LOCUS       BGC0002064              8887 bp    DNA     linear   BCT 31-OCT-2019
DEFINITION  Amycolatopsis sp. YIM 10 chromosome, complete genome.
ACCESSION   BGC0002064
VERSION     BGC0002064
KEYWORDS    .
SOURCE      Amycolatopsis sp. YIM 10
  ORGANISM  Amycolatopsis sp. YIM 10
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis.
COMMENT     Annotated using prokka v1.11 from http://www.vicbioinformatics.com.
            ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 16:50:09
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 8887
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..1719)
                     /EC_number="3.6.3.-"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 181.2; E-value:
                     5.7e-55)"
                     /gene_kind="transport"
                     /inference="ab initio prediction:Prodigal:2.6"
                     /inference="similar to AA sequence:UniProtKB:Q99T13"
                     /locus_tag="YIM_29235"
                     /product="Putative multidrug export ATP-binding/permease
                     protein"
                     /protein_id="QFU91019.1"
                     /transl_table=11
                     /translation="MNSVAWRMISPPINKNRRALVMVLCWSLLGAVPTLLSGLLVAVAL
                     DRGFLAGNAGFGLAILGCYGASLGLGAVATRQAMGPMAVLAEAVRDHLVHQVVHTSLHT
                     AVSAGFAARTGFAARIIGQTETVRQILSNLVMAISSAVLMTIAACAGLVALVPAMVVAL
                     VPIMLPAGVLLVRLSGVWRRRYEKSLACEEELAAELDLVLAGTRDIAACDAAGRAAGDT
                     DRRLRASAEAATGVAGISGARIGVIGLAGHLPLIVLLLLAPVLVSRGALTVGELVGAIT
                     YLATGLEPAWRAITELLGNQALEVATVLARLSGTGISAESGGSLEASRYDLALRGVTFR
                     YGPQSEPVLANADLTLDEGTRLVVVGPSGIGKSTLVNVFAGLESPEAGSVALGGVNLRD
                     LRTEWLRRSVALVPQEAYVFAGTVRENLAYLAPAAEDAELVSAAAVFGLTELITRHGGL
                     DGEIRPDNLSGGERQLITLARVYLSPARVVILDEATCHLDPRAEAVAEEAFARRPGTLI
                     VVAHRISSAMRAERVLLMGAGSLVQGTHEELLHGSADYARLVDYWTRDGGTVAVD"
     protocluster    1..8887
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[4478:6951]"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      4479..6951
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     cand_cluster    1..8887
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..8887
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0002064"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..8887
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lassopeptide"
                     /region_number="1"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            complement(1..1719)
                     /locus_tag="YIM_29235"
     gene            complement(1716..3428)
                     /gene="msbA1"
                     /locus_tag="YIM_29240"
     CDS             complement(1716..3428)
                     /EC_number="3.6.3.-"
                     /codon_start=1
                     /gene="msbA1"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 304.4; E-value:
                     2.7e-92)"
                     /gene_kind="transport"
                     /inference="ab initio prediction:Prodigal:2.6"
