BGC0002079: omnipeptin biosynthetic gene cluster from uncultured bacterium
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Location: 20,541 - 101,692 nt. (total: 81,152 nt).
This entry is originally from NCBI GenBank MN161666.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002079
Short description omnipeptin biosynthetic gene cluster from uncultured bacterium
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
MN161666.1
20541 - 101692
via Heterologous expression
Compounds
  • omnipeptin
Species uncultured bacterium [taxonomy]
References
Chemical products information
omnipeptin Evidence: NMR, Mass spectrometry
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C64H82Cl1N13O22
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • QEO75068.1
 20541 - 21026 (-) flavin reductase domain protein FMN-binding
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    • QEO75069.1
    		 21023 - 22294 (-) sodium/hydrogen exchanger
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      • QEO75070.1
      		 22310 - 23827 (-) halogenase
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        • QEO75071.1
        		 24110 - 25792 (+) AMP-dependent synthetase and ligase
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          • QEO75072.1
          		 25789 - 26037 (+) phosphopantetheine-binding domain-containing pro
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            • QEO75073.1
            		 26039 - 35719 (+) condensation domain-containing protein
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              • QEO75074.1
              		 35665 - 39531 (+) condensation domain-containing protein
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                • QEO75075.1
                		 39528 - 56042 (+) condensation domain-containing protein
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                  • QEO75076.1
                  		 55993 - 59052 (+) AMP-dependent synthetase and ligase
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                    • QEO75077.1
                    		 59052 - 65960 (+) condensation domain-containing protein
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                      • QEO75078.1
                      		 65977 - 66192 (+) mbtH-like protein
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                        • QEO75079.1
                        		 66224 - 68527 (+) hypothetical protein
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                          • QEO75080.1
                          		 68534 - 69331 (+) alpha/beta hydrolase fold protein
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                            • QEO75081.1
                            		 69341 - 70513 (+) glycosyltransferase, MGT family
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                              • QEO75082.1
                              		 70510 - 72219 (+) hypothetical protein
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                                • QEO75083.1
                                		 72181 - 72960 (-) ABC-2 type transporter
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                                  • QEO75084.1
                                  		 72957 - 73892 (-) ABC transporter ATP-binding protein
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                                    • QEO75085.1
                                    		 73882 - 75105 (-) hypothetical protein
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                                      • QEO75086.1
                                      		 75102 - 76076 (-) hypothetical protein
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                                        • QEO75087.1
                                        		 76087 - 77298 (-) hypothetical protein
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                                          • QEO75088.1
                                          		 77295 - 77732 (-) hypothetical protein
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                                            • QEO75089.1
                                            		 77710 - 78654 (-) ArsR family transcriptional regulator
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                                              • QEO75090.1
                                              		 78764 - 81658 (-) hypothetical protein
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                                                • QEO75091.1
                                                		 81698 - 84127 (-) ABC transporter, permease component
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                                                  • QEO75092.1
                                                  		 84121 - 84840 (-) ABC transporter ATP-binding protein
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                                                    • QEO75093.1
                                                    		 84973 - 86166 (+) sensor histidine kinase
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                                                      • QEO75094.1
                                                      		 86142 - 86810 (+) hypothetical protein
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                                                        • QEO75095.1
                                                        		 86815 - 88005 (-) hypothetical protein
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                                                          • QEO75096.1
                                                          		 88304 - 89137 (+) hypothetical protein
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                                                            • QEO75097.1
                                                            		 89160 - 89960 (+) hypothetical protein
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                                                              • QEO75098.1
                                                              		 89957 - 91033 (+) hypothetical protein
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                                                                • QEO75099.1
                                                                		 91030 - 92157 (+) hypothetical protein
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                                                                  • QEO75100.1
                                                                  		 92157 - 92936 (+) hypothetical protein
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                                                                    • QEO75101.1
                                                                    		 92933 - 94381 (+) hypothetical protein
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                                                                      • QEO75102.1
                                                                      		 94378 - 95229 (+) hypothetical protein
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                                                                        • QEO75103.1
                                                                        		 95226 - 96272 (+) hypothetical protein
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                                                                          • QEO75104.1
                                                                          		 96269 - 97660 (+) hypothetical protein
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                                                                            • QEO75105.1
                                                                            		 97730 - 98524 (+) transcriptional regulator, SARP family
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                                                                              • QEO75106.1
                                                                              		 98526 - 99161 (+) TetR family transcriptional regulator
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                                                                                • QEO75107.1
                                                                                		 99139 - 99750 (-) TetR family transcriptional regulator
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                                                                                  • QEO75108.1
                                                                                  		 99896 - 100843 (+) hypothetical protein
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                                                                                    • QEO75109.1
                                                                                    		 100892 - 101692 (+) NAD-dependent epimerase/dehydratase
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                                                                                      Biosynthesis information

