BGC0002083: gladiofungin A biosynthetic gene cluster from Burkholderia gladioli
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 1,150,314 - 1,205,481 nt. (total: 55,168 nt).
This entry is originally from NCBI GenBank WITE01000004.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Polyketide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002083
Short description gladiofungin A biosynthetic gene cluster from Burkholderia gladioli
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Other)
Loci NCBI GenBank: WITE01000004.1
Compounds
  • gladiofungin A
  • gladiofungin B
Species Burkholderia gladioli [taxonomy]
References
Chemical products information
gladiofungin A
Copy SMILES
C27H39N1O8
Chemical database entries
NPAtlas
gladiofungin B
Copy SMILES
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • LvStA_05064
  • KAF1058469.1
  • aldA_1
 1150362 - 1151879 (-) putative aldehyde dehydrogenase AldA
copy AA seq
copy Nt seq
  • LvStA_05065
  • KAF1058470.1
 1151949 - 1152821 (-) 2-(hydroxymethyl)glutarate dehydrogenase
copy AA seq
copy Nt seq
  • LvStA_05066
  • KAF1058471.1
  • cmpR_9
 1152965 - 1153873 (+) HTH-type transcriptional activator CmpR
copy AA seq
copy Nt seq
  • LvStA_05067
  • KAF1058472.1
  • yfmJ
 1154171 - 1155193 (-) putative NADP-dependent oxidoreductase YfmJ
copy AA seq
copy Nt seq
  • LvStA_05068
  • KAF1058473.1
 1155228 - 1155941 (-) hypothetical protein
copy AA seq
copy Nt seq
  • LvStA_05069
  • KAF1058474.1
  • pksN_1
 1156002 - 1186547 (-) Polyketide synthase PksN
copy AA seq
copy Nt seq
  • LvStA_05070
  • KAF1058475.1
  • pksL_1
 1186548 - 1196294 (-) Polyketide synthase PksL
copy AA seq
copy Nt seq
  • LvStA_05071
  • KAF1058476.1
  • asnB_1
 1196287 - 1198284 (-) Asparagine synthetase [glutamine-hydrolyzing] 1
copy AA seq
copy Nt seq
  • LvStA_05072
  • KAF1058477.1
  • dltC
 1198379 - 1198621 (-) D-alanine--poly(phosphoribitol) ligase subunit 2
copy AA seq
copy Nt seq
  • LvStA_05073
  • KAF1058478.1
  • baeE_1
 1198663 - 1202022 (-) Polyketide biosynthesis protein BaeE
copy AA seq
copy Nt seq
  • LvStA_05074
  • KAF1058479.1
 1202098 - 1202799 (-) hypothetical protein
copy AA seq
copy Nt seq
  • LvStA_05075
  • KAF1058480.1
 1204551 - 1205270 (+) hypothetical protein
copy AA seq
copy Nt seq
Polyketide-specific information
Subclass Other
Starter unit Malonyl-CoA
Cyclic? no
Polyketide-synthases
Genes Properties Modules
pksL_1
+
baeE_1
+
pksN_1 		Synthase subclass: Trans-AT type I
Trans-acyltansferases: baeE_1
Module 0
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: baeE_1
Core domains: Acyltransferase, Acyltransferase, Enoylreductase
Module 1
Genes: pksL_1
Core domains: Ketosynthase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 2
Genes: pksL_1
Core domains: Ketosynthase, B, Thiolation (ACP/PCP)
Scaffold-modifying domains: Michael branching
Module 3
Genes: pksL_1, pksN_1
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 4
Genes: pksN_1
Core domains: Ketosynthase, Thiolation (ACP/PCP)
Module 5
Genes: pksN_1
Core domains: Ketosynthase, Dehydratase, Ketoreductase, MT, Thiolation (ACP/PCP), Thiolation (ACP/PCP)
Scaffold-modifying domains: Methylation
KR-domain stereochemistry: D-OH
Module 6
Genes: pksN_1
Core domains: Ketosynthase, Dehydratase, Thiolation (ACP/PCP)
Module 7
Genes: pksN_1
Core domains: Ketosynthase, Ketoreductase, Thiolation (ACP/PCP), Thiolation (ACP/PCP), Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 8
Genes: pksN_1
Core domains: Ketosynthase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 9
Genes: pksN_1
Core domains: Ketosynthase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 10
Genes: pksN_1
Core domains: Ketosynthase, AFSA
Annotation changelog
MIBiG version Submitter Notes
3.0
  • Hidden contributor (ID: Z7AIIJAM3U3HR6IYDPQOINM4, no GDPR consent given).
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Hidden contributor (ID: 3UOU7PODQJXIM6BEPUHHRRA5, no GDPR consent given).
  • Submitted
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • Merged cross-CDS PKS modules
  • Sorted modules by module number
  • Added version to NCBI accession
  • Convert from RefSeq to Genbank
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
  • Changed chemical structures for compounds: gladiofungin A.
  • Added chemical structures for compounds: gladiofungin B.
  • Added NPAtlas links to compounds: gladiofungin B.
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.