BGC0002070 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002070 (Saccharothrix espanaensis DSM 44229)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T2PKS	1	72,480	High	SEK90/pentangumycin	PKS

BGC0002070 - Region 1 - T2PKS

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Location: 1 - 72,480 nt. (total: 72,480 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 72,481
Label		BGC0002070

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase oxygenase

BN6_54730: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

BN6_54790: pyridine nucleotide-disulfide oxidoreductase

smcogs: SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

BN6_54820: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

BN6_54890: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

BN6_54910: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

BN6_54920: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

Transferases: aminotransferase carboxylase methyltransferase transferase

BN6_54750: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

BN6_54760: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

BN6_54840: acetyl-CoA carboxylase biotin carboxylase

smcogs: SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

BN6_54930: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

Lyases: cyclase

BN6_54850: Polyketide synthesis cyclase

smcogs: SMCOG1225: Polyketide synthesis cyclase

BN6_54900: cyclase/dehydrase

smcogs: SMCOG1128: cyclase/dehydrase

Ligases: synthase

BN6_54860: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

BN6_54870: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002070.3	1.00	PKS	SEK90, pentangumycin	Saccharothrix espanaensis DSM 44229
BGC0000234.5	0.84	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000231.5	0.83	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0001723.5	0.76	PKS	oviedomycin	Streptomyces antibioticus
BGC0002672.2	0.61	PKS	saccharothrixin D, saccharothrixin E, saccharothrixin F, saccharothrixin G, saccharothrixin H, saccharothrixin I, saccharothrixin J, saccharothrixin K, saccharothrixin L, saccharothrixin M	Saccharothrix sp.
BGC0000235.5	0.60	PKS	kiamycin	Streptomyces sp. W007
BGC0000272.3	0.60	PKS	spore pigment	Streptomyces collinus
BGC0002047.2	0.58	PKS	brasiliquinone A, brasiliquinone B	Nocardia brasiliensis
BGC0002276.2	0.58	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0000253.4	0.57	PKS	oviedomycin	Streptomyces antibioticus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002070.3	1.00	PKS	SEK90, pentangumycin	Saccharothrix espanaensis DSM 44229
BGC0000234.5	0.84	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000231.5	0.83	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0001723.5	0.76	PKS	oviedomycin	Streptomyces antibioticus
BGC0002672.2	0.61	PKS	saccharothrixin D, saccharothrixin E, saccharothrixin F, saccharothrixin G, saccharothrixin H, saccharothrixin I, saccharothrixin J, saccharothrixin K, saccharothrixin L, saccharothrixin M	Saccharothrix sp.
BGC0000235.5	0.60	PKS	kiamycin	Streptomyces sp. W007
BGC0000272.3	0.60	PKS	spore pigment	Streptomyces collinus
BGC0002047.2	0.58	PKS	brasiliquinone A, brasiliquinone B	Nocardia brasiliensis
BGC0002276.2	0.58	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0000253.4	0.57	PKS	oviedomycin	Streptomyces antibioticus

Similar known clusters from MIBiG 4.0

Detailed domain annotation

Selected features only

Show module domains

Type II PKS

Type II PKS gene cluster prediction details

Cluster section:: 0 to 72480
Starter unit(s):: acetyl-CoA (Score: 0.0; E-value: 0)
Malonyl elongations:: 8|9 (Score: 683.6; E-value: 1.7e-208)
Product class(es):: angucycline
Product molecular weight(s):: acetyl-CoA_8: 382 Da
acetyl-CoA_9: 424 Da

BN6_54760: MET (Score: 307.2; E-value: 3.2e-94)
BN6_54820: KR (Score: 36.4; E-value: 1.1e-11)
BN6_54850: CYC C4-C17/C2-C19 (Score: 190.0; E-value: 9.6e-59)
BN6_54860: KS (Score: 770.8; E-value: 7.3e-235)
BN6_54870: CLF 8|9 (Score: 683.6; E-value: 1.7e-208)
BN6_54880: ACP (Score: 120.8; E-value: 4.1e-38)
BN6_54890: KR C9 (Score: 472.7; E-value: 6.7e-145)
BN6_54900: CYC C7-C12 (Score: 478.8; E-value: 1.3e-146)
BN6_54910: OXY (Score: 558.7; E-value: 2.7e-170)
BN6_54920: OXY (Score: 586.0; E-value: 1.4e-178)