LOCUS       BGC0002081             20404 bp    DNA     linear   BCT 20-AUG-2019
DEFINITION  Streptomyces sp. Tue6314 streptoketides biosynthetic gene cluster,
            complete sequence.
ACCESSION   BGC0002081
VERSION     BGC0002081
KEYWORDS    .
SOURCE      Streptomyces sp. Tue6314
  ORGANISM  Streptomyces sp. Tue6314
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2024-10-17 16:52:01
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 5926
            Orig. end    :: 26330
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     subregion       1..20404
                     /aStool="mibig"
                     /contig_edge="False"
                     /label="PKS"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..20404
                     /contig_edge="False"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     CDS             complement(2..247)
                     /NRPS_PKS="Domain: ACP (10-79). E-value: 4.1e-16. Score:
                     51.0. Matches aSDomain: nrpspksdomains_QED90611.1_ACP.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1129:acyl carrier protein (Score: 115.8; E-value:
                     1.2e-35)"
                     /gene_kind="biosynthetic-additional"
                     /note="Skt1"
                     /product="acyl carrier protein"
                     /protein_id="QED90611.1"
                     /sec_met_domain="PP-binding (E-value: 4.3e-12, bitscore:
                     36.8, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKGFTLADLKRVMRECAGEDENVDLDGDILDAPFENLGYDSLALL
                     ETATRIERELGVRMPEEVLSGARTPRLLLDAVASAR"
     misc_feature    2..20404
                     /note="streptoketides biosynthetic gene cluster"
     aSDomain        complement(11..217)
                     /aSDomain="ACP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_QED90611.1_ACP.1"
                     /evalue="4.10E-16"
                     /label="QED90611.1_ACP.1"
                     /locus_tag="QED90611.1"
                     /protein_end="79"
                     /protein_start="10"
                     /score="51.0"
                     /tool="antismash"
                     /translation="RVMRECAGEDENVDLDGDILDAPFENLGYDSLALLETATRIEREL
                     GVRMPEEVLSGARTPRLLLDAVAS"
     CDS             complement(286..1554)
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (82-414). E-value:
                     2e-22. Score: 71.5. Matches aSDomain:
                     nrpspksdomains_QED90612.1_PKS_KS.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) T2PKS:
                     t2clf"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1093:Beta-ketoacyl synthase (Score: 556.3; E-value:
                     5.4e-169)"
                     /gene_kind="biosynthetic"
                     /note="Skt2"
                     /product="ketosynthase chain-length factor"
                     /protein_id="QED90612.1"
                     /sec_met_domain="t2clf (E-value: 4.5e-174, bitscore: 569.1,
                     seeds: 26, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAPAPASTAPGTRRGTALVTGLDVRAANGDGTEEFWRSLLEGRG
                     GIGPITRFDASGYPSRLAGEIARDPGEDLPGRLLPQTDRVTQLALACAAEVLRDSGLDP
                     AGAPEYGIGVVTANAAGGFEFGQRELENLWAKGPLYVSAYQSFAWFYAVNTGQISIRHG
                     LRGPSGVLVTGQSGGLDAVGHARRMLRKGTPAVLTGAMESALCPWGHVAELTGGRLSTA
                     DRSEDACLPFGERAAGHVVAEGGALLMLEDEASAHARGGIRPYGEVAGYAACFDPPPGS
                     GRPTGPARAARAALADAGVEPADIGAVFAEGAAVPDLDAQEAGAIAGVFGPDAVPVTAI
                     TSRTGRPGAGASALDLAAALLAVRDGLIPPTADVGRVPAAYRIDLVTGRPRPMAGDAAL
                     VLARGYGGFNSAVVVRRCGPTPR"
     aSDomain        complement(313..1308)
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_QED90612.1_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="2.00E-22"
                     /label="QED90612.1_PKS_KS.1"
                     /locus_tag="QED90612.1"
                     /protein_end="414"
                     /protein_start="82"
                     /score="71.5"
                     /tool="antismash"
                     /translation="DRVTQLALACAAEVLRDSGLDPAGAPEYGIGVVTANAAGGFEFGQ
                     RELENLWAKGPLYVSAYQSFAWFYAVNTGQISIRHGLRGPSGVLVTGQSGGLDAVGHAR
                     RMLRKGTPAVLTGAMESALCPWGHVAELTGGRLSTADRSEDACLPFGERAAGHVVAEGG
                     ALLMLEDEASAHARGGIRPYGEVAGYAACFDPPPGSGRPTGPARAARAALADAGVEPAD
                     IGAVFAEGAAVPDLDAQEAGAIAGVFGPDAVPVTAITSRTGRPGAGASALDLAAALLAV
                     RDGLIPPTADVGRVPAAYRIDLVTGRPRPMAGDAALVLARGYGGFNSAVVV"
     CDS             complement(1551..2822)
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (4-395). E-value:
                     1.4e-57. Score: 187.4. Matches aSDomain:
                     nrpspksdomains_QED90637.1_PKS_KS.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) T2PKS:
                     t2ks"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 466.1; E-value:
                     1.9e-141)"
                     /gene_kind="biosynthetic"
                     /note="Skt3"
                     /product="beta-ketoacyl-[acyl-carrier-protein] synthase
                     family protein"
                     /protein_id="QED90637.1"
                     /sec_met_domain="t2ks (E-value: 1.6e-227, bitscore: 745.6,
                     seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNRRVAVTGIGVVAPGGTGTKEFWSLITSGRTATGPLTAFDATPY
                     RSRIAAQCAFDPLAAGFSAREVRRLDRAALFAVACAREALADAGLASGTSPVPERTGVS
                     LGTAVGCTTSLENEYAVVSDGGRDWLVDHRHAVPQLVDYLVPSSLAREVAWAADALGPA
                     AVISAGCTSGLDAVGHACEIIREGTADVMLTGGTDAPISPITVASFDAIRATSARNDDP
                     ATASRPFDRTRDGFVLGEGAAVLVLEEWSHAVGRGAHVYAEIGGHASRGNAYHMTGLRP
                     DGREMAEAITRALDEARLDPTAVDYVNAHGSGTLQNDRHESAAFLRALGEHARGIPVSS
                     IKSMIGHSLGAIGAIEIAACALALEHGVVPPTANLHEPDPDCPLDYVPVTAREQRLDAV
                     LTVGSGFGGFQSAMVLTRPEGTRR"
     aSDomain        complement(1638..2810)
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_QED90637.1_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="1.40E-57"
                     /label="QED90637.1_PKS_KS.1"
                     /locus_tag="QED90637.1"
                     /protein_end="395"
                     /protein_start="4"
                     /score="187.4"
                     /tool="antismash"
                     /translation="VAVTGIGVVAPGGTGTKEFWSLITSGRTATGPLTAFDATPYRSRI
                     AAQCAFDPLAAGFSAREVRRLDRAALFAVACAREALADAGLASGTSPVPERTGVSLGTA
                     VGCTTSLENEYAVVSDGGRDWLVDHRHAVPQLVDYLVPSSLAREVAWAADALGPAAVIS
                     AGCTSGLDAVGHACEIIREGTADVMLTGGTDAPISPITVASFDAIRATSARNDDPATAS
                     RPFDRTRDGFVLGEGAAVLVLEEWSHAVGRGAHVYAEIGGHASRGNAYHMTGLRPDGRE
                     MAEAITRALDEARLDPTAVDYVNAHGSGTLQNDRHESAAFLRALGEHARGIPVSSIKSM
                     IGHSLGAIGAIEIAACALALEHGVVPPTANLHEPDPDCPLDYVPVTAREQR"
     CDS_motif       complement(1722..1796)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_QED90637.1_0001"
                     /evalue="2.10E-02"
                     /label="PKSI-AT-mM_m3"
                     /locus_tag="QED90637.1"
                     /protein_end="367"
                     /protein_start="342"
                     /score="7.9"
                     /tool="antismash"
                     /translation="SMIGHSLGAIGAIEIAACALALEHG"
     CDS             3169..3672
                     /codon_start=1
                     /gene_functions="regulatory (smcogs)
                     SMCOG1284:transcriptional regulator, MarR family (Score:
                     100; E-value: 1.6e-30)"
                     /gene_kind="regulatory"
                     /note="Skt4"
                     /product="MarR family transcriptional regulator"
                     /protein_id="QED90613.1"
                     /transl_table=11
                     /translation="MAVRPAVSLGDFSTLFALAGRSTRLRSERLLNDFGLHVGQQFFMR
                     CLWEQDGSTVGDLARRVRVEAPTATQAVKRMEAAGMVRRTPDEQDARRSRVWLTPLGRR
                     TWPLVTAALAELERDLLAPFTQPEREQFMSLLLRLYETSLPADGPGADGTGTGPDATGG
                     SRAD"
     CDS             3756..4211
                     /codon_start=1
