BGC0002060: secimide biosynthetic gene cluster from Pseudomonas syringae pv. syringae B728a
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Location: 5,119,626 - 5,167,579 nt. (total: 47,954 nt).
This entry is originally from NCBI GenBank CP000075.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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Gene details
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General
Compounds
Genes
Polyketide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002060
Short description secimide biosynthetic gene cluster from Pseudomonas syringae pv. syringae B728a
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Other)
Loci NCBI GenBank: CP000075.1
Compounds
  • secimide
Species Pseudomonas syringae pv. syringae B728a [taxonomy]
References
Chemical products information
secimide
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C16H23N1O6
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • Psyr_4293
  • AAY39323.1
 5119626 - 5120495 (-) Acyl-CoA thioesterase
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  • Psyr_4294
  • AAY39324.1
 5120635 - 5121204 (-) Histone deacetylase family protein
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  • Psyr_4295
  • AAY39325.1
 5121325 - 5122242 (+) Histone deacetylase superfamily
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  • Psyr_4296
  • AAY39326.1
 5122313 - 5123587 (+) HI0933-like protein
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  • Psyr_4297
  • AAY39327.1
 5123836 - 5125164 (-) Helicase, C-terminal:DEAD/DEAH box helicase, N-terminal
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  • Psyr_4298
  • AAY39328.1
 5125227 - 5126141 (-) Protein of unknown function DUF6
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  • Psyr_4299
  • AAY39329.1
 5126309 - 5126776 (+) transcriptional regulator, AsnC family
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  • Psyr_4300
  • AAY39330.1
 5126781 - 5127395 (-) DNA polymerase III, epsilon subunit
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  • Psyr_4301
  • AAY39331.1
 5127414 - 5127890 (-) Protein of unknown function DUF88
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  • Psyr_4302
  • AAY39332.1
 5128171 - 5128875 (-) conserved hypothetical protein
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  • Psyr_4303
  • AAY39333.1
 5129073 - 5129735 (+) Protein of unknown function UPF0259
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  • Psyr_4304
  • AAY39334.1
 5129769 - 5130911 (+) Endonuclease/exonuclease/phosphatase
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  • Psyr_4305
  • AAY39335.1
 5131096 - 5131344 (+) conserved hypothetical protein
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  • Psyr_4306
  • AAY39336.1
 5131449 - 5131646 (-) conserved hypothetical protein
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  • Psyr_4307
  • AAY39337.1
 5132214 - 5133149 (-) Protein of unknown function DUF142
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  • Psyr_4308
  • AAY39338.1
 5133734 - 5135290 (-) conserved hypothetical protein
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  • Psyr_4309
  • AAY39339.1
 5135391 - 5136005 (-) hypothetical protein
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  • Psyr_4310
  • AAY39340.1
 5136129 - 5137064 (-) hypothetical protein
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  • Psyr_4311
  • AAY39341.1
 5137115 - 5140282 (-) Malonyl CoA-acyl carrier protein transacylase
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  • Psyr_4312
  • AAY39342.1
 5140287 - 5147069 (-) Erythronolide synthase
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  • Psyr_4313
  • AAY39343.1
 5147125 - 5154306 (-) Beta-ketoacyl synthase:Beta-ketoacyl synthase:Phosphopantetheine-binding protein
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  • Psyr_4314
  • AAY39344.1
 5154317 - 5164012 (-) Beta-ketoacyl synthase:Beta-ketoacyl synthase:Phosphopantetheine-binding protein
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  • Psyr_4315
  • AAY39345.1
 5164033 - 5166009 (-) Asparagine synthase, glutamine-hydrolyzing
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  • Psyr_4316
  • AAY39346.1
 5166246 - 5166491 (-) conserved hypothetical protein
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  • Psyr_4317
  • AAY39347.1
 5166566 - 5167579 (-) Probable taurine catabolism dioxygenase-like protein
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Polyketide-specific information
Subclass Other
Starter unit Malonamyl-CoA
Cyclic? no
Polyketide-synthases
Genes Properties Modules
Psyr_4313
+
Psyr_4294
+
Psyr_4314
+
Psyr_4312 		Synthase subclass: Trans-AT type I
Trans-acyltansferases: Psyr_4294
Module 1
Genes: Psyr_4314
Core domains: Ketosynthase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 2
Genes: Psyr_4314
Core domains: Ketosynthase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Michael branching
Module 3
Genes: Psyr_4314, Psyr_4313
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: Unknown
Module 4
Genes: Psyr_4313
Core domains: Ketosynthase, Thiolation (ACP/PCP)
Module 5
Genes: Psyr_4313, Psyr_4312
Core domains: Ketosynthase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: Unknown
Module 6
Genes: Psyr_4312
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Annotation changelog
MIBiG version Submitter Notes
3.0
  • Hidden contributor (ID: NXU2DC3KF53Q3BQ3CSVJITHE, no GDPR consent given).
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • Merged cross-CDS PKS modules
  • Added version to NCBI accession
  • Fix invalid gene IDs
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Changed chemical structures for compounds: secimide.
  • Added NPAtlas links to compounds: secimide.
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