BGC0002048: endopyrrole B biosynthetic gene cluster from Mycetohabitans rhizoxinica HKI 454
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Location: 1,835,600 - 1,866,150 nt. (total: 30,551 nt).
This entry is originally from NCBI GenBank FR687359.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002048
Short description endopyrrole B biosynthetic gene cluster from Mycetohabitans rhizoxinica HKI 454
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP (Cyclic depsipeptide)
Loci NCBI GenBank: FR687359.1
Compounds
  • endopyrrole B
  • endopyrrole A
Species Mycetohabitans rhizoxinica HKI 454 [taxonomy]
References
Chemical products information
endopyrrole B
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C41H60N8O12
Chemical database entries
NPAtlas
endopyrrole A
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C50H67N9O13
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • RBRH_03984
  • CBW75451.1
 1835672 - 1846288 (-) Non-ribosomal peptide synthetase modules
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  • RBRH_04313
  • CBW75452.1
 1846246 - 1853268 (-) Non-ribosomal peptide synthetase modules (EC 6.3.2.-)
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  • RBRH_03867
  • CBW75453.1
 1853249 - 1861846 (-) Non-ribosomal peptide synthetase modules (EC 6.3.2.-)
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  • RBRH_03865
  • CBW75454.1
 1862930 - 1863286 (+)
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  • RBRH_03864
  • CBW75455.1
 1863283 - 1864887 (+) D-alanine-activating enzyme (EC 6.3.2.-)
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  • RBRH_03863
  • CBW75456.1
 1864871 - 1866016 (+) Isovaleryl-CoA dehydrogenase (EC 1.3.99.10)
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NRP-specific information
Subclass Cyclic depsipeptide
Cyclic? yes
Release type
  • Macrolactonization
NRP-synthases
Gene Modules
RBRH_03864
Module 0
Specificity: pyrrole-2-carboxylic acid
Evidence for specificity:
  • Structure-based inference
RBRH_03865
Module 1
RBRH_03867
Module 1
Specificity: valine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: Starter
Module 2
Specificity: proline
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Module 3
Specificity: valine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
RBRH_04313
Module 4
Specificity: valine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Module 5
Specificity: threonine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: Dual
RBRH_03984
Module 6
Specificity: serine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Module 7
Specificity: tyrosine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: Dual
Module 8
Specificity: tyrosine
Evidence for specificity:
  • Structure-based inference
Condensation domain type: LCL
Annotation changelog
MIBiG version Submitter Notes
3.0
  • Hidden contributor (ID: Z7AIIJAM3U3HR6IYDPQOINM4, no GDPR consent given).
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
  • Corrected NRP module activity
  • Added version to NCBI accession
  • Updated NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Changed chemical structures for compounds: endopyrrole B, endopyrrole A.
  • Added NPAtlas links to compounds: endopyrrole B, endopyrrole A.
Detailed domain annotation
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