BGC0002085: everninomicin D biosynthetic gene cluster from Micromonospora carbonacea
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Location: 861,569 - 936,996 nt. (total: 75,428 nt).
This entry is originally from NCBI GenBank CP058322.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0002085
Short description everninomicin D biosynthetic gene cluster from Micromonospora carbonacea
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • saccharide (oligosaccharide)
Loci
CP058322.1
866393 - 925867
via Knock-out studies, Enzymatic assays, Heterologous expression
Compounds
  • everninomicin D
  • everninomicin E
  • everninomicin G
  • everninomicin F
Species Micromonospora carbonacea [taxonomy]
References
Chemical products information
everninomicin D Evidence: NMR, Mass spectrometry, X-ray crystallography, Total synthesis
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Chemical database entries
PubCHEM
NPAtlas
everninomicin E Evidence:
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everninomicin G Evidence:
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everninomicin F Evidence:
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List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • HXZ27_03900
  • QLD23462.1
 866229 - 866414 (+) hypothetical protein
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    • HXZ27_03905
    • QLD23463.1
    • evdM1
    		 866393 - 867145 (-) H-ring C4' O-methyltransferase
    • Tailoring
    • Activity assay Knock-out
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    • HXZ27_03910
    • QLD23464.1
    • evdU1
    		 867925 - 869253 (+) Unknown
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      • HXZ27_03915
      • QLD23465.2
      • evdX1
      		 869290 - 870447 (+) RNA methyltrasnferase
      • Resistance/immunity
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      • HXZ27_03920
      • QLD23466.1
      • evdU2
      		 870452 - 871921 (-) Unknown
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        • HXZ27_03925
        • QLD23467.1
        • evdM2
        		 872566 - 873390 (+) H-ring C2/C3 O-methyltransferase
        • Tailoring
        • Knock-out
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        • HXZ27_03930
        • QLD23468.1
        • evdM3
        		 873387 - 874676 (+) D-ring C3 C-methyltransferase
        • Tailoring
        • Knock-out
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        • HXZ27_03935
        • QLD23469.1
        • evdM4
        		 874673 - 875857 (+) G-ring C2 O-methyltransferase
        • Tailoring
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        • HXZ27_03940
        • QLD23470.1
        • evdGT1
        		 875864 - 876883 (+) Glycosyltransferase
        • Scaffold biosynthesis
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        • HXZ27_03945
        • QLD23471.1
        • evdU3
        		 876999 - 877412 (+) Unknown
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          • HXZ27_03950
          • QLD23472.1
          • evdS1
          		 877468 - 878412 (-) 4-ketoreductase
          • Precursor biosynthesis
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          • HXZ27_03955
          • QLD28327.2
          • evdM5
          		 878453 - 879481 (-) A1-ring -methyltransferase
          • Tailoring
          • Activity assay Knock-out
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          • HXZ27_03960
          • QLD23473.1
          • evdU4
          		 879474 - 880304 (-) Unknown
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            • HXZ27_03965
            • QLD23474.2
            • evdX2
            		 880407 - 881204 (-) RNA methyltrasnferase
            • Resistance/immunity
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            • HXZ27_03970
            • QLD23475.1
            • evdD1
            		 881569 - 882603 (+) Acyltransferase
            • Precursor biosynthesis
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            • HXZ27_03975
            • QLD23476.1
            • evdM6
            		 882769 - 883491 (-) F-ring C6 O-methyltransferase
            • Tailoring
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            • HXZ27_03980
            • QLD23477.1
            • evdGT2
            		 883491 - 884807 (-) Glycosyltransferase
            • Scaffold biosynthesis
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            • HXZ27_03985
            • QLD23478.1
            • evdS2
            		 885075 - 886292 (-) Epimerase (F-ring C-2)
            • Precursor biosynthesis
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            • HXZ27_03990
            • QLD23479.1
            • evdO1
            		 886309 - 887250 (-) Orthester synthase
            • Scaffold biosynthesis
            • Knock-out
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            • HXZ27_03995
            • QLD28328.2
            • evdM7
            		 887250 - 887981 (-) F-ring C2 O-methyltransferase
            • Tailoring
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            • HXZ27_04000
            • QLD23480.1
            • evdD2
            		 887978 - 889423 (-) Halogenase
            • Tailoring
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            • HXZ27_04005
            • QLD23481.1
            • evdGT3
            		 889737 - 890879 (+) Glycosyltransferase
            • Scaffold biosynthesis
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            • HXZ27_04010
            • QLD23482.2
            • evdU5
            		 890957 - 891934 (+) Pyruvate dehydrogenase subunit alpha
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              • HXZ27_04015
              • QLD23483.1
              • evdU6
              		 891939 - 892901 (+) Pyruvate dehydrogenase subunit beta
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                • HXZ27_04020
                • QLD23484.1
                • evdGT4
                		 892949 - 893962 (+) Glycosyltransferase
                • Scaffold biosynthesis
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                • HXZ27_04025
                • QLD23485.1
                • evdU7
                		 893959 - 895011 (+) Unknown
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                  • HXZ27_04030
                  • QLD23486.1
                  • evdO2
                  		 895031 - 895789 (-) Orthester synthase
                  • Scaffold biosynthesis
                  • Knock-out
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                  • HXZ27_04035
                  • QLD23487.1
                  • evdS3
                  		 896144 - 897073 (+) Epimerase/dehydratase
                  • Precursor biosynthesis
