BGC0002060: secimide biosynthetic gene cluster from Pseudomonas syringae pv. syringae B728a
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Location: 5,119,626 - 5,167,579 nt. (total: 47,954 nt).
This entry is originally from NCBI GenBank CP000075.1.

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core biosynthetic genes
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transport-related genes
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002060
Short description secimide biosynthetic gene cluster from Pseudomonas syringae pv. syringae B728a
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Trans-AT type I)
Loci
CP000075.1
5119626 - 5167579
via Knock-out studies
Compounds
  • secimide
Species Pseudomonas syringae pv. syringae B728a [taxonomy]
References
Chemical products information
secimide Evidence: NMR, Mass spectrometry, Chemical derivatisation
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C16H23N1O6
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • Psyr_4293
  • AAY39323.1
 5119626 - 5120495 (-) Acyl-CoA thioesterase
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    • Psyr_4294
    • AAY39324.1
    		 5120635 - 5121204 (-) Histone deacetylase family protein
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      • Psyr_4295
      • AAY39325.1
      		 5121325 - 5122242 (+) Histone deacetylase superfamily
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        • Psyr_4296
        • AAY39326.1
        		 5122313 - 5123587 (+) HI0933-like protein
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          • Psyr_4297
          • AAY39327.1
          		 5123836 - 5125164 (-) Helicase, C-terminal:DEAD/DEAH box helicase, N-terminal
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            • Psyr_4298
            • AAY39328.1
            		 5125227 - 5126141 (-) Protein of unknown function DUF6
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              • Psyr_4299
              • AAY39329.1
              		 5126309 - 5126776 (+) transcriptional regulator, AsnC family
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                • Psyr_4300
                • AAY39330.1
                		 5126781 - 5127395 (-) DNA polymerase III, epsilon subunit
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                  • Psyr_4301
                  • AAY39331.1
                  		 5127414 - 5127890 (-) Protein of unknown function DUF88
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                    • Psyr_4302
                    • AAY39332.1
                    		 5128171 - 5128875 (-) conserved hypothetical protein
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                      • Psyr_4303
                      • AAY39333.1
                      		 5129073 - 5129735 (+) Protein of unknown function UPF0259
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                        • Psyr_4304
                        • AAY39334.1
                        		 5129769 - 5130911 (+) Endonuclease/exonuclease/phosphatase
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                          • Psyr_4305
                          • AAY39335.1
                          		 5131096 - 5131344 (+) conserved hypothetical protein
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                            • Psyr_4306
                            • AAY39336.1
                            		 5131449 - 5131646 (-) conserved hypothetical protein
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                              • Psyr_4307
                              • AAY39337.1
                              		 5132214 - 5133149 (-) Protein of unknown function DUF142
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                                • Psyr_4308
                                • AAY39338.1
                                		 5133734 - 5135290 (-) conserved hypothetical protein
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                                  • Psyr_4309
                                  • AAY39339.1
                                  		 5135391 - 5136005 (-) hypothetical protein
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                                    • Psyr_4310
                                    • AAY39340.1
                                    		 5136129 - 5137064 (-) hypothetical protein
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                                      • Psyr_4311
                                      • AAY39341.1
                                      		 5137115 - 5140282 (-) Malonyl CoA-acyl carrier protein transacylase
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                                        • Psyr_4312
                                        • AAY39342.1
                                        		 5140287 - 5147069 (-) Erythronolide synthase
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                                          • Psyr_4313
                                          • AAY39343.1
                                          		 5147125 - 5154306 (-) Beta-ketoacyl synthase:Beta-ketoacyl synthase:Phosphopantetheine-binding protein
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                                            • Psyr_4314
                                            • AAY39344.1
                                            		 5154317 - 5164012 (-) Beta-ketoacyl synthase:Beta-ketoacyl synthase:Phosphopantetheine-binding protein
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                                              • Psyr_4315
                                              • AAY39345.1
                                              		 5164033 - 5166009 (-) Asparagine synthase, glutamine-hydrolyzing
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                                                • Psyr_4316
                                                • AAY39346.1
                                                		 5166246 - 5166491 (-) conserved hypothetical protein
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                                                  • Psyr_4317
                                                  • AAY39347.1
                                                  		 5166566 - 5167579 (-) Probable taurine catabolism dioxygenase-like protein
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                                                    Biosynthesis information

                                                    Biosynthetic modules

                                                    Name
                                                    1
                                                    Type
                                                    pks-trans-at
                                                    Genes
                                                    Psyr_4314
                                                    Substrates
                                                    Integrated Monomers
                                                    Domains
                                                    ketosynthase, dehydratase, ketoreductase, carrier (ACP)
                                                    Name
                                                    2
                                                    Type
                                                    pks-trans-at
                                                    Genes
                                                    Psyr_4314
                                                    Substrates
                                                    Integrated Monomers
                                                    Domains
                                                    ketosynthase, branching, carrier (ACP)
                                                    Name
                                                    3
                                                    Type
                                                    pks-trans-at
                                                    Genes
                                                    Psyr_4314 Psyr_4313
                                                    Substrates
                                                    Integrated Monomers
                                                    Domains
                                                    ketosynthase, ketoreductase, methyltransferase, carrier (ACP)
                                                    Name
                                                    4
                                                    Type
                                                    pks-trans-at
                                                    Genes
                                                    Psyr_4313
                                                    Substrates
                                                    Integrated Monomers
                                                    Domains
                                                    ketosynthase, carrier (ACP)
                                                    Name
                                                    5
                                                    Type
                                                    pks-trans-at
                                                    Genes
                                                    Psyr_4313 Psyr_4312
                                                    Substrates
                                                    Integrated Monomers
                                                    Domains
                                                    ketosynthase, dehydratase, ketoreductase, methyltransferase, carrier (ACP)
                                                    Name
                                                    6
                                                    Type
                                                    pks-trans-at
                                                    Genes
                                                    Psyr_4312
                                                    Substrates
                                                    Integrated Monomers
                                                    Domains
                                                    ketosynthase, ketoreductase, carrier (ACP)
                                                    Annotation changelog

                                                    Entry version: 2

                                                    Date
                                                    Changes
                                                    Submitters
                                                    Reviewers
                                                    2022-10-07
                                                    Changed chemical structures for compounds: secimide.
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    2022-10-07
                                                    Added NPAtlas links to compounds: secimide.
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                    Entry version: 1

                                                    Date
                                                    Changes
                                                    Submitters
                                                    Reviewers
                                                    2022-09-15
                                                    Submitted
                                                    • (ID: NXU2DC3KF53Q3BQ3CSVJITHE)
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    2022-09-15
                                                    Removed ketoreductase stereochemistry annotation from modules without ketoreductases
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    2022-09-15
                                                    Merged cross-CDS PKS modules
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    2022-09-15
                                                    Added version to NCBI accession
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    2022-09-15
                                                    Fix invalid gene IDs
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    Detailed domain annotation
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