BGC0002046: lobatamide A biosynthetic gene cluster from Gynuella sunshinyii YC6258
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Location: 3,757,939 - 3,827,497 nt. (total: 69,559 nt).
This entry is originally from NCBI GenBank CP007142.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002046
Short description lobatamide A biosynthetic gene cluster from Gynuella sunshinyii YC6258
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Trans-AT type I)
Loci
CP007142.1
3757939 - 3827497
via Enzymatic assays
Compounds
  • lobatamide A
Species Gynuella sunshinyii YC6258 [taxonomy]
References
Chemical products information
lobatamide A Evidence: NMR [1]
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C27H32N2O8
Chemical database entries
PubCHEM
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • YC6258_03634
  • AJQ95670.1
 3757939 - 3758403 (+) methyl-accepting chemotaxis protein
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    • YC6258_03635
    • AJQ95671.1
    		 3758377 - 3758529 (-) hypothetical Protein
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      • YC6258_03636
      • AJQ95672.1
      		 3758545 - 3759483 (-) putative permease, DMT superfamily
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        • YC6258_03637
        • AJQ95673.1
        		 3759644 - 3760522 (+) transcriptional regulator
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          • YC6258_03638
          • AJQ95674.1
          		 3760544 - 3764008 (-) polyketide synthase modules-related protein
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            • YC6258_03639
            • AJQ95675.1
            		 3764020 - 3774951 (-) polyketide synthase modules-related protein
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              • YC6258_03640
              • AJQ95676.1
              		 3774948 - 3791723 (-) polyketide synthase modules-related protein
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                • YC6258_03641
                • AJQ95677.1
                		 3791794 - 3802590 (-) polyketide synthase modules-related protein
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                  • YC6258_03642
                  • AJQ95678.1
                  		 3802590 - 3816992 (-) polyketide synthase modules-related protein
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                    • YC6258_03643
                    • AJQ95679.1
                    		 3817855 - 3818040 (-) hypothetical Protein
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                      • YC6258_03644
                      • AJQ95680.1
                      		 3818284 - 3818715 (-) acetyltransferase
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                        • YC6258_03645
                        • AJQ95681.1
                        		 3819040 - 3819201 (+) hypothetical Protein
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                          • YC6258_03646
                          • AJQ95682.1
                          		 3819515 - 3820042 (-) adenylate kinase and related kinase
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                            • YC6258_03647
                            • AJQ95683.1
                            		 3820112 - 3820573 (-) putative acetyltransferase
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                              • YC6258_03648
                              • AJQ95684.1
                              		 3820821 - 3820952 (+) hypothetical Protein
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                                • YC6258_03649
                                • AJQ95685.1
                                		 3821103 - 3821957 (-) NAD-dependent protein deacetylase, SIR2 family
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                                  • YC6258_03650
                                  • AJQ95686.1
                                  		 3821945 - 3822841 (-) putative phosphatase, C-terminal domain of histone macroH2A1-like protein
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                                    • YC6258_03651
                                    • AJQ95687.1
                                    		 3822904 - 3823698 (-) hypothetical protein
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                                      • YC6258_03652
                                      • AJQ95688.1
                                      		 3823889 - 3824761 (-) araC-type DNA-binding domain-containing protein
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                                        • YC6258_03653
                                        • AJQ95689.1
                                        		 3825530 - 3826501 (-) nucleoside-diphosphate-sugar epimerase
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                                          • YC6258_03654
                                          • AJQ95690.1
                                          		 3826514 - 3827497 (-) 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)
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                                            Biosynthesis information

