BGC0002064 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002064 (Amycolatopsis sp. YIM 10)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	lassopeptide	1	8,887	felipeptin A2/felipeptin A1	ribosomal:RiPP	100%

BGC0002064 - Region 1 - lassopeptide

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Location: 1 - 8,887 nt. (total: 8,887 nt) Show pHMM detection rules used

Region on contig edge.

lassopeptide: (PF13471 and Asn_synthase or micJ25 or mcjC)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

MIBiG comparison

KnownClusterBlast

Lasso peptides

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 8,888
Label		BGC0002064

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002064	0.93	RiPP	felipeptin A2, felipeptin A1	Amycolatopsis sp. YIM 10
BGC0001539	0.35	RiPP	cattlecin	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0002053	0.35	RiPP	ulleungdin	Streptomyces sp.
BGC0001548	0.34	RiPP	citrulassin A	Streptomyces albulus
BGC0002150	0.32	RiPP	triculamin	Streptomyces triculaminicus
BGC0002151	0.32	RiPP	alboverticillin	Streptomyces griseocarneus
BGC0001496	0.32	RiPP	actinokineosin	Actinokineospora spheciospongiae
BGC0002006	0.32	RiPP	albusnodin	Streptomyces albus
BGC0001507	0.32	RiPP	anantin C	Streptomyces olindensis
BGC0001552	0.31	RiPP	citrulassin F	Streptomyces avermitilis MA-4680 = NBRC 14893

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002064	0.98	RiPP	felipeptin A2, felipeptin A1	Amycolatopsis sp. YIM 10
BGC0001539	0.68	RiPP	cattlecin	Streptomyces cattleya NRRL 8057 = DSM 46488
BGC0002053	0.68	RiPP	ulleungdin	Streptomyces sp.
BGC0001548	0.67	RiPP	citrulassin A	Streptomyces albulus
BGC0002150	0.66	RiPP	triculamin	Streptomyces triculaminicus
BGC0002151	0.65	RiPP	alboverticillin	Streptomyces griseocarneus
BGC0001496	0.65	RiPP	actinokineosin	Actinokineospora spheciospongiae
BGC0002006	0.65	RiPP	albusnodin	Streptomyces albus
BGC0001507	0.65	RiPP	anantin C	Streptomyces olindensis
BGC0001552	0.64	RiPP	citrulassin F	Streptomyces avermitilis MA-4680 = NBRC 14893

Similar known gene clusters from MIBiG 4.0

Lasso peptide predictions

Lassopeptide(s) for YIM_29265

YIM_29265

Leader:

MIDENTVYEPPAMTSVGEFDEVTL

Full core:

GGGGRGYEYNKQCLIFC

Putative macrolactam:

GGGGRGYE

antiSMASH-DB 4.0 matches for YIM_29265

100.0% NZ_CP045480.1: Lassopeptides: YIM_RS29075_lassopeptide

GGGGRGYEYNKQCLIFC

70.6% NZ_JANAVO010000007.1: Lassopeptides: NLX83_RS29380_lassopeptide

GGGGRGYEYNKQCLIFC

GGGGRGY+Y++QC I C

GGGGRGYDYSRQCWIIC

44.4% NZ_CP045480.1: Lassopeptides: YIM_RS29080_lassopeptide

GGGGRGYEYNKQCLIFC

G G G+E +CLI+C

GSRGWGFEPGVRCLIWC

with 7 more sequence matches

41.2% NZ_CP058693.1: Lassopeptides: HYQ63_RS23815_lassopeptide

GGGGRGYEYNKQCLIFC

GG G G++ ++C +FC

GGEGHGWDAVQECAMFC

38.9% NZ_JANAVO010000007.1: Lassopeptides: NLX83_RS29385_lassopeptide

GGGGRGYEYNKQCLIFC

G G G+E++ +CL +C

GPKGWGFEWDVRCLTWC

35.3% NZ_CP014859.1: Lassopeptides: TL08_RS27980_lassopeptide

GGGGRGYEYNKQCLIFC

G G G+E + C++ C

GRPGWGFEADWTCVMLC

35.3% NZ_JACJIA010000014.1: Lassopeptides: HNR61_RS37845_lassopeptide

GGGGRGYEYNKQCLIFC

G G+E + C++FC

GRPSWGFEADWTCVMFC

35.3% NZ_WBMT01000001.1: Lassopeptides: F8566_RS01795_lassopeptide

GGRGYEYNKQCLIFC

G G++ QC I C

GTWGWDDYDQCWILC

28.6% NZ_FNVO01000018.1: Lassopeptides: C4U03_RS29970_lassopeptide

GGGGRGYEYNKQCLI

G G++Y QCL

GPKTWGFDYTWQCLF

26.1% NZ_CP050134.2and 3 others:

NZ_EQ973330.1 Lanthipeptides: CORMATOL_RS10565_lanthipeptideNZ_LR134504.1 Lanthipeptides: EL293_RS07240_lanthipeptideNZ_LR134504.1 Lanthipeptides: EL293_RS07240_lanthipeptide