                     /note="Skt5"
                     /product="putative cyclase"
                     /protein_id="QED90614.1"
                     /transl_table=11
                     /translation="MPHTGTAPLDPARPGTAGLHGEITHFYARQMQALDDGRTDDWART
                     FTEDGVFLLHGGHDRAEGRPALAASSAKARAALAEQGVTHRHWLGMLTVDPRPDGSVVA
                     RCYALVVATHLGGTPALHRSTVCEDVLVRDGDAWLVRHRQVSRDDLA"
     CDS             complement(4271..5077)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs)
                     SMCOG1041:transcriptional regulator, SARP family (Score:
                     316.9; E-value: 5.7e-96)"
                     /gene_kind="regulatory"
                     /note="Skt6"
                     /product="SARP family transcriptional regulator"
                     /protein_id="QED90615.1"
                     /transl_table=11
                     /translation="MMDISVVILGILDLRFGDMVCVPSAPKPKKVLALLLIYRNQIVPV
                     SALVEELWGNRPPASARTTLQTYILTLRKLLQAAAPSAGELLVTAGPGYMLRIPDDAVD
                     LHRFGRLAKEGREAISRGDDETGVVLLSQALDLYRGQVLADVDTGQRVTAHVTRLEELR
                     LTTLGLCIDAEMRLGRHQELLDGLAALTAHHRFHENLHAQYMRALWRSGRRSCALDVYQ
                     RLRRALAEELGMEPAWFLQQLQRAILSSASPQPQMLAGGMPYETAG"
     CDS             complement(5357..6913)
                     /codon_start=1
                     /note="Skt7"
                     /product="cholesterol oxidase"
                     /protein_id="QED90616.1"
                     /transl_table=11
                     /translation="MSGRKSLSRRRFLTGVAAGTALGALPLRSAVASAAEPVEILIIGS
                     GYAGSVAALRFAQAGLHSVVLERGRRWPVTAQGGTFATPAAPDGRASWLNSWSPFVPQQ
                     LDVYPGVLEAFRADGVIALAGAGVGGGSLVNNAVMLKPSEAAFNRAFGTDIDFDEMSER
                     WYARARSLIGPAPMPDDVYASSHYTAARSFTAETAAAGLAPFRADMAVDWQAVREEQAG
                     TREASLIIARSIWGANSGAKRSVDRTVLAAAEATGRVSVETLTRVVDVVPSGGRYVVRC
                     ERIDDTGAVVARPDYSAKRVFFAAGSLGTSRLLVAARGRGSLPALRASVGKGWGTNSDR
                     QTVRVGMPWNNSTQGGPSGIVAQDLDNPYEPVTMINFPWPVPPADGTGALGALAMTTCA
                     AEGFFSYDAATDGVSLTWPATGASAVRATQAVTATVNRINAANPGTSTLRVNADTTSHT
                     LGGAVLGKACRLDGRLYGYDNLHVIDSSLIPGTMATVPPALTVTALADRCVHKALDRML
                     N"
     CDS             complement(7053..7727)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Methyltransf_3"
                     /gene_kind="biosynthetic-additional"
                     /note="Skt8"
                     /product="SAM-dependent methyltransferase"
                     /protein_id="QED90617.1"
                     /sec_met_domain="Methyltransf_3 (E-value: 4.6e-55,
                     bitscore: 176.4, seeds: 4, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEFPADQPMRVQATQEVVDYVVASGIAPLPAHHELVARTEKETGD
                     KAGMRIAPEQGALITLLARTVGARRAVEVGTFTGYSSLSIARALPADGHLLCCDTSEEW
                     TRIARDGWESAGLAGLIELRLGPALETLRALPVDEDIDFSFVDADKTGYAAYFEELVVR
                     TRPGGLIVFDNVLYGGRVLGDEPVTGNAAALREFNPALAADPRVDVVMLPLADGLTIAR
                     KR"
     CDS             7974..8777
                     /NRPS_PKS="Domain: PKS_KR (13-123). E-value: 5e-14. Score:
                     44.5. Matches aSDomain: nrpspksdomains_QED90618.1_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     255.1; E-value: 1.1e-77)"
                     /gene_kind="biosynthetic-additional"
                     /note="Skt9"
                     /product="ketoacyl reductase"
                     /protein_id="QED90618.1"
                     /sec_met_domain="adh_short (E-value: 2e-40, bitscore:
                     129.0, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPASAPSTPADPRTALITGATSGIGLAVARALAASGLRVFLCARS
                     ADDVAATVEELRDHGYEADGAACDVRSRAEVADLVATAVAAFGPVDVLVNNAGRNGGGV
                     TAQLPDEIWYDVVDTNLNSVFLVTREVLAAGGMLERPRGRIINIASTGGKQGVVLAAPY
                     SASKAGVIGMTKAVGLELASSGTTVNAVCPGYVETPMAERVRKAYAEAWDTGEEQVRER
                     FEAKIPLGRYTTPEEVAAMVGYLVSPAADAVTAQALNVCGGLGSH"
     aSDomain        8013..8342
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_QED90618.1_PKS_KR.1"
                     /evalue="5.00E-14"
                     /label="QED90618.1_PKS_KR.1"
                     /locus_tag="QED90618.1"
                     /protein_end="123"
                     /protein_start="13"
                     /score="44.5"
                     /tool="antismash"
                     /translation="TALITGATSGIGLAVARALAASGLRVFLCARSADDVAATVEELRD
                     HGYEADGAACDVRSRAEVADLVATAVAAFGPVDVLVNNAGRNGGGVTAQLPDEIWYDVV
                     DTNLNS"
     CDS_motif       8019..8105
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_QED90618.1_0001"
                     /evalue="1.10E-06"
                     /label="PKSI-KR_m1"
                     /locus_tag="QED90618.1"
                     /protein_end="44"
                     /protein_start="15"
                     /score="21.3"
                     /tool="antismash"
                     /translation="LITGATSGIGLAVARALAASGLRVFLCAR"
     CDS             8810..9853
                     /NRPS_PKS="Domain: Polyketide_cyc2 (35-179). E-value:
                     1.9e-18. Score: 59.0. Matches aSDomain:
                     nrpspksdomains_QED90619.1_Polyketide_cyc2.1"
                     /NRPS_PKS="Domain: Polyketide_cyc2 (189-342). E-value:
                     1.7e-08. Score: 26.8. Matches aSDomain:
                     nrpspksdomains_QED90619.1_Polyketide_cyc2.2"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1128:cyclase/dehydrase (Score: 381.8; E-value:
                     4.3e-116)"
                     /gene_kind="biosynthetic-additional"
                     /note="Skt10"
                     /product="putative cyclase"
                     /protein_id="QED90619.1"
                     /transl_table=11
                     /translation="MSQTSPRTTTPPTGPDVVGSPSTRTPGERPGDPARVDVAHTVTVP
                     AAPDVVFALLADVERWPLIFPPTVHARFLERAPDEGGPERLQLWATANGGVRTWTSRRL
                     VDPVRRRISFGQDRPQSPVAAMGGEWIVSPADAGSEVVLTHTYAAVGDDAETLGWLEKA
                     VDGNSRAELAALAEAAREKEAGLETAFTFRDSLHIESTAAEVYGFLDRAERWEQCLPHV
                     ARVRLTEDLPGVQILEMDTRTADGSSHTTRSVRICRASRSIHYKQLVTPALLRVHTGSW
                     LLTEDDRGVTVVAEHTVVLETAAVAQVLGPDADVRQARAFVRDALGRNSSATLRQAKAF
                     AEGTSGA"
     aSDomain        8915..9346
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_QED90619.1_Polyketide_cyc2.1"
                     /domain_subtypes="Polyketide_cyc2"
                     /evalue="1.90E-18"
                     /label="QED90619.1_Polyketide_cyc2.1"
                     /locus_tag="QED90619.1"
                     /protein_end="179"
                     /protein_start="35"
                     /score="59.0"
                     /tool="antismash"
                     /translation="VDVAHTVTVPAAPDVVFALLADVERWPLIFPPTVHARFLERAPDE
                     GGPERLQLWATANGGVRTWTSRRLVDPVRRRISFGQDRPQSPVAAMGGEWIVSPADAGS
                     EVVLTHTYAAVGDDAETLGWLEKAVDGNSRAELAALAEAA"
     aSModule        8915..9835
                     /domains="nrpspksdomains_QED90619.1_Polyketide_cyc2.1"
                     /domains="nrpspksdomains_QED90619.1_Polyketide_cyc2.2"
                     /incomplete
                     /locus_tags="QED90619.1"
                     /tool="antismash"
                     /type="unknown"
     aSDomain        9377..9835
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_QED90619.1_Polyketide_cyc2.2"
                     /domain_subtypes="Polyketide_cyc2"
                     /evalue="1.70E-08"
                     /label="QED90619.1_Polyketide_cyc2.2"
                     /locus_tag="QED90619.1"
                     /protein_end="342"
                     /protein_start="189"
                     /score="26.8"
                     /tool="antismash"
                     /translation="FTFRDSLHIESTAAEVYGFLDRAERWEQCLPHVARVRLTEDLPGV
                     QILEMDTRTADGSSHTTRSVRICRASRSIHYKQLVTPALLRVHTGSWLLTEDDRGVTVV
                     AEHTVVLETAAVAQVLGPDADVRQARAFVRDALGRNSSATLRQAKAFAE"
     CDS             9846..11693
                     /NRPS_PKS="Domain: AMP-binding (16-415). E-value: 5.8e-79.
