LOCUS       BGC0002051             13500 bp    DNA     linear   BCT 06-OCT-2020
DEFINITION  Streptomyces sp. strain ID38640 antipain biosynthetic gene cluster,
            complete sequence.
ACCESSION   BGC0002051
VERSION     BGC0002051
KEYWORDS    .
SOURCE      Streptomyces sp
  ORGANISM  Streptomyces sp.
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2024-10-17 16:47:57
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13500
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..13500
                     /db_xref="taxon:1931"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces sp."
                     /strain="ID38640"
     subregion       1..13500
                     /aStool="mibig"
                     /contig_edge="True"
                     /label="NRPS"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..13500
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            163..1470
                     /gene="efflux transporter"
                     /locus_tag="NAI38-460"
     CDS             163..1470
                     /codon_start=1
                     /gene="efflux_transporter"
                     /gene_functions="transport (smcogs) SMCOG1020:major
                     facilitator transporter (Score: 322.6; E-value: 5.9e-98)"
                     /gene_kind="transport"
                     /locus_tag="NAI38-460"
                     /product="putative multidrug-efflux transporter"
                     /protein_id="QOE83921.1"
                     /transl_table=11
                     /translation="MPAIPRPAASGPLRLRDFRLLLAGAAAGQLGAQVTLVALPLVAVL
                     ELNAPAFQVGLLTAAETAAFLLVGLPAGAWVDRMRKLPLMIRADVVRAVAMASIPLAAV
                     ADVLTMAQLYLVALVTGVATVFFDVAHQSFLPQLLPKEHLVSGNGALETIRSSAQVAGP
                     GLGGGLVQLLGASLAIVADAAGYVLSALFLWGIKQPESRPSRVAGSSLRQDIAEGLRFV
                     CGHRLLRVIAVTTGLANFFTATLMATQSVFLVRVLGLAPGVVGLVLAASAVGGLTGALC
                     AGRLAARLGQARIIWLSLLATGPFALLWPLSGRGAGAALFAVGSGVVFFGAVVYNVAQV
                     SFRQALCPPRLLGRMNATLRFLMWGTLPLGALAGGALADAFGARTALAWCAAGILVVPL
                     PLLFSPLRRMRDLPAADAAEDAPADSADPAQPASVG"
     misc_feature    163..12936
                     /note="antipain biosynthetic gene cluster"
     gene            1588..2883
                     /gene="dhbF"
                     /locus_tag="NAI38-461"
     CDS             1588..2883
                     /NRPS_PKS="Domain: Condensation_LCL (24-304). E-value:
                     6e-18. Score: 56.7. Matches aSDomain:
                     nrpspksdomains_NAI38-461_Condensation_LCL.1"
                     /codon_start=1
                     /gene="dhbF"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Condensation"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127:condensation domain-containing protein (Score:
                     100.1; E-value: 2.8e-30)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="NAI38-461"
                     /note="NAI38-461"
                     /product="dimodular nonribosomal peptide synthase"
                     /protein_id="QOE83922.1"
                     /sec_met_domain="Condensation (E-value: 4.3e-17, bitscore:
                     50.7, seeds: 42, tool: rule-based-clusters)"
                     /transl_except=(pos:1588..1590,aa:Met)
                     /transl_table=11
                     /translation="MLSITSQYLARYRRLAAGDGSPVLLPVTGAQRRFALVRAMDPAGR
                     PDLVPMFFAFPRGTVDPVRLAAAANRLAARHPVLRARPTVLRGTPVLRLEQPQVPVTPV
                     ACAPGEDAAAVLRRALGRWAPEGSPLRLFLVPDGPEGAEEVLAVVLDHSACDGQSLDRI
                     VAELGAGYDEGPGADGPSPADVAAELADYREAVLRQLDAEERAGAPDSMAYWGGRLRTV
                     REQAPVARPEPLSPGALPSGSATLRMPAAPDGVPFPELLHACRAAAAVLYGVGHVVPLG
                     YPWGGRPAGAAPVLGCFLNTVVFPAATGETPSASATAAAWWDDLDHAATPFDAVVHAAR
                     AAGSGWSGRLDGMLTVDDSRRRPPLCLGGVTGREIHVDGRAVRGPFAVSVTQGSELRLR
                     MVWDRAVLPDRTAESAFTALADAVRTPAPTAG"
     aSDomain        1660..2499
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_NAI38-461_Condensation_LCL.1"
                     /domain_subtypes="Condensation_LCL"
                     /evalue="6.00E-18"
                     /label="NAI38-461_Condensation_LCL.1"
                     /locus_tag="NAI38-461"
                     /protein_end="304"
                     /protein_start="24"
                     /score="56.7"
                     /tool="antismash"
                     /translation="LPVTGAQRRFALVRAMDPAGRPDLVPMFFAFPRGTVDPVRLAAAA
                     NRLAARHPVLRARPTVLRGTPVLRLEQPQVPVTPVACAPGEDAAAVLRRALGRWAPEGS
                     PLRLFLVPDGPEGAEEVLAVVLDHSACDGQSLDRIVAELGAGYDEGPGADGPSPADVAA
                     ELADYREAVLRQLDAEERAGAPDSMAYWGGRLRTVREQAPVARPEPLSPGALPSGSATL
                     RMPAAPDGVPFPELLHACRAAAAVLYGVGHVVPLGYPWGGRPAGAAPVLGCFLNTVVF"
     CDS_motif       1756..1833
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NAI38-461_0001"
                     /evalue="7.80E-08"
                     /label="C2_DCL_024-062"
                     /locus_tag="NAI38-461"
                     /protein_end="82"
                     /protein_start="56"
                     /score="24.6"
                     /tool="antismash"
                     /translation="RGTVDPVRLAAAANRLAARHPVLRAR"
     CDS_motif       2041..2100
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NAI38-461_0002"
                     /evalue="3.80E-04"
                     /label="C3_LCL_132-143"
                     /locus_tag="NAI38-461"
                     /protein_end="171"
                     /protein_start="151"
                     /score="13.2"
                     /tool="antismash"
                     /translation="HSACDGQSLDRIVAELGAGY"
     CDS_motif       2425..2496
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NAI38-461_0003"
                     /evalue="2.30E-04"
                     /label="C5_LCL_267-296"
                     /locus_tag="NAI38-461"
                     /protein_end="303"
                     /protein_start="279"
                     /score="13.7"
                     /tool="antismash"
                     /translation="LGYPWGGRPAGAAPVLGCFLNTVV"
     gene            3033..6227
                     /gene="tycC"
                     /locus_tag="NAI38-462"
     CDS             3033..6227
                     /NRPS_PKS="Domain: Condensation_LCL (1-296). E-value:
                     4.8e-65. Score: 211.4. Matches aSDomain:
                     nrpspksdomains_NAI38-462_Condensation_LCL.1"
                     /NRPS_PKS="Domain: AMP-binding (474-857). E-value: 8.5e-77.
