BGC0002066: harzianopyridone biosynthetic gene cluster from Trichoderma harzianum
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Location: 16,184 - 48,619 nt. (total: 32,436 nt).
This entry is originally from NCBI GenBank JOKZ01000072.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002066
Short description harzianopyridone biosynthetic gene cluster from Trichoderma harzianum
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Iterative type I)
Loci
JOKZ01000072.1
16184 - 48619
via Enzymatic assays, Heterologous expression, Gene expression correlated with compound production
Compounds
  • harzianopyridone
Species Trichoderma harzianum [taxonomy]
References
Chemical products information
harzianopyridone Evidence: NMR, Mass spectrometry, Total synthesis
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Chemical database entries
PubCHEM
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • THAR02_03282
  • KKP04592.1
 16184 - 18506 (+) Transcription factor
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    • THAR02_03283
    • KKP04593.1
    		 18799 - 20174 (-) O-methyl transferase
    • Tailoring
    • Activity assay
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    • THAR02_03284
    • KKP04594.1
    		 21374 - 22719 (+) Flavin-dependent monooxygenase
    • Tailoring
    • Activity assay
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    • THAR02_03285
    • KKP04595.1
    		 23291 - 25243 (-) cytochrome P450 monooxygenase
    • Tailoring
    • Activity assay
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    • THAR02_03286
    • KKP04596.1
    		 25628 - 26741 (+) trans enoyl-reductase
    • Precursor biosynthesis
    • Other in vivo study
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    • THAR02_03287
    • KKP04597.1
    		 27410 - 29044 (+) Flavin-dependent monooxygenase
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      • THAR02_03288
      • KKP04598.1
      		 29500 - 31120 (-) cytochrome P450 monooxygenase
      • Scaffold biosynthesis
      • Other in vivo study
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      • THAR02_03289
      • KKP04599.1
      		 31830 - 43697 (+) Non-ribosomal peptide synthetase - Polyketide synthase
      • Precursor biosynthesis
      • Other in vivo study
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      • THAR02_03290
      • KKP04600.1
      		 43947 - 45158 (-) Transcription factor
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        • THAR02_03291
        • KKP04601.1
        		 46187 - 48619 (+) major facilitator superfamily transporter
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          Biosynthesis information

          Biosynthetic modules

          Name
          2
          Type
          nrps-type1
          Genes
          THAR02_03289
          Substrates
          tyrosine (evidence: Structure-based inference, Heterologous expression)
          Integrated Monomers
          Domains
          condensation (LCL), adenylation
          Name
          1
          Type
          pks-modular
          Genes
          THAR02_03289
          Substrates
          Integrated Monomers
          Domains
          acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, methyltransferase
          Annotation changelog

          Entry version: 2

          Date
          Changes
          Submitters
          Reviewers
          2022-10-07
          Update chemical activity to schema version 2.11
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          2022-10-07
          Changed chemical structures for compounds: harzianopyridone.
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          2022-10-07
          Added NPAtlas links to compounds: harzianopyridone.
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

          Entry version: 1

          Date
          Changes
          Submitters
          Reviewers
          2022-09-15
          Submitted
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          2022-09-15
          Corrected NRP module activity
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          2022-09-15
          Removed gene names of 'No gene ID'
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          2022-09-15
          Added version to NCBI accession
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          2022-09-15
          Added SMILES
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          Detailed domain annotation
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