                     Score: 257.4. Matches aSDomain:
                     nrpspksdomains_QED90620.1_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     339.3; E-value: 5.4e-103)"
                     /gene_kind="biosynthetic-additional"
                     /note="Skt11"
                     /product="AMP-dependent ligase"
                     /protein_id="QED90620.1"
                     /sec_met_domain="AMP-binding (E-value: 7.5e-86, bitscore:
                     278.5, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPDLLDGLPARADLLLRAAAQRHGDRPALVLGSRTVTYAELDAAV
                     DRCAAVLRERFGGGGAVVAIGADLHPDVVVAYHGALRSGNQALMVIPLLREQQLQYVLE
                     ASGARAALVGAGLYDRLDRVRHGLPGLELVAVLGEEPADAAPGAPRLAGLLESAVPGAP
                     EWHADPEAPAALHFTSGTTGLPKAVVLSHRNVTVNAVQTARAQGLEAGSVTLVHFPSYH
                     PMHMNSALAAGATQVLVPEADPAHAMERARACGAAFVYSLPARLARLAAHPRLSGMRLP
                     DAVMIASGGSALAPALAGTLSRHFGVPVVQGYGLAEASPLTHFDRPGDHLPGSVGRPVE
                     GTEHRAVSLEDGSGLPPGEHGEIQVRGPQVMRGYLDPAHGPAVDADGWLATGDVGRIDG
                     DGRLHLTDRIKDVFKCDNWLVAPSEIEALLAEDPAVADSVVLDRPDPVSGAVAHALLVL
                     ADPDSPGEAEEALGRLNARLPYYKRIRSHDVVARIPRTPNGKIPRRELRASFHARLDGG
                     SPMVILINEFILTSAPEEFEKVFEASSVYMREQPGFIDHTLVRSMTNPNTYINIARWED
                     AAAHIEVVRSEGFQDHIRQLAGVAKATPQLHTVVSHVER"
     aSDomain        9894..11090
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_QED90620.1_AMP-binding.1"
                     /evalue="5.80E-79"
                     /label="QED90620.1_AMP-binding.1"
                     /locus_tag="QED90620.1"
                     /protein_end="415"
                     /protein_start="16"
                     /score="257.4"
                     /tool="antismash"
                     /translation="RAAAQRHGDRPALVLGSRTVTYAELDAAVDRCAAVLRERFGGGGA
                     VVAIGADLHPDVVVAYHGALRSGNQALMVIPLLREQQLQYVLEASGARAALVGAGLYDR
                     LDRVRHGLPGLELVAVLGEEPADAAPGAPRLAGLLESAVPGAPEWHADPEAPAALHFTS
                     GTTGLPKAVVLSHRNVTVNAVQTARAQGLEAGSVTLVHFPSYHPMHMNSALAAGATQVL
                     VPEADPAHAMERARACGAAFVYSLPARLARLAAHPRLSGMRLPDAVMIASGGSALAPAL
                     AGTLSRHFGVPVVQGYGLAEASPLTHFDRPGDHLPGSVGRPVEGTEHRAVSLEDGSGLP
                     PGEHGEIQVRGPQVMRGYLDPAHGPAVDADGWLATGDVGRIDGDGRLHLTDRIKDVFKC
                     "
     CDS_motif       10368..10421
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_QED90620.1_0001"
                     /evalue="3.40E-06"
                     /label="NRPS-A_a3"
                     /locus_tag="QED90620.1"
                     /protein_end="192"
                     /protein_start="174"
                     /score="19.7"
                     /tool="antismash"
                     /translation="LHFTSGTTGLPKAVVLSH"
     CDS_motif       10911..10973
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_QED90620.1_0002"
                     /evalue="6.90E-07"
                     /label="NRPS-A_a6"
                     /locus_tag="QED90620.1"
                     /protein_end="376"
                     /protein_start="355"
                     /score="21.7"
                     /tool="antismash"
                     /translation="PPGEHGEIQVRGPQVMRGYLD"
     CDS             11683..12423
                     /NRPS_PKS="Domain: PKS_KR (12-176). E-value: 8.8e-09.
                     Score: 27.4. Matches aSDomain:
                     nrpspksdomains_QED90621.1_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     137.6; E-value: 8.3e-42)"
                     /gene_kind="biosynthetic-additional"
                     /note="Skt12"
                     /product="short-chain dehydrogenase/reductase SDR"
                     /protein_id="QED90621.1"
                     /transl_table=11
                     /translation="MSADPLGLAGVPVLVAGATGRVGGAVARAFAARGAEVLVHGRSDG
                     GTKTLADALTAGYGVRAHPLTADLTSPDAPRALRAGLAAAGVERLNVLVNCVTGYDGLP
                     RSAADLTAEEFRAVLETDLVAVHTLVATALPLLVASGRARVVLLSSLAGVRGRPAAAHL
                     CAAKAGVAGLTLALAHDLAGQGVRVNCVAPGPVQEPGVAHAGPLGPGVAPNTPDEVAGC
                     VVALASDLSSPVTGHLQVVNGGRP"
     aSDomain        11719..12210
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_QED90621.1_PKS_KR.1"
                     /evalue="8.80E-09"
                     /label="QED90621.1_PKS_KR.1"
                     /locus_tag="QED90621.1"
                     /protein_end="176"
                     /protein_start="12"
                     /score="27.4"
                     /tool="antismash"
                     /translation="VLVAGATGRVGGAVARAFAARGAEVLVHGRSDGGTKTLADALTAG
                     YGVRAHPLTADLTSPDAPRALRAGLAAAGVERLNVLVNCVTGYDGLPRSAADLTAEEFR
                     AVLETDLVAVHTLVATALPLLVASGRARVVLLSSLAGVRGRPAAAHLCAAKAGVAGLTL
                     A"
     CDS_motif       11722..11799
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_QED90621.1_0001"
                     /evalue="6.90E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="QED90621.1"
                     /protein_end="39"
                     /protein_start="13"
                     /score="15.5"
                     /tool="antismash"
                     /translation="LVAGATGRVGGAVARAFAARGAEVLV"
     CDS             12447..13238
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     150.3; E-value: 1.1e-45)"
                     /gene_kind="biosynthetic-additional"
                     /note="Skt13"
                     /product="short-chain dehydrogenase"
                     /protein_id="QED90622.1"
                     /sec_met_domain="adh_short_C2 (E-value: 1e-31, bitscore:
                     101.1, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNAPLTHHSPRPERHPGLLPPGRIALVTGASRGLGRAVAHRLRTD
                     GCHVYLNYAHDDAAAADAVEAAAGLPGSTTPVKGDIRSADFLEGLLDRIRDDHGQLDIL
                     VHNAATMHPMLPVAPEVAPLFDEIALALNPLLHGAATVAKLMPEGGRVVAVSGNGAFEV
                     IPHYLATGVAKAALENLVRYLAVDLAPFGITVNAVSTHLLDKGEHTSNPAIAGLLASRT
                     PNGRLTRPEDVADVIALLCAPEAAWIQGQVVVADGGLGLRA"
     CDS             13249..14502
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1050:monooxygenase FAD-binding (Score: 252.2; E-value:
                     1.9e-76)"
                     /gene_kind="biosynthetic-additional"
                     /note="Skt14"
                     /product="FAD-binding monooxygenase"
                     /protein_id="QED90623.1"
                     /transl_table=11
                     /translation="MDITTDICVVGAGPAGLTLALLMLRSGARVTVLDRTRSFEREYRG
                     EILQPGAMTLLDRLGVLDGARARGGYELGRFQLVENERLLMDIDYGTLPPPYGFLLSLP
                     QRHLLTELFEACSRYPEFTYLEGCGIRELVREGGAVTGVVCGRGDDRRRITAPVTVAAD
                     GRYSRTRRLAGIEQHRLDAFAHDILWFRVPAGGRTDRSVRVHRTGGTPVLIYDSYPDCV
                     QIGWTLPHNGYRRLAEEGVESLRSRIAHAVPDYAEQVLDQVKTLNDLTLLDVFSGYADR
                     WADDGLVLVGDSAHTHSPIGAQGINLALQDAALLHPVLMDALDSGDFGESALSRWVPER
                     RKDIDAVFTLQARQSKAMLGGGSRLAGAVRPLAARALAHTPLYGKILRAIAFGARPITV
                     RSDLFGEAEPLRGEAAGA"
     CDS             14499..15272
                     /codon_start=1
                     /note="Skt15"
                     /product="putative cyclase"
                     /protein_id="QED90624.1"
                     /transl_table=11
                     /translation="MRIIDLSSPVDASFWEPDEVVHRVLDAHQAAVHVRDEMKEHFGLE
                     LDPEVFPDGAFLTNDYLTLTAHTGTHVDAPAHYGPAEGSHTPRTIDRMPLDWFVRPGMV
                     LDLRDVGTGTAGVAHLEREFERVGRRPRPMDVVLLHTGADRNLGKPEYFTEFTGLDGPA
                     TRLLLELGVRVIGTDAFSLDAPFTHIIREFHRTGDKAVLWPAHFAGRREEYCQLERLAN
                     LQDLPVSTGFTVSCLPVKIAGAGAGWSRVVALLDE"
     CDS             15445..16431
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039:aldo/keto reductase family oxidoreductase (Score:
                     353.5; E-value: 1.5e-107)"
                     /gene_kind="biosynthetic-additional"
                     /note="Skt16"
                     /product="aldo/keto reductase"
                     /protein_id="QED90625.1"
                     /transl_table=11
                     /translation="MENRKLGAAGLGVSALGLGCMGMAGAYGTADTDEAVATVRRALDL
                     GVTLIDTADFYGPGTAEKIVATALEGRRDEAVVATKFGMRRPAAGPPFVDGSPAYVREA
                     CEASLQRMGLDHIDLYYLARLDPKVDVEETVGALGELVAEGKVRHIGLCEVSARTLRRA
                     NAVHPIAALQTEYSLWERHVEAEILPACRELGTGFVAYSPLGRGFLTGAFDSAEDLAED
                     DQRRNHPRFQSENFDHNRDLVRTVEDMAKEKGVSLTQLALAWVLAQGGDVVPIPGTRRV
                     SHLEQNVSAADVRLTEDEVARLSGLFPAGATAGLRYPAHFMRTIDQS"
     CDS             complement(16517..17548)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PKS-like: ksIII"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1084:3-oxoacyl-(acyl carrier protein) synthase III
                     (Score: 112.6; E-value: 3.4e-34)"
                     /gene_kind="biosynthetic"
                     /note="Skt17"
                     /product="3-oxoacyl-ACP synthase III"
                     /protein_id="QED90626.1"
                     /sec_met_domain="ksIII (E-value: 3.7e-91, bitscore: 295.6,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRCDQLYVAGLGTWLPPAEPVAEAVARGDVDEAAARRSGMRSVTV
                     CQDDAPAPAEMAVRAAGLALRRAGTDGSDVRMLLHASLYDQGNALWGTASYVQRRSVRA
                     GCPALEVRQVSNGGMAALLLASAVLAQGGGEVLLTTADRFCPPGFDRWRSDPGTVYADG
                     GTAMLLSAGGGFARVRSLAVVSDPELEGMHREGDPFGEARTAPAGVLDLEAHKKRYVAR
                     AGMSFSVARVTAGQRDAVKEALADAGVKAADISRWVLPHFGRRRLETNCLRPLGIGADR
                     TTWEFSSRVGHLGAGDQTAGLEHLVRSGALGQGGLCVLMGVGAGFTWSCAVVEILRVPG
                     WTA"
     CDS             17723..18724
                     /NRPS_PKS="Domain: PKS_AT (18-296). E-value: 2.6e-67.
