BGC0002062 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002062 (Paecilomyces divaricatus)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	34,222	High	agnestin A/agnestin B	PKS

BGC0002062 - Region 1 - T1PKS

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Location: 1 - 34,222 nt. (total: 34,222 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 34,223
Label		BGC0002062

Tailoring functions

Oxidoreductases: Acetylation Dioxygenation dehydrogenase

AgnL3: Dioxygenation

MITE: MITE0000158Dioxygenation (identity: 63.90%)

AgnL4: Acetylation, Reduction

MITE: MITE0000161Acetylation, Reduction (identity: 61.00%)

AgnL6: Biaryl bond formation, Reduction

MITE: MITE0000160Biaryl bond formation, Reduction (identity: 68.20%)
smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: Acetylation acylase methyltransferase

AgnL4: Acetylation, Reduction

MITE: MITE0000161Acetylation, Reduction (identity: 61.00%)

AgnL9: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

Agnpks1: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Hydrolases: hydrolase

AgnL7: Decarboxylation

MITE: MITE0000163Decarboxylation (identity: 64.50%)
smcogs: SMCOG1170: metallo-beta-lactamase family protein

Lyases: Dehydration hydrolase

AgnL7: Decarboxylation

MITE: MITE0000163Decarboxylation (identity: 64.50%)
smcogs: SMCOG1170: metallo-beta-lactamase family protein

AgnL8: Dehydration

MITE: MITE0000159Dehydration (identity: 60.50%)

Ligases: dehydrogenase

AgnL6: Biaryl bond formation, Reduction

MITE: MITE0000160Biaryl bond formation, Reduction (identity: 68.20%)
smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002062.2	0.98	PKS	agnestin A, agnestin B	Paecilomyces divaricatus
BGC0001284.4	0.78	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001258.3	0.76	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0001257.3	0.76	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0002154.2	0.76	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0002175.3	0.75	PKS	YWA1	Aspergillus oryzae RIB40
BGC0000107.3	0.75	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0001273.3	0.66	PKS	asperlactone	Aspergillus ochraceus
BGC0001276.3	0.65	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0002191.2	0.65	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002062.2	1.00	PKS	agnestin A, agnestin B	Paecilomyces divaricatus
BGC0001284.4	0.78	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001258.3	0.76	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0001257.3	0.76	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0002154.2	0.76	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0002175.3	0.75	PKS	YWA1	Aspergillus oryzae RIB40
BGC0000107.3	0.75	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0001273.3	0.66	PKS	asperlactone	Aspergillus ochraceus
BGC0001276.3	0.65	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0002191.2	0.65	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 4428 - 34222:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

Agnpks1: mal

PKS_AT (947..1246): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 70.8%; inactive: 62.5%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 98.6
inactive: 66.5
Methylmalonyl-CoA: 54.5
Methoxymalonyl-CoA: 48.7
Propionyl-CoA: 31.9
Benzoyl-CoA: 22.0
Isobutyryl-CoA: 21.9
2-Methylbutyryl-CoA: 20.3
Ethylmalonyl-CoA: 18.1
CHC-CoA: 17.6
fatty_acid: 15.9
trans-1,2-CPDA: 14.2
Acetyl-CoA: 11.3
3-Methylbutyryl-CoA: 9.0

Link to PARAS substrate predictor