BGC0002056: peloruside A biosynthetic gene cluster from sponge metagenome
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Location: 1 - 53,043 nt. (total: 53,043 nt).
This entry is originally from NCBI GenBank JAAHTH010000242.1.

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core biosynthetic genes
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Gene details
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General
Compounds
Genes
Polyketide
NRP
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0002056
Short description peloruside A biosynthetic gene cluster from sponge metagenome
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: incomplete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide
Loci NCBI GenBank: JAAHTH010000242.1
Compounds
  • peloruside A
Species sponge metagenome [taxonomy]
References
Chemical products information
peloruside A
Copy SMILES
C27H48O11
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • pelE
103 - 912 (-) hydroxylase
  • Tailoring (Hydroxylation)
Sequence-based prediction
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  • pelD
1164 - 26273 (-) polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • pelC
26261 - 50140 (-) polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • pelB
50207 - 51568 (-) acyl-CoA/ACP ligase
  • Activation / processing
Sequence-based prediction
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  • pelA
51633 - 52034 (-) acyl carrier protein
  • Activation / processing
Sequence-based prediction
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Polyketide-specific information
Subclass Unknown
Cyclic? yes
Release type
  • Macrolactonization
Polyketide-synthases
Genes Properties Modules
pelC
+
pelB
Synthase subclass: Trans-AT type I
Module 8
Genes: pelB
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
Module 9
Genes: pelB
Core domains: Ketosynthase, Thiolation (ACP/PCP)
Module 10
Genes: pelB
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
Module 11
Genes: pelB
Core domains: Ketosynthase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
Module 12
Genes: pelB
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 13
Genes: pelB
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 14
Genes: pelB
Core domains: Ketosynthase, Thioesterase
Module 1
Genes: pelC
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: D-OH
Module 2
Genes: pelC
Core domains: Ketosynthase, Thiolation (ACP/PCP), Thioesterase
Module 3
Genes: pelC
Core domains: Ketosynthase, Thiolation (ACP/PCP)
Module 5
Genes: pelC
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
Module 6
Genes: pelC
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 7
Genes: pelC
Core domains: Ketosynthase
Scaffold-modifying domains: Methylation
NRP-specific information
Subclass n/a
Cyclic? no
NRP-synthases
Gene Modules
pelB
Module 0
pelC
Module 4 [active]
Condensation domain type: LCL
Annotation changelog
MIBiG version Submitter Notes
2.1
  • Hidden contributor (ID: DSCNCSJNYVZZHSG74Z2O37QE, no GDPR consent given).
  • Submitted
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Detailed domain annotation
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