                     /inference="similar to AA sequence:UniProtKB:P63359"
                     /locus_tag="YIM_29240"
                     /product="Lipid A export ATP-binding/permease protein MsbA"
                     /protein_id="QFU91020.1"
                     /transl_table=11
                     /translation="MPVGDLRRDARTLWSSVRSSGRDGLALLVLTAVEVAALLAVPGAL
                     AAAVDAISGRGSSGAAIALVCVVLVLGSAAGAGTVVLEKRAQVSGTLSLRRRLVRHLLR
                     LDLGAFRRYGTGDLLGRISQSAAMTSSAVTALTALLVSVVTSIAGLVLLVLLDLRLGLI
                     VLAAAPLIWWQAGLLTRRMSANTTDYQTRQGELTGRFTDAVRGARTIRASGTAAREVDR
                     VVAGLPALTAAGHEFWRVLRTAAFRVNLVMPLLQVAVLAVAGYSVLHGRMTAGELLAAQ
                     GYFGFAVGMFQQTMVLGRVARALGSATMVAEVLAEPVRPAGTRTLPPGPGALSLRGVRV
                     SPVLDGVDVDFPPGVAIAIVGRSGAGKSTLTEVAGGLLVPEAGSVRLDGVPLTELRRDE
                     LGGAVTYAFEKPVLHGETVADAIAYADHPATPAQVEQALRVSAAADFVRRLPAGAGTRR
                     SRLLLSGGELQRLGLARAAWRDARVVVLDDATSSLDTATEAEVTAALDRALRGRTRLIV
                     AHRAATAASADLVAWLDSGRIRALAPHRELVRDPDYRALFGLRQPAAAGSEVR"
     gene            complement(3415..4461)
                     /gene="luxA2"
                     /locus_tag="YIM_29245"
     CDS             complement(3415..4461)
                     /EC_number="1.14.14.3"
                     /codon_start=1
                     /gene="luxA2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1083:oxidoreductase (Score: 136.3; E-value: 2.4e-41)"
                     /gene_kind="biosynthetic-additional"
                     /inference="ab initio prediction:Prodigal:2.6"
                     /inference="similar to AA sequence:UniProtKB:P07740"
                     /locus_tag="YIM_29245"
                     /product="Alkanal monooxygenase alpha chain"
                     /protein_id="QFU91021.1"
                     /transl_table=11
                     /translation="MSAADSVRFGVLLGSHRDAGQSDTDVLRRSVALARQADALGVDDV
                     WITEHHFLDSVVSPSSMALAAYLLGATERITVGTAVTLLPLHSPVHTAEQAALLDQVSG
                     GRFVLGVGRGQPLVEYDVIGGGVEHWRSGMTGALDHTLAALDGKVPGPEPLPLVPLPAT
                     PGGPPVYVAANSEDSVRLAAERGLPMLLYFDKDAATKALMIEDYRRFAGDATAPADHAF
                     ALYTYLTETADEARELMRERARAMLKGGNRDRMLIAMPDTRPSGAELEALTEEITDRLL
                     AMHAVGDAETCVDRLVHNISVSGCHRVLCQVEPFGRTSAAPGVLDRLAREVFPAVRARL
                     AGGSDAGR"
     gene            complement(4479..4889)
                     /locus_tag="YIM_29250"
     CDS             complement(4479..4889)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="ab initio prediction:Prodigal:2.6"
                     /locus_tag="YIM_29250"
                     /product="hypothetical protein"
                     /protein_id="QFU91022.1"
                     /sec_met_domain="PF13471 (E-value: 1.4e-29, bitscore: 91.9,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLPITLETAGRVPVPKRIAAHAAVTVARILMHAKPFRLRKVLEL
                     AKTGARPATAEQAMGARQAVVSVSKRCAGQQCLQRAIATALLCRLTGTWPDWRTGVRTE
                     PFRAHAWVEVDGNAIGEAEDMRAYHVVLSVPA"
     gene            complement(4886..5143)
