BGC0002085: everninomicin D biosynthetic gene cluster from Micromonospora carbonacea
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Location: 866,393 - 925,867 nt. (total: 59,475 nt).
This entry is originally from NCBI GenBank CP058322.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002085
Short description everninomicin D biosynthetic gene cluster from Micromonospora carbonacea
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • saccharide (oligosaccharide)
Loci
CP058322.1
866393 - 925867
via Knock-out studies, Enzymatic assays, Heterologous expression
Compounds
  • everninomicin D
  • everninomicin E
  • everninomicin G
  • everninomicin F
Species Micromonospora carbonacea [taxonomy]
References
Chemical products information
everninomicin D Evidence: NMR, Mass spectrometry, X-ray crystallography, Total synthesis
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Chemical database entries
PubCHEM
NPAtlas
everninomicin E Evidence:
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everninomicin G Evidence:
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everninomicin F Evidence:
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List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • HXZ27_03905
  • QLD23463.1
  • evdM1
 866393 - 867145 (-) H-ring C4' O-methyltransferase
  • Tailoring
  • Activity assay Knock-out
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  • HXZ27_03910
  • QLD23464.1
  • evdU1
 867925 - 869253 (+) Unknown
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    • HXZ27_03915
    • QLD23465.2
    • evdX1
    		 869290 - 870447 (+) RNA methyltrasnferase
    • Resistance/immunity
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    • HXZ27_03920
    • QLD23466.1
    • evdU2
    		 870452 - 871921 (-) Unknown
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      • HXZ27_03925
      • QLD23467.1
      • evdM2
      		 872566 - 873390 (+) H-ring C2/C3 O-methyltransferase
      • Tailoring
      • Knock-out
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      • HXZ27_03930
      • QLD23468.1
      • evdM3
      		 873387 - 874676 (+) D-ring C3 C-methyltransferase
      • Tailoring
      • Knock-out
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      • HXZ27_03935
      • QLD23469.1
      • evdM4
      		 874673 - 875857 (+) G-ring C2 O-methyltransferase
      • Tailoring
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      • HXZ27_03940
      • QLD23470.1
      • evdGT1
      		 875864 - 876883 (+) Glycosyltransferase
      • Scaffold biosynthesis
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      • HXZ27_03945
      • QLD23471.1
      • evdU3
      		 876999 - 877412 (+) Unknown
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        • HXZ27_03950
        • QLD23472.1
        • evdS1
        		 877468 - 878412 (-) 4-ketoreductase
        • Precursor biosynthesis
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        • HXZ27_03955
        • QLD28327.2
        • evdM5
        		 878453 - 879481 (-) A1-ring -methyltransferase
        • Tailoring
        • Activity assay Knock-out
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        • HXZ27_03960
        • QLD23473.1
        • evdU4
        		 879474 - 880304 (-) Unknown
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          • HXZ27_03965
          • QLD23474.2
          • evdX2
          		 880407 - 881204 (-) RNA methyltrasnferase
          • Resistance/immunity
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          • HXZ27_03970
          • QLD23475.1
          • evdD1
          		 881569 - 882603 (+) Acyltransferase
          • Precursor biosynthesis
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          • HXZ27_03975
          • QLD23476.1
          • evdM6
          		 882769 - 883491 (-) F-ring C6 O-methyltransferase
          • Tailoring
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          • HXZ27_03980
          • QLD23477.1
          • evdGT2
          		 883491 - 884807 (-) Glycosyltransferase
          • Scaffold biosynthesis
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          • HXZ27_03985
          • QLD23478.1
          • evdS2
          		 885075 - 886292 (-) Epimerase (F-ring C-2)
          • Precursor biosynthesis
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          • HXZ27_03990
          • QLD23479.1
          • evdO1
          		 886309 - 887250 (-) Orthester synthase
          • Scaffold biosynthesis
          • Knock-out
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          • HXZ27_03995
          • QLD28328.2
          • evdM7
          		 887250 - 887981 (-) F-ring C2 O-methyltransferase
          • Tailoring
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          • HXZ27_04000
          • QLD23480.1
          • evdD2
          		 887978 - 889423 (-) Halogenase
          • Tailoring
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          • HXZ27_04005
          • QLD23481.1
          • evdGT3
          		 889737 - 890879 (+) Glycosyltransferase
          • Scaffold biosynthesis
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          • HXZ27_04010
          • QLD23482.2
          • evdU5
          		 890957 - 891934 (+) Pyruvate dehydrogenase subunit alpha
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            • HXZ27_04015
            • QLD23483.1
            • evdU6
            		 891939 - 892901 (+) Pyruvate dehydrogenase subunit beta
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              • HXZ27_04020
              • QLD23484.1
              • evdGT4
              		 892949 - 893962 (+) Glycosyltransferase
              • Scaffold biosynthesis
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              • HXZ27_04025
              • QLD23485.1
              • evdU7
              		 893959 - 895011 (+) Unknown
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                • HXZ27_04030
                • QLD23486.1
                • evdO2
                		 895031 - 895789 (-) Orthester synthase
                • Scaffold biosynthesis
                • Knock-out
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                • HXZ27_04035
                • QLD23487.1
                • evdS3
                		 896144 - 897073 (+) Epimerase/dehydratase
                • Precursor biosynthesis
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                • HXZ27_04040
                • QLD23488.1
                • evdS4