                     Score: 250.3. Matches aSDomain:
                     nrpspksdomains_NAI38-462_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (981-1045). E-value: 2.3e-14. Score:
                     45.2. Matches aSDomain: nrpspksdomains_NAI38-462_PCP.1"
                     /codon_start=1
                     /gene="tycC"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     279.6; E-value: 6.5e-85)"
                     /gene_kind="biosynthetic"
                     /locus_tag="NAI38-462"
                     /product="tyrocidine synthase 3"
                     /protein_id="QOE83923.1"
                     /sec_met_domain="Condensation (E-value: 2.2e-52, bitscore:
                     166.6, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 6.3e-84, bitscore:
                     270.5, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 4.7e-12, bitscore:
                     35.1, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLPLSSSQEIVWLHEQVQPGSRAYNFTAALDLWGTLDTEALRHGL
                     AATLDRHAGLRLELVALADAVPGQRVADACAPRLRTVDLSGAADPEAAFQELLRTEAET
                     PLDTYEAPLLRWTLVRLADDRHRLIHVEHHLIHDGHSFAILLRDVFTVYRGRLLGEPVE
                     LPPAPSYADHVRARSGDQATAERREGLEFWAGALREMSYDMPLPGLARPGARRRHHGGQ
                     LRQSIGADLAERLRAHARTRGLTPFATLLGLFAELLRRHSGRSQMVIGTAVGNRPRGFE
                     ETVGMFVNTIPLPLRLDPAAPAEDSMDEVTDTLIRALPHQEVPIQELTRALGLHTSGAD
                     NPLFGVMFSAHDADLPDIDVPGLDITLFEGFNTGTTRFDLDVVLLPDDRRGVGPRHGAA
                     GMTLVWDYDADLFGEDVAKLLAGRFLDLLRAYLDAPGTALADLAPPPAPPALPAAAPEA
                     PRHDPLDPATAHDRSLPALLVGARRITYGDLADRVAALAQRMLAAGVTAGQPVAAVLPR
                     GADSVVTLLACLRTRAVYCPLSPSDPPARLTLLMERLNPALVLTSADATVSVPDGLPSA
                     TVDAEVLPSARAAEAVPGAAYLIHTSGSTGIPKPVAVGRAALENHLTGAAGRFGLRPGD
                     RVLLFAQPSFDVALEEVLPSLYAGACLVAPEREVPTGTELAELLTAARVTVANLPTSYF
                     LATRQEMRPALRDGHWAPRLLVLGGERLPADALRAFLADTDSTVLNVYGVTEAAISSTV
                     HEITRDGLTDGAEIPLGTELPGERVHVLDAHHRPLPDGAVGELAIAGAGLAEGYAGNPE
                     ATEARFRRIEALGGERVYLTGDRGYRGRDGLLYFLGRLDHQVKLRGYRIELEEVEAAAS
                     AALGGRSCAVVLDREAPGGPRLVGFLESADEDGPWDEQALHTELSRRLPSALVPGRWAR
                     LDVMPRLAGGKPNRTALTRRAAALEPAAPAAPAAEPGDGQPAEPADPMTALLVEGWREA
                     LGHGRFDLSSDFFRSGGHSLLAAQLASWLEPRLGQRPPLRLLFQNPVLTDQAAALAAVG
                     TATPVPAASTTVTESR"
     aSDomain        3036..3920
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_NAI38-462_Condensation_LCL.1"
                     /domain_subtypes="Condensation_LCL"
                     /evalue="4.80E-65"
                     /label="NAI38-462_Condensation_LCL.1"
                     /locus_tag="NAI38-462"
                     /protein_end="296"
                     /protein_start="1"
                     /score="211.4"
                     /tool="antismash"
                     /translation="LPLSSSQEIVWLHEQVQPGSRAYNFTAALDLWGTLDTEALRHGLA
                     ATLDRHAGLRLELVALADAVPGQRVADACAPRLRTVDLSGAADPEAAFQELLRTEAETP
                     LDTYEAPLLRWTLVRLADDRHRLIHVEHHLIHDGHSFAILLRDVFTVYRGRLLGEPVEL
                     PPAPSYADHVRARSGDQATAERREGLEFWAGALREMSYDMPLPGLARPGARRRHHGGQL
                     RQSIGADLAERLRAHARTRGLTPFATLLGLFAELLRRHSGRSQMVIGTAVGNRPRGFEE
                     TVGMFVNTIPLPLR"
     aSModule        3036..6167
                     /complete
                     /domains="nrpspksdomains_NAI38-462_Condensation_LCL.1"
                     /domains="nrpspksdomains_NAI38-462_AMP-binding.1"
                     /domains="nrpspksdomains_NAI38-462_PCP.1"
                     /locus_tags="NAI38-462"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       3099..3200
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NAI38-462_0001"
                     /evalue="3.80E-07"
                     /label="C2_LCL_024-062"
                     /locus_tag="NAI38-462"
                     /protein_end="56"
                     /protein_start="22"
                     /score="22.5"
                     /tool="antismash"
                     /translation="AYNFTAALDLWGTLDTEALRHGLAATLDRHAGLR"
     CDS_motif       3429..3491
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NAI38-462_0002"
                     /evalue="4.30E-06"
                     /label="C3_DCL_135-156"
                     /locus_tag="NAI38-462"
                     /protein_end="153"
                     /protein_start="132"
                     /score="19.3"
                     /tool="antismash"
                     /translation="HHLIHDGHSFAILLRDVFTVY"
     CDS_motif       3759..3818
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NAI38-462_0003"
                     /evalue="4.50E-04"
                     /label="Cy4"
                     /locus_tag="NAI38-462"
                     /protein_end="262"
                     /protein_start="242"
                     /score="13.3"
                     /tool="antismash"
                     /translation="GLTPFATLLGLFAELLRRHS"
     CDS_motif       3834..3911
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NAI38-462_0004"
                     /evalue="1.30E-09"
                     /label="C5_LCL_267-296"
                     /locus_tag="NAI38-462"
                     /protein_end="293"
                     /protein_start="267"
                     /score="30.5"
                     /tool="antismash"
                     /translation="VIGTAVGNRPRGFEETVGMFVNTIPL"
     CDS_motif       3966..4079
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NAI38-462_0005"
                     /evalue="1.10E-07"
                     /label="C67_LCL_14fromHMM"
                     /locus_tag="NAI38-462"
                     /protein_end="349"
                     /protein_start="311"
                     /score="24.1"
                     /tool="antismash"
                     /translation="DTLIRALPHQEVPIQELTRALGLHTSGADNPLFGVMFS"
     CDS_motif       4059..4109
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NAI38-462_0006"
                     /evalue="1.50E+01"
                     /label="C5_DCL_263-294"
                     /locus_tag="NAI38-462"
                     /protein_end="359"
                     /protein_start="342"
                     /score="-1.7"
                     /tool="antismash"
                     /translation="LFGVMFSAHDADLPDID"
     aSDomain        4455..5603
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_NAI38-462_AMP-binding.1"
                     /evalue="8.50E-77"
                     /label="NAI38-462_AMP-binding.1"
                     /locus_tag="NAI38-462"
                     /protein_end="857"
                     /protein_start="474"
                     /score="250.3"
                     /tool="antismash"
                     /translation="PALLVGARRITYGDLADRVAALAQRMLAAGVTAGQPVAAVLPRGA
                     DSVVTLLACLRTRAVYCPLSPSDPPARLTLLMERLNPALVLTSADATVSVPDGLPSATV
                     DAEVLPSARAAEAVPGAAYLIHTSGSTGIPKPVAVGRAALENHLTGAAGRFGLRPGDRV
                     LLFAQPSFDVALEEVLPSLYAGACLVAPEREVPTGTELAELLTAARVTVANLPTSYFLA
                     TRQEMRPALRDGHWAPRLLVLGGERLPADALRAFLADTDSTVLNVYGVTEAAISSTVHE
                     ITRDGLTDGAEIPLGTELPGERVHVLDAHHRPLPDGAVGELAIAGAGLAEGYAGNPEAT
                     EARFRRIEALGGERVYLTGDRGYRGRDGLLYFLGRLDHQVKLR"
     CDS_motif       4818..4871
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NAI38-462_0007"
                     /evalue="1.50E-05"
                     /label="NRPS-A_a3"
                     /locus_tag="NAI38-462"
                     /protein_end="613"
                     /protein_start="595"
                     /score="17.7"
                     /tool="antismash"
                     /translation="AYLIHTSGSTGIPKPVAV"
     CDS_motif       5397..5486
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NAI38-462_0008"
                     /evalue="1.70E-12"
                     /label="NRPS-A_a6"
                     /locus_tag="NAI38-462"
                     /protein_end="818"
                     /protein_start="788"
                     /score="39.5"
                     /tool="antismash"
                     /translation="PDGAVGELAIAGAGLAEGYAGNPEATEARF"
     CDS_motif       5568..5633
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NAI38-462_0009"
                     /evalue="5.60E-11"
                     /label="NRPS-A_a8"
                     /locus_tag="NAI38-462"
                     /protein_end="867"
                     /protein_start="845"
                     /score="34.4"
                     /tool="antismash"
                     /translation="FLGRLDHQVKLRGYRIELEEVE"
     CDS_motif       5835..5882
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NAI38-462_0010"
                     /evalue="1.30E+01"
                     /label="NRPS-A_a6"
                     /locus_tag="NAI38-462"
                     /protein_end="950"
                     /protein_start="934"
                     /score="-1.5"
                     /tool="antismash"
                     /translation="PRLAGGKPNRTALTRR"
     aSDomain        5976..6167
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_NAI38-462_PCP.1"
                     /evalue="2.30E-14"
                     /label="NAI38-462_PCP.1"
                     /locus_tag="NAI38-462"
                     /protein_end="1045"
                     /protein_start="981"
                     /score="45.2"
                     /tool="antismash"
                     /translation="LVEGWREALGHGRFDLSSDFFRSGGHSLLAAQLASWLEPRLGQRP
                     PLRLLFQNPVLTDQAAALA"
     gene            6224..8167
                     /gene="lgrD"
                     /locus_tag="NAI38-463"
     CDS             6224..8167
                     /NRPS_PKS="Domain: AMP-binding (47-452). E-value: 2.4e-75.
