BGC0002056: peloruside A biosynthetic gene cluster from sponge metagenome
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Location: 1 - 53,043 nt. (total: 53,043 nt).
This entry is originally from NCBI GenBank JAAHTH010000242.1, but has been modified (see Modifications tab for details).

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
Modifications
General information about the BGC
MIBiG accession BGC0002056
Short description peloruside A biosynthetic gene cluster from sponge metagenome
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: partial
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Trans-AT type I)
Loci
JAAHTH010000242.1
via
Compounds
  • peloruside A
Species sponge metagenome [taxonomy]
References
Chemical products information
peloruside A Evidence: NMR
Copy SMILES
C27H48O11
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • pelE
 103 - 912 (-) hydroxylase
  • Tailoring
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  • pelD
 1164 - 26273 (-) polyketide synthase
  • Scaffold biosynthesis
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  • pelC
 26261 - 50140 (-) polyketide synthase
  • Scaffold biosynthesis
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  • pelB
 50207 - 51568 (-) acyl-CoA/ACP ligase
  • Activation / processing
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  • pelA
 51633 - 52034 (-) acyl carrier protein
  • Activation / processing
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Biosynthesis information

Biosynthetic modules

Name
1
Type
pks-trans-at
Genes
pelC
Substrates
Integrated Monomers
Domains
ketosynthase, ketoreductase, methyltransferase, carrier (ACP)
Name
2
Type
pks-trans-at
Genes
pelC
Substrates
Integrated Monomers
Domains
ketosynthase, thioesterase, carrier (ACP)
Name
3
Type
pks-trans-at
Genes
pelC
Substrates
Integrated Monomers
Domains
ketosynthase, carrier (ACP)
Name
5
Type
pks-trans-at
Genes
pelC
Substrates
Integrated Monomers
Domains
ketosynthase, ketoreductase, carrier (ACP)
Name
6
Type
pks-trans-at
Genes
pelC
Substrates
Integrated Monomers
Domains
ketosynthase, ketoreductase, carrier (ACP)
Name
7
Type
pks-trans-at
Genes
pelC
Substrates
Integrated Monomers
Domains
ketosynthase, methyltransferase
Name
8
Type
pks-trans-at
Genes
pelB
Substrates
Integrated Monomers
Domains
ketosynthase, ketoreductase, methyltransferase, carrier (ACP)
Name
9
Type
pks-trans-at
Genes
pelB
Substrates
Integrated Monomers
Domains
ketosynthase, carrier (ACP)
Name
10
Type
pks-trans-at
Genes
pelB
Substrates
Integrated Monomers
Domains
ketosynthase, ketoreductase, carrier (ACP)
Name
11
Type
pks-trans-at
Genes
pelB
Substrates
Integrated Monomers
Domains
ketosynthase, methyltransferase, carrier (ACP)
Name
12
Type
pks-trans-at
Genes
pelB
Substrates
Integrated Monomers
Domains
ketosynthase, ketoreductase, carrier (ACP)
Name
13
Type
pks-trans-at
Genes
pelB
Substrates
Integrated Monomers
Domains
ketosynthase, ketoreductase, carrier (ACP)
Name
14
Type
pks-trans-at
Genes
pelB
Substrates
Integrated Monomers
Domains
ketosynthase, thioesterase
Annotation changelog

Entry version: 2

Date
Changes
Submitters
Reviewers
2022-10-07
Update chemical activity to schema version 2.11
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

Entry version: 1

Date
Changes
Submitters
Reviewers
2022-09-15
Submitted
  • (ID: DSCNCSJNYVZZHSG74Z2O37QE)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
2022-09-15
Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
2022-09-15
Sorted modules by module number
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
2022-09-15
Fixed biosynthetic classes
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
Detailed domain annotation
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Similar known gene clusters from MIBiG 4.0
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Modifications to original record
  • pelE was added
  • pelD was added
  • pelC was added
  • pelB was added
  • pelA was added