                		 897271 - 898338 (+) Glucose-1-phosphate thymidyltransferase
                • Precursor biosynthesis
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                • HXZ27_04045
                • QLD23489.2
                • evdS5
                		 898338 - 899327 (+) 4,6 dehydratase
                • Precursor biosynthesis
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                • HXZ27_04050
                • QLD23490.1
                • evdS6
                		 899382 - 900410 (+) 4-epimerase
                • Precursor biosynthesis
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                • HXZ27_04060
                • QLD28329.2
                • evdMO1
                		 900465 - 901817 (+) Oxidase/E-ring C4 O-methyltransferase
                • Tailoring
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                • HXZ27_04065
                • QLD23491.1
                • evdD3
                		 901972 - 905775 (-) Polyketide synthase
                • Precursor biosynthesis
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                • HXZ27_04070
                • QLD28330.1
                • evdU8
                		 906255 - 907004 (+) Unknown
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                  • HXZ27_04075
                  • QLD23492.1
                  • evdS7
                  		 907001 - 907924 (+) 4-ketoreductase
                  • Precursor biosynthesis
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                  • HXZ27_04080
                  • QLD28331.2
                  • evdGT5
                  		 907903 - 908790 (-) Glycosyltransferase
                  • Scaffold biosynthesis
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                  • HXZ27_04085
                  • QLD23493.1
                  • evdR1
                  		 908852 - 909100 (-) Regulator
                  • Regulation
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                  • HXZ27_04095
                  • QLD23495.2
                  • evdS8
                  		 909924 - 910949 (-) 3-ketoreductase
                  • Precursor biosynthesis
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                  • HXZ27_04100
                  • QLD28332.2
                  • evdS9
                  		 910946 - 912358 (-) 2,3-dehydratase
                  • Precursor biosynthesis
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                  • HXZ27_04105
                  • QLD28333.1
                  • evdS10
                  		 912355 - 913395 (-) 4,6-dehydratase
                  • Precursor biosynthesis
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                  • HXZ27_04110
                  • QLD23496.1
                  • evdX3
                  		 913599 - 914363 (-) RNA Methyltrasnferase
                  • Resistance/immunity
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                  • HXZ27_04115
                  • QLD23497.1
                  • evdS11
                  		 914462 - 915400 (-) UDP-glucose 4-epimerase
                  • Precursor biosynthesis
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                  • HXZ27_04120
                  • QLD23498.2
                  • evdN1
                  		 915794 - 916996 (+) Nitrosynthase
                  • Tailoring
                  • Activity assay
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                  • HXZ27_04125
                  • QLD23499.2
                  • evdS12
                  		 916993 - 918120 (+) 3-aminotransferase
                  • Precursor biosynthesis
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                  • HXZ27_04130
                  • QLD23500.1
                  • evdM8
                  		 918150 - 919400 (+) A-ring C3 C-methyltransferase
                  • Tailoring
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                  • HXZ27_04133
                  • QLL25664.1
                  • evdS13
                  		 919409 - 920032 (+) 3,5 epimerase
                  • Precursor biosynthesis
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                  • HXZ27_04135
                  • QLD23501.1
                  • evdS14
                  		 919853 - 920962 (-) 4-ketoreductase
                  • Precursor biosynthesis
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                  • HXZ27_04140
                  • QLD23502.1
                  • evdM9
                  		 920959 - 921879 (-) A-ring C4 O-methyltransferase
                  • Tailoring
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                  • HXZ27_04145
                  • QLD23503.1
                  • evdU9
                  		 922051 - 923604 (-) Unknown
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                    • HXZ27_04150
                    • QLD23504.1
                    • evdR2
                    		 923679 - 924539 (-) Regulator
                    • Regulation
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                    • HXZ27_04155
                    • QLD23505.1
                    • evdR3
                    		 924557 - 925867 (-) Regulator
                    • Regulation
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                    Biosynthesis information
                    Annotation changelog

                    Entry version: 2

                    Date
                    Changes
                    Submitters
                    Reviewers
                    2022-10-07
                    Update chemical activity to schema version 2.11
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    2022-10-07
                    Changed chemical structures for compounds: everninomicin D.
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    2022-10-07
                    Added NPAtlas links to compounds: everninomicin D.
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                    Entry version: 1

                    Date
                    Changes
                    Submitters
                    Reviewers
                    2022-09-15
                    Submitted
                    • (ID: VXQQS2VBYGA6KXCJ4IF2SC56)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    2022-09-15
                    Added version to NCBI accession
                    • (ID: AYT6WP6PINVPWSBOCVXGSMXM)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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