                     Score: 245.5. Matches aSDomain:
                     nrpspksdomains_NAI38-463_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (572-637). E-value: 1.9e-11. Score:
                     35.9. Matches aSDomain: nrpspksdomains_NAI38-463_PCP.1"
                     /codon_start=1
                     /gene="lgrD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     286.9; E-value: 4.1e-87)"
                     /gene_kind="biosynthetic"
                     /locus_tag="NAI38-463"
                     /product="linear gramicidin synthase subunit D"
                     /protein_id="QOE83924.1"
                     /sec_met_domain="AMP-binding (E-value: 1.6e-81, bitscore:
                     262.5, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 1.3e-08, bitscore:
                     24.1, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQPMTARTAAPTTAAGAGRHTPHPGTLSIAHGARPATDGAAGVL
                     ACFEEWVRRSPEAPAVIDGAHSWTYGQIGTAADEVAQALRARVRPGDLVGVCLDRSAAL
                     VVTAVALARIGAVYLPLGPRPGERRTDAVTEDLDVVCLIGDPGLLPPRHQTADRMDLAL
                     PGEGANAAATVVAAFAAPGATAHSTPAGAFYAVLTSGSTGRPKAVAVGEPALGGLLDWY
                     RATTGLGPGDRQSLLIGVAFDPHLLELWAGLTSGAALVPAPDEVRWDSVVLADWWRTAG
                     VSVSVAATPMVEPLLDRPWPQDLRLRHLMAGGDRMRRRPGAEVTATVHNAYGPAEATVI
                     ATTYAMHGTDSAAGTDSAPPIGHPVPGVTVIVAGQDGRPVERGTEGELLIGGSGLALGY
                     LDPELTARRFTAVPEGLELPGVERVYRTGDRVRMAADGRLEFLGRLDDQVKISGVRIEP
                     AEVEAAFEQDPAVLSAVVTAPRTTDGRARLVAYVRAAADSGLTADALLPTLRTWLPEQA
                     VPSDVRIVGSFPLDANGKVDRAELTRRAAESAAPRPGGTAPDDGAPAGATPGERLVLSA
                     VRDLLDRPGTSLADNFTEAGGTSVLAARLLTVIEKESGVRLRAPELLRQPDLRAVALLV
                     DQRCASRQPAGA"
     aSDomain        6365..7579
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_NAI38-463_AMP-binding.1"
                     /evalue="2.40E-75"
                     /label="NAI38-463_AMP-binding.1"
                     /locus_tag="NAI38-463"
                     /protein_end="452"
                     /protein_start="47"
                     /score="245.5"
                     /tool="antismash"
                     /translation="FEEWVRRSPEAPAVIDGAHSWTYGQIGTAADEVAQALRARVRPGD
                     LVGVCLDRSAALVVTAVALARIGAVYLPLGPRPGERRTDAVTEDLDVVCLIGDPGLLPP
                     RHQTADRMDLALPGEGANAAATVVAAFAAPGATAHSTPAGAFYAVLTSGSTGRPKAVAV
                     GEPALGGLLDWYRATTGLGPGDRQSLLIGVAFDPHLLELWAGLTSGAALVPAPDEVRWD
                     SVVLADWWRTAGVSVSVAATPMVEPLLDRPWPQDLRLRHLMAGGDRMRRRPGAEVTATV
                     HNAYGPAEATVIATTYAMHGTDSAAGTDSAPPIGHPVPGVTVIVAGQDGRPVERGTEGE
                     LLIGGSGLALGYLDPELTARRFTAVPEGLELPGVERVYRTGDRVRMAADGRLEFLGRLD
                     DQVKIS"
     aSModule        6365..8134
                     /complete
                     /domains="nrpspksdomains_NAI38-463_AMP-binding.1"
                     /domains="nrpspksdomains_NAI38-463_PCP.1"
                     /locus_tags="NAI38-463"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       6803..6853
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NAI38-463_0001"
                     /evalue="7.50E-06"
                     /label="NRPS-A_a3"
                     /locus_tag="NAI38-463"
                     /protein_end="210"
                     /protein_start="193"
                     /score="18.6"
                     /tool="antismash"
                     /translation="YAVLTSGSTGRPKAVAV"
     CDS_motif       7370..7450
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NAI38-463_0002"
                     /evalue="1.10E-11"
                     /label="NRPS-A_a6"
                     /locus_tag="NAI38-463"
                     /protein_end="409"
                     /protein_start="382"
                     /score="37.0"
                     /tool="antismash"
                     /translation="GTEGELLIGGSGLALGYLDPELTARRF"
     CDS_motif       7544..7609
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NAI38-463_0003"
                     /evalue="1.50E-10"
                     /label="NRPS-A_a8"
                     /locus_tag="NAI38-463"
                     /protein_end="462"
                     /protein_start="440"
                     /score="33.1"
                     /tool="antismash"
                     /translation="FLGRLDDQVKISGVRIEPAEVE"
     aSDomain        7940..8134
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_NAI38-463_PCP.1"
                     /evalue="1.90E-11"
                     /label="NAI38-463_PCP.1"
                     /locus_tag="NAI38-463"
                     /protein_end="637"
                     /protein_start="572"
                     /score="35.9"
                     /tool="antismash"
                     /translation="VLSAVRDLLDRPGTSLADNFTEAGGTSVLAARLLTVIEKESGVRL
                     RAPELLRQPDLRAVALLVDQ"
     gene            8169..10088
                     /gene="lgrB_1"
                     /locus_tag="NAI38-464"
     CDS             8169..10088
                     /NRPS_PKS="Domain: AMP-binding (48-437). E-value: 6.9e-102.
