BGC0002054: amipurimycin biosynthetic gene cluster from Streptomyces novoguineensis
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Location: 1 - 57,776 nt. (total: 57,776 nt).
This entry is originally from NCBI GenBank MK257770.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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resistance
TTA codons
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General
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NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002054
Short description amipurimycin biosynthetic gene cluster from Streptomyces novoguineensis
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide
  • NRP
  • Saccharide
Loci NCBI GenBank: MK257770.1
Compounds
  • amipurimycin
Species Streptomyces novoguineensis [taxonomy]
References
Chemical products information
amipurimycin
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C20H29N7O8
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • QHW08538.1
  • apmA1
 13102 - 14484 (-) Long-chain-fatty-acid--CoA ligase
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  • QHW08540.1
  • apmA2
 14490 - 15044 (-) hypothetical protein
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  • QHW08539.1
  • apmA3
 15041 - 16234 (-) beta-ketoacyl-[acyl-carrier-protein] synthase family protein
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  • QHW08541.1
  • apmA4
 16228 - 16737 (-) 3-hydroxyacyl-[acyl-carrier-protein] dehydratase
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  • QHW08542.1
  • apmA5
 16718 - 17185 (-) thioesterase
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  • QHW08543.1
  • apmA6
 17182 - 18597 (-) aminotransferase
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  • QHW08544.1
  • apmA7
 18602 - 18868 (-) acyl carrier protein
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  • QHW08545.1
  • apmA8
 18888 - 20138 (-) ATP-grasp domain-containing protein
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  • QHW08546.1
  • apmR1
 20887 - 21699 (+) SARP family transcriptional regulator
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  • QHW08547.1
  • apmD
 21798 - 22409 (-) TIGR00730 family Rossman fold protein
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  • QHW08548.1
  • apmE
 22396 - 23130 (-) SDR family oxidoreductase
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  • QHW08549.1
  • apmF
 23130 - 23753 (-) class I SAM-dependent methyltransferase
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  • QHW08550.1
  • apmB1
 23750 - 24832 (-) HAD-IIIC family phosphatase
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  • QHW08551.1
  • apmB2
 24832 - 25962 (-) acyl-CoA dehydrogenase
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  • QHW08552.1
  • apmB3
 25959 - 26222 (-) acyl carrier protein
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  • QHW08553.1
  • apmB4
 26227 - 27069 (-) 3-hydroxybutyryl-CoA dehydrogenase
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  • QHW08554.1
  • apmB5
 27066 - 30071 (-) polyketide synthase
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  • QHW08555.1
  • apmB6
 30078 - 32444 (-) non-ribosomal peptide synthetase
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  • QHW08556.1
  • apmG
 32441 - 33931 (-) FAD-dependent oxidoreductase
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  • QHW08557.1
  • apmH
 33924 - 34913 (-) hypothetical protein
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  • QHW08558.1
  • apmI
 34910 - 36172 (-) hypothetical protein
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  • QHW08559.1
  • apmC1
 36169 - 37146 (-) transketolase
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  • QHW08560.1
  • apmC2
 37157 - 37936 (-) transketolase
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  • QHW08561.1
  • apmJ
 38229 - 39233 (+) branched-chain amino acid aminotransferase
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  • QHW08562.1
  • apmK
 39230 - 40291 (+) gfo/Idh/MocA family oxidoreductase
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  • QHW08563.1
  • apmL
 40414 - 41379 (+) hypothetical protein
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  • QHW08564.1
  • apmM
 41403 - 42185 (+) SDR family oxidoreductase
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  • QHW08565.1
  • apmR2
 42363 - 44129 (-) SARP family pathway specific regulatory protein
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  • QHW08566.1
  • apmR3
 44310 - 45599 (+) MFS superfamily transporter
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  • QHW08567.1
  • apmN
 45683 - 46195 (-) hypothetical protein
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Annotation changelog
MIBiG version Submitter Notes
3.0
  • Hidden contributor (ID: ICOIWUET5GIWWSDSPJ7RYJQQ, no GDPR consent given).
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
  • Added version to NCBI accession
Detailed domain annotation
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