                     /locus_tag="YIM_29255"
     CDS             complement(4886..5143)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lasso_Fused_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic-additional"
                     /inference="ab initio prediction:Prodigal:2.6"
                     /locus_tag="YIM_29255"
                     /product="hypothetical protein"
                     /protein_id="QFU91023.1"
                     /sec_met_domain="Lasso_Fused_RRE (E-value: 1.9e-13,
                     bitscore: 39.7, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 2.7e-26,
                     bitscore: 80.8, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 3.9e-15, bitscore: 45.3,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLVLADHVSVTETDSGMVLLDQRSGRYWQLNTTAAVVIRTLLDG
                     GQPDDAATVLCARFPADAERVAETVSEFTRALRQAKLVTG"
     gene            complement(5140..6951)
                     /gene="asnB3"
                     /locus_tag="YIM_29260"
     CDS             complement(5140..6951)
                     /EC_number="6.3.5.4"
                     /codon_start=1
                     /gene="asnB3"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177:asparagine synthase (glutamine-hydrolyzing)
                     (Score: 123.9; E-value: 1.3e-37)"
                     /gene_kind="biosynthetic"
                     /inference="ab initio prediction:Prodigal:2.6"
                     /inference="similar to AA sequence:UniProtKB:P64248"
                     /locus_tag="YIM_29260"
                     /product="Putative asparagine synthetase
                     [glutamine-hydrolyzing]"
                     /protein_id="QFU91024.1"
                     /sec_met_domain="Asn_synthase (E-value: 2.7e-40, bitscore:
                     128.3, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKFTIFPDSDPGRAVAESAEPSARTIAYPSGRPWIAGEWRDDEIV
                     STRIGDRVLVLLGWPGITEAKLRSELERVEDLSQLDRLAGALPGSSHLLAAFGGRVRAQ
                     GTISAVCQIYYTRVRGTTVLADRPQTLAALAGTGLDESLLARYLMVTAPPWPLEDECAW
                     HGIERVPPDAYLTMKPDGGCRISAWWTIPEPELPLREGAAAVRAALEAGVAARASLPGR
                     TSSDLSGGMDSTSLAFLLAKHPGELLTTRFEAVDSANDDVIWASKAAADLPDAEHLVIA
                     RDDAPMNLAGALTPEPDAEGPSSWLRTHGLHYHHVRLLAEHGVARHLTGHGGDELFYVM
                     PQHDHSLLRTAPLSYLPHLRSNLSLRRWTLGRALRFLADNTSYRRWLADCARTLTEPLP
                     KTSDPSMGWGEPPRMPPWTTSRAVELNRALLLAAARRAPKPLSPLRAQHATLDMVRVCG
                     DGVRRASWMSARHDVSWHAPFVDDRVVEAALSIRLQDRVAANRYKPVLAEAMRPVVPGH
                     VLGRPTKGEFSADVYAGFAHHKRELLEQCEQLELERFGLVDADAFRRALLAPHPASRDL
                     MPLLGTLACEAWLRSVAALTTTTGGKS"
     gene            complement(7071..7196)
                     /locus_tag="YIM_29265"
     CDS             complement(7071..7196)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (lassopeptides)
                     predicted lassopeptide"
                     /gene_kind="biosynthetic-additional"
                     /inference="ab initio prediction:Prodigal:2.6"
                     /locus_tag="YIM_29265"
                     /product="hypothetical protein"