                     Score: 332.9. Matches aSDomain:
                     nrpspksdomains_NAI38-464_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (551-619). E-value: 2e-17. Score:
                     55.1. Matches aSDomain: nrpspksdomains_NAI38-464_PCP.1"
                     /codon_start=1
                     /gene="lgrB_1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     377.9; E-value: 1e-114)"
                     /gene_kind="biosynthetic"
                     /locus_tag="NAI38-464"
                     /product="linear gramicidin synthase subunit B"
                     /protein_id="QOE83925.1"
                     /sec_met_domain="AMP-binding (E-value: 1.4e-111, bitscore:
                     361.6, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 7.8e-15, bitscore:
                     44.0, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTIPRTPAFPSSPDTRKEGPVPTEGTPSPAPGPSGERTAPAAGLP
                     ALVARHAARTPHALAVADGDTTLTYAQLVSSARALAGQLRAHGVGPGDSVALLMPRCAR
                     TVVAQLALWWAGAVCVPLDPAHPRARSEALAAEAGATLTVGDSKLLESAALTGATLALP
                     GEPLVEGDHLPAAEPGPDATAFIMFTSGSTGRPKGVAVPHHAIAELVTDPAYLTLTSRD
                     RVLFHSPMTFDASTFEVWGALANGAAVVVCTAERPSFEDLARQVERHGVTVAFFTTALF
                     HQLAGRRSRIFSLLRTVIVGGEALSAHHARAVLRAFPWLELVNGYGPTEATTFTTTHRV
                     TDADCDGQVPIGRPIAGATVHLLDDNGHPVPDGEHGELWIGGSRLAHGYTGQPELTAER
                     FVDHPGLGRLYRSGDLVSRRPDGHLDFHGRTDDQVKIRGFRIEPAEIEHALRERPEVAD
                     AAVTVHRPAPDDARLAAFVVAAAGPVPRPDTLRERLTAVLPAHLVPDEVQFVDALPLTP
                     SGKVDRRALTGLLTADGPGTPAGPLGPLGPLSPLEQAVAEIWSRSLGREVTRVDADFLA
                     LGGHSLLALAVTDDLREDLGVELTLADFFAAPTVAGHAALVERALLATHSDLRPGAPED
                     TDGH"
     aSDomain        8313..9479
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_NAI38-464_AMP-binding.1"
                     /evalue="6.90E-102"
                     /label="NAI38-464_AMP-binding.1"
                     /locus_tag="NAI38-464"
                     /protein_end="437"
                     /protein_start="48"
                     /score="332.9"
                     /tool="antismash"
                     /translation="ARHAARTPHALAVADGDTTLTYAQLVSSARALAGQLRAHGVGPGD
                     SVALLMPRCARTVVAQLALWWAGAVCVPLDPAHPRARSEALAAEAGATLTVGDSKLLES
                     AALTGATLALPGEPLVEGDHLPAAEPGPDATAFIMFTSGSTGRPKGVAVPHHAIAELVT
                     DPAYLTLTSRDRVLFHSPMTFDASTFEVWGALANGAAVVVCTAERPSFEDLARQVERHG
                     VTVAFFTTALFHQLAGRRSRIFSLLRTVIVGGEALSAHHARAVLRAFPWLELVNGYGPT
                     EATTFTTTHRVTDADCDGQVPIGRPIAGATVHLLDDNGHPVPDGEHGELWIGGSRLAHG
                     YTGQPELTAERFVDHPGLGRLYRSGDLVSRRPDGHLDFHGRTDDQVKIR"
     aSModule        8313..10025
                     /complete
                     /domains="nrpspksdomains_NAI38-464_AMP-binding.1"
                     /domains="nrpspksdomains_NAI38-464_PCP.1"
                     /locus_tags="NAI38-464"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       8496..8537
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NAI38-464_0001"
                     /evalue="3.30E-03"
                     /label="NRPS-A_a2"
                     /locus_tag="NAI38-464"
                     /protein_end="123"
                     /protein_start="109"
                     /score="11.1"
                     /tool="antismash"
                     /translation="LALWWAGAVCVPLD"
     CDS_motif       8718..8777
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NAI38-464_0002"
                     /evalue="1.60E-09"
                     /label="NRPS-A_a3"
                     /locus_tag="NAI38-464"
                     /protein_end="203"
                     /protein_start="183"
                     /score="29.7"
                     /tool="antismash"
                     /translation="AFIMFTSGSTGRPKGVAVPH"
     CDS_motif       8886..8918
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NAI38-464_0003"
                     /evalue="7.60E+01"
                     /label="NRPS-A_a2"
                     /locus_tag="NAI38-464"
                     /protein_end="250"
                     /protein_start="239"
                     /score="-2.0"
                     /tool="antismash"
                     /translation="WGALANGAAVV"
     CDS_motif       9279..9368
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NAI38-464_0004"
                     /evalue="6.70E-14"
                     /label="NRPS-A_a6"
                     /locus_tag="NAI38-464"
                     /protein_end="400"
                     /protein_start="370"
                     /score="44.0"
                     /tool="antismash"
                     /translation="PDGEHGELWIGGSRLAHGYTGQPELTAERF"
     CDS_motif       9444..9509
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NAI38-464_0005"
                     /evalue="2.60E-12"
                     /label="NRPS-A_a8"
                     /locus_tag="NAI38-464"
                     /protein_end="447"
                     /protein_start="425"
                     /score="38.6"
                     /tool="antismash"
                     /translation="FHGRTDDQVKIRGFRIEPAEIE"
     aSDomain        9822..10025
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_NAI38-464_PCP.1"
                     /evalue="2.00E-17"
                     /label="NAI38-464_PCP.1"
                     /locus_tag="NAI38-464"
                     /protein_end="619"
                     /protein_start="551"
                     /score="55.1"
                     /tool="antismash"
                     /translation="EQAVAEIWSRSLGREVTRVDADFLALGGHSLLALAVTDDLREDLG
                     VELTLADFFAAPTVAGHAALVER"
     gene            10078..12936
                     /gene="lgrB_2"
                     /locus_tag="NAI38-465"
     CDS             10078..12936