Lanthipeptides: HBA49_RS00770_lanthipeptide

GGGGRGYEYNKQCLIFC

G GR K+C+ C

GNNGRWCTITKECMPSC

MIBiG 3.1 matches for YIM_29265

13.6% BGC0000553 (SSGG_RS09925): Lanthipeptide: SRO15-2212

EYNKQCLIFC

EY+ ++ C

EYSSLSVVLC

Lassopeptide(s) for YIM_29270

YIM_29270

Leader:

MAESPPSEKELVFVNNESTVFEAPALIEVGDFDKVTL

Full core:

GSRGWGFEPGVRCLIWCD

Putative macrolactam:

GSRGWGFE

antiSMASH-DB 4.0 matches for YIM_29270

100.0% NZ_CP045480.1: Lassopeptides: YIM_RS29080_lassopeptide

GSRGWGFEPGVRCLIWCD

72.2% NZ_JANAVO010000007.1: Lassopeptides: NLX83_RS29385_lassopeptide

GSRGWGFEPGVRCLIWCD

G +GWGFE VRCL WCD

GPKGWGFEWDVRCLTWCD

44.4% NZ_CP014859.1: Lassopeptides: TL08_RS27980_lassopeptide

GSRGWGFEPGVRCLIWC

G GWGFE C++ C

GRPGWGFEADWTCVMLC

with 11 more sequence matches

44.4% NZ_CP045480.1: Lassopeptides: YIM_RS29075_lassopeptide

GSRGWGFEPGVRCLIWC

G G G+E +CLI+C

GGGGRGYEYNKQCLIFC

42.1% NZ_CP013979.1: Lanthipeptides: allorf_0350694_0350801_lanthipeptide

SRGWGFEPGVRCLIWCD

S GWGFE +R + C

SEGWGFES-LRAHLHCK

38.9% NZ_CP016076.1and 1 other:

NZ_CP022521.1 Lassopeptides: AHOG_RS07240_lassopeptide

Lassopeptides: UA74_RS07790_lassopeptide

GSRGWGFEPGVRCLIWC

G WGFE C++ C

GRPSWGFEADWSCVMVC

38.9% NZ_CP053892.1and 1 other:

NZ_PVZC01000005.1 Lassopeptides: CLV72_RS18890_lassopeptide

Lassopeptides: ACTIVE_RS19740_lassopeptide

GSRGWGFEPGVRCLIWC

G WGFE C++ C

GRPSWGFENDWSCVMLC

38.9% NZ_JACJIA010000014.1: Lassopeptides: HNR61_RS37845_lassopeptide

GSRGWGFEPGVRCLIWC

G WGFE C+++C

GRPSWGFEADWTCVMFC

38.9% NZ_JAICDG010000008.1: Lassopeptides: K2F47_RS37585_lassopeptide

GSRGWGFEPGVRCLIW

G R WGF+ +C +W

GDRSWGFDRINQCAMW

28.6% NZ_FNVO01000018.1: Lassopeptides: C4U03_RS29970_lassopeptide

GSRGWGFEPGVRCLI

G + WGF+ +CL

GPKTWGFDYTWQCLF

25.0% NZ_JAHFZY010000001.1and 2 others:

NZ_JAICDF010000001.1 Lassopeptides: K2F48_RS02145_lassopeptideNZ_WOFH01000001.1 Lassopeptides: GNZ18_RS04445_lassopeptide

Lassopeptides: KLI87_RS04430_lassopeptide

GSRGWGFEPGVRCLIW

G + WGF+ +C +

GDKTWGFDRINQCAFY

23.5% NZ_CP022203.1: Lanthipeptides: allorf_7615693_7615869_lanthipeptide

RGWGFEPGVRCLI

RGW G RCLI

RGWPLYAGRRCLI

20.0% NZ_CP051884.1and 2 others:

NZ_CP051884.1 Lanthipeptides: HGK68_RS15125_lanthipeptideNZ_CP051884.1 Lanthipeptides: HGK68_RS15125_lanthipeptide

Lanthipeptides: HGK68_RS15125_lanthipeptide

GSRGWGFEPGVRCLIWC

G+ GW C+ WC

GNNGWLCTITHECMSWC

11.4% NZ_CDME01000002.1: Lanthipeptides: allorf_0013521_0013739_lanthipeptide

EPGVRCLIW

+P +RCL W

QPSLRCLPW

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Lasso peptides

Core peptide predictions

YIM_29265 - Class III: Cleavage pHMM score: -1.00; RODEO score: 23; Monoisotopic mass: 1847.8 Da; Molecular weight: 1849.1 Da; Number of bridges: 1
YIM_29270 - Class III: Cleavage pHMM score: 6.40; RODEO score: 22; Monoisotopic mass: 2020.9 Da; Molecular weight: 2022.3 Da; Number of bridges: 1