                     /protein_id="QFU91025.1"
                     /transl_table=11
                     /translation="MIDENTVYEPPAMTSVGEFDEVTLGGGGRGYEYNKQCLIFC"
     CDS_motif       complement(7125..7196)
                     /prepeptide="leader"
                     /note="peptide class: {self.peptide_class}"
                     /note="predicted sequence: MIDENTVYEPPAMTSVGEFDEVTL"
                     /locus_tag="YIM_29265_lassopeptide"
                     /aSTool="lassopeptides"
                     /tool="antismash"
     CDS_motif       complement(7071..7124)
                     /prepeptide="core"
                     /locus_tag="YIM_29265_lassopeptide"
                     /peptide="lassopeptide"
                     /predicted_class="Class III"
                     /score="-1.00"
                     /molecular_weight="1849.1"
                     /monoisotopic_mass="1847.8"
                     /core_sequence="GGGGRGYEYNKQCLIFC"
                     /aSTool="lassopeptides"
                     /tool="antismash"
                     /leader_sequence="MIDENTVYEPPAMTSVGEFDEVTL"
                     /leader_location="[7124:7196](-)"
     gene            complement(7233..7400)
                     /locus_tag="YIM_29270"
     CDS             complement(7233..7400)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (lassopeptides)
                     predicted lassopeptide"
                     /gene_kind="biosynthetic-additional"
                     /inference="ab initio prediction:Prodigal:2.6"
                     /locus_tag="YIM_29270"
                     /product="hypothetical protein"
                     /protein_id="QFU91026.1"
                     /transl_table=11
                     /translation="MAESPPSEKELVFVNNESTVFEAPALIEVGDFDKVTLGSRGWGFE
                     PGVRCLIWCD"
     CDS_motif       complement(7290..7400)
                     /prepeptide="leader"
                     /note="peptide class: {self.peptide_class}"
                     /note="predicted sequence:
                     MAESPPSEKELVFVNNESTVFEAPALIEVGDFDKVTL"
                     /locus_tag="YIM_29270_lassopeptide"
                     /aSTool="lassopeptides"
                     /tool="antismash"
     CDS_motif       complement(7233..7289)
                     /prepeptide="core"
                     /locus_tag="YIM_29270_lassopeptide"
                     /peptide="lassopeptide"
                     /predicted_class="Class III"
                     /score="6.40"
                     /molecular_weight="2022.3"
                     /monoisotopic_mass="2020.9"
                     /core_sequence="GSRGWGFEPGVRCLIWCD"
                     /aSTool="lassopeptides"
                     /tool="antismash"
                     /leader_sequence="MAESPPSEKELVFVNNESTVFEAPALIEVGDFDKVTL"
                     /leader_location="[7289:7400](-)"
     gene            complement(7457..8887)
                     /gene="afsR29"
                     /locus_tag="YIM_29275"
     CDS             complement(7457..8887)
                     /codon_start=1
                     /gene="afsR29"
