BGC0002054: amipurimycin biosynthetic gene cluster from Streptomyces novoguineensis
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Location: 1 - 57,776 nt. (total: 57,776 nt).
This entry is originally from NCBI GenBank MK257770.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002054
Short description amipurimycin biosynthetic gene cluster from Streptomyces novoguineensis
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
  • NRPS (Type I)
  • saccharide (None)
Loci
MK257770.1
via Gene expression correlated with compound production, Knock-out studies
Compounds
  • amipurimycin
Species Streptomyces novoguineensis [taxonomy]
References
Chemical products information
amipurimycin Evidence:
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C20H29N7O8
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • QHW08538.1
  • apmA1
 13102 - 14484 (-) Long-chain-fatty-acid--CoA ligase
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    • QHW08540.1
    • apmA2
    		 14490 - 15044 (-) hypothetical protein
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      • QHW08539.1
      • apmA3
      		 15041 - 16234 (-) beta-ketoacyl-[acyl-carrier-protein] synthase family protein
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        • QHW08541.1
        • apmA4
        		 16228 - 16737 (-) 3-hydroxyacyl-[acyl-carrier-protein] dehydratase
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          • QHW08542.1
          • apmA5
          		 16718 - 17185 (-) thioesterase
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            • QHW08543.1
            • apmA6
            		 17182 - 18597 (-) aminotransferase
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              • QHW08544.1
              • apmA7
              		 18602 - 18868 (-) acyl carrier protein
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                • QHW08545.1
                • apmA8
                		 18888 - 20138 (-) ATP-grasp domain-containing protein
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                  • QHW08546.1
                  • apmR1
                  		 20887 - 21699 (+) SARP family transcriptional regulator
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                    • QHW08547.1
                    • apmD
                    		 21798 - 22409 (-) TIGR00730 family Rossman fold protein
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                      • QHW08548.1
                      • apmE
                      		 22396 - 23130 (-) SDR family oxidoreductase
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                        • QHW08549.1
                        • apmF
                        		 23130 - 23753 (-) class I SAM-dependent methyltransferase
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                          • QHW08550.1
                          • apmB1
                          		 23750 - 24832 (-) HAD-IIIC family phosphatase
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                            • QHW08551.1
                            • apmB2
                            		 24832 - 25962 (-) acyl-CoA dehydrogenase
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                              • QHW08552.1
                              • apmB3
                              		 25959 - 26222 (-) acyl carrier protein
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                                • QHW08553.1
                                • apmB4
                                		 26227 - 27069 (-) 3-hydroxybutyryl-CoA dehydrogenase
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                                  • QHW08554.1
                                  • apmB5
                                  		 27066 - 30071 (-) polyketide synthase
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                                    • QHW08555.1
                                    • apmB6
                                    		 30078 - 32444 (-) non-ribosomal peptide synthetase
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                                      • QHW08556.1
                                      • apmG
                                      		 32441 - 33931 (-) FAD-dependent oxidoreductase
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                                        • QHW08557.1
                                        • apmH
                                        		 33924 - 34913 (-) hypothetical protein
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                                          • QHW08558.1
                                          • apmI
                                          		 34910 - 36172 (-) hypothetical protein
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                                            • QHW08559.1
                                            • apmC1
                                            		 36169 - 37146 (-) transketolase
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                                              • QHW08560.1
                                              • apmC2
                                              		 37157 - 37936 (-) transketolase
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                                                • QHW08561.1
                                                • apmJ
                                                		 38229 - 39233 (+) branched-chain amino acid aminotransferase
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                                                  • QHW08562.1
                                                  • apmK
                                                  		 39230 - 40291 (+) gfo/Idh/MocA family oxidoreductase
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                                                    • QHW08563.1
                                                    • apmL
                                                    		 40414 - 41379 (+) hypothetical protein
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                                                      • QHW08564.1
                                                      • apmM
                                                      		 41403 - 42185 (+) SDR family oxidoreductase
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                                                        • QHW08565.1
                                                        • apmR2
                                                        		 42363 - 44129 (-) SARP family pathway specific regulatory protein
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                                                          • QHW08566.1
                                                          • apmR3
                                                          		 44310 - 45599 (+) MFS superfamily transporter
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                                                            • QHW08567.1
                                                            • apmN
                                                            		 45683 - 46195 (-) hypothetical protein
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                                                              Biosynthesis information
                                                              Annotation changelog

                                                              Entry version: next

                                                              Date
                                                              Changes
                                                              Submitters
                                                              Reviewers
                                                              2024-08-10
                                                              MIBiG v4 annotathon
                                                              • (ID: 4CEPXXFDQQ46VQJXBT4B4AUO)
                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                              Entry version: 1

                                                              Date
                                                              Changes
                                                              Submitters
                                                              Reviewers
                                                              2022-09-15
                                                              Submitted
                                                              • (ID: ICOIWUET5GIWWSDSPJ7RYJQQ)
                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                              2022-09-15
                                                              Added version to NCBI accession
                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                              Detailed domain annotation
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