                     /NRPS_PKS="Domain: Condensation_LCL (38-329). E-value:
                     3.4e-81. Score: 264.4. Matches aSDomain:
                     nrpspksdomains_NAI38-465_Condensation_LCL.1"
                     /NRPS_PKS="Domain: PCP (584-635). E-value: 1.4e-12. Score:
                     39.5. Matches aSDomain: nrpspksdomains_NAI38-465_PCP.1"
                     /codon_start=1
                     /gene="lgrB_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Condensation"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127:condensation domain-containing protein (Score:
                     349.1; E-value: 7.5e-106)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="NAI38-465"
                     /product="linear gramicidin synthase subunit B"
                     /protein_id="QOE83926.1"
                     /sec_met_domain="Condensation (E-value: 1.8e-63, bitscore:
                     203.0, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 2.1e-11, bitscore:
                     33.0, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="RmlD_sub_bind (E-value: 3.2e-08, bitscore:
                     21.6, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATDTPAAAALQEELLRRARSRAARPAPAPAPEAVHHGPAPLSHA
                     QRRMWLMDRLGQGSASYSVPFATRLRGPLDLDALAAALTSLVGRHEILRTRYGQQDGEP
                     YQEVLPAPEAMALRVVETAADGAGALLAEEAHRPFDLAAGPVPRALVLRHGPQDHTLLL
                     TFHHIALDGASLETVAGELAELYSAAARGAAAEQPAPPQYADFARREQAAADRLEEGLR
                     HWEGRLEGVTPLRLPRPAGPPTDGGTRSAGTHSTPLDPRVPAALRELGRQHRATLFTVA
                     LAAAFAALHRFTGQDDLVIGVAGTHRQGAEMRGLVGLCVNTLPVRVNTAGDPSFTALVE
                     RVREALLDAQQCREVPFDLILERLGAAARDTDGTPLIRVTADVLGAPTTLRLPGTVGEY
                     VEVGPGEAKFDLSFGLVDTDAPAALVQYGRTALDEEAAAGLGAHYAALLTAVADEPALR
                     LSRLPGAAPAPRDETVGHPAEALLRSHPGVAEAAVLEPAGGPLLAYAVLREIGGPTSSE
                     LRSLLRDALAPEQVPAAVTLLDALPRTADGTADPSRLPGMPSAPAPEGARAEAVTEGFT
                     ALLGRPPRPDDDFFLLGGHSLIAVQLAERLRLALKLPLTGLDILQARTPRAVTALLDAR
                     AAERAAAPSVTTARPRRTREGTVLVTGGTGGVGAFALRELAARGRPVLALARPESAHLV
                     AGDGVDVIEGDLTDLDGLRKAVDSADAVIHAACTFTRAEVDVTAMAAMVGAWSRGPFVF
                     VSSVDAYGHPAGEWVAEESAPGQPLSPYGQAKLDCEALLLQAAGSQGRGGASAVRSPLV
                     WGPHQRLRDQLRWGATGVLYQAAREGRPIAVPRPGAGGHAWYGAAWVHAAALARSVVSC
                     LDSPVHGVANAVSGHVTWRDLAVTLTELLGSDSEILETDEVHPDLDHRWHYHSDRLSPS
                     LRLQPGEDWRSVLAAMAGPSEG"
     aSDomain        10192..11064
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_NAI38-465_Condensation_LCL.1"
                     /domain_subtypes="Condensation_LCL"
                     /evalue="3.40E-81"
                     /label="NAI38-465_Condensation_LCL.1"
                     /locus_tag="NAI38-465"
                     /protein_end="329"
                     /protein_start="38"
                     /score="264.4"
                     /tool="antismash"
                     /translation="PAPLSHAQRRMWLMDRLGQGSASYSVPFATRLRGPLDLDALAAAL
                     TSLVGRHEILRTRYGQQDGEPYQEVLPAPEAMALRVVETAADGAGALLAEEAHRPFDLA
                     AGPVPRALVLRHGPQDHTLLLTFHHIALDGASLETVAGELAELYSAAARGAAAEQPAPP
                     QYADFARREQAAADRLEEGLRHWEGRLEGVTPLRLPRPAGPPTDGGTRSAGTHSTPLDP
                     RVPAALRELGRQHRATLFTVALAAAFAALHRFTGQDDLVIGVAGTHRQGAEMRGLVGLC
                     VNTLPVRVNT"
     aSModule        10192..11982
                     /domains="nrpspksdomains_NAI38-465_Condensation_LCL.1"
                     /domains="nrpspksdomains_NAI38-465_PCP.1"
                     /incomplete
                     /locus_tags="NAI38-465"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       10255..10368
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NAI38-465_0001"
                     /evalue="2.10E-16"
                     /label="C2_LCL_024-062"
                     /locus_tag="NAI38-465"
                     /protein_end="97"
                     /protein_start="59"
                     /score="52.3"
                     /tool="antismash"
                     /translation="ASYSVPFATRLRGPLDLDALAAALTSLVGRHEILRTRY"
     CDS_motif       10570..10635
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NAI38-465_0002"
                     /evalue="1.00E-07"
                     /label="C3_LCL_132-143"
                     /locus_tag="NAI38-465"
                     /protein_end="186"
                     /protein_start="164"
                     /score="24.5"
                     /tool="antismash"
                     /translation="FHHIALDGASLETVAGELAELY"
     CDS_motif       10966..11055
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NAI38-465_0003"
                     /evalue="2.70E-08"
                     /label="C5_LCL_267-296"
                     /locus_tag="NAI38-465"
                     /protein_end="326"
                     /protein_start="296"
                     /score="26.3"
                     /tool="antismash"
                     /translation="DLVIGVAGTHRQGAEMRGLVGLCVNTLPVR"
     CDS_motif       11104..11214
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NAI38-465_0004"
                     /evalue="1.60E-05"
                     /label="C67_LCL_14fromHMM"
                     /locus_tag="NAI38-465"
                     /protein_end="379"
                     /protein_start="342"
                     /score="17.1"
                     /tool="antismash"
                     /translation="REALLDAQQCREVPFDLILERLGAAARDTDGTPLIRV"
     aSDomain        11830..11982
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_NAI38-465_PCP.1"
                     /evalue="1.40E-12"
                     /label="NAI38-465_PCP.1"
                     /locus_tag="NAI38-465"
                     /protein_end="635"
                     /protein_start="584"
                     /score="39.5"
                     /tool="antismash"
