BGC0002047 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002047 (Nocardia brasiliensis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T2PKS	1	14,165	High	brasiliquinone A/brasiliquinone B	PKS

BGC0002047 - Region 1 - T2PKS

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Location: 1 - 14,165 nt. (total: 14,165 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 14,166
Label		BGC0002047

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

brqD: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

brqF: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

brqG: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

Transferases: aminotransferase transferase

brqI: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs: SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

brqJ: DegT/DnrJ/EryC1/StrS aminotransferase

smcogs: SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase

Lyases: cyclase

brqE: cyclase/dehydrase

smcogs: SMCOG1128: cyclase/dehydrase

brqN: Polyketide synthesis cyclase

smcogs: SMCOG1225: Polyketide synthesis cyclase

Ligases: synthase

brqA: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

brqB: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002047.2	1.00	PKS	brasiliquinone A, brasiliquinone B	Nocardia brasiliensis
BGC0000231.5	0.82	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000234.5	0.76	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001723.5	0.76	PKS	oviedomycin	Streptomyces antibioticus
BGC0000236.5	0.65	PKS	kinamycin	Streptomyces murayamaensis
BGC0001596.3	0.64	PKS	fluostatin M, fluostatin N, fluostatin O, fluostatin P, fluostatin Q	Streptomyces albus
BGC0000235.5	0.62	PKS	kiamycin	Streptomyces sp. W007
BGC0000253.4	0.61	PKS	oviedomycin	Streptomyces antibioticus
BGC0000272.3	0.60	PKS	spore pigment	Streptomyces collinus
BGC0002504.2	0.59	PKS	nocardiopsistin A, nocardiopsistin B, nocardiopsistin C	Nocardiopsis sp.

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002047.2	1.00	PKS	brasiliquinone A, brasiliquinone B	Nocardia brasiliensis
BGC0000231.5	0.82	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000234.5	0.76	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001723.5	0.76	PKS	oviedomycin	Streptomyces antibioticus
BGC0000236.5	0.65	PKS	kinamycin	Streptomyces murayamaensis
BGC0001596.3	0.64	PKS	fluostatin M, fluostatin N, fluostatin O, fluostatin P, fluostatin Q	Streptomyces albus
BGC0000235.5	0.62	PKS	kiamycin	Streptomyces sp. W007
BGC0000253.4	0.61	PKS	oviedomycin	Streptomyces antibioticus
BGC0000272.3	0.60	PKS	spore pigment	Streptomyces collinus
BGC0002504.2	0.59	PKS	nocardiopsistin A, nocardiopsistin B, nocardiopsistin C	Nocardiopsis sp.

Similar known clusters from MIBiG 4.0

Detailed domain annotation

Selected features only

Show module domains

Type II PKS

Type II PKS gene cluster prediction details

Cluster section:: 0 to 14165
Starter unit(s):: acetyl-CoA (Score: 0.0; E-value: 0)
Malonyl elongations:: 8|9 (Score: 668.0; E-value: 9.4e-204)
Product class(es):: angucycline
Product molecular weight(s):: acetyl-CoA_8: 365 Da
acetyl-CoA_9: 407 Da

brqA: KS (Score: 760.4; E-value: 1e-231)
brqB: CLF 8|9 (Score: 668.0; E-value: 9.4e-204)
brqC: ACP (Score: 104.8; E-value: 4.3e-33)
brqD: KR C9 (Score: 466.5; E-value: 5.2e-143)
brqE: CYC C7-C12 (Score: 461.0; E-value: 3.3e-141)
brqF: OXY (Score: 519.1; E-value: 2.8e-158)
brqG: OXY (Score: 571.6; E-value: 3.2e-174)
brqN: CYC C4-C17/C2-C19 (Score: 193.5; E-value: 8.2e-60)