                     Score: 219.1. Matches aSDomain:
                     nrpspksdomains_QED90627.1_PKS_AT.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PKS_AT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1021:malonyl CoA-acyl carrier protein transacylase
                     (Score: 263.9; E-value: 5.6e-80)"
                     /gene_kind="biosynthetic-additional"
                     /note="Skt18"
                     /product="acyltransferase domain-containing protein"
                     /protein_id="QED90627.1"
                     /sec_met_domain="PKS_AT (E-value: 8.7e-68, bitscore: 219.1,
                     seeds: 1682, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTNPTPAPAAEPLPVALLLPGQGAQHPGMATGLYGHDEVFTGAAD
                     EVFDALGAPGTHVRDDWLGERPGVPMDHVTRSQILLFTIDYALGRTVESWGVRPAVLLG
                     HSVGEMAAAVLADVFTLADAARLMWDRVTRLADGPAGGMVAVAAAPDALTPYLRDDVVV
                     GAHNAPRQTILAGPEPHLGQVTRELREQGLVCRTVPSSTPFHSPVLAPLAARAEPAFAA
                     VRARPPALPLISGYTAAPLTARQAADPAWWSSHPVAQVRFWPALDHLLGGPGRQLVECG
                     PGRGLSALARRHPAVLAGRSRVLPLLPAGPADASRTRDDLAAARSFLTAHSA"
     CDS_motif       17774..17824
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_QED90627.1_0001"
                     /evalue="3.50E-05"
                     /label="PKSI-AT-mM_m1"
                     /locus_tag="QED90627.1"
                     /protein_end="34"
                     /protein_start="17"
                     /score="16.3"
                     /tool="antismash"
                     /translation="LLPGQGAQHPGMATGLY"
     aSDomain        17777..18610
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_QED90627.1_PKS_AT.1"
                     /evalue="2.60E-67"
                     /label="QED90627.1_PKS_AT.1"
                     /locus_tag="QED90627.1"
                     /protein_end="296"
                     /protein_start="18"
                     /score="219.1"
                     /tool="antismash"
                     /translation="LPGQGAQHPGMATGLYGHDEVFTGAADEVFDALGAPGTHVRDDWL
                     GERPGVPMDHVTRSQILLFTIDYALGRTVESWGVRPAVLLGHSVGEMAAAVLADVFTLA
                     DAARLMWDRVTRLADGPAGGMVAVAAAPDALTPYLRDDVVVGAHNAPRQTILAGPEPHL
                     GQVTRELREQGLVCRTVPSSTPFHSPVLAPLAARAEPAFAAVRARPPALPLISGYTAAP
                     LTARQAADPAWWSSHPVAQVRFWPALDHLLGGPGRQLVECGPGRGLSALARRHPAV"
     CDS_motif       18008..18115
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_QED90627.1_0002"
                     /evalue="3.20E-16"
                     /label="PKSI-AT-M_m3"
                     /locus_tag="QED90627.1"
                     /protein_end="131"
                     /protein_start="95"
                     /score="51.4"
                     /tool="antismash"
                     /translation="GVRPAVLLGHSVGEMAAAVLADVFTLADAARLMWDR"
     CDS             18794..20404
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1059:acetyl-CoA carboxylase, carboxyl transferase,
                     (Score: 712.7; E-value: 4.8e-216)"
                     /gene_kind="biosynthetic-additional"
                     /note="Skt19"
                     /product="methylmalonyl-CoA carboxyltransferase"
                     /protein_id="QED90628.1"
                     /transl_table=11
                     /translation="MTTTDSPAPTAGPVPAPPAASGMRRRVGELGALRAQVHAGPGEKA
                     TGAQHARGKLTARERIDLLLDPGTFQEVERFRRHRATGFGLEANRPYTDGVITGWGEVE
                     GRTVFVYAHDFRMFGGALGEAHAAKIHKIMDMALAAGAPLVSLNDGAGARIQEGVSALA
                     GYGGIFRRNTRASGVIPQISVMLGPCAGGAAYSPALTDFVFMVRGTSQMFITGPDVVRA
                     VTGEEVTLSGLGGADVHAETSGVCHFAYDDEESCLVEVRYLLGLLPANNRERPPRAETG
                     DPAGRRSPRLLDLVPAEGSRPYDMREVIAELADDEEVLEVHERWAPNILCVLIRLAGEV
                     VGVVANQPLSLAGVLDIKASEKAARFVQMCDTFNIPLVTLVDVPGFLPGVGQEHDGIIR
                     HGAKLLYAYCDATVPRITVILRKAYGGAYIVMNSQSIGADLTFAWPTNEIAVMGAEGAA
                     NVIFRRQIAEAEDPDETRARLVKEYRAELMHPYYAAERGLVDDVIDPAATRETLAAALT
                     VLRTKTAEAAPRKHGNPPL"
ORIGIN
        1 gtcagcgggc ggatgccacg gcgtccagca ggagccgggg cgtcctggcc ccgctcagca
       61 cctcctccgg catgcgcaca ccgagctccc gctcgatccg ggtcgccgtc tcgagcagcg
      121 cgagcgagtc gtagccgagg ttctcgaacg gcgcgtccag gatgtcgccg tccaggtcga
      181 cgttctcgtc ctccccggcg cattcccgca tcacgcgctt caggtcggcg agggtgaagc
      241 ccttcatggt ggtcaccttt cactggggat ttgtccaggg atgggtcatc ggggtgtcgg
      301 tccgcaccgg cgcacgacca cggcgctgtt gaagccgccg tacccacgcg ccagcaccag
      361 tgccgcgtcg ccggccatcg gccggggccg gccggtcacg aggtcgatcc ggtacgccgc
      421 cgggacccgg ccgacgtcgg cggtcggggg gatcagcccg tcacggaccg cgagcagcgc
      481 cgccgcgagg tcgagcgcgg aggcgccggc ccccgggcgt ccggtgcggg aggtgatcgc
      541 ggtgaccggc acggcgtccg gcccgaagac cccggcgatc gccccggcct cctgcgcgtc
      601 gagatccgga accgcggctc cctcggcgaa caccgcgccg atgtccgccg gttccactcc
      661 cgcgtcggcc agcgccgcgc gcgcggcccg cgccgggccc gtgggccgcc ccgagcccgg
      721 gggagggtcg aagcaggccg cgtaacccgc cacctcgccg tacgggcgga tgcctcctct
      781 ggcgtgagcc gaggcctcgt cctccagcat cagcagcgcg ccgccctccg cgacgacatg
      841 accggcggcg cgctccccga aaggcaggca ggcgtcctcg gaccggtcgg cggtactcag
      901 ccggccgccg gtcagctccg ccacgtgccc ccaggggcac agcgccgact ccatcgcccc
      961 ggtgagcacc gccggggtgc ccttgcgcag catgcggcgc gcgtggccca ccgcgtccag
     1021 gccgccggac tggccggtga ccaggacgcc gctggggccg cgcaggccgt gccggatgga
     1081 gatctggccg gtgttgacgg cgtagaacca ggcgaacgac tggtaggcgc tgacgtacag
     1141 ggggcctttc gcccacaggt tctccagctc ccgctgaccg aactcgaacc cgccggcggc
     1201 attggcggtg accaccccga tcccgtactc cggcgccccg gccgggtcca ggcccgagtc
     1261 cctcagcacc tcggcggcac aggccagcgc gagctgtgtg acgcggtcgg tctggggcag
     1321 caggcggccg ggcaggtcct cgccggggtc gcgtgcgatc tcgccggcca gccggctcgg
     1381 gtagccggag gcgtcgaagc gggtgatcgg gccgatgccg ccgcgtccct ccagcaggct
     1441 ccgccagaac tcctcggtgc cgtccccgtt ggccgcccgc acgtcgaggc cggtcaccag
