BGC0002056: peloruside A biosynthetic gene cluster from sponge metagenome
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Location: 1 - 53,043 nt. (total: 53,043 nt).
This entry is originally from NCBI GenBank JAAHTH010000242.1, but has been modified (see Modifications tab for details).

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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Gene details
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General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
Modifications
General information about the BGC
MIBiG accession BGC0002056
Short description peloruside A biosynthetic gene cluster from sponge metagenome
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: incomplete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide
Loci NCBI GenBank: JAAHTH010000242.1
Compounds
  • peloruside A
Species sponge metagenome [taxonomy]
References
Chemical products information
peloruside A
Copy SMILES
C27H48O11
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • pelE
 103 - 912 (-) hydroxylase
  • Tailoring (Hydroxylation)
Sequence-based prediction
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  • pelD
 1164 - 26273 (-) polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • pelC
 26261 - 50140 (-) polyketide synthase
  • Scaffold biosynthesis
Sequence-based prediction
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  • pelB
 50207 - 51568 (-) acyl-CoA/ACP ligase
  • Activation / processing
Sequence-based prediction
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  • pelA
 51633 - 52034 (-) acyl carrier protein
  • Activation / processing
Sequence-based prediction
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Polyketide-specific information
Subclass Unknown
Cyclic? yes
Release type
  • Macrolactonization
Polyketide-synthases
Genes Properties Modules
pelC
+
pelB 		Synthase subclass: Trans-AT type I
Module 1
Genes: pelC
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: D-OH
Module 2
Genes: pelC
Core domains: Ketosynthase, Thiolation (ACP/PCP), Thioesterase
Module 3
Genes: pelC
Core domains: Ketosynthase, Thiolation (ACP/PCP)
Module 5
Genes: pelC
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 6
Genes: pelC
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 7
Genes: pelC
Core domains: Ketosynthase
Scaffold-modifying domains: Methylation
Module 8
Genes: pelB
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: Unknown
Module 9
Genes: pelB
Core domains: Ketosynthase, Thiolation (ACP/PCP)
Module 10
Genes: pelB
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 11
Genes: pelB
Core domains: Ketosynthase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
Module 12
Genes: pelB
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 13
Genes: pelB
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 14
Genes: pelB
Core domains: Ketosynthase, Thioesterase
NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
pelB
Module 0 [inactive]
pelC
Module 4
Condensation domain type: LCL
Annotation changelog
MIBiG version Submitter Notes
3.0
  • Hidden contributor (ID: DSCNCSJNYVZZHSG74Z2O37QE, no GDPR consent given).
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • Sorted modules by module number
  • Fixed biosynthetic classes
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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Modifications to original record
  • pelE was added
  • pelD was added
  • pelC was added
  • pelB was added
  • pelA was added