BGC0002067: atpenin B biosynthetic gene cluster from Penicillium oxalicum 114-2
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Location: 3,583,596 - 3,620,596 nt. (total: 37,001 nt).
This entry is originally from NCBI GenBank KB644415.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002067
Short description atpenin B biosynthetic gene cluster from Penicillium oxalicum 114-2
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Iterative type I)
Loci
KB644415.1
3583596 - 3620596
via Heterologous expression
Compounds
  • atpenin B
Species Penicillium oxalicum 114-2 [taxonomy]
References
Chemical products information
atpenin B Evidence: NMR, Total synthesis
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Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • PDE_09192
  • EPS34228.1
 3583596 - 3584690 (-) hypothetical protein
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    • PDE_09193
    • EPS34229.1
    		 3585551 - 3586517 (+) hypothetical protein
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      • PDE_09194
      • EPS34230.1
      		 3586739 - 3588169 (-) flavin-dependent monooxygenase
      • Tailoring
      • Other in vivo study
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      • PDE_09195
      • EPS34231.1
      		 3589650 - 3590401 (+) hypothetical protein
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        • PDE_09196
        • EPS34232.1
        		 3592283 - 3593795 (+) o-methyl transferase
        • Tailoring
        • Other in vivo study
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        • PDE_09197
        • EPS34233.1
        		 3594131 - 3596247 (-) transcription factor
        • Regulation
        • Other in vivo study
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        • PDE_09198
        • EPS34234.1
        		 3599468 - 3611389 (-) nonribosomal peptide synthatase-polyketide synthase
        • Precursor biosynthesis
        • Other in vivo study
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        • PDE_09199
        • EPS34235.1
        		 3611851 - 3613568 (+) cytochrome P450 monooxygenase
        • Scaffold biosynthesis
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        • PDE_09200
        • EPS34236.1
        		 3614695 - 3616551 (-) flavin-dependent monooxygenase
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          • PDE_09201
          • EPS34237.1
          		 3617022 - 3618180 (-) trans-enoyl reductase
          • Precursor biosynthesis
          • Other in vivo study
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          • PDE_09202
          • EPS34238.1
          		 3618667 - 3620596 (+) cytochrome P450 monooxygenase
          • Tailoring
          • Other in vivo study
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          Biosynthesis information

          Biosynthetic modules

          Name
          2
          Type
          nrps-type1
          Genes
          PDE_09198
          Substrates
          tyrosine (evidence: Structure-based inference, Homology)
          Integrated Monomers
          Domains
          condensation (LCL), adenylation
          Name
          1
          Type
          pks-modular
          Genes
          PDE_09198
          Substrates
          Integrated Monomers
          Domains
          acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, methyltransferase
          Annotation changelog

          Entry version: 2

          Date
          Changes
          Submitters
          Reviewers
          2022-10-07
          Update chemical activity to schema version 2.11
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

          Entry version: 1

          Date
          Changes
          Submitters
          Reviewers
          2022-09-15
          Submitted
          • (ID: PAM2M7KUAUIJ3CVOXWVXWGKQ)
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          2022-09-15
          Corrected NRP module activity
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          2022-09-15
          Removed gene names of 'No gene ID'
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          2022-09-15
          Added version to NCBI accession
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          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          2022-09-15
          Remove duplicated gene ID
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          2022-09-15
          Updated bioactivity data
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          2022-09-15
          Updated NRP substrate specificities
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          Detailed domain annotation
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