                     /gene_functions="regulatory (smcogs)
                     SMCOG1041:transcriptional regulator, SARP family (Score:
                     411.8; E-value: 1.2e-124)"
                     /gene_kind="regulatory"
                     /inference="ab initio prediction:Prodigal:2.6"
                     /inference="similar to AA sequence:UniProtKB:Q9S0Y6"
                     /locus_tag="YIM_29275"
                     /product="Regulatory protein AfsR"
                     /protein_id="QFU91027.1"
                     /transl_table=11
                     /translation="MLLFRVRLLGTFEIERTDESVEIIAMPAGRLRALFSALALRPGRP
                     VSMTEIADRLWDDEPPPGARTTIRGYIKRLRRLLDVPAEPSVISSGQHGYRLEMDPEHI
                     DLHRFRALLTRAAAATGTDDEPALLREALALWRGPAFCDVSSASLHREVVPALHEQYHE
                     AVHRRIECDLAAGAAADVIAELRHLVSENPLREGFWAQLMRALHDAGRPAEALAAYERC
                     RTVLAENLGADPGARLRELHRRILADGPEAAVPLVRPHQLPPEVPRFVGRERELSRLDE
                     ERSAPVVISGPPGVGKTALVTRWGRRHQDRFPDGELYVDLTGLSTLEALEILLAGIGGT
                     ARLPSGVNARSALFRTLLAGRRMLLVLDNALSAEQVRPLLPGGAHVVLITSVDTLPGLT
                     TSAGAERLELAPLSADEASALLGELLGSRRRAVESKGLIELAGVCSGLPLTLRVAAEHA
                     DRNPGLSLAEYAAVLRSE"
ORIGIN
        1 tcagtcgacg gcgacggtgc ctccgtccct tgtccagtag tcgaccaggc gcgcgtagtc
       61 cgccgaaccg tgcaggagtt cctcgtgcgt gccctgcacc agcgatcccg cacccatcag
      121 caggacccgc tcggcacgca tcgccgaact gatccggtgg gcgaccacga tcagcgtgcc
      181 cggccgccgc gcgaacgcct cttcggcgac cgcttcggcc cgcgggtcca gatggcaggt
      241 cgcttcgtcc aggatcacca cgcgggccgg cgacagatac accctggcga gcgtgatcag
      301 ttgccgctcg ccaccggaaa ggttgtccgg ccggatctcc ccgtcgagcc cgccgtgccg
      361 ggtgatcagt tcggtcaaac cgaacaccgc ggccgcgctg accagttccg cgtcctcggc
      421 ggccggtgcg agatacgcga ggttctcccg caccgtgccg gcgaagacat acgcctcctg
      481 cggcaccagc gcgacagacc ggcgaagcca ttccgtgcgc aggtcccgca ggttgacgcc
      541 accgagcgcc acgctacccg cttcggggga ttcgagtccg gcgaacacgt tgaccaatgt
      601 ggacttcccg atgccgctcg gcccgaccac gaccagccgg gtgccctcgt cgagggtcag
      661 gtccgcgttc gcgagtaccg gttcggactg ggggccgtag cggaaggtga cccctcgcaa
      721 cgcgaggtcg taccggctcg cttcgagaga gcctccgctc tccgcggaaa tcccggtgcc
      781 ggacaacctc gccagcacgg tcgcgacttc cagggcctgg ttgccgagca gttcggtgat
      841 cgcgcgccag gcgggttcga gtccggtcgc caggtacgtg atcgcgccga ccagttcccc
      901 aacggtcaac gcccctcgcg agaccagaac cggtgccagc agcaacagga cgatcaacgg
      961 caggtgcccg gccaggccga tcacgccgat cctcgcaccg ctgatcccgg caaccccggt
     1021 cgccgcttcc gcgctcgcgc gcagtcggcg atcggtgtcg ccggcggccc gcccggccgc
     1081 gtcacaggcg gcgatgtcgc gcgttcccgc cagcaccagg tccagttcgg cggccagctc
     1141 ttcctcgcac gccaacgact tctcgtacct gcgccgccac acccccgaca accggacgag
     1201 caggaccccg gccggcagca tgatcggcac cagcgcgacg accatcgcgg gcaccagtgc
     1261 caccaggccg gcgcacgccg cgatggtcat cagcaccgcc gagctgatcg ccatcaccag
     1321 gttggacagg atctggcgaa ccgtctcggt ctggccgatg atccgcgcgg cgaaacccgt
     1381 ccgcgccgcg aatccggccg aaaccgcggt gtgcaggctg gtgtggacca cttggtgcac
     1441 gaggtggtca cgcaccgctt cggccaggac ggccatcggc cccatcgcct gccgcgtggc