     1501 ggctgtgccc cgccgggttc cgggtgccgt ggacgcgggt gcgggggcgg tcatcggcgt
     1561 gtcccttcgg gccgggtgag caccatggcg ctctggaagc cgccgaaacc gctgcccacc
     1621 gtgaggacgg cgtccaggcg ctgctccctg gcggtgaccg gcacgtagtc cagcgggcag
     1681 tcggggtccg gttcgtggag gttggcggtg ggaggcacga ctccgtgctc cagggcgagg
     1741 gcgcacgccg cgatctctat ggccccgatc gcgccgagcg agtggccgat catcgacttg
     1801 atggagctga cgggaatgcc ccgggcgtgc tcgccgagcg cgcgcaggaa ggcggccgac
     1861 tcgtgccggt cgttctgcag cgttccggag ccgtgcgcgt tgacgtagtc gaccgcggtc
     1921 gggtccagcc gggcctcgtc gagggcccgg gtgatcgcct ccgccatctc ccggccgtcc
     1981 ggccgcagac ccgtcatgtg gtaggcgttg ccgcgcgagg cgtgaccgcc tatctcggcg
     2041 tagacgtgcg caccccggcc cacggcgtgc gaccactcct ccagcaccag cacggcggcg
     2101 ccctcaccga ggacgaagcc gtcccgggtg cggtcgaacg gccgcgaggc ggtcgccggg
     2161 tcgtcgttgc gcgcggaggt cgccctgatg gcgtcgaagg aggcgacggt gatgggggag
     2221 atcggcgcgt cggtcccgcc ggtgagcatg acgtcggcgg tgccctcgcg gatgatctcg
     2281 caggcgtgcc ccacggcgtc gagcccggac gtgcagccgg ccgagatcac cgcggcgggg
     2341 ccgagggcgt ccgccgccca cgccacctcc cgggccaggc tgctggggac gaggtagtcc
     2401 accagctgcg gcacggcgtg gcggtggtcc acgagccagt cgcggccgcc gtcgctgacg
     2461 acggcgtact cgttctccag gctcgtcgtg cagccgaccg cggtgcccag ggacacaccg
     2521 gtccgctcgg gcaccgggga agtgccggac gcgagcccgg cgtccgcgag cgcctcccgg
     2581 gcgcaggcca cggcgaacag ggccgcgcgg tccagtctgc ggacctcacg cgcggagaag
     2641 ccggcggcca gcgggtcgaa ggcgcactgc gcggcgatgc gcgaacggta gggcgtcgcg
     2701 tcgaaggccg tcagggggcc cgtcgcggtc cggccggaag tgatcagtga ccagaactcc
     2761 ttcgtcccgg tgccgccggg tgcgaccacg ccgattccgg tgacggcgac cctgcggttc
     2821 acctcggcac gtccacggaa tggccggatc tgcaccaagc gaaaacagat ggtttccagt
     2881 ggtccggtag attctgcgcg gtctccgccc tgtgctgggc ggcccccgtc gcacgctgtg
     2941 cgctgtccat ctgatcgacc ctttcccgtg ctcggccggt ggcgtgacgc atcccccgtg
     3001 gagggacgcg gatcatcctt ggccgcgccg ctggaggggg gcttgggaac cggtggaacc
     3061 gggaagcggc ccgggattcc gggccgcgta tcatcgccgg gggcgtgcgg tccgtcgtgt
     3121 cgtgagcccg cccgtacacc gcccgcaacc cgcgaaggtc acttccgcat ggctgttcgg
     3181 cccgccgtgt ccctcgggga cttcagcacc ctgttcgccc tggccgggcg ttccacccgc
     3241 ctccggtccg aacgtctgct caacgacttc ggactccacg tcggtcagca gttcttcatg
     3301 cgctgtctct gggagcagga cgggagcacg gtcggagacc tcgcccggcg ggtcagggtg
     3361 gaggcaccga cggcgaccca ggcggtcaag cgcatggagg cggccgggat ggtgcgccgc
     3421 acccccgacg agcaggacgc ccggcgcagc cgggtgtggc tgacgccgct cgggcggcgg
     3481 acgtggccgc tggtcaccgc cgcgctcgcc gagctggagc gggatctgct cgcgcccttc
     3541 acacagccgg aacgggagca gttcatgtcg ctgctgctgc ggctctacga gacgtccctc
     3601 cccgcggacg gaccgggtgc ggacgggacc ggcaccggcc cggacgccac cggcggaagc
     3661 cgcgcggact gagcgcccgg cgctccagcg gggctccagc cgccttccag accggccgag
     3721 cacgctggtg gcccctacag cgcgaaggag gtccgatgcc gcacaccggc acggcaccgc
     3781 tcgacccggc ccgacccggc accgccgggc tccacggcga gatcacccac ttctacgcac
     3841 ggcagatgca ggccctcgac gacggcagga ccgacgactg ggcgcggacg ttcaccgagg
     3901 acggggtctt cctcctgcac ggcggccacg accgggcgga gggccgcccc gcgctcgccg
     3961 cgagcagcgc gaaggcccgc gccgcgctcg ccgagcaggg cgtcacgcac cggcactggc
     4021 tcggcatgct gacggtggac cccaggcccg acggaagcgt cgtggcccgc tgctacgccc
     4081 tggtcgtcgc cacccacctt ggcgggaccc cggcgctgca ccgcagcacc gtgtgcgagg
     4141 acgtgctggt gcgcgacgga gacgcctggc tggtccggca ccggcaggtc agccgcgacg
     4201 acctggcctg acggcatgcc gcggggcccc tcccggggcc ccgcggaccg tcaaggccgc
     4261 ccggccgggc tcagccggcc gtctcgtacg gcattccgcc cgccagcatc tggggctgcg
     4321 gcgaggccga cgagagtatg gcgcgctgga gctgctggag gaaccaggcg ggctccatgc
     4381 cgagttcctc ggccagggcg cgtcggagcc gctggtacac gtccagggcg cacgagcggc
     4441 gccccgaccg ccacagtgcc ctcatgtact gggcgtgcag gttctcgtgg aagcggtgat
     4501 gggcggtcag cgcggccagc ccgtccagga gttcctggtg ccggccgagc ctcatctcgg
     4561 cgtcgatgca gagccccaga gtggtcagcc gcagctcctc gagccgggtg acgtgggccg
     4621 tgacgcgttg gcccgtgtcc acgtccgcga gcacctgccc gcggtagagg tcgagggcct
     4681 gtgagaggag caccacgccc gtctcgtcgt cccccctgct gatggcctcg cgcccctctt
     4741 tggcgagccg gccgaagcgg tgcaggtcga cggcgtcgtc ggggatccgg agcatgtatc
     4801 cgggacccgc cgtcaccagc agttcccccg ccgagggtgc ggcggcctgc agcagtttgc
     4861 ggagcgtcag tatgtacgtc tggagcgtcg tcctggcgct ggccggcggg cggttgcccc
     4921 acagctcctc caccagcgcg gagacgggga cgatctggtt gcggtagatg aggagaagtg
     4981 ccagcacctt cttcggtttc ggtgcgctgg gaacgcaaac catgtcaccg aaccgtaaat
     5041 ccaggatccc cagtatgacg acggaaatgt ccatcatttc ccccccaaga tctgcattgc
     5101 cgtggtcatg acggactccc ccgagtaccg gtgcgacctg gccgctttgt gtgtagtgcc
     5161 tgtgatgcac ccgaacgcta cccagacggg ccgtgggtac tgtcgaatgg acgcgtcgag
     5221 gctcggcgcg aattgtcctg aaggcgcttg cactgttcat gaggtgctgc tagacggtgg
     5281 gcggcggatc tcccggaggg ttccgcgggt ggtccgccct tccctgccgg ggcggggaag
     5341 ggcgtgaggc acggcgtcag ttcagcatgc ggtccagcgc cttgtgcacg cagcggtcgg
     5401 cgagagcggt gacggtcagg gcggggggaa ccgtcgccat cgtgccgggt atcagcgagc
     5461 tgtcgatgac gtgcaggttg tcgtacccgt acagccggcc gtccagcctg cacgccttgc
     5521 cgaggaccgc tccaccgagc gtgtgcgacg tggtgtcggc gttcacgcgc agggtcgagg
     5581 taccggggtt ggcggcgttg atgcggttca cggtggccgt caccgcctgg gtggcgcgta
     5641 cggccgaggc tcccgtggcc ggccaggtca gggagacccc gtcggtcgcc gcgtcgtagc
     5701 tgaagaaccc ctctgcggcg cacgtggtca tggccagggc gccgagcgct ccggtcccgt
     5761 ccgcgggcgg caccggccac gggaagttga tcatcgtcac cggttcgtac gggttgtcga
     5821 ggtcctgggc gacgatgccg gacggtcctc cctgcgtgga gttgttccag ggcatcccca
     5881 cccgcaccgt ctgccggtcg ctgttggtgc cccagccctt gccgacggag gcgcggagcg
     5941 cgggcaggct gccgcgtccc cgcgcggcca ccagcagccg gctggtcccc agtgaaccgg
     6001 cggcgaagaa cacgcgcttc gcgctgtagt cgggccgggc caccacggcc cccgtgtcgt
     6061 cgatgcgttc gcaccgcacc acgtagcggc cgcccgaggg caccacgtcc accacccgcg
     6121 tcagtgtctc caccgacacc cggccggtcg cctcggcggc ggccaggacg gtccggtcga
     6181 cactgcgctt ggccccgctg ttggcacccc agatggaacg ggcgatgatc agcgacgcct