                                                                                      Biosynthetic modules

                                                                                      Name
                                                                                      Unk01
                                                                                      Type
                                                                                      nrps-type1
                                                                                      Genes
                                                                                      QEO75073.1
                                                                                      Substrates
                                                                                      aspartic acid branched (evidence: Structure-based inference, Heterologous expression)
                                                                                      Integrated Monomers
                                                                                      Domains
                                                                                      adenylation
                                                                                      Name
                                                                                      Unk02
                                                                                      Type
                                                                                      nrps-type1
                                                                                      Genes
                                                                                      QEO75073.1
                                                                                      Substrates
                                                                                      beta-hydroxytyrosine (evidence: Structure-based inference, Heterologous expression)
                                                                                      Integrated Monomers
                                                                                      Domains
                                                                                      adenylation
                                                                                      Name
                                                                                      Unk03
                                                                                      Type
                                                                                      nrps-type1
                                                                                      Genes
                                                                                      QEO75073.1
                                                                                      Substrates
                                                                                      serine (evidence: Structure-based inference, Heterologous expression)
                                                                                      Integrated Monomers
                                                                                      Domains
                                                                                      adenylation
                                                                                      Name
                                                                                      Unk04
                                                                                      Type
                                                                                      nrps-type1
                                                                                      Genes
                                                                                      QEO75074.1
                                                                                      Substrates
                                                                                      glutamic acid (evidence: Structure-based inference, Heterologous expression)
                                                                                      Integrated Monomers
                                                                                      Domains
                                                                                      adenylation
                                                                                      Name
                                                                                      Unk05
                                                                                      Type
                                                                                      nrps-type1
                                                                                      Genes
                                                                                      QEO75075.1
                                                                                      Substrates
                                                                                      threonine (evidence: Structure-based inference, Heterologous expression)
                                                                                      Integrated Monomers
                                                                                      Domains
                                                                                      adenylation
                                                                                      Name
                                                                                      Unk06
                                                                                      Type
                                                                                      nrps-type1
                                                                                      Genes
                                                                                      QEO75075.1
                                                                                      Substrates
                                                                                      serine (evidence: Structure-based inference, Heterologous expression)
                                                                                      Integrated Monomers
                                                                                      Domains
                                                                                      adenylation
                                                                                      Name
                                                                                      Unk07
                                                                                      Type
                                                                                      nrps-type1
                                                                                      Genes
                                                                                      QEO75075.1
                                                                                      Substrates
                                                                                      Integrated Monomers
                                                                                      Domains
                                                                                      adenylation
                                                                                      Name
                                                                                      Unk08
                                                                                      Type
                                                                                      nrps-type1
                                                                                      Genes
                                                                                      QEO75075.1
                                                                                      Substrates
                                                                                      3-methylasparagine (evidence: Structure-based inference, Heterologous expression)
                                                                                      Integrated Monomers
                                                                                      Domains
                                                                                      adenylation
                                                                                      Name
                                                                                      Unk09
                                                                                      Type
                                                                                      nrps-type1
                                                                                      Genes
                                                                                      QEO75075.1
                                                                                      Substrates
                                                                                      6-chlorotryptophan (evidence: Structure-based inference, Heterologous expression)
                                                                                      Integrated Monomers
                                                                                      Domains
                                                                                      adenylation
                                                                                      Name
                                                                                      Unk10
                                                                                      Type
                                                                                      nrps-type1
                                                                                      Genes
                                                                                      QEO75076.1
                                                                                      Substrates
                                                                                      valine (evidence: Structure-based inference, Heterologous expression)
                                                                                      Integrated Monomers
                                                                                      Domains
                                                                                      adenylation
                                                                                      Name
                                                                                      Unk11
                                                                                      Type
                                                                                      nrps-type1
                                                                                      Genes
                                                                                      QEO75077.1
                                                                                      Substrates
                                                                                      phenylalanine (evidence: Structure-based inference, Heterologous expression)
                                                                                      Integrated Monomers
                                                                                      Domains
                                                                                      adenylation
                                                                                      Name
                                                                                      Unk12
                                                                                      Type
                                                                                      nrps-type1
                                                                                      Genes
                                                                                      QEO75077.1
                                                                                      Substrates
                                                                                      3-hydroxy-4-methylproline (evidence: Structure-based inference, Heterologous expression)
                                                                                      Integrated Monomers
                                                                                      Domains
                                                                                      adenylation
                                                                                      Annotation changelog

                                                                                      Entry version: 1

                                                                                      Date
                                                                                      Changes
                                                                                      Submitters
                                                                                      Reviewers
                                                                                      2022-09-15
                                                                                      Submitted
                                                                                      • (ID: KZLBDERD7NZFELVOLOQJLADT)
                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                      2022-09-15
                                                                                      Added version to NCBI accession
                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                      2022-09-15
                                                                                      Added NRP substrate specificities
                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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