                     /translation="PDDDFFLLGGHSLIAVQLAERLRLALKLPLTGLDILQARTPRAVT
                     ALLDAR"
     CDS_motif       12046..12132
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_NAI38-465_0005"
                     /evalue="2.00E-06"
                     /label="PKSI-KR_m1"
                     /locus_tag="NAI38-465"
                     /protein_end="685"
                     /protein_start="656"
                     /score="20.4"
                     /tool="antismash"
                     /translation="TVLVTGGTGGVGAFALRELAARGRPVLAL"
ORIGIN
        1 gcattcctcg ttcatcagaa acgcagcagg tggcagtcct ccggccgttg ccgggatctg
       61 gcggaaaatt ttttgtcgtg atgggcaaat ggtgaagaaa gccgaccgaa agtgtgcatc
      121 gggttttgac cattgatcgg ccgctccgcg atggtccttc gtatgcccgc cataccccga
      181 cccgcggcca gcggccctct gcgcctgcgc gacttccgtc ttctgctcgc cggtgccgcg
      241 gccggacaac tcggcgccca ggtcaccctg gtcgccctgc ccctcgtcgc ggtactcgag
      301 ctcaacgccc ccgcattcca ggtggggttg ctcacggctg ccgagaccgc cgcgttcctg
      361 ctggtcgggc tgccggccgg ggcctgggtc gaccggatgc gcaaactgcc gctgatgatc
      421 cgggccgatg tcgtacgggc cgtggcgatg gcgagcatcc ccctggccgc cgtcgccgat
      481 gtgctgacga tggcgcagct gtatctcgtc gccctggtca ccggtgtggc gacggtcttc
      541 ttcgacgtgg cccaccagag cttcctgccc cagctgctgc ccaaggagca tctggtctcg
      601 ggcaacgggg cgctggagac catccgttcc tccgcgcagg tggccggtcc cgggctcggc
      661 ggcggtctcg tccagctgct cggggcgtcc ctggccatcg tcgccgacgc ggccggctat
      721 gtgctctcgg cactgttcct gtggggcatc aaacagcccg agagccgccc gtcgcgcgtc
      781 gccggttcgt ccctgcgcca ggacatcgct gaagggctgc ggttcgtgtg cgggcaccgc
      841 ctgctgcgcg tgatcgcggt gacgaccggc ctggcgaact tcttcaccgc cacactgatg
      901 gccactcagt ccgtcttcct ggtgcgggtg ctcgggctgg ccccgggagt ggtgggcctc
      961 gtgctggccg cctcggcggt gggcgggctc accggcgcac tgtgtgcggg ccggctcgcc
     1021 gcccggctcg gccaggccag gatcatctgg ctgtccctgc tggccaccgg cccgttcgcg
     1081 ctgctgtggc cgctgtccgg gcgcggcgcg ggcgccgcac tgttcgccgt cggctccggt
     1141 gtggtcttct tcggtgccgt cgtctacaac gtcgcacagg tgagcttccg tcaggcgctg
     1201 tgcccgccgc ggctgctcgg ccggatgaac gccactctgc ggttcctgat gtggggcacc
     1261 ctgccgctcg gcgccctggc cggcggtgcg ctggccgatg cgttcggcgc ccgcacggcg
     1321 ctggcgtggt gcgcggccgg aatcctggtc gtcccgctgc cgctgctgtt ctccccgctg
     1381 cgccggatgc gggacctgcc ggccgccgac gcggccgagg acgccccggc cgattccgcg
     1441 gacccggccc agcccgcgtc cgtcggctga cgaccgagga ccgacggacg accgccgtat
     1501 ccggccccgc ccgtccctcc ccccccacac ggccttcccc ccgcatcccc tccggcgatg
     1561 cggctccgtc acgacaaaga ggatcacgtg ctcagcatca cgagccagta cctggcccgc
     1621 taccggcggc tcgccgccgg tgacggcagc ccggtcctgc tgcccgtcac gggcgcccag
     1681 cgtcgctttg cgctggtgcg tgccatggac cccgccgggc ggccggatct cgtgccgatg
     1741 ttcttcgcct ttccgcgcgg cacggtggac cccgtacggc tcgcggcggc cgcgaaccgg
     1801 ctcgccgccc ggcaccccgt gctgcgtgcc cggcccaccg tgctgcgcgg cacccccgta
     1861 ctccgcctgg agcagccgca ggtccccgtg accccggtgg cctgcgcgcc cggcgaggac
     1921 gcggccgccg tgctgcgccg tgccctgggc cggtgggcgc cggagggctc accgctgcgg
     1981 ctgttcctgg tgccggacgg tccggagggt gccgaggagg tgctcgccgt cgtactggac
     2041 cacagcgcgt gcgacggcca gtcgctggac cggatcgtcg cagaactcgg cgccggctac
     2101 gacgaaggtc ccggcgccga cggcccctcg cccgccgacg tcgcggccga gctggccgac
     2161 taccgggaag ccgtgctgcg gcagctcgac gcggaggaac gcgcgggtgc tccggactcc
     2221 atggcgtact ggggcggacg gctgcgcaca gtacgcgaac aggccccggt ggcacggccg
     2281 gaacccctct cccccggtgc gctgccgagc ggctcggcga ccctgcggat gcccgcggcc
     2341 cccgacgggg tgcccttccc cgagctgctc cacgcctgcc gggcggcggc agcggtgctg
     2401 tacggagtgg gccatgtggt gccgctcggc tacccgtggg gcggccggcc ggccggtgcc
     2461 gctccggtgc tcggctgctt cctcaacacc gtggtcttcc cggccgccac gggcgagacg
     2521 ccctccgcgt ccgcgacggc agctgcctgg tgggacgacc tggaccatgc cgccaccccc
     2581 ttcgacgccg tggtgcacgc cgcccgcgcg gccggctccg gctggagcgg ccggctcgac
     2641 ggcatgctga ccgtcgacga ctcccgccgc cggcccccgc tgtgcctggg cggggtgacc
     2701 ggccgggaga tccatgtcga cggcagagcg gtccgcggcc cgttcgccgt ctccgtcacc
     2761 cagggctccg aactgcggct gcgcatggtg tgggaccgcg cggtcctccc cgaccgcacc
     2821 gccgagagcg ccttcaccgc cctcgccgac gcggtgcgga caccggcacc gacagccggc
     2881 tgacccaccc cgggggcccc gcccccgcac ccaccgaccg aacaccgcca gacctgccgc
     2941 gcgatccgtg gcgcggtctg cgcacccaac aggccgggcc cgaccatgcc ccggccggag
     3001 cacacccgcc ccgacgacct cagggatcgc ccatgcttcc gctctcctcc tcgcaggaga
     3061 tcgtctggct gcacgaacag gtgcaaccgg gcagccgcgc ctacaacttc accgccgccc
     3121 tcgacctgtg gggcacgctc gacaccgagg cactgcgcca cggactcgcc gccaccctcg
     3181 accggcacgc cggcctgcgg ctggaactcg tcgccctcgc cgacgcggtg cccggacagc
     3241 gggtcgccga cgcctgcgca ccgcggctgc gcacagtgga cctgagcggg gcggcggacc
     3301 cggaggccgc gttccaggag ctgctgcgga ccgaggcgga gaccccgctc gacacctacg
     3361 aggcaccgct gctgcgctgg acgctggtcc ggctcgcgga cgaccggcac cggctcatcc
     3421 acgtcgaaca ccatctgatc cacgacggcc actcgttcgc gatcctgctg cgggatgtgt
     3481 tcaccgtcta ccggggccgc ctcctgggcg agccggtgga gctgccgccc gctccctcgt
     3541 acgccgacca tgtccgtgcc cggtccgggg accaggcgac cgccgagcgc cgggaaggcc
     3601 tggagttctg ggccggggca ctgcgggaga tgtcctacga catgccgctg cccggtctgg
     3661 cccggcccgg tgcccggcgc cggcaccacg gcggccagtt acgccagtcg atcggtgcgg
     3721 atctggcgga acgcctccgg gcccacgccc gtacccgtgg tctgacgccg ttcgccacgc
     3781 tcctcgggct cttcgccgag ctgctgcgcc ggcacagcgg ccgctcgcag atggtgatcg
     3841 gcaccgcggt gggcaaccgt ccgcgcggtt tcgaggaaac cgtgggcatg ttcgtcaaca
     3901 ccatcccgct cccgctccgg ctggacccgg ccgccccggc cgaggactcc atggacgagg
     3961 tgaccgacac cctcatccgc gcgctgccgc accaggaggt gccgatccag gagctgaccc
     4021 gcgcgctcgg tctgcacacc tcgggtgccg acaacccgct gttcggcgtc atgttcagcg
     4081 cgcacgacgc cgacctgccc gacatcgacg tccccggcct ggacatcacc ctgttcgagg
     4141 gcttcaacac cggcaccacc cggttcgacc tggacgtggt gctgctgccg gacgaccgcc
