BGC0002066: harzianopyridone biosynthetic gene cluster from Trichoderma harzianum
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Location: 16,184 - 48,619 nt. (total: 32,436 nt).
This entry is originally from NCBI GenBank JOKZ01000072.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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Gene details
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General
Compounds
Genes
Polyketide
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002066
Short description harzianopyridone biosynthetic gene cluster from Trichoderma harzianum
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP
  • Polyketide (Other)
Loci NCBI GenBank: JOKZ01000072.1
Compounds
  • harzianopyridone
Species Trichoderma harzianum [taxonomy]
References
Chemical products information
harzianopyridone
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Chemical database entries
PubCHEM
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • THAR02_03282
  • KKP04592.1
 16184 - 18506 (+) Transcription factor
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  • THAR02_03283
  • KKP04593.1
 18799 - 20174 (-) O-methyl transferase
  • Tailoring (Methylation)
Activity assay
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  • THAR02_03284
  • KKP04594.1
 21374 - 22719 (+) Flavin-dependent monooxygenase
  • Tailoring (Hydroxylation)
Activity assay
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  • THAR02_03285
  • KKP04595.1
 23291 - 25243 (-) cytochrome P450 monooxygenase
  • Tailoring (Hydroxylation)
Activity assay
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  • THAR02_03286
  • KKP04596.1
 25628 - 26741 (+) trans enoyl-reductase
  • Precursor biosynthesis
Other in vivo study
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  • THAR02_03287
  • KKP04597.1
 27410 - 29044 (+) Flavin-dependent monooxygenase
  • Unknown
Other in vivo study
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  • THAR02_03288
  • KKP04598.1
 29500 - 31120 (-) cytochrome P450 monooxygenase
  • Scaffold biosynthesis
Other in vivo study
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  • THAR02_03289
  • KKP04599.1
 31830 - 43697 (+) Non-ribosomal peptide synthetase - Polyketide synthase
  • Precursor biosynthesis
Other in vivo study
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  • THAR02_03290
  • KKP04600.1
 43947 - 45158 (-) Transcription factor
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  • THAR02_03291
  • KKP04601.1
 46187 - 48619 (+) major facilitator superfamily transporter
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Polyketide-specific information
Subclass Other
Starter unit Acetyl-CoA
Cyclic? no
Polyketide-synthases
Genes Properties Modules
THAR02_03289
+
THAR02_03289 		Synthase subclass: Iterative type I
Iterative PKS type: Partially reducing, Unknown
Iteration counts: 3
Module 1
Specificity: Acetyl-CoA
Evidence for specificity: Sequence-based prediction
Genes: THAR02_03289
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Ketoreductase
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: Unknown
Non-canonical activity:
  • Iterated
Evidence for non-canonical activity:
  • Structure-based inference
NRP-specific information
Subclass N/A
Cyclic? yes
NRP-synthases
Gene Modules
THAR02_03289
Module 2 [inactive]
Specificity: tyrosine
Evidence for specificity:
  • Structure-based inference
  • Heterologous expression
Condensation domain type: LCL
Annotation changelog
MIBiG version Submitter Notes
3.0
  • Hidden contributor (ID: PAM2M7KUAUIJ3CVOXWVXWGKQ, no GDPR consent given).
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Hidden contributor (ID: 3UOU7PODQJXIM6BEPUHHRRA5, no GDPR consent given).
  • Submitted
  • Corrected NRP module activity
  • Removed gene names of 'No gene ID'
  • Added version to NCBI accession
  • Added SMILES
  • Updated NRP substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
  • Changed chemical structures for compounds: harzianopyridone.
  • Added NPAtlas links to compounds: harzianopyridone.
Detailed domain annotation
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