BGC0002083: gladiofungin A biosynthetic gene cluster from Burkholderia gladioli
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Location: 1,150,314 - 1,205,481 nt. (total: 55,168 nt).
This entry is originally from NCBI GenBank WITE01000004.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002083
Short description gladiofungin A biosynthetic gene cluster from Burkholderia gladioli
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Trans-AT type I)
Loci
WITE01000004.1
1150314 - 1205481
via Knock-out studies
Compounds
  • gladiofungin A
  • gladiofungin B
Species Burkholderia gladioli [taxonomy]
References
Chemical products information
gladiofungin A Evidence: NMR, Mass spectrometry
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C27H39N1O8
Chemical database entries
NPAtlas
gladiofungin B Evidence:
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Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • LvStA_05064
  • KAF1058469.1
  • aldA_1
 1150362 - 1151879 (-) putative aldehyde dehydrogenase AldA
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    • LvStA_05065
    • KAF1058470.1
    		 1151949 - 1152821 (-) 2-(hydroxymethyl)glutarate dehydrogenase
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      • LvStA_05066
      • KAF1058471.1
      • cmpR_9
      		 1152965 - 1153873 (+) HTH-type transcriptional activator CmpR
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        • LvStA_05067
        • KAF1058472.1
        • yfmJ
        		 1154171 - 1155193 (-) putative NADP-dependent oxidoreductase YfmJ
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          • LvStA_05068
          • KAF1058473.1
          		 1155228 - 1155941 (-) hypothetical protein
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            • LvStA_05069
            • KAF1058474.1
            • pksN_1
            		 1156002 - 1186547 (-) Polyketide synthase PksN
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              • LvStA_05070
              • KAF1058475.1
              • pksL_1
              		 1186548 - 1196294 (-) Polyketide synthase PksL
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                • LvStA_05071
                • KAF1058476.1
                • asnB_1
                		 1196287 - 1198284 (-) Asparagine synthetase [glutamine-hydrolyzing] 1
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                  • LvStA_05072
                  • KAF1058477.1
                  • dltC
                  		 1198379 - 1198621 (-) D-alanine--poly(phosphoribitol) ligase subunit 2
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                    • LvStA_05073
                    • KAF1058478.1
                    • baeE_1
                    		 1198663 - 1202022 (-) Polyketide biosynthesis protein BaeE
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                      • LvStA_05074
                      • KAF1058479.1
                      		 1202098 - 1202799 (-) hypothetical protein
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                        • LvStA_05075
                        • KAF1058480.1
                        		 1204551 - 1205270 (+) hypothetical protein
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                          Biosynthesis information

                          Biosynthetic modules

                          Name
                          0
                          Type
                          pks-modular-starter
                          Genes
                          baeE_1
                          Substrates
                          Integrated Monomers
                          Domains
                          acyltransferase, enoylreductase
                          Name
                          1
                          Type
                          pks-trans-at
                          Genes
                          pksL_1
                          Substrates
                          Integrated Monomers
                          Domains
                          ketosynthase, dehydratase, ketoreductase, carrier (ACP)
                          Name
                          2
                          Type
                          pks-trans-at
                          Genes
                          pksL_1
                          Substrates
                          Integrated Monomers
                          Domains
                          ketosynthase, branching, branching, carrier (ACP)
                          Name
                          3
                          Type
                          pks-trans-at
                          Genes
                          pksL_1 pksN_1
                          Substrates
                          Integrated Monomers
                          Domains
                          ketosynthase, ketoreductase, carrier (ACP)
                          Name
                          4
                          Type
                          pks-trans-at
                          Genes
                          pksN_1
                          Substrates
                          Integrated Monomers
                          Domains
                          ketosynthase, carrier (ACP)
                          Name
                          5
                          Type
                          pks-trans-at
                          Genes
                          pksN_1
                          Substrates
                          Integrated Monomers
                          Domains
                          ketosynthase, dehydratase, ketoreductase, methyltransferase, methyltransferase, carrier (ACP), carrier (ACP)
                          Name
                          6
                          Type
                          pks-trans-at
                          Genes
                          pksN_1
                          Substrates
                          Integrated Monomers
                          Domains
                          ketosynthase, dehydratase, carrier (ACP)
                          Name
                          7
                          Type
                          pks-trans-at
                          Genes
                          pksN_1
                          Substrates
                          Integrated Monomers
                          Domains
                          ketosynthase, ketoreductase, carrier (ACP), carrier (ACP), carrier (ACP)
                          Name
                          8
                          Type
                          pks-trans-at
                          Genes
                          pksN_1
                          Substrates
                          Integrated Monomers
                          Domains
                          ketosynthase, dehydratase, ketoreductase, carrier (ACP)
                          Name
                          9
                          Type
                          pks-trans-at
                          Genes
                          pksN_1
                          Substrates
                          Integrated Monomers
                          Domains
                          ketosynthase, dehydratase, ketoreductase, carrier (ACP)
                          Name
                          10
                          Type
                          pks-trans-at
                          Genes
                          pksN_1
                          Substrates
                          Integrated Monomers
                          Domains
                          ketosynthase, other (A-factor synthase A)
                          Annotation changelog

                          Entry version: 2

                          Date
                          Changes
                          Submitters
                          Reviewers
                          2022-10-07
                          Update chemical activity to schema version 2.11
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          2022-10-07
                          Changed chemical structures for compounds: gladiofungin A.
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          2022-10-07
                          Added chemical structures for compounds: gladiofungin B.
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          2022-10-07
                          Added NPAtlas links to compounds: gladiofungin B.
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                          Entry version: 1

                          Date
                          Changes
                          Submitters
                          Reviewers
                          2022-09-15
                          Submitted
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          2022-09-15
                          Removed ketoreductase stereochemistry annotation from modules without ketoreductases
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          2022-09-15
                          Merged cross-CDS PKS modules
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          2022-09-15
                          Sorted modules by module number
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          2022-09-15
                          Added version to NCBI accession
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                          Detailed domain annotation
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