BGC0002058: mutanocyclin biosynthetic gene cluster from Streptococcus mutans B04Sm5
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Location: 29,680 - 42,300 nt. (total: 12,621 nt).
This entry is originally from NCBI GenBank NZ_ALYY01000026.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002058
Short description mutanocyclin biosynthetic gene cluster from Streptococcus mutans B04Sm5
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
  • NRPS (Type I)
Loci
NZ_ALYY01000026.1
29680 - 42300
via Gene expression correlated with compound production
Compounds
  • mutanocyclin
Species Streptococcus mutans B04Sm5 [taxonomy]
References
Chemical products information
mutanocyclin Evidence:
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Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • B900_RS0101610
  • WP_002277502.1
 29691 - 31487 (-) multi efflux pump, transporter
  • Transport
  • Knock-out
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  • B900_RS0101615
  • WP_002277501.1
 31666 - 32208 (+) TetR, AcrR family transcriptional regulator
  • Regulation
  • Knock-out
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  • B900_RS0101620
  • WP_002283497.1
 32350 - 32892 (-) TetR family transcriptional regulator
  • Regulation
  • Knock-out
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  • B900_RS0101625
  • WP_002277499.1
 33022 - 33525 (+) aminoacylase
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    • B900_RS0101630
    • WP_002283498.1
    		 33714 - 36455 (-) PKS
    • Scaffold biosynthesis
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    • B900_RS0101635
    • WP_002308266.1
    		 36459 - 39533 (-) NRPS, A-domain Leucine
    • Scaffold biosynthesis
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    • B900_RS0101640
    • WP_002277496.1
    		 39540 - 39986 (-) Putative C-acetyltransferase
    • Tailoring
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    • B900_RS0101645
    • WP_002277495.1
    		 39987 - 41198 (-) Thiolase
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      • B900_RS0101650
      • WP_002277494.1
      		 41213 - 42292 (-) Hydroxymethyl-glutaryl-CoA synthase
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        Biosynthesis information

        Biosynthetic modules

        Name
        2
        Type
        pks-trans-at
        Genes
        B900_RS0101630
        Substrates
        Integrated Monomers
        Domains
        ketosynthase, thioesterase, carrier (ACP)
        Annotation changelog

        Entry version: 2

        Date
        Changes
        Submitters
        Reviewers
        2022-10-07
        Update chemical activity to schema version 2.11
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        2022-10-07
        Removed compounds: reutericyclin A, reutericyclin B, reutericyclin C, reutericyclin D.
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        2022-10-07
        Added compounds: mutanocyclin.
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

        Entry version: 1

        Date
        Changes
        Submitters
        Reviewers
        2022-09-15
        Submitted
        • (ID: BBFIVXCXOEHHFWOS2XMPTW4C)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        2022-09-15
        Corrected NRP module activity
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        2022-09-15
        Removed ketoreductase stereochemistry annotation from modules without ketoreductases
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        2022-09-15
        Changed reference accession to RefSeq for gene annotations
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        2022-09-15
        Fixed gene identifiers of 'no_accession'
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
        Detailed domain annotation
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