BGC0002062 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002062 (Paecilomyces divaricatus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	34,222	agnestin A/agnestin B	PKS	100%

BGC0002062 - Region 1 - T1PKS

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Location: 1 - 34,222 nt. (total: 34,222 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 34,223
Label		BGC0002062

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002062	0.93	Polyketide	agnestin A, agnestin B	Paecilomyces divaricatus
BGC0001284	0.37	Polyketide	alternariol	Parastagonospora nodorum SN15
BGC0001258	0.36	Polyketide	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0001257	0.36	Polyketide	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0002154	0.36	Polyketide	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0002175	0.36	Polyketide	YWA1	Aspergillus oryzae RIB40
BGC0000107	0.35	Polyketide	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0001304	0.33	Polyketide	aflavarin	Aspergillus flavus NRRL3357
BGC0001266	0.32	Polyketide	grayanic acid	Cladonia grayi
BGC0001865	0.30	Polyketide	elsinochrome C	Parastagonospora nodorum SN15

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002062	1.00	Polyketide	agnestin A, agnestin B	Paecilomyces divaricatus
BGC0001284	0.69	Polyketide	alternariol	Parastagonospora nodorum SN15
BGC0001258	0.69	Polyketide	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0001257	0.69	Polyketide	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0002154	0.69	Polyketide	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0002175	0.68	Polyketide	YWA1	Aspergillus oryzae RIB40
BGC0000107	0.68	Polyketide	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0001583	0.68	Polyketide	emodin	Escovopsis weberi
BGC0001304	0.66	Polyketide	aflavarin	Aspergillus flavus NRRL3357
BGC0001865	0.66	Polyketide	elsinochrome C	Parastagonospora nodorum SN15

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 4428 - 34222:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

Agnpks1

PKS_AT (947..1246): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 70.8%; inactive: 62.5%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 98.6
inactive: 66.5
Methylmalonyl-CoA: 54.5
Methoxymalonyl-CoA: 48.7
Propionyl-CoA: 31.9
Benzoyl-CoA: 22.0
Isobutyryl-CoA: 21.9
2-Methylbutyryl-CoA: 20.3
Ethylmalonyl-CoA: 18.1
CHC-CoA: 17.6
fatty_acid: 15.9
trans-1,2-CPDA: 14.2
Acetyl-CoA: 11.3
3-Methylbutyryl-CoA: 9.0