                                            Biosynthetic modules

                                            Name
                                            0
                                            Type
                                            nrps-type1
                                            Genes
                                            YC6258_03642
                                            Substrates
                                            glycine (evidence: Structure-based inference)
                                            Integrated Monomers
                                            Domains
                                            adenylation
                                            Name
                                            5
                                            Type
                                            nrps-type1
                                            Genes
                                            YC6258_03641
                                            Substrates
                                            glycine (evidence: Structure-based inference)
                                            Integrated Monomers
                                            Domains
                                            condensation (LCL), adenylation
                                            Name
                                            1
                                            Type
                                            pks-trans-at
                                            Genes
                                            YC6258_03642
                                            Substrates
                                            Integrated Monomers
                                            Domains
                                            ketosynthase, oxidase, carrier (ACP)
                                            Name
                                            2
                                            Type
                                            pks-trans-at
                                            Genes
                                            YC6258_03642
                                            Substrates
                                            Integrated Monomers
                                            Domains
                                            ketosynthase, methyltransferase, carrier (ACP)
                                            Name
                                            3
                                            Type
                                            pks-trans-at
                                            Genes
                                            YC6258_03642
                                            Substrates
                                            Integrated Monomers
                                            Domains
                                            ketosynthase, ketoreductase, carrier (ACP)
                                            Name
                                            4
                                            Type
                                            pks-trans-at
                                            Genes
                                            YC6258_03642 YC6258_03641
                                            Substrates
                                            Integrated Monomers
                                            Domains
                                            ketosynthase, dehydratase, carrier (ACP)
                                            Name
                                            6
                                            Type
                                            pks-trans-at
                                            Genes
                                            YC6258_03641
                                            Substrates
                                            Integrated Monomers
                                            Domains
                                            ketosynthase, dehydratase, ketoreductase, carrier (ACP)
                                            Name
                                            7
                                            Type
                                            pks-trans-at
                                            Genes
                                            YC6258_03641 YC6258_03640
                                            Substrates
                                            Integrated Monomers
                                            Domains
                                            ketosynthase, ketoreductase, carrier (ACP)
                                            Name
                                            8
                                            Type
                                            pks-trans-at
                                            Genes
                                            YC6258_03640
                                            Substrates
                                            Integrated Monomers
                                            Domains
                                            ketosynthase, methyltransferase, oxidase, carrier (ACP)
                                            Name
                                            9
                                            Type
                                            pks-trans-at
                                            Genes
                                            YC6258_03640
                                            Substrates
                                            Integrated Monomers
                                            Domains
                                            ketosynthase, dehydratase, ketoreductase, carrier (ACP)
                                            Name
                                            10
                                            Type
                                            pks-trans-at
                                            Genes
                                            YC6258_03640 YC6258_03639
                                            Substrates
                                            Integrated Monomers
                                            Domains
                                            ketosynthase, dehydratase, ketoreductase, methyltransferase, carrier (ACP)
                                            Name
                                            11
                                            Type
                                            pks-trans-at
                                            Genes
                                            YC6258_03639
                                            Substrates
                                            Integrated Monomers
                                            Domains
                                            ketosynthase, dehydratase, ketoreductase, carrier (ACP)
                                            Name
                                            12
                                            Type
                                            pks-trans-at
                                            Genes
                                            YC6258_03639
                                            Substrates
                                            Integrated Monomers
                                            Domains
                                            ketosynthase, carrier (ACP)
                                            Name
                                            13
                                            Type
                                            pks-trans-at
                                            Genes
                                            YC6258_03639
                                            Substrates
                                            Integrated Monomers
                                            Domains
                                            ketosynthase, ketoreductase, carrier (ACP)
                                            Name
                                            14
                                            Type
                                            pks-trans-at
                                            Genes
                                            YC6258_03638
                                            Substrates
                                            Integrated Monomers
                                            Domains
                                            ketosynthase, dehydratase, thioesterase, carrier (ACP)
                                            Annotation changelog

                                            Entry version: next

                                            Date
                                            Changes
                                            Submitters
                                            Reviewers
                                            2024-04-23
                                            MIBiG v4 annotathon
                                            • (ID: GLNIA6HUGFRXN2FRDQ7ILDE7)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                            Entry version: 2

                                            Date
                                            Changes
                                            Submitters
                                            Reviewers
                                            2022-10-07
                                            Update chemical activity to schema version 2.11
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                            Entry version: 1

                                            Date
                                            Changes
                                            Submitters
                                            Reviewers
                                            2022-09-15
                                            Submitted
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            2022-09-15
                                            Corrected NRP module activity
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            2022-09-15
                                            Removed ketoreductase stereochemistry annotation from modules without ketoreductases
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            2022-09-15
                                            Changed polyketide information to that described by reference paper
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            2022-09-15
                                            Added version to NCBI accession
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            2022-09-15
                                            Switch to GenBank reference/identifiers
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                            Detailed domain annotation
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