pro)

Stachelhaus prediction details:

Stachelhaus sequence:: DVQFVAHVVK
Nearest Stachelhaus code(s):: Pro DVQFVAHVVK (100% 8Å match); ohPro DVQFVAHVVK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (3685..4085): Arg

nrpys: Arg

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVENVGAINK
Nearest Stachelhaus code(s):: Arg DVENVGAINK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (4736..5139): Asp

nrpys: Asp

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: asp,asn (Asp, Asn)
Single AA prediction:: asp (Asp)

Stachelhaus prediction details:

Stachelhaus sequence:: DMKELGMVDK
Nearest Stachelhaus code(s):: Asp DMKELGMVDK (100% 8Å match)
Stachelhaus code match:: 100% (strong)