     6241 cacgggtgcc cgcctgctcc tcccgcaccg cctgccagtc gacggccatg tccgcccgga
     6301 acggggccag gcccgccgcc gcggtctcgg cggtgaagga acgggcggcc gtgtagtgcg
     6361 acgaggcgta gacgtcgtcc ggcatcgggg ccggaccgat cagggagcgg gcccgcgcgt
     6421 accagcgctc gctcatctcg tcgaagtcga tgtcggtgcc gaacgcccgg ttgaacgccg
     6481 cctcggacgg cttgagcatc accgcgttgt tgaccaggga gccaccgccg acacccgcgc
     6541 cggcgagagc gatgacgccg tcggcgcgga aggcctcgag cacacccggg tagacgtcga
     6601 gctgctgggg gacgaacgga ctccaggagt tgagccagga cgcccggccg tcaggcgccg
     6661 cgggggtggc gaacgtaccg ccctgcgccg tgaccggcca gcgcctgcct cgttcgagga
     6721 ccaccgagtg caggcccgcc tgggcgaacc ggagggcggc gacgctgccc gcgtacccac
     6781 tgccgatgat gaggatctcc acgggctccg cggcggacgc cacggcggac cgcagcggca
     6841 gcgccccgag cgccgtacct gccgcgacgc cggtgaggaa ccgccgacgg gagagcgact
     6901 ttctgcctga cattccactc ctcgtgttga gcgaaggact acggcagggg gcgcgccgag
     6961 gccggaaacc ggcccgcggg acgcgccccc gcgtacggtg acctccccgc cacggcggcc
     7021 cggagcgagc gggacgggcg gggggcaccg gatcagcgct tgcgcgcgat ggtcagaccg
     7081 tcggcgagcg gcagcatgac cacatcgacc ctggggtcgg cggcgagcgc ggggttgaac
     7141 tcccgcaggg cggcggcgtt tccggtcacc ggctcgtcac cgagcacacg gccgccgtac
     7201 aggacgttgt cgaagacgat caggcccccc ggccgggtcc tgaccaccag ttcctcgaag
     7261 tacgccgcgt aaccggtctt gtccgcgtcc acgaacgaga agtcgatgtc ctcatcgacg
     7321 ggcagcgccc gcagggtctc cagggccggg ccgaggcgca gctcgatcag accggccagc
     7381 cccgcggact cccagccgtc ccgggctatg cgcgtccact cctcgctggt gtcgcagcag
     7441 agcaggtgcc cgtcggccgg cagcgcccgg gcgatggaga gcgacgagta gccggtgaag
     7501 gtgcccacct cgaccgcccg ccgcgctccg accgtcctgg ccagcagcgt gatgagagcc
     7561 ccctgttcgg gggcgatccg catgccggcc ttgtcgccgg tctccttctc ggtgcgcgcc
     7621 accagctcgt ggtgggcggg cagcggtgcg atgccgctcg cgaccacgta gtcgacgacc
     7681 tcctgggtgg cctgcacccg catcggctgg tcggcaggaa attccatcgt cactcctctt
     7741 tcagggcccc cacgggcccc ggcagtcgcc aagacctgca caacgtagga gcggcggctg
     7801 gagaagcact tgagggccag tccacgggcc ggtggtgacg tcccggacgc tccagccgtg
     7861 ttcgagccgg actcgaccgt gcccggcaag cctctctggc gacgccggac acgggcccac
     7921 gcctccggcc cgtgccacga gacgccgcac agcggccagg aacgaggagt gagatgcctg
     7981 ccagcgcccc cagcaccccg gcggacccgc gtacggccct gatcacgggc gccaccagtg
     8041 gaatcgggct cgcggtcgcc cgcgccctgg ccgcctccgg actccgcgtg ttcctgtgcg
     8101 cccgctccgc ggacgacgtg gccgcgacgg tcgaggaact gcgcgaccac ggctacgagg
     8161 cggacggcgc ggcctgcgac gtccgctccc gcgcggaggt ggccgacctg gtcgccaccg
     8221 ccgtcgcggc gttcggaccg gtcgacgtcc tggtcaacaa cgccggccgc aacggcggcg
     8281 gagtcaccgc ccagctcccc gacgagatct ggtacgacgt cgtcgacacc aacctcaaca
     8341 gtgtcttcct ggtgacccgg gaggtgctgg cggccggcgg gatgctggag cggccgcgcg
     8401 gacggatcat caacatcgcg tccaccgggg gcaagcaggg ggtcgtcctg gcagccccgt
     8461 actccgcgtc caaagccggc gtgatcggca tgaccaaggc cgtcggactg gaactcgcct
     8521 cctcgggaac caccgtcaac gcggtctgcc ccggctacgt ggagacgccc atggccgagc
     8581 gggtgcgcaa ggcgtacgcc gaggcctggg acaccggcga ggaacaggtc cgcgaacgct
     8641 tcgaggccaa gatcccgctc ggccgctaca ccacgcccga ggaggtggcg gccatggtcg
     8701 gctacctcgt gtcgcccgcc gcggacgccg tcaccgcgca ggcgctcaac gtctgcggcg
     8761 gtctcggcag ccactgaccc ccgccgcccc cttcggaagg tgcacacccg tgtcccagac
     8821 cagcccccgc accaccaccc cgcccaccgg cccggacgtc gtcggcagtc cctcgacgcg
     8881 cacaccgggc gagcgccccg gcgaccccgc acgtgtcgac gtggcgcaca ccgtcaccgt
     8941 gccggcggcg ccggacgtcg tcttcgccct gctcgcggat gtcgagagat ggccgctgat
     9001 cttcccgccc accgtgcacg cccggttcct ggagcgggct ccggacgaag gcggcccgga
     9061 acggctccag ctgtgggcca ccgccaacgg cggcgtacgc acctggacgt cccgccgcct
     9121 cgtcgacccc gtacgccggc gcatctcctt cgggcaggac cgcccgcaga gtcccgtcgc
     9181 cgccatgggc ggggagtgga tcgtcagccc cgcggacgcc ggcagcgagg tggtcctcac
     9241 ccacacgtac gcggccgtcg gggacgacgc cgagacgctc ggctggctgg agaaggcggt
     9301 cgacggcaac agccgtgccg aactggccgc cctcgccgag gcggcgcggg agaaggaggc
     9361 gggcctggag acggccttca ccttccgcga cagcctgcac atcgagagca ccgccgccga
     9421 ggtctacggc ttcctggacc gcgcggaacg ctgggagcag tgcctgccgc acgtggcgcg
     9481 ggtgcgtctg accgaggacc tgcccggtgt gcagatcctg gagatggaca cccggaccgc
     9541 ggacgggtcg tcccacacca cccggtccgt ccgtatctgc cgggcgtccc gcagcatcca
     9601 ctacaagcag ctcgtcactc ccgccctgct ccgggtgcac accggcagct ggctcctgac
     9661 ggaggacgac cggggcgtca cggtcgtcgc ggagcacacc gtcgtcctgg agacggccgc
     9721 cgtggcccag gtgctcggtc cggacgccga cgtgcggcag gcccgggcct tcgtccggga
     9781 cgccctgggc cgcaacagct ccgccacgct gaggcaggcc aaggccttcg ccgaggggac
     9841 gtccggtgcc tgacctcctg gacgggctcc ccgcccgcgc cgacctgctg ctgcgcgccg
     9901 ccgcgcagcg ccacggggac cggcccgcgc tcgtcctcgg cagccgtacg gtcacctacg
     9961 cggagctcga cgccgccgtg gaccggtgcg ccgccgtcct gcgggaacgc ttcggcggcg
    10021 ggggagcggt cgtggcgatc ggagcagacc tgcaccccga cgtggtggtc gcctaccacg
    10081 gcgccctgcg cagcggtaac caggcgctga tggtgatccc gctgctgcgc gagcagcaac
    10141 tgcagtacgt gctggaggcg tccggggcgc gggccgcgct ggtgggagcg gggctgtacg
    10201 accggttgga ccgggtgcgg cacgggctgc ccgggctgga gctcgtcgcc gtgctggggg
    10261 aggagcccgc cgacgccgcc cccggagcgc cccgcctcgc cgggctgctg gagagcgcgg
    10321 tgcccggggc gcccgagtgg cacgccgacc cggaggcccc ggccgcgctg cacttcacca
    10381 gcggcaccac gggactgccg aaggccgtgg tgctcagcca ccgcaacgtg acggtcaacg
    10441 ccgtgcagac cgcgcgggcg caagggctgg aggccggctc cgtcaccctc gtgcacttcc
    10501 ccagctacca ccccatgcac atgaactccg cgctggccgc cggggcgacc caggtgctgg
    10561 tgccggaggc cgaccccgcc cacgcgatgg aacgggcccg tgcgtgcggt gccgcgttcg
    10621 tctactcgct gcccgcccgg ctggcccggt tggcggcgca cccccggctc tccggaatgc
    10681 gcctgccgga cgccgtgatg atcgcctccg ggggttccgc cctggcacct gccctcgccg
    10741 gcaccctctc ccggcacttc ggcgttcccg tggtccaggg gtacgggctc gcggaggcgt
    10801 ccccgctgac ccacttcgac cggccgggcg accacctgcc cggatcggtc ggcagacccg
    10861 tcgaagggac ggagcaccgt gcggtctcgc tggaggacgg ctccggactg ccgcccgggg
    10921 agcacgggga gatccaggtc agggggccgc aggtgatgcg cggatacctc gatccggcgc