     4201 gcggcgtcgg cccccggcac ggcgcagcgg ggatgacgct ggtctgggac tacgacgccg
     4261 acctgttcgg cgaggacgtg gcgaagctgc tcgccgggcg gttcctggac ctgctgcggg
     4321 cgtatctcga cgcgcccggc accgccctcg cggacctggc gccgccgccg gccccgccgg
     4381 ctctcccggc cgccgctccc gaggcgccgc ggcacgaccc gctcgacccc gccaccgccc
     4441 acgaccgctc gctgcccgcg ctgctcgtcg gcgcccgccg gatcacctac ggcgacctgg
     4501 cggaccgggt cgccgcgctc gcgcagcgga tgctggcggc cggggtgacc gccggtcagc
     4561 cggtggccgc ggtgctgccc cgcggtgccg actcggtcgt gacgctgctg gcctgtctgc
     4621 ggacccgggc ggtgtactgc ccgctctcgc cgtccgatcc gccggcccgc ttgacgctgc
     4681 tgatggagcg gctgaacccg gcgctggtgc tgacctcggc ggatgccacc gtctccgtac
     4741 ccgacggtct gccgtcggcc actgtcgacg ccgaggtcct gccgtcggcg cgggcggccg
     4801 aggccgtgcc cggtgccgcg tacctcattc acacctccgg ctcgacgggc atccccaagc
     4861 ccgtcgccgt cggccgcgcg gccctggaga accatctgac cggagcggcc gggcgattcg
     4921 gcctgcgccc gggtgaccgg gtgctgctgt tcgcccagcc gtcgttcgac gtggccctcg
     4981 aagaggtgct gccgtcgctg tacgccgggg cgtgcctcgt cgcccccgag cgcgaggtcc
     5041 cgaccggcac cgagctggcc gaactgctga ccgccgcccg cgtcaccgtg gccaatctgc
     5101 ccaccagcta cttcctggcc acccgtcagg agatgcgccc cgcactccgc gacggtcact
     5161 gggcaccgcg gctgctggtg ctcggcggtg aacgcctccc ggcggatgcg ctgcgcgcgt
     5221 tcctggccga caccgacagc accgtgctca atgtctatgg cgtcaccgag gccgcgatca
     5281 gctccaccgt ccacgagatc acccgggacg gtctgaccga cggggcggag attccgctgg
     5341 gcaccgagct gcccggcgaa cgggtccatg tcctggacgc ccaccaccgg ccgctgccgg
     5401 acggcgcggt cggtgaactg gccatcgccg gggcggggtt ggccgagggc tatgccggca
     5461 accccgaggc caccgaagcc cggttccgcc ggatcgaggc tctcggcggt gagcgggtct
     5521 acctcaccgg cgaccgcggc taccgtggcc gcgacgggct gctgtacttc ctcggacgcc
     5581 tggaccacca ggtcaaactg cggggttacc gcatcgaact cgaagaggtg gaggcggccg
     5641 cctcggccgc gctcggcggc cggtcctgcg ccgtcgtcct ggatcgcgaa gccccgggcg
     5701 ggccccggct ggtcggcttc ctggagagcg cggacgagga cgggccgtgg gacgagcagg
     5761 cgttgcacac ggagctgagc cgacggctgc cgagcgccct cgtaccggga cgctgggccc
     5821 ggctcgacgt catgccgagg ctggccggcg gcaaaccgaa ccgcaccgcg ctgacgcgcc
     5881 gcgccgccgc gctggagccg gccgcgcccg ccgcccccgc cgcggagccc ggtgacgggc
     5941 agcccgcgga gccggccgat ccgatgacgg cgctgctcgt cgagggctgg cgcgaggccc
     6001 tgggccacgg acgtttcgac ctgtcctcgg acttcttccg gtccggtggc cactcgctgc
     6061 tcgccgcgca gcttgcctcc tggctggagc cgcgattggg acaacgtccg cccctgcggc
     6121 tgctgttcca gaacccggtg ctgaccgacc aggccgccgc gctcgccgcc gtcggcaccg
     6181 ccacgcccgt tcccgccgcc tcgaccaccg tgacggagtc ccgatgaccc agccgatgac
     6241 cgcccggacg gcggcgccga cgaccgccgc cggcgccgga cggcacaccc cgcaccccgg
     6301 cacgctcagc atcgcccacg gcgcccggcc cgccaccgac ggcgcggccg gagtcctcgc
     6361 ctgcttcgag gagtgggtcc gccgctcccc ggaggctccc gcggtgatcg acggggccca
     6421 cagctggacg tacggccaga tcggcaccgc cgcggacgag gtcgcccagg cgctgcgcgc
     6481 ccgggtgcgg cccggggacc tggtcggcgt ctgcctcgac cggtcggccg ccctcgtggt
     6541 gaccgccgtc gcactcgcca ggatcggcgc cgtctatctg ccgctgggcc cccgccccgg
     6601 cgagcgccgc accgacgccg tcaccgagga cctcgacgtc gtctgtctga tcggcgatcc
     6661 cgggctcctg ccgccccggc accaaaccgc cgaccggatg gacctggcgc tgcccggcga
     6721 gggggccaat gccgccgcca cggtcgtggc ggcgttcgcc gcgccgggtg ccaccgcgca
     6781 ctccacgccc gccggggcgt tctacgccgt gctgacctcc ggctccaccg gccgccccaa
     6841 ggcggtggcc gtgggtgagc ccgcgctcgg cgggctgctc gactggtacc gcgccacgac
     6901 cgggctcggc cccggtgacc gacagtcgct gctcatcggc gtcgcgttcg acccccatct
     6961 gctggagctg tgggccgggc tgacgtccgg agcggccctg gtacccgcgc cggacgaggt
     7021 ccgctgggac tccgtggtgc tcgccgactg gtggcgtacg gccggggtct cggtgtcggt
     7081 cgcggcgacc ccgatggtcg agccgctgct ggaccggccc tggccacagg atctgaggct
     7141 gcgtcatctg atggccggcg gcgaccggat gcgccgccgc cccggcgcgg aggtgaccgc
     7201 caccgtccac aacgcctacg gcccggccga ggccaccgtg atcgccacca cctacgccat
     7261 gcacggcacg gacagcgcgg cgggcacgga ctccgcgccc ccgatcggcc accccgtacc
     7321 gggcgtgacc gtgatcgtcg ccggccagga cggccggccc gtcgagcgcg gtacggaggg
     7381 cgaactcctc atcgggggaa gcgggctggc gctcggctat ctggaccccg agctgaccgc
     7441 gcgccgcttc accgccgtgc ccgagggcct cgaactgccg ggagtggagc gggtgtaccg
     7501 caccggggac cgggtgcgga tggcggccga cggacggctg gagttcctgg gccgcctcga
     7561 cgaccaggtc aagatcagcg gggtccggat cgaacccgcc gaggtggagg ccgcgttcga
     7621 gcaggacccg gcggtcctga gcgccgtcgt caccgcaccg cgcaccaccg acggccgggc
     7681 ccgcctggtg gcgtacgtac gggcggctgc cgattccggg ctcacggcgg acgcgctgct
     7741 gcccactttg cggacctggc tgcccgagca ggccgtcccc tcggacgtac ggatcgtggg
     7801 ctccttcccg ctggacgcca acggcaaggt ggaccgcgcc gagctgaccc gacgggcggc
     7861 cgagtccgcc gcgccccgcc ccggcggcac cgccccggac gacggagcgc ccgccggcgc
     7921 cacccccggt gagcggctcg tactgagcgc cgtccgcgat ctgctcgacc ggcccgggac
     7981 ctccctggcg gacaacttca ccgaggccgg cggcacctct gtcctcgccg cccggctgct
     8041 gaccgtcatc gagaaggaga gcggggtacg gctgcgcgcc cccgagctgc tccgccagcc
     8101 ggatctgcgt gccgtggccc tgctcgtcga tcagcggtgt gcctcccggc agccggcggg
     8161 agcctgagat gaccatcccc cgtacccccg cgtttccgtc ctcccccgac acccggaagg
     8221 aaggccccgt gcccaccgaa ggcaccccgt cgcccgcgcc cggcccgtcc ggcgagcgca
     8281 ccgcgcccgc ggccggactg ccggccctcg tggcccggca cgccgcacgg accccgcacg
     8341 ccctggccgt ggcggacggc gacaccacgc tcacctacgc ccagctcgtg tcgtcggccc
     8401 gcgcgctcgc cgggcagctg cgggcgcacg gcgtcggccc gggtgactcc gtggcgctgc
     8461 tgatgccgcg ctgtgcccgt acggtcgtcg cccagctcgc actgtggtgg gcgggcgccg
     8521 tgtgtgtgcc gctggatccg gcgcatccgc gcgcccgttc cgaggccctg gccgccgagg
     8581 cgggcgcgac gctgaccgtc ggcgacagca agctcctcga atccgcggca ctcaccggcg
     8641 ccacccttgc gctgcccggg gagccgctgg tggagggcga ccacctcccg gcggccgaac
     8701 cgggcccgga cgccaccgcg ttcatcatgt tcacctcggg ctccaccggc cgccccaagg
     8761 gggtggccgt gccgcaccac gcgatcgccg agctggtcac ggatccggcg tatctcaccc
