BGC0002071: virginiafactin A biosynthetic gene cluster from Pseudomonas sp. QS1027
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Location: 289,715 - 316,980 nt. (total: 27,266 nt).
This entry is originally from NCBI GenBank NZ_PHSU01000004.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002071
Short description virginiafactin A biosynthetic gene cluster from Pseudomonas sp. QS1027
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
NZ_PHSU01000004.1
289715 - 316980
via Knock-out studies
Compounds
  • virginiafactin A
  • virginiafactin B
  • virginiafactin C
  • virginiafactin D
Species Pseudomonas sp. QS1027 [taxonomy]
References
Chemical products information
virginiafactin A Evidence: Total synthesis
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C53H97N9O13
Chemical database entries
NPAtlas
virginiafactin B Evidence:
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Chemical database entries
NPAtlas
virginiafactin C Evidence:
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Chemical database entries
NPAtlas
virginiafactin D Evidence:
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Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CWE01_RS05095
  • WP_100939442.1
 289715 - 299209 (+) non-ribosomal peptide synthetase
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    • CWE01_RS05100
    • WP_100939443.1
    		 299206 - 316980 (+) non-ribosomal peptide synthetase
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      Biosynthesis information

      Biosynthetic modules

      Name
      1
      Type
      nrps-type1
      Genes
      CWE01_RS05095
      Substrates
      leucine (evidence: Structure-based inference [2])
      Integrated Monomers
      Domains
      condensation (Starter), adenylation
      Name
      2
      Type
      nrps-type1
      Genes
      CWE01_RS05095
      Substrates
      leucine (evidence: Structure-based inference [2])
      Integrated Monomers
      Domains
      condensation (Dual), adenylation
      Name
      3
      Type
      nrps-type1
      Genes
      CWE01_RS05095
      Substrates
      glutamine (evidence: Structure-based inference [2])
      Integrated Monomers
      Domains
      condensation (Dual), adenylation
      Name
      4
      Type
      nrps-type1
      Genes
      CWE01_RS05100
      Substrates
      leucine (evidence: Structure-based inference [2])
      Integrated Monomers
      Domains
      condensation (Dual), adenylation, epimerase
      Name
      5
      Type
      nrps-type1
      Genes
      CWE01_RS05100
      Substrates
      serine (evidence: Structure-based inference [2])
      Integrated Monomers
      Domains
      condensation (LCL), adenylation
      Name
      6
      Type
      nrps-type1
      Genes
      CWE01_RS05100
      Substrates
      isoleucine, valine (evidence: Structure-based inference [2])
      Integrated Monomers
      Domains
      condensation (Dual), adenylation, epimerase
      Name
      7
      Type
      nrps-type1
      Genes
      CWE01_RS05100
      Substrates
      leucine (evidence: Structure-based inference [2])
      Integrated Monomers
      Domains
      condensation (LCL), adenylation
      Name
      8
      Type
      nrps-type1
      Genes
      CWE01_RS05100
      Substrates
      leucine (evidence: Structure-based inference [2])
      Integrated Monomers
      Domains
      condensation (Dual), adenylation, epimerase
      Annotation changelog

      Entry version: 1

      Date
      Changes
      Submitters
      Reviewers
      2022-09-15
      Submitted
      • (ID: O3ZSI4V6BQREG2DOQHOQ27FT)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      2022-09-15
      Corrected NRP module activity
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      2022-09-15
      Added version to NCBI accession
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      2022-09-15
      Updated NRP substrate specificities
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
      Detailed domain annotation
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