     1501 gaccgcgccg agcccgagag acgcgccgta gcagccgagg atcgccagtc cgaacccggc
     1561 gttcccggcc aggaatcccc ggtccagcgc caccgcgacc agcaggccgg acaacagcgt
     1621 ggggaccgcg cccagcaacg accagcacag caccatcacc agcgcacggc ggtttttgtt
     1681 gatcggcggt gaaatcatcc gccacgccac ggagttcacc gcacctccga cccggcggcg
     1741 gccggttgcc gcaggccgaa caacgcgcgg tagtccggat cccgcacgag ttcccgatga
     1801 ggggccaacg cccggatccg gccgctgtcc agccaggcga ccagatccgc cgacgccgcg
     1861 gtggccgccc ggtgcgcgac gatcagccgg gtccggccac gcagtgcacg gtccagcgcc
     1921 gccgtgacct cggcttcggt cgcggtgtcc aaactggacg tggcgtcgtc cagcacgacc
     1981 accctcgcgt cccgccacgc cgccctggcg aggccgaggc gttgcagctc accgccggac
     2041 agcagcaacc ggctccggcg cgtcccggct ccggcaggca ggcggcgcac gaaatcggct
     2101 gccgcgctga cccgcagcgc ctgctcgacc tgcgccgggg tggccgggtg atcggcgtag
     2161 gcgatcgcgt ccgcgaccgt ttcgccgtgc agcaccggct tttcgaaggc gtaggtcacc
     2221 gccccgccca gctcgtcacg ccggagttcg gtcagcggca cgccgtcgag gcgcaccgac
     2281 cccgcctccg gaaccagcag gccaccggcg acctcggtca gcgtggactt cccggcgccg
     2341 gaccggccga cgatcgcgat cgccaccccc ggcgggaagt cgacgtcgac gccgtcgagc
     2401 accgggctca cccgtacccc gcgcaggctc agcgcgcccg gccccggcgg cagcgtcctg
     2461 gtaccggccg gccgcaccgg ctccgccagc acctcggcga ccatggtcgc cgaacccagc
     2521 gcccgcgcga ccctgcccag caccatggtc tgctggaaca tgccgacggc gaagccgaag
     2581 tacccctgcg cggcgaggag ttcaccggcg gtcatccgtc cgtgcagcac gctgtagccc
     2641 gccaccgcga gcacggccac ctgcagcaac ggcatcacca ggttgacgcg gaaggccgcg
     2701 gtccggagca cccgccagaa ctcgtgcccc gcggcggtca gcgcgggcag tcccgcgacc
     2761 acgcggtcga cctcgcgagc ggccgttccg ctcgccctga tcgtccgcgc cccgcggacc
     2821 gcgtcggtga accggccggt caactccccc tgccgggtct ggtaatcggt ggtgttcgca
     2881 ctcatccggc gggtcagcag gcccgcctgc caccagatca gtggtgccgc ggccagcacg
     2941 atcaggccca gccggaggtc gagcagcacg agcagcacca gtccggcgat cgaggtgacc
     3001 accgagacca gcagggcggt cagcgcggtc accgcgctcg aggtcatcgc ggccgactgc
     3061 gagatccggc cgagcaggtc accggtgccg taccgccgga acgcgccgag atccaggcgg
     3121 agcaggtgcc gcaccagcct gcgccggagc gacaacgtgc cactgacctg cgcccgtttc
     3181 tccagcacca ccgtgcccgc cccggcggcg gagcccagca cgagcacgac gcagaccagc
     3241 gcgatcgcgg cgccgctgct cccccggccg ctgatcgcgt ccaccgcggc cgccagtgca
     3301 cccggcacgg ccagcagcgc cgccacctcg accgccgtca gtaccagcaa cgcgagaccg
     3361 tcacgacccg aggaccgcac cgaactccac agtgtcctgg cgtcgcggcg gagatcaccg
     3421 accggcatcg gatccgccgg ccagccgtgc ccgtaccgcg gggaaaacct cgcgcgccag
     3481 ccgatcgagc acaccgggcg cggccgaggt ccggccgaac ggctcgacct ggcacagcac
     3541 ccggtgacac ccggacacgg agatgttgtg caccaggcgg tccacacagg tttcggcatc
     3601 acccaccgcg tgcatcgcca gcagccggtc ggtgatctcc tcggtcagcg cttccagctc
     3661 ggccccgctg ggccgggtgt cgggcatcgc gatcagcatc cggtcccggt tgccgccctt
     3721 gagcatggcg cgggcacgct cacgcatcag ctcgcgtgct tcgtccgccg tctccgtgag
     3781 gtaggtgtac aacgcgaacg cgtggtcggc cggggccgtc gcgtcacccg cgaagcgccg
     3841 gtagtcctcg atcatcaggg ccttggtcgc ggcgtccttg tcgaagtaga ggagcatcgg
     3901 cagcccgcgt tcggccgcca gccgcaccga gtcctcggaa ttggccgcca cgtacaccgg
