BGC0002058: mutanocyclin biosynthetic gene cluster from Streptococcus mutans B04Sm5
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Location: 29,680 - 42,300 nt. (total: 12,621 nt).
This entry is originally from NCBI GenBank NZ_ALYY01000026.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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Gene details
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General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002058
Short description mutanocyclin biosynthetic gene cluster from Streptococcus mutans B04Sm5
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide
  • NRP
Loci NCBI GenBank: NZ_ALYY01000026.1
Compounds
  • mutanocyclin
Species Streptococcus mutans B04Sm5 [taxonomy]
References
Chemical products information
mutanocyclin
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Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • B900_RS0101610
  • WP_002277502.1
 29691 - 31487 (-) multi efflux pump, transporter
  • Transport
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  • B900_RS0101615
  • WP_002277501.1
 31666 - 32208 (+) TetR, AcrR family transcriptional regulator
  • Regulation
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  • B900_RS0101620
  • WP_002283497.1
 32350 - 32892 (-) TetR family transcriptional regulator
  • Regulation
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  • B900_RS0101625
  • WP_002277499.1
 33022 - 33525 (+) aminoacylase
  • Other enzymatic
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  • B900_RS0101630
  • WP_002283498.1
 33714 - 36455 (-) PKS
  • Scaffold biosynthesis
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  • B900_RS0101635
  • WP_002308266.1
 36459 - 39533 (-) NRPS, A-domain Leucine
  • Scaffold biosynthesis
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  • B900_RS0101640
  • WP_002277496.1
 39540 - 39986 (-) Putative C-acetyltransferase
  • Tailoring (Unknown)
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  • B900_RS0101645
  • WP_002277495.1
 39987 - 41198 (-) Thiolase
  • Other enzymatic
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  • B900_RS0101650
  • WP_002277494.1
 41213 - 42292 (-) Hydroxymethyl-glutaryl-CoA synthase
  • Other enzymatic
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Polyketide-specific information
Subclass Unknown
Cyclic? no
Polyketide-synthases
Genes Properties Modules
B900_RS0101630 Synthase subclass:
Module 2
Genes: B900_RS0101630
Core domains: Ketosynthase, Thiolation (ACP/PCP), Thioesterase
NRP-specific information
Subclass N/A
Cyclic? no
NRP-synthases
Gene Modules
B900_RS0101635
Module 1
Condensation domain type: LCL
Annotation changelog
MIBiG version Submitter Notes
3.0
  • Hidden contributor (ID: BBFIVXCXOEHHFWOS2XMPTW4C, no GDPR consent given).
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
  • Corrected NRP module activity
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • Changed reference accession to RefSeq for gene annotations
  • Fixed gene identifiers of 'no_accession'
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
  • Removed compounds: reutericyclin A, reutericyclin B, reutericyclin C, reutericyclin D.
  • Added compounds: mutanocyclin.
Detailed domain annotation
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