     8821 tgacctcccg cgaccgggtg ctcttccact cgccgatgac cttcgacgcg tcgacgttcg
     8881 aggtgtgggg agccctggcc aacggcgccg cggtggtggt gtgcaccgcc gaacggccgt
     8941 cgttcgagga cctggcccgg caggtggaac gccacggcgt caccgtcgcc ttcttcacca
     9001 ccgcgctctt ccaccagctg gccggccgcc gctcccggat cttctcgctg ctgcgcacgg
     9061 tgatcgtggg cggcgaggcg ctgtccgcgc accatgcccg cgcggtcctg cgggccttcc
     9121 cctggctgga gctggtcaac ggctacggcc cgacggaggc gacgaccttc accaccaccc
     9181 accgcgtcac cgacgccgac tgcgacggcc aggtgcccat cggccggccg atcgccggtg
     9241 cgaccgtgca tctcctcgac gacaacggcc acccggtccc ggacggtgag cacggcgaac
     9301 tgtggatcgg gggcagccgg ctggcgcacg gctacaccgg gcagccggag ctgaccgccg
     9361 agcgctttgt cgaccacccc gggctggggc gcctctaccg cagtggcgac ctcgtctccc
     9421 ggcgcccgga cggacacctc gacttccacg ggcgcacgga cgaccaggtg aagatacgcg
     9481 gcttccggat cgaacccgcc gagatcgaac acgccctgcg cgagcggccc gaggtggcgg
     9541 acgcggccgt gaccgtgcac cgccccgccc ccgacgacgc ccgcctggcc gcgttcgtgg
     9601 tggccgcggc cgggccggtc ccccgccccg acactctgcg cgaacggctc accgccgtcc
     9661 tgcccgccca tctggtgccc gacgaggtgc agttcgtcga cgcgctgccg ctcacgccct
     9721 ccggcaaggt cgaccgccgc gccctgacgg gcctcctcac ggcggacggg cccggcactc
     9781 cggccggtcc gctcggtccg ctcggtccgc tcagtccgct ggagcaggcg gtcgccgaga
     9841 tctggagccg gtcgctgggc cgtgaagtca cccgtgtgga tgccgacttc ctcgcgctgg
     9901 gcggtcattc gctgctggcg ctcgccgtca ccgacgacct gcgcgaggac ctcggcgtcg
     9961 agctgaccct cgccgacttc ttcgccgccc ccacggtggc gggacatgcc gcgctggtcg
    10021 agcgcgccct gctcgccacg cacagcgatc tgcgccccgg cgccccggag gacaccgatg
    10081 gccactgaca cccccgccgc ggcggcgctg caggaggaac tgctgcgccg ggcacgctcc
    10141 cgcgccgccc gccccgctcc cgctcccgcc cccgaggccg tccaccacgg acccgcgccg
    10201 ctctcccacg cccagcgccg gatgtggctg atggaccggc tgggccaggg cagcgcctcg
    10261 tacagcgtgc cgttcgccac ccggctgcgc ggtccgctcg acctggacgc gctggccgcc
    10321 gcgctgacct cgctggtggg acgccacgag atcctgcgta cccggtacgg gcaacaggac
    10381 ggtgagccct accaggaggt gctgcccgca ccggaggcga tggcgctgcg cgtggtggag
    10441 acggccgccg acggtgccgg cgccctgctg gccgaggagg cgcaccgccc gttcgacctc
    10501 gccgccggtc ccgtaccgcg cgcgctggtc ctgcggcacg gcccgcagga ccacaccctg
    10561 ctgctgacgt tccatcacat cgccctcgac ggtgcctcac tggagaccgt cgccggggaa
    10621 ctggccgagc tctactcggc cgccgcccgg ggcgccgctg ccgagcagcc ggctcccccg
    10681 cagtacgcgg acttcgcacg gcgcgagcag gcggccgccg accgcctcga agagggcctg
    10741 cgtcactggg aaggccgcct cgaaggcgtc accccgctgc ggctcccccg ccccgccggc
    10801 ccgcccaccg acggtggcac ccggtccgcc ggaacgcatt ccaccccgct cgacccgcgg
    10861 gtgccggcgg ccctgcgcga gctgggccgg cagcaccggg ccactctctt caccgtggcc
    10921 ctcgccgcgg ccttcgccgc cctgcaccgc ttcaccggcc aggacgacct ggtgatcggg
    10981 gtcgccggca cccaccggca gggcgcggag atgcgcggcc tggtcggcct gtgcgtcaac
    11041 accctcccgg tccgggtgaa cacggccggc gatccgtcct tcaccgcgct ggtggagcgc
    11101 gtacgcgagg cgctgctcga cgcccagcag tgccgcgagg tgcccttcga tctcatcctg
    11161 gagcggctcg gcgccgccgc ccgcgacacg gacgggacgc cgctgatacg ggtcaccgcg
    11221 gatgtcctgg gtgcaccgac caccctgcgg ctgcccggca cggtgggcga gtacgtcgaa
    11281 gtcgggcccg gcgaggccaa gttcgacctc tccttcggcc tggtggacac cgatgccccc
    11341 gccgcgctcg tccagtacgg ccggaccgcg ctggacgagg aggcggcggc cggtctcggt
    11401 gcgcactacg ccgcgctgct caccgcggtc gccgacgaac cggccctgcg gctgtcccgg
    11461 ttgcccggtg cggcgccggc gccgcgggac gagaccgtcg ggcacccggc cgaggcgctg
    11521 ctgcggtcgc accccggggt ggccgaggcc gcggtactcg aaccggccgg cggcccgctg
    11581 ctggcctatg ccgtactgcg cgagatcggc ggccccacgt cttccgagct ccgctccctt
    11641 ctgcgggacg cgctggctcc ggagcaggtg cccgccgcgg tgaccctgct ggacgcgctg
    11701 ccgcggacgg ccgacggcac ggccgatccg tcccggcttc ccggtatgcc gtccgcgccc
    11761 gcaccggaag gcgcccgcgc cgaggccgtg accgaaggct tcaccgcgct gctgggccgg
    11821 ccgccccggc cggacgacga cttcttcctc ctcggcggcc actcgctgat cgccgtccag
    11881 ctcgccgaac ggctgcgcct ggccctgaaa ctgccgctga ccggtctgga catcctccag
    11941 gcccgcaccc cgcgcgcggt caccgcgctg ctggatgccc gcgcggcgga gcgggccgcc
    12001 gccccctcgg tcaccacggc ccgtccgcgg cgcacgcgcg agggcaccgt cctggtcacc
    12061 ggcggtaccg gcggggtcgg cgccttcgcc ctgcgtgaac tggccgcccg ggggcgcccg
    12121 gtgctggccc tggcccgccc cgaatccgcg catctggtcg ccggggacgg ggtggacgtc
    12181 atcgagggcg acctcaccga cctggacggt ctgcgcaagg ccgtcgacag cgccgatgcg
    12241 gtcatccacg ccgcctgtac cttcacccgc gccgaggtcg atgtgacggc gatggcagcg
    12301 atggtcggcg cctggtcgcg cggcccgttc gtcttcgtca gcagcgtgga cgcctatgga
    12361 caccccgccg gcgagtgggt ggcggaggag tccgcccccg ggcagccgct gagcccgtac
    12421 ggacaggcga agctcgactg tgaagcgctg ctgctgcagg ccgccggttc ccagggccgg
    12481 ggcggggcga gcgccgtccg ctcccccctc gtctggggcc cgcaccagcg gctgcgggac
    12541 cagttgcgct ggggtgccac cggtgtgctc taccaggccg cgcgggaggg ccggccgatc
    12601 gctgtgcccc ggccgggtgc cggtggccat gcctggtacg gcgcggcctg ggtgcacgcg
    12661 gcggcgctgg cccggtccgt ggtgtcctgc ctggactccc ccgtgcacgg cgtcgccaac
    12721 gccgtcagcg gacatgtcac ctggcgggac ctcgccgtga cgctgaccga actgctcggc
    12781 agcgacagcg agatcctcga aacggacgag gtccatccgg acctcgacca ccgctggcac
    12841 taccactccg accggctgtc cccgtccctg cgcctgcagc cgggcgagga ctggcgctcc
    12901 gtcctggccg cgatggccgg tccgtccgag gggtgagccg cccggtggcc gacgcgcccg
    12961 gtggctcccc ggccaccggg cgccctcctg cctcgccgcc cccgtacgcg gatcagacgg
    13021 ccaggaacgc ggccgcggtc gcggcaccga gggcggcgcc ggccgcggtc tgggcgacgg
    13081 tgtggtacgc cagcgcgacc cgcgaccagc acaccgcggc cgccagcgca ccggccgcca
    13141 gccaccacgg agagtgcacc accgccagga gcgcgacgac ggcggcggcg accgcggagt
    13201 ccaccgagat cttccagacc gtgttgaccg tcagaaggac gaccgtcatc gcccacagcg
    13261 cgagcatcgc gaccaggatg ccggccggcg cccgcccgag gaccatgacg agcgtgccgg
    13321 caccgatgga cgccaggggt gacacctgat cacgcgaacg ggctcacttt cctgagccgg
    13381 atcaccgtaa caaggccgaa atgccgcctt tcggcctgcc ccacgccgtt tcctgcgctc
    13441 cgcttgcgac catgggcggg ctgccggggc tgatgccctc aggggtgcct gaccgccgcg
//
