BGC0002079: omnipeptin biosynthetic gene cluster from uncultured bacterium
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Location: 20,541 - 101,692 nt. (total: 81,152 nt).
This entry is originally from NCBI GenBank MN161666.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
NRP
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002079
Short description omnipeptin biosynthetic gene cluster from uncultured bacterium
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRP (Cyclic depsipeptide)
Loci NCBI GenBank: MN161666.1
Compounds
  • omnipeptin
Species uncultured bacterium [taxonomy]
References
Chemical products information
omnipeptin
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C64H82Cl1N13O22
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • QEO75068.1
 20541 - 21026 (-) flavin reductase domain protein FMN-binding
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  • QEO75069.1
 21023 - 22294 (-) sodium/hydrogen exchanger
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  • QEO75070.1
 22310 - 23827 (-) halogenase
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  • QEO75071.1
 24110 - 25792 (+) AMP-dependent synthetase and ligase
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  • QEO75072.1
 25789 - 26037 (+) phosphopantetheine-binding domain-containing pro
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  • QEO75073.1
 26039 - 35719 (+) condensation domain-containing protein
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  • QEO75074.1
 35665 - 39531 (+) condensation domain-containing protein
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  • QEO75075.1
 39528 - 56042 (+) condensation domain-containing protein
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  • QEO75076.1
 55993 - 59052 (+) AMP-dependent synthetase and ligase
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  • QEO75077.1
 59052 - 65960 (+) condensation domain-containing protein
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  • QEO75078.1
 65977 - 66192 (+) mbtH-like protein
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  • QEO75079.1
 66224 - 68527 (+) hypothetical protein
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  • QEO75080.1
 68534 - 69331 (+) alpha/beta hydrolase fold protein
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  • QEO75081.1
 69341 - 70513 (+) glycosyltransferase, MGT family
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  • QEO75082.1
 70510 - 72219 (+) hypothetical protein
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  • QEO75083.1
 72181 - 72960 (-) ABC-2 type transporter
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  • QEO75084.1
 72957 - 73892 (-) ABC transporter ATP-binding protein
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  • QEO75085.1
 73882 - 75105 (-) hypothetical protein
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  • QEO75086.1
 75102 - 76076 (-) hypothetical protein
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  • QEO75087.1
 76087 - 77298 (-) hypothetical protein
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  • QEO75088.1
 77295 - 77732 (-) hypothetical protein
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  • QEO75089.1
 77710 - 78654 (-) ArsR family transcriptional regulator
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  • QEO75090.1
 78764 - 81658 (-) hypothetical protein
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  • QEO75091.1
 81698 - 84127 (-) ABC transporter, permease component
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  • QEO75092.1
 84121 - 84840 (-) ABC transporter ATP-binding protein
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  • QEO75093.1
 84973 - 86166 (+) sensor histidine kinase
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  • QEO75094.1
 86142 - 86810 (+) hypothetical protein
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  • QEO75095.1
 86815 - 88005 (-) hypothetical protein
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  • QEO75096.1
 88304 - 89137 (+) hypothetical protein
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  • QEO75097.1
 89160 - 89960 (+) hypothetical protein
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  • QEO75098.1
 89957 - 91033 (+) hypothetical protein
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  • QEO75099.1
 91030 - 92157 (+) hypothetical protein
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  • QEO75100.1
 92157 - 92936 (+) hypothetical protein
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  • QEO75101.1
 92933 - 94381 (+) hypothetical protein
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  • QEO75102.1
 94378 - 95229 (+) hypothetical protein
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  • QEO75103.1
 95226 - 96272 (+) hypothetical protein
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  • QEO75104.1
 96269 - 97660 (+) hypothetical protein
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  • QEO75105.1
 97730 - 98524 (+) transcriptional regulator, SARP family
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  • QEO75106.1
 98526 - 99161 (+) TetR family transcriptional regulator
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  • QEO75107.1
 99139 - 99750 (-) TetR family transcriptional regulator
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  • QEO75108.1
 99896 - 100843 (+) hypothetical protein
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  • QEO75109.1
 100892 - 101692 (+) NAD-dependent epimerase/dehydratase
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NRP-specific information
Subclass Cyclic depsipeptide
Cyclic? yes
Thioesterase genes
  • QEO75077.1 (Type I)
NRP-synthases
Gene Modules
QEO75073.1
Module ?
Specificity: aspartic acid branched
Evidence for specificity:
  • Structure-based inference
  • Heterologous expression
Module ?
Specificity: beta-hydroxytyrosine
Evidence for specificity:
  • Structure-based inference
  • Heterologous expression
Module ?
Specificity: serine
Evidence for specificity:
  • Structure-based inference
  • Heterologous expression
QEO75074.1
Module ?
Specificity: glutamic acid
Evidence for specificity:
  • Structure-based inference
  • Heterologous expression
QEO75075.1
Module ?
Specificity: threonine
Evidence for specificity:
  • Structure-based inference
  • Heterologous expression
Module ?
Specificity: serine
Evidence for specificity:
  • Structure-based inference
  • Heterologous expression
Module ?
Specificity:
Evidence for specificity:
  • Sequence-based prediction
  • Heterologous expression
Module ?
Specificity: 3-methylasparagine
Evidence for specificity:
  • Structure-based inference
  • Heterologous expression
Module ?
Specificity: 6-chlorotryptophan
Evidence for specificity:
  • Structure-based inference
  • Heterologous expression
QEO75076.1
Module ?
Specificity: valine
Evidence for specificity:
  • Structure-based inference
  • Heterologous expression
QEO75077.1
Module ?
Specificity: phenylalanine
Evidence for specificity:
  • Structure-based inference
  • Heterologous expression
Module ?
Specificity: 3-hydroxy-4-methylproline
Evidence for specificity:
  • Structure-based inference
  • Heterologous expression
Annotation changelog
MIBiG version Submitter Notes
3.0
  • Hidden contributor (ID: KZLBDERD7NZFELVOLOQJLADT, no GDPR consent given).
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
  • Added version to NCBI accession
  • Added NRP substrate specificities
Detailed domain annotation
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