BGC0002063 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002063 (Cryptosporiopsis sp. 8999)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	82,565	High	cryptosporioptide B/cryptosporioptide A/cryptosporioptide C	PKS:Iterative type I

BGC0002063 - Region 1 - T1PKS

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Location: 1 - 82,565 nt. (total: 82,565 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 82,566
Label		BGC0002063

Tailoring functions

Oxidoreductases: Acetylation Dioxygenation Monooxygenation dehydrogenase oxygenase

dmxL3: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

dmxR18: Biaryl bond formation, Reduction

MITE: MITE0000160Biaryl bond formation, Reduction (identity: 82.40%)
smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

dmxR3: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

dmxR5: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

dmxR6: Dioxygenation

MITE: MITE0000158Dioxygenation (identity: 70.30%)

dmxR7: Acetylation, Reduction

MITE: MITE0000161Acetylation, Reduction (identity: 71.70%)

dmxR8: Reduction

MITE: MITE0000157Reduction (identity: 68.30%)
smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

dmxR9: Monooxygenation

MITE: MITE0000156Monooxygenation (identity: 61.00%)

Transferases: Acetylation carboxylase

dmxL1: acetyl-CoA carboxylase biotin carboxylase

smcogs: SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

dmxR7: Acetylation, Reduction

MITE: MITE0000161Acetylation, Reduction (identity: 71.70%)

Hydrolases: hydrolase

dmxR1: Decarboxylation

MITE: MITE0000163Decarboxylation (identity: 72.60%)
smcogs: SMCOG1170: metallo-beta-lactamase family protein

Lyases: Dehydration hydrolase

dmxR1: Decarboxylation

MITE: MITE0000163Decarboxylation (identity: 72.60%)
smcogs: SMCOG1170: metallo-beta-lactamase family protein

dmxR17: Dehydration

MITE: MITE0000159Dehydration (identity: 69.50%)

Ligases: dehydrogenase synthase

dmx-nrPKS: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

dmxL2: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

dmxR18: Biaryl bond formation, Reduction

MITE: MITE0000160Biaryl bond formation, Reduction (identity: 82.40%)
smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002063.3	0.98	PKS	cryptosporioptide B, cryptosporioptide A, cryptosporioptide C	Cryptosporiopsis sp. 8999
BGC0001284.4	0.78	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001258.3	0.76	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0002154.2	0.76	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001257.3	0.76	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0000107.3	0.76	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0002175.3	0.75	PKS	YWA1	Aspergillus oryzae RIB40
BGC0002191.2	0.67	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001275.3	0.66	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001276.3	0.66	PKS	6-methylsalicyclic acid	Aspergillus terreus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002063.3	1.00	PKS	cryptosporioptide B, cryptosporioptide A, cryptosporioptide C	Cryptosporiopsis sp. 8999
BGC0001284.4	0.78	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001258.3	0.76	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0002154.2	0.76	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001257.3	0.76	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0000107.3	0.76	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0002175.3	0.75	PKS	YWA1	Aspergillus oryzae RIB40
BGC0002191.2	0.67	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001275.3	0.66	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001276.3	0.66	PKS	6-methylsalicyclic acid	Aspergillus terreus

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 60852:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (pk) + (mal)
Non-colinear ordering:: dmxL2 + dmx-nrPKS

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

dmxL2: pk

PKS_AT (574..892): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 70.8%; Methylmalonyl-CoA: 58.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 71.0
Methoxymalonyl-CoA: 69.3
Malonyl-CoA: 52.4
Isobutyryl-CoA: 45.3
trans-1,2-CPDA: 36.6
2-Methylbutyryl-CoA: 32.4
Propionyl-CoA: 28.8
CHC-CoA: 23.3
Benzoyl-CoA: 22.4
fatty_acid: 14.6
Acetyl-CoA: 12.4
inactive: 12.1
3-Methylbutyryl-CoA: 10.6
Ethylmalonyl-CoA: -0.6

dmx-nrPKS: mal

PKS_AT (926..1225): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 66.7%; inactive: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 87.9
inactive: 57.2
Methylmalonyl-CoA: 54.8
Methoxymalonyl-CoA: 47.9
Propionyl-CoA: 39.3
fatty_acid: 28.2
Ethylmalonyl-CoA: 24.4
2-Methylbutyryl-CoA: 24.2
Benzoyl-CoA: 23.1
Isobutyryl-CoA: 18.3
CHC-CoA: 17.5
Acetyl-CoA: 14.9
trans-1,2-CPDA: 10.8
3-Methylbutyryl-CoA: 9.6

Link to PARAS substrate predictor