BGC0002068: labrenzin biosynthetic gene cluster from Labrenzia sp. PHM005
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Location: 764,878 - 871,112 nt. (total: 106,235 nt).
This entry is originally from NCBI GenBank CP041191.1, but has been modified (see Modifications tab for details).

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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Gene details
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
Modifications
General information about the BGC
MIBiG accession BGC0002068
Short description labrenzin biosynthetic gene cluster from Labrenzia sp. PHM005
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Unknown)
Loci
CP041191.1
776792 - 856348
via Knock-out studies
Compounds
  • labrenzin
Species Labrenzia sp. PHM005 [taxonomy]
References
Chemical products information
labrenzin Evidence: NMR, Mass spectrometry
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Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • FJ695_03535
  • QDG75015.1
 776792 - 777850 (+) DUF3089 domain-containing protein
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    • FJ695_03540
    • QDG75016.1
    		 777969 - 778625 (+) ParA family protein
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      • FJ695_03545
      • QDG75017.1
      		 778622 - 779281 (+) DUF697 domain-containing protein
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        • FJ695_03550
        • QDG75018.1
        		 779515 - 780105 (+) DUF697 domain-containing protein
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          • FJ695_03555
          • QDG75019.1
          		 780635 - 781501 (+) prohibitin family protein
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            • FJ695_03560
            • QDG75020.1
            		 781467 - 782804 (+) ABC transporter substrate-binding protein
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              • FJ695_03565
              • QDG75021.1
              		 782831 - 783025 (+) hypothetical protein
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                • FJ695_03570
                • QDG75022.1
                		 783074 - 783316 (-) acyl carrier protein
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                  • FJ695_03575
                  • QDG75023.1
                  		 783405 - 784682 (+) hydroxymethylglutaryl-CoA synthase family protein
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                    • FJ695_03580
                    • QDG75024.1
                    		 784878 - 798437 (+) trans- AT polyketide synthase type I
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                      • FJ695_03585
                      • QDG75025.1
                      		 798434 - 799555 (+) LLM class flavin-dependent oxidoreductase
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                        • FJ695_03590
                        • QDG75026.1
                        		 799633 - 800589 (+) methyltransferase domain-containing protein
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                          • FJ695_03595
                          • QDG75027.1
                          		 800665 - 801969 (-) cytochrome P450
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                            • FJ695_03600
                            • QDG75028.1
                            		 801935 - 803302 (-) FMN-dependent oxidoreductase
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                              • FJ695_03605
                              • QDG75029.1
                              		 803299 - 804312 (-) acyltransferase domain-containing protein
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                                • FJ695_03610
                                • QDG75030.1
                                • fabD
                                		 804407 - 805534 (+) ACP S-malonyltransferase
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                                  • FJ695_03615
                                  • QDG75031.1
                                  		 805611 - 806348 (-) enoyl-CoA hydratase/isomerase
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                                    • FJ695_03620
                                    • QDG75032.1
                                    		 806358 - 807593 (-) polyketide beta-ketoacyl:ACP synthase
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                                      • FJ695_03625
                                      • QDG75033.1
                                      		 807586 - 825486 (-) mixed type I polyketide synthase - peptide synthetase
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                                        • FJ695_03630
                                        • QDG75034.1
                                        		 825368 - 826681 (-) monooxygenase
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                                          • FJ695_03635
                                          • QDG75035.1
                                          		 826678 - 851112 (-) mixed type I polyketide synthase - peptide synthetase
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                                            • FJ695_03640
                                            • QDG75036.1
                                            		 851240 - 852076 (-) methyltransferase domain-containing protein
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                                              • FJ695_03645
                                              • QDG75037.1
                                              		 852262 - 853953 (-) ATP-binding cassette domain-containing protein
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                                                • FJ695_03650
                                                • QDG75038.1
                                                		 853896 - 855521 (-) cyclic peptide export ABC transporter
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                                                  • FJ695_03655
                                                  • QDG75039.1
                                                  		 855685 - 856347 (+) 4'-phosphopantetheinyl transferase superfamily protein
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                                                    Biosynthesis information

                                                    Biosynthetic modules

                                                    Name
                                                    Unk01
                                                    Type
                                                    nrps-type1
                                                    Genes
                                                    FJ695_03635
                                                    Substrates
                                                    glycine (evidence: Structure-based inference [2])
                                                    Integrated Monomers
                                                    Domains
                                                    adenylation
                                                    Name
                                                    Unk02
                                                    Type
                                                    nrps-type1
                                                    Genes
                                                    FJ695_03625
                                                    Substrates
                                                    arginine (evidence: Structure-based inference, Homology, Sequence-based prediction)
                                                    Integrated Monomers
                                                    Domains
                                                    adenylation
                                                    Annotation changelog

                                                    Entry version: 2

                                                    Date
                                                    Changes
                                                    Submitters
                                                    Reviewers
                                                    2022-10-07
                                                    Update chemical activity to schema version 2.11
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    2022-10-07
                                                    Changed chemical structures for compounds: labrenzin.
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    2022-10-07
                                                    Added NPAtlas links to compounds: labrenzin.
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    2022-10-07
                                                    Synonyms added: 18-o-demethylpederin for labrenzin.
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                    Entry version: 1

                                                    Date
                                                    Changes
                                                    Submitters
                                                    Reviewers
                                                    2022-09-15
                                                    Submitted
                                                    • (ID: RWYY5IOXGZUT2OPVWGVF5SYB)
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    2022-09-15
                                                    Added version to NCBI accession
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    2022-09-15
                                                    Added NRP substrate specificities
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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                                                    Identifier
                                                    Identity
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                                                    Detailed domain annotation
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                                                    Modifications to original record
                                                    • FJ695_00115 crossed the origin and was split into two features