BGC0002072: linearmycin A biosynthetic gene cluster from Streptomyces sp. Mg1
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Location: 1,061,319 - 1,236,790 nt. (total: 175,472 nt).
This entry is originally from NCBI GenBank CP011664.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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resistance
TTA codons
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Gene details
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General
Compounds
Genes
Polyketide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002072
Short description linearmycin A biosynthetic gene cluster from Streptomyces sp. Mg1
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Polyene)
Loci NCBI GenBank: CP011664.1
Compounds
  • linearmycin A
  • linearmycin B
  • linearmycin C
  • linearmycin C
Species Streptomyces sp. Mg1 [taxonomy]
References
Chemical products information
linearmycin A
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Chemical database entries
PubCHEM
NPAtlas
linearmycin B
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Chemical database entries
PubCHEM
NPAtlas
linearmycin C
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Chemical database entries
PubCHEM
NPAtlas
linearmycin C
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Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • M444_04750
  • AKL64821.1
  • lnyT
 1061319 - 1062308 (-) agmatinase
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  • M444_04755
  • AKL64822.1
  • lnyS
 1062415 - 1063971 (-) methylmalonyl-CoA carboxyltransferase
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  • M444_04760
  • AMB20391.1
  • lnyR
 1064457 - 1067375 (+) transcriptional regulator
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  • M444_04765
  • AKL64823.1
  • lnyQ
 1067356 - 1068252 (+) metallophosphoesterase
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  • M444_04770
  • AKL64824.1
  • lnyP
 1068249 - 1068992 (+) 4'-phosphopantetheinyl transferase
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  • M444_04775
  • AKL64825.1
  • lnyO
 1069184 - 1070845 (+) amine oxidase
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  • M444_04780
  • AKL64826.1
  • lnyN
 1070939 - 1072351 (-) acyl--CoA ligase
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  • M444_04785
  • AKL69762.1
  • lnyM
 1072435 - 1073028 (-) thioesterase
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  • M444_04790
  • AMB20392.1
  • lnyL
 1073166 - 1073738 (-) glucose-1-phosphate thymidylyltransferase
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  • M444_04795
  • AKL64827.1
  • lnyK
 1074063 - 1075127 (+) daunorubicin ABC transporter ATPase
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  • M444_04800
  • AKL69763.1
  • lnyJ
 1075226 - 1075996 (+) ABC transporter
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  • M444_04805
  • AKL64828.1
  • lnyI
 1076160 - 1077197 (+) ACP S-malonyltransferase
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  • M444_04810
  • AMB20393.1
  • lnyHI
 1077302 - 1094107 (-) polyketide synthase
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  • M444_04815
  • AKL64829.1
  • lnyHH
 1094175 - 1116644 (-) polyketide synthase
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  • M444_04820
  • AKL64830.1
  • lnyHG
 1116707 - 1126318 (-) polyketide synthase
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  • M444_04825
  • AKL64831.1
  • lnyHF
 1126413 - 1142603 (-) polyketide synthase
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  • M444_04830
  • AMB20394.1
  • lnyHE
 1142689 - 1158345 (-) polyketide synthase
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  • M444_04835
  • AKL64832.1
  • lnyHD
 1158599 - 1163497 (-) polyketide synthase
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  • M444_04840
  • AKL64833.1
  • lnyHC
 1163620 - 1183653 (-) polyketide synthase
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  • M444_04845
  • AKL69764.1
  • lnyHB
 1183678 - 1193985 (-) polyketide synthase
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  • M444_04850
  • AKL64834.1
  • lnyHA
 1194150 - 1228586 (-) polyketide synthase
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  • M444_04855
  • AKL64835.1
  • lnyG
 1228902 - 1230452 (-) membrane protein
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  • M444_04860
  • AKL69765.1
  • lnyF
 1230449 - 1230949 (-) membrane protein
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  • M444_04865
  • AKL64836.1
  • lnyE
 1231012 - 1231545 (-) LnyE
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  • M444_04870
  • AKL64837.1
  • lnyD
 1231711 - 1233006 (+) histidine kinase
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  • M444_04875
  • AKL69766.1
  • lnyC
 1233071 - 1233631 (+) LuxR family transcriptional regulator
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  • M444_04880
  • AKL69767.1
  • lnyB
 1233701 - 1236565 (-) transcriptional regulator
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Polyketide-specific information
Subclass Polyene
Cyclic? no
Release type
  • Hydrolysis
Polyketide-synthases
Genes Properties Modules
lnyHA
+
lnyHI
+
lnyHF
+
lnyHB
+
lnyHC
+
lnyHG
+
lnyHE
+
lnyHD
+
lnyHH
+
lnyM 		Synthase subclass: Modular type I
Thioesterases:
  • lnyM (Type II)
Module 1
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: lnyHA
Core domains: Thiolation (ACP/PCP), Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 2
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: lnyHA
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 3
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: lnyHA
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 4
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: lnyHA
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 5
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: lnyHA
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 6
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: lnyHA
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 7
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: lnyHA
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Module 8
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: lnyHB
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 9
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: lnyHB
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: L-OH
Module 10
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: lnyHC
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 11
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: lnyHC
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 12
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: lnyHC
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 13
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: lnyHC
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 14
Specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
Genes: lnyHD
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Inactive
Module 15
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: lnyHE
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 16
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: lnyHE
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 17
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: lnyHE
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 18
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: lnyHF
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 19
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: lnyHF
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 20
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: lnyHF
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 21
Specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
Genes: lnyHG
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 22
Specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
Genes: lnyHG
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 23
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: lnyHH
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 24
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: lnyHH
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Enoylreductase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 25
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: lnyHH
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 26
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: lnyHH
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 27
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: lnyHI
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 28
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: lnyHI
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: D-OH
Module 29
Specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
Genes: lnyHI
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP), Thioesterase
KR-domain stereochemistry: D-OH
Annotation changelog
MIBiG version Submitter Notes
3.0
  • Hidden contributor (ID: R7Q3ADVMVK5DLOD43C64GWJ2, no GDPR consent given).
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
  • Added version to NCBI accession
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
  • Added chemical structures for compounds: linearmycin C.
  • Added NPAtlas links to compounds: linearmycin C.
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