     3961 cggcccacca ggcgtggcgg gcagcggcac cagcggcagc ggttccggac cgggtacttt
     4021 gccgtcgagt gcggcgagcg tgtgatcgag ggcgccggtc atccccgaac gccagtgttc
     4081 gacgccgccg ccgatgacgt cgtattcgac caacggctgg ccgcggccga caccgagcac
     4141 gaaccggccg ccggagacct ggtcgagcaa cgccgcctgc tcggcggtgt gcaccggcga
     4201 gtgcagcggg agcagggtga ccgcggtacc gacggtgatc cgctcggtgg cgccgagcag
     4261 gtaggccgcg agcgccatcg aggaggggga caccaccgaa tccaggaagt ggtgctcggt
     4321 gatccagacg tcgtccaccc cgagcgcgtc ggcttgcctg gccagcgcca ccgagcggcg
     4381 gagcacgtcg gtgtcggact ggccggcgtc ccggtgcgag ccgagcagca ccccgaaccg
     4441 gacggaatcg gcagctgaca tggcggggcc ctcttttctc atgcgggtac ggacagcacg
     4501 acgtggtagg cacgcatgtc ttcggcctcg ccgatggcgt tgccgtcgac ctcgacccag
     4561 gcgtgcgccc ggaacggttc cgtgcgcacg cccgtgcgcc agtcgggcca ggttccggtc
     4621 aaccggcaga gcaacgcggt cgcgatggcc cgctggaggc actgctgccc ggcgcaccgc
     4681 ttgctcaccg acaccaccgc ctgacgcgcg cccatcgcct gctccgcggt cgccgggcgg
     4741 gcacccgtct tcgccagttc gaggactttg cggagccgga agggtttggc gtgcatgaga
     4801 atccgcgcga cggtcacggc ggcatgagcg gcgatccgct tcggaaccgg gacccggccg
     4861 gcggtttcga gggtgatcgg cagcgtcatc ccgtcaccag cttcgcctgt cgcagcgcac
     4921 gcgtgaactc ggagaccgtt tcggcgaccc gctcggcgtc cgccgggaac cgtgcacaca
     4981 ggacagtcgc cgcgtcgtcc ggctgtccgc cgtcgaggag ggtgcggatg accaccgccg
     5041 ccgtcgtgtt gagctgccag taccggccgg atcgctggtc cagcaacacc attccactgt
     5101 cggtttcggt caccgacacg tggtcggcca gtaccaggct catgactttc ctccagtcgt
     5161 ggtggtgagc gcggcgaccg accgcagcca ggcctcgcag gccagggtgc ccagcagcgg
     5221 catcaggtcg cgggacgcgg gatggggcgc cagcagcgcc cggcggaacg cgtcggcgtc
     5281 gaccaggccg aaccgctcca gttccagttg ctcgcactgc tccagcagtt cacgcttgtg
     5341 gtgggcgaaa ccggcgtaga cgtcggcgct gaactcaccc ttggtcggcc tgccgagcac
     5401 gtgccccggc acgaccggcc gcatggcctc ggccagcacc ggcttgtacc ggttcgccgc
     5461 gacgcggtcc tgtagtcgga tcgacaacgc cgcctcgacc acccggtcgt cgacgaacgg
     5521 cgcgtgccag ctcacgtcgt gccgggcgct catccagctc gcccggcgca caccgtcacc
     5581 gcaaacgcgc accatgtcga gcgtcgcgtg ctgggcccgc aagggagaca acggcttcgg
     5641 cgcccgccgg gcggcggcga gcaggagcgc gcggttcagt tcgaccgcgc gcgaagtggt
     5701 ccacggtggc atcctcggcg gctcacccca gcccatgctg ggatcggagg tcttcggcag
     5761 cggttcggtg agcgtgcgag cgcagtcggc cagccagcgc cggtagctgg tgttgtccgc
     5821 gaggaagcgc agggcacgcc ccagcgtcca gcggcgcagg ctgaggttgg accgcaggtg
     5881 cggcaggtag ctcagcggcg cggttcgcag caggctgtgg tcgtgctggg gcatcacgta
     5941 gaacagctcg tccccgccgt gcccggtcag atgccttgcc acgccgtgtt ccgcgagcaa
     6001 ccgcacgtgg tggtagtgca gtccgtgcgt ccgcagccag gacgacggtc cttccgcgtc
     6061 cggctcggga gtgagcgcgc cggcgaggtt catcggcgcg tcatcgcgcg cgatgaccag
     6121 gtgttcggcg tccggcaggt cggcggcggc cttcgacgcc cagatcacat cgtcgttcgc
     6181 gctgtccact gcctcgaacc gcgtcgtgag cagctcaccg gggtgtttcg cgagcaggaa
     6241 ggcaagactg gtcgagtcca tcccgccgga caggtccgag ctggtgcggc cgggcagcga
     6301 agcacgcgcg gccaccccgg cttcgagcgc ggccctgacc gcggccgccc cttcccgcaa
     6361 cggcagttcc ggctccggaa tggtccacca cgccgaaatc cggcaaccgc cgtccggttt