    10981 acggcccggc cgtcgacgcc gacggctggc tggccaccgg tgacgtcggc cgcatcgacg
    11041 gggacggccg gctgcatctc accgaccgga tcaaggacgt cttcaagtgc gacaactggc
    11101 tcgtggcacc gagcgagatc gaggcgctgc tggccgagga ccccgcggtc gccgacagcg
    11161 tcgtcctcga caggccggac ccggtgtccg gcgcggtcgc ccacgcgctc ctcgtcctcg
    11221 ccgacccgga ctccccgggg gaggcggagg aggcactcgg ccggctcaac gcccgcctgc
    11281 cctactacaa gcggatccgc agccacgacg tggtcgctcg gatcccccgt acccccaacg
    11341 gcaagatccc gcggcgcgaa ctgcgggctt ccttccacgc acgactcgac ggaggttccc
    11401 cgatggtgat cctgatcaac gagttcatcc tgacctcggc acccgaggag ttcgagaagg
    11461 tcttcgaggc cagctcggtg tacatgcgcg agcagccggg cttcatcgac cacaccctgg
    11521 tccgctccat gaccaacccg aacacctaca tcaacatcgc gcgctgggag gatgccgccg
    11581 cgcacatcga ggtcgtccgg tccgagggct tccaggacca catccggcaa ctcgcgggcg
    11641 tcgccaaggc gaccccccag ctgcacaccg tggtgtcgca cgttgagcgc tgacccgctg
    11701 ggcctggcgg gcgtcccggt cctggtggcc ggggcgaccg gcagggtcgg cggcgcggtc
    11761 gcccgcgcct tcgccgcacg gggggccgag gtgctggtgc acggccggag cgacgggggc
    11821 accaagaccc tcgccgacgc cctcaccgcc gggtacggcg tccgcgcgca cccgctgacc
    11881 gcggacctca cctcacccga cgcgccgcgg gcgctgcgcg cgggactcgc ggcggccggc
    11941 gtggaacggc tgaacgtcct ggtgaactgc gtgaccgggt acgacggact gccccggtcc
    12001 gcggccgacc tgacggccga ggagttccgc gccgtgctgg agaccgacct ggtggcggtg
    12061 cacacgctgg tcgccaccgc cctcccgctg ctcgtcgcgt ccggccgggc cagggtggtg
    12121 ctgctgtcct cgctcgccgg ggtccgcggc cggccggccg ccgcccacct ctgcgccgcg
    12181 aaggcggggg tggcgggcct gacgctggct ctggcccacg acctggcggg ccagggcgtc
    12241 cgggtcaact gcgtcgcacc cggccccgtg caggagcccg gcgtcgcgca cgccggcccg
    12301 ctggggcccg gcgtcgcgcc caacaccccc gacgaagtgg cgggttgcgt cgtcgcactc
    12361 gcctccgacc tgtccagccc cgtcaccggc cacctccagg tggtcaacgg cgggcggccc
    12421 tgaccacacg aaggcggtca cacagcatga acgcgcccct cacgcaccac agtcctcgtc
    12481 ccgagaggca tccgggcctc ctcccgcccg gccggatcgc cctggtcacc ggagcctccc
    12541 gcggcctcgg ccgagccgtc gcgcaccggc tgcgcacgga cggctgccac gtctacctca
    12601 actacgccca cgacgacgcc gccgccgccg acgcggtcga ggcggcggcc ggcctcccgg
    12661 gcagtacgac ccccgtcaag ggggacatcc gctcggcgga cttcctcgag gggctcctcg
    12721 acaggatccg ggacgatcac ggacagctgg acatcctcgt gcacaacgcc gcgaccatgc
    12781 acccgatgct tcccgtggcc ccggaggtcg cccccctctt cgacgagatc gccctcgccc
    12841 tgaaccccct gctgcacggc gccgccaccg tcgccaagct catgccggag ggcggcaggg
    12901 tcgtcgcggt ctccggcaac ggggcgttcg aggtgatccc gcactacctg gcgaccggtg
    12961 tcgccaaggc ggccctggag aacctggtgc gctacctggc cgtcgacctc gcgccgttcg
    13021 ggatcaccgt caacgccgtc tccacccatc tcctcgacaa gggggagcac acctccaacc
    13081 ccgccatcgc cggcctgctg gcctcccgca ccccaaacgg gcgtctcacc cggccggagg
    13141 acgtggccga cgtgatcgcc ctgctgtgcg caccggaggc cgcctggatc cagggacagg
    13201 tcgtcgtggc cgacggcggt ctcggcctgc gtgcctgagg aggcggacat ggacatcacc
    13261 accgacatct gcgtggtcgg ggccggcccg gcgggtctca ccctggccct gctgatgctg
    13321 cgttcgggcg cccgggtcac ggtcctggac cgcacccgct ccttcgagcg cgagtaccgc
    13381 ggcgagatcc tccagcccgg cgccatgacc ctgctcgacc gtctcggggt gctcgacggg
    13441 gcacgcgcgc gcggcgggta cgagctcggc cggttccagc tggtcgagaa cgagcgcctg
    13501 ctgatggaca tcgactacgg cacccttcca ccgccctacg gcttcctgct cagcctgccc
    13561 caacggcacc tgctgaccga gctgttcgag gcctgctccc ggtacccgga gttcacctac
    13621 ctggagggct gcggcatccg ggaactcgta cgggaggggg gcgccgtcac cggcgtggtg
    13681 tgcggccggg gtgacgaccg ccgccggatc accgccccgg tcaccgtcgc cgcggacggc
    13741 cgctactcca ggacccgccg gctggcgggc atcgaacagc accggctgga cgccttcgcc
    13801 cacgacatcc tgtggttcag ggttccggcc gggggcagga cggaccgctc ggtgcgggtg
    13861 caccgcaccg gagggacacc ggtgctcatc tacgactcgt accccgactg cgtgcagatc
    13921 ggatggaccc tgccccacaa cgggtaccgg cggctggccg aggagggagt cgagtcgctg
    13981 cgctcacgga tcgcgcacgc ggtgcccgac tacgccgagc aggtcctcga ccaggtgaag
    14041 acgctcaacg acctgaccct gctcgacgtc ttctccggct acgcggaccg gtgggcggac
    14101 gacggactgg tcctggtcgg ggacagcgcg cacacccaca gtccgatcgg ggcgcagggg
    14161 atcaacctcg ccctgcagga cgccgcactg ctgcacccgg tcctgatgga cgccctggac
    14221 agcggtgact tcggcgagtc cgcgctctcg cgctgggtgc ccgagcgcag gaaggacatc
    14281 gacgccgtct tcaccctcca ggccagacag agcaaggcca tgctcggggg cgggagccgg
    14341 ctggccgggg cggtacggcc cctggcggcg cgcgccctcg cgcacacccc gctctacggg
    14401 aagatcctcc gtgccatcgc gttcggcgcc cggccgatca ccgtgcgctc ggatctgttc
    14461 ggcgaggcgg aacccctgcg cggagaggcg gccggagcat gaggatcatc gatctgtcct
    14521 cacccgtcga cgcgtcgttc tgggaaccgg acgaggtggt gcaccgcgtg ctcgacgccc
    14581 accaggccgc cgtgcacgta cgggacgaga tgaaggagca cttcgggctg gagctggatc
    14641 ccgaggtctt cccggacggc gccttcctca ccaacgacta cctgacgctc accgcccaca
    14701 ccgggacgca cgtcgacgcc cccgcgcact acggtcccgc ggaagggtca cacacgcccc
    14761 ggaccatcga ccggatgccg ctggactggt tcgtacggcc cggaatggtc ctcgacctcc
    14821 gggacgtggg tacgggaaca gccggagtcg cccatctgga gcgggagttc gagcgggtgg
    14881 ggcgccggcc ccggccgatg gacgtggtgc tgctgcacac cggtgccgac cggaacctcg
    14941 gcaaaccgga gtacttcacc gagttcaccg gcctggacgg gccggccacc cgcctgctgc
    15001 tcgaactggg ggtgcgggtc atcggcaccg acgccttcag cctcgacgcg ccgttcaccc
    15061 acatcatccg cgagttccac cgcacggggg acaaggcggt cctgtggccc gcccacttcg
    15121 ccgggcgccg tgaggagtac tgccagctcg aacggctcgc caacctccag gacctgccgg
    15181 tgtcgaccgg gttcaccgtc agctgcctcc ccgtgaagat cgccggagcc ggagcgggct
    15241 ggtcgagggt ggtggcgctg ctcgacgagt gaacaccggc cgcgtccggg ggcgtcgtcc
    15301 ggcgtgccgt gcgatcgcct gtcaggtcat tagttagtcg gctatatttt gaccggcgcg
    15361 agctccaact cgcgtccctc gcggcgcatt cggcgccggt tcccttcgca ccgcccgcat
    15421 cgggcgggct atggaaaggc attcatggag aacaggaagc tcggcgccgc cggcctcggc
    15481 gtctcggccc tcggcctcgg ctgcatgggc atggccggcg cgtacggcac ggcggacacg
    15541 gacgaggcag tcgccacggt ccgccgggcg ctggacctcg gggtcaccct gatcgacacg
    15601 gccgacttct acgggccggg caccgccgag aagatcgtcg ccacggcact cgagggacgc
