BGC0002070: SEK90 biosynthetic gene cluster from Saccharothrix espanaensis DSM 44229
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 6,124,164 - 6,148,184 nt. (total: 24,021 nt).
This entry is originally from NCBI GenBank HE804045.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002070
Short description SEK90 biosynthetic gene cluster from Saccharothrix espanaensis DSM 44229
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
Loci
HE804045.1
6124164 - 6148184
via Heterologous expression, Knock-out studies, Gene expression correlated with compound production
Compounds
  • SEK90
  • pentangumycin
Species Saccharothrix espanaensis DSM 44229 [taxonomy]
References
Chemical products information
SEK90 Evidence:
Copy SMILES
Chemical database entries
NPAtlas
pentangumycin Evidence:
Copy SMILES
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BN6_54730
  • CCH32732.1
 6124164 - 6125342 (+) Cytochrome P450 monooxygenase
    copy AA seq
    copy Nt seq
    • BN6_54740
    • CCH32733.1
    		 6125397 - 6125591 (+) putative ferrodoxin protein
      copy AA seq
      copy Nt seq
      • BN6_54750
      • CCH32734.1
      		 6125598 - 6127742 (+) putative aminotransferase
        copy AA seq
        copy Nt seq
        • BN6_54760
        • CCH32735.1
        		 6127854 - 6128876 (+) Methyltransferase
          copy AA seq
          copy Nt seq
          • BN6_54770
          • CCH32736.1
          		 6128896 - 6129633 (+) Anthrone monooxygenase
            copy AA seq
            copy Nt seq
            • BN6_54780
            • CCH32737.1
            		 6129603 - 6130025 (+) hypothetical protein
              copy AA seq
              copy Nt seq
              • BN6_54790
              • CCH32738.1
              		 6130108 - 6131307 (+) Ferredoxin reductase
                copy AA seq
                copy Nt seq
                • BN6_54800
                • CCH32739.1
                		 6131369 - 6132214 (-) Transcriptional regulator, XRE family
                  copy AA seq
                  copy Nt seq
                  • BN6_54810
                  • CCH32740.1
                  		 6132350 - 6133849 (+) Permease, MFS-type
                    copy AA seq
                    copy Nt seq
                    • BN6_54820
                    • CCH32741.1
                    		 6133898 - 6134797 (-) Aldo/keto reductase
                      copy AA seq
                      copy Nt seq
                      • BN6_54830
                      • CCH32742.1
                      		 6134891 - 6135316 (-) hypothetical protein
                        copy AA seq
                        copy Nt seq
                        • BN6_54840
                        • CCH32743.1
                        		 6135666 - 6137423 (+) Acyl-CoA carboxylase
                          copy AA seq
                          copy Nt seq
                          • BN6_54850
                          • CCH32744.1
                          		 6137456 - 6137785 (+) Polyketide synthase cyclase
                            copy AA seq
                            copy Nt seq
                            • BN6_54860
                            • CCH32745.1
                            		 6137782 - 6139053 (+) Polyketide ketosynthase
                              copy AA seq
                              copy Nt seq
                              • BN6_54870
                              • CCH32746.1
                              		 6139050 - 6140261 (+) putative chain length determinant
                                copy AA seq
                                copy Nt seq
                                • BN6_54880
                                • CCH32747.1
                                • acp5
                                		 6140295 - 6140552 (+) Acyl carrier protein
                                  copy AA seq
                                  copy Nt seq
                                  • BN6_54890
                                  • CCH32748.1
                                  • fabG7
                                  		 6140567 - 6141346 (+) Ketoreductase
                                    copy AA seq
                                    copy Nt seq
                                    • BN6_54900
                                    • CCH32749.1
                                    		 6141372 - 6142328 (+) Cyclase/dehydratase family protein
                                      copy AA seq
                                      copy Nt seq
                                      • BN6_54910
                                      • CCH32750.1
                                      		 6142325 - 6143794 (+) Bifunctional monooxygenase-dehydratase like protein
                                        copy AA seq
                                        copy Nt seq
                                        • BN6_54920
                                        • CCH32751.1
                                        		 6143794 - 6145260 (+) Methylmalonyl-CoA decarboxylase, alpha subunit
                                          copy AA seq
                                          copy Nt seq
                                          • BN6_54930
                                          • CCH32752.1
                                          		 6145394 - 6146896 (+) Methylmalonyl-CoA decarboxylase, alpha subunit
                                            copy AA seq
                                            copy Nt seq
                                            • BN6_54940
                                            • CCH32753.1
                                            		 6146922 - 6147167 (+) hypothetical protein
                                              copy AA seq
                                              copy Nt seq
                                              • BN6_54950
                                              • CCH32754.1
                                              		 6147456 - 6148184 (+) Transcriptional regulator
                                                copy AA seq
                                                copy Nt seq
                                                Biosynthesis information
                                                Annotation changelog

                                                Entry version: 2

                                                Date
                                                Changes
                                                Submitters
                                                Reviewers
                                                2022-10-07
                                                Changed chemical structures for compounds: pentangumycin, SEK90.
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                2022-10-07
                                                Added NPAtlas links to compounds: pentangumycin, SEK90.
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                Entry version: 1

                                                Date
                                                Changes
                                                Submitters
                                                Reviewers
                                                2022-09-15
                                                Entry added
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                Detailed domain annotation
                                                Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
                                                A domain glossary is available here, and an explanation of the visualisation is available here.
                                                Selected features only
                                                Show module domains
                                                Similar known gene clusters from MIBiG 4.0
                                                Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
                                                Click on reference genes to show details of similarities to genes within the current region.
                                                Click on an accession to open that entry in the MiBIG database.