     6421 catcgtcagg taggcgtccg gcggtacccg ctcgatgccg tgccacgcgc actcgtcctc
     6481 caacggccac ggtggcgccg tgaccatgag gtagcgggcg agcaacgact cgtcgaggcc
     6541 cgttccggcg agtgccgcca gcgtttgcgg ccgatcggcg agcacggtgg tgccgcgcac
     6601 gcgtgtgtag tagatctggc agactgcgga gatcgtgccc tgcgcgcgaa cccgtccgcc
     6661 gaacgccgcc agcagatgac tgcttcccgg caacgcgccg gccagccggt cgagctgcga
     6721 aaggtcctcc acgcgctcga gttccgaacg cagtttcgct tcggtgatcc ccggccagcc
     6781 gagcagcacg agcacgcggt caccgatccg ggtggagacg atctcgtcgt cccgccattc
     6841 accggcgatc catggccgcc cggacgggta cgcgatcgtc cgggcggacg gctcggccga
     6901 ttcggcgacc gcccggccgg gatcactgtc cgggaaaatc gtgaacttca ctttcagcct
     6961 ccagcggcca atggcggaac agcgccattt ttcgacgttc tccgtgaaat cccgtgccgg
     7021 cgcgggggca gggaaacacc gcaccggcac gggcgttcag cgcacgcgga tcagcagaag
     7081 atcaggcact gcttgttgta ctcgtatccc cggccgccgc caccgagggt gacctcgtcg
     7141 aactcaccga cggacgtcat cgcgggcggc tcgtaaaccg tgttttcgtc gatcatcttt
     7201 cagctcccag ttctgtgatg ggggaattgc ggtcagtcgc accagatgag gcagcgcacg
     7261 ccgggctcga aaccccagcc gcgcgaaccg agggtcacct tgtcgaaatc gccgacctcg
     7321 atcagcgccg gcgcctcgaa cacagtggac tcgttgttca cgaaaaccag ctccttctcg
     7381 cttggcgggc tttccgccac gagaacgacg ctcccacccc ggcgtggcaa tcgcgttgca
     7441 ccgcggtggc aacgaatcat tccgaccgca gtaccgccgc gtattccgcc agtgagagac
     7501 cgggattccg gtcggcgtgt tcggcggcga cgcgcaaggt cagcggcagt cccgaacaca
     7561 ccccggcgag ttcgatgagg cccttcgatt cgacggcacg gcggcgcgag ccgagcagtt
     7621 cccccagcag ggccgatgcc tcgtccgcac tgagcggcgc gagttcgagt cgttccgcgc
     7681 cggcggaggt ggtcagcccc ggcaaggtgt cgacgctggt gatgagcacc acgtgcgccc
     7741 cgccgggcag cagcggccgc acctgttcgg cgctgagcgc gttgtccagt accagcaaca
     7801 tcctccggcc cgccagcaga gtccggaaca gggcgctcct ggcgttcaca ccggagggca
     7861 ggcgagcggt gccgccgatc ccggcgagga ggatctccag cgcttccagc gtgctgagac
     7921 cggtgagatc cacgtacagc tcaccgtcgg ggaaacggtc ctggtgtctt cgtccccagc
     7981 gcgtcacgag ggcggtcttg ccgaccccgg gcggtccgct gatgacgacc ggtgcggacc
     8041 gctcctcgtc caggcgcgaa agttcgcgct cacgcccgac gaagcggggc acttcaggcg
     8101 gtagctggtg cggccgcacc agcgggacgg ccgcttccgg tccgtcggcg aggatgcgcc
     8161 ggtgcagttc gcgcagccgg gcgcccgggt cggcgcccag gttctcggcg aggacggtgc
     8221 ggcatcgctc gtaggcggcg agtgcctcgg ccgggcggcc cgcgtcgtgg agcgcacgca
     8281 tgagctgggc ccagaagcct tcccgcagcg ggttttcgct caccaggtga cggagttcgg
     8341 cgatgacgtc ggccgccgcg ccggcggcga ggtcgcattc gatgcggcgg tggacggctt
     8401 cgtggtactg ctcgtgcaac gccggtacca cttcgcggtg caaggatgca ctggagacgt
     8461 cacagaaagc cggtccgcgc cacaaggcga gcgcctcgcg gagcagcgcg ggttcgtcgt
     8521 cggtgccggt ggccgccgcg gcacgggtca gcaaggcgcg gaagcggtgg agatcgatgt
     8581 gttcggggtc catttccaac cggtagccgt gctgaccgga agaaatgacc gaaggctccg
     8641 ccgggacgtc gagcaaacgg cggaggcgtt tgatgtaacc gcggatggtg gtgcgggcac
     8701 cgggtggtgg ttcgtcgtcc cacaggcgat ccgcgatttc ggtcatcgag accggcctgc
     8761 ccggccggag tgccaacgcg gagaacaacg cgcgaagcct gcctgccggc atggcgatga
     8821 tctcgacgga ttcgtccgtc cgctcgatct cgaaggtgcc gagcaggcgc acacggaaca
     8881 ggagcac
//