    15661 cgcgacgagg ccgtggtcgc cacgaagttc ggcatgcggc gcccggcggc cggcccgccg
    15721 ttcgtcgacg gcagccccgc gtacgtccgc gaggcctgcg aggcgtccct gcagcgcatg
    15781 gggctggacc acatcgacct gtactacctc gcccgcctcg accccaaggt cgacgtcgag
    15841 gagaccgtcg gagccctcgg cgagctcgtc gccgagggca aggtccggca catcgggctc
    15901 tgcgaggtct ccgcacgcac cctgcgaagg gcgaacgcgg tccacccgat cgccgccctg
    15961 cagaccgagt actcgctgtg ggagcggcac gtcgaggcgg agatcctgcc cgcctgccgt
    16021 gagctcggca ccggcttcgt ggcgtacagc ccgctcggcc gcggattcct cacgggcgcc
    16081 ttcgacagcg ccgaggacct ggccgaggac gaccagcgcc gcaaccaccc gcgcttccag
    16141 agcgagaact tcgaccacaa ccgcgacctg gtgcgcacgg tcgaggacat ggcgaaggag
    16201 aagggcgtca gcctcaccca gctcgcgctg gcgtgggtgc tggcccaggg cggcgacgtc
    16261 gtgccgatcc ccggcacccg gcgcgtctcc cacctggagc agaacgtctc ggccgccgac
    16321 gtgcggctga ccgaggacga ggtcgcccgg ctctccggcc tcttccccgc cggtgccacc
    16381 gccggactgc gctaccccgc gcacttcatg cggacgatcg accagagctg acgcgtgccg
    16441 gcccgtcgcg gcggaagggt gccgtccctc cgccgcgacg ggccgcggcg cttcccggct
    16501 ccggctcagc gcccgttcac gccgtccagc cgggcacgcg caggatctcc accaccgcgc
    16561 acgaccaggt gaatccggcg cccacgccca tcaggacaca gaggccgccc tgcccgagcg
    16621 cgcccgagcg gaccagatgc tccagcccgg ccgtctggtc acccgcgccc aggtgcccca
    16681 cccggctgct gaattcccag gtcgtccggt cggccccgat ccccagcgga cgcaggcagt
    16741 tggtctccag ccggcggcgc ccgaaatgcg gcagcaccca ccgggagatg tccgcggcct
    16801 tgacccccgc gtcggccagc gcctccttga cggcgtcccg ctgccccgcg gtcacccgcg
    16861 ccacactgaa cgacatcccg gcccgggcca cgtaccgctt cttgtgcgcc tccaggtcca
    16921 ggacacccgc cggcgcggtc cgggcctcgc cgaaggggtc gccctcccgg tgcatcccct
    16981 ccagttcggg gtccgagacc acggccagcg aacgcacccg cgcgaagccg ccccccgccg
    17041 acagcagcat cgccgtcccg ccgtcggcgt agaccgtccc cgggtcgctg cgccaccggt
    17101 cgaagcccgg cggacagaac cggtcggcgg tggtgagcag cacctccccg cccccctggg
    17161 ccagcaccgc ggacgccagc agcagggccg ccatgccccc gttggacacc tggcgcacct
    17221 ccagcgccgg gcagccggcg cggacggacc gccgctggac gtacgacgcg gtgccccaca
    17281 gggcgttgcc ctggtcgtac agactggcgt gcagcagcat ccgcacgtcc gagccgtccg
    17341 ttcccgcgcg ccgcagagcg aggcccgcgg cccgtaccgc catctccgcg ggggccggcg
    17401 cgtcgtcctg gcacaccgtc accgaccgca tgccgctccg ccgtgccgcg gcctcgtcca
    17461 catcgccccg ggccaccgcc tcggccaccg gctcggcggg cggcagccag gtgccgagac
    17521 cggcgacgta gagctgatcg cacctcatgg acatcctctc cgggcccgca cccacgggcg
    17581 cccctcagat cgtccggccc gcttctcgac cgccgatcga ggactgctgg aggacctcga
    17641 tccgcggtcg agcgtgcctg tagcgggcac ggcgaggatc ggccccgcgg accgcccttc
    17701 gcggtacgcg ggaggggaaa cgatgacgaa cccgacgccg gcgcccgccg ccgagccact
    17761 gcccgtcgcg ctcctgctgc cgggccaggg agcccagcac cccggcatgg ccaccggact
    17821 ctacgggcac gacgaggtct tcaccggtgc ggcggacgag gtgttcgacg ctctcggcgc
    17881 cccgggcacc cacgtacgcg acgactggct gggggagcgg cccggcgtac cgatggacca
    17941 tgtcacccgg tcccagatcc tgctgttcac gatcgactac gccctcggcc ggaccgtgga
    18001 gtcatggggg gtccgcccgg cggtgctgct cggccacagc gtcggcgaga tggcggcggc
    18061 cgtcctggcc gacgtgttca ccctcgccga cgccgcgcgt ctgatgtggg accgtgtgac
    18121 ccgcctcgcc gacggcccgg ccggcgggat ggtcgcggtg gcggccgccc ccgacgcgct
    18181 gacgccctac ctccgcgacg acgtcgtggt gggagcgcac aacgcgcccc gccagacgat
    18241 cctggccggc cccgaaccgc acctgggcca ggtcacccgg gagttgcgcg agcaggggct
    18301 cgtctgccgg accgtgccgt cctcgacgcc cttccacagt ccggtgctcg cccccctcgc
    18361 cgcccgggcg gaaccggcct tcgcggcggt ccgtgcccgg ccacccgccc tcccgctgat
    18421 ctccggttac accgccgccc cgctcaccgc gcgccaggcc gcggaccctg cctggtggtc
    18481 ctcccatccg gtggcgcagg tgaggttctg gccggcgctg gaccacctgc tgggcggccc
    18541 ggggcggcag ctcgtcgaat gcgggcccgg ccgggggctg tccgccctcg cccggcgcca
    18601 ccccgcggta ctggccgggc gcagcagggt ccttccgctc ctgcccgccg gcccggccga
    18661 cgcgtcccgt acccgtgacg acctggccgc cgcccgctcg ttcctgaccg cgcacagcgc
    18721 ctgaccggtg cccctccgtc ccggcgggcc gccaccggcc ggaccgaccc cgcagagcag
    18781 aaaggccgac ccgatgacga ccacggactc cccggcgccg acagccggac cggtacccgc
    18841 cccgcccgcc gcctccggca tgcgccgccg cgtcggtgaa ctcggcgccc tgcgcgccca
    18901 ggtgcacgcc gggccgggcg agaaggcgac cggggcccag cacgcccgcg gcaaactgac
    18961 cgcccgggag cgcatcgacc tcctgctgga cccgggcacc ttccaggagg tggagcggtt
    19021 ccgccggcac cgggccaccg gcttcggcct ggaggcgaac cgcccgtaca cggacggggt
    19081 gatcaccggc tggggggagg tcgaggggcg gaccgtcttc gtgtacgcac acgacttccg
    19141 catgttcggg ggcgcgctcg gcgaggccca cgcggcgaag atccacaaga tcatggacat
    19201 ggccctcgcg gcgggagcgc ccctggtctc cctgaacgac ggggccggtg cccgcatcca
    19261 ggagggggtc tcggcgctcg cgggctacgg cgggatcttc cggcgcaaca cccgcgcctc
    19321 gggggtgatc ccgcagatca gcgtcatgct cggaccgtgt gcgggcggcg ccgcgtacag
    19381 ccccgcgctc accgacttcg tgttcatggt gcgggggacg tcccagatgt tcatcacggg
    19441 tccggacgtg gtgagggcgg tcaccggtga ggaggtcacc ctgagcggcc tcggcggcgc
    19501 ggacgtccac gcggagacct ccggggtctg tcacttcgcc tacgacgacg aggagtcctg
    19561 cctcgtcgag gtccgctacc tgctcggact gctgccggcg aacaaccggg aacgcccgcc
    19621 ccgtgccgag accggcgacc cggccggacg gcgctcgccg aggctgctgg acctggttcc
    19681 cgccgagggc agcagaccgt acgacatgcg cgaggtgatc gccgaactgg cggacgacga
    19741 agaggtgctg gaggtccacg agcgctgggc ccccaacatc ctgtgcgtcc tgatcagact
    19801 ggccggggag gtcgtgggcg tggtcgcgaa ccagccgctg tcgctggccg gggtgctgga
    19861 catcaaggcg tccgagaagg cggcgcggtt cgtccagatg tgcgacacgt tcaacatccc
    19921 cctggtgacc ctggtggacg tcccggggtt cctgcccggc gtcggccagg agcacgacgg
    19981 aatcatccgg cacggcgcca agctgctcta cgcctactgc gacgccacgg tccccaggat
    20041 caccgtcatc ctgcgcaagg cgtacggagg cgcgtacatc gtcatgaact cgcagtccat
    20101 cggcgccgac ctcaccttcg cgtggcccac caacgagatc gccgtgatgg gtgccgaggg
    20161 cgcggccaac gtcatcttcc ggaggcagat cgccgaggcg gaggacccgg acgagacccg
    20221 tgcccggctg gtgaaggagt accgggccga actcatgcac ccctactacg cggcggaacg
    20281 tgggctggtg gacgacgtca tcgaccccgc cgccacccgg gagaccctgg cagcggccct
    20341 caccgtgctg cggaccaaga ccgccgaggc ggcaccccgc aagcacggca acccaccgct
    20401 gtag
//