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                  • HXZ27_04040
                  • QLD23488.1
                  • evdS4
                  		 897271 - 898338 (+) Glucose-1-phosphate thymidyltransferase
                  • Precursor biosynthesis
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                  • HXZ27_04045
                  • QLD23489.2
                  • evdS5
                  		 898338 - 899327 (+) 4,6 dehydratase
                  • Precursor biosynthesis
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                  • HXZ27_04050
                  • QLD23490.1
                  • evdS6
                  		 899382 - 900410 (+) 4-epimerase
                  • Precursor biosynthesis
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                  • HXZ27_04060
                  • QLD28329.2
                  • evdMO1
                  		 900465 - 901817 (+) Oxidase/E-ring C4 O-methyltransferase
                  • Tailoring
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                  • HXZ27_04065
                  • QLD23491.1
                  • evdD3
                  		 901972 - 905775 (-) Polyketide synthase
                  • Precursor biosynthesis
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                  • HXZ27_04070
                  • QLD28330.1
                  • evdU8
                  		 906255 - 907004 (+) Unknown
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                    • HXZ27_04075
                    • QLD23492.1
                    • evdS7
                    		 907001 - 907924 (+) 4-ketoreductase
                    • Precursor biosynthesis
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                    • HXZ27_04080
                    • QLD28331.2
                    • evdGT5
                    		 907903 - 908790 (-) Glycosyltransferase
                    • Scaffold biosynthesis
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                    • HXZ27_04085
                    • QLD23493.1
                    • evdR1
                    		 908852 - 909100 (-) Regulator
                    • Regulation
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                    • HXZ27_04095
                    • QLD23495.2
                    • evdS8
                    		 909924 - 910949 (-) 3-ketoreductase
                    • Precursor biosynthesis
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                    • HXZ27_04100
                    • QLD28332.2
                    • evdS9
                    		 910946 - 912358 (-) 2,3-dehydratase
                    • Precursor biosynthesis
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                    • HXZ27_04105
                    • QLD28333.1
                    • evdS10
                    		 912355 - 913395 (-) 4,6-dehydratase
                    • Precursor biosynthesis
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                    • HXZ27_04110
                    • QLD23496.1
                    • evdX3
                    		 913599 - 914363 (-) RNA Methyltrasnferase
                    • Resistance/immunity
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                    • HXZ27_04115
                    • QLD23497.1
                    • evdS11
                    		 914462 - 915400 (-) UDP-glucose 4-epimerase
                    • Precursor biosynthesis
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                    • HXZ27_04120
                    • QLD23498.2
                    • evdN1
                    		 915794 - 916996 (+) Nitrosynthase
                    • Tailoring
                    • Activity assay
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                    • HXZ27_04125
                    • QLD23499.2
                    • evdS12
                    		 916993 - 918120 (+) 3-aminotransferase
                    • Precursor biosynthesis
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                    • HXZ27_04130
                    • QLD23500.1
                    • evdM8
                    		 918150 - 919400 (+) A-ring C3 C-methyltransferase
                    • Tailoring
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                    • HXZ27_04133
                    • QLL25664.1
                    • evdS13
                    		 919409 - 920032 (+) 3,5 epimerase
                    • Precursor biosynthesis
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                    • HXZ27_04135
                    • QLD23501.1
                    • evdS14
                    		 919853 - 920962 (-) 4-ketoreductase
                    • Precursor biosynthesis
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                    • HXZ27_04140
                    • QLD23502.1
                    • evdM9
                    		 920959 - 921879 (-) A-ring C4 O-methyltransferase
                    • Tailoring
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                    • HXZ27_04145
                    • QLD23503.1
                    • evdU9
                    		 922051 - 923604 (-) Unknown
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                      • HXZ27_04150
                      • QLD23504.1
                      • evdR2
                      		 923679 - 924539 (-) Regulator
                      • Regulation
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                      • HXZ27_04155
                      • QLD23505.1
                      • evdR3
                      		 924557 - 925867 (-) Regulator
                      • Regulation
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                      Biosynthesis information

                      No biosynthesis information available for this record.

                      Annotation changelog

                      Entry version: 2

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2022-10-07
                      Update chemical activity to schema version 2.11
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      2022-10-07
                      Changed chemical structures for compounds: everninomicin D.
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      2022-10-07
                      Added NPAtlas links to compounds: everninomicin D.
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                      Entry version: 1

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2022-09-15
                      Submitted
                      • (ID: VXQQS2VBYGA6KXCJ4IF2SC56)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      2022-09-15
                      Added version to NCBI accession
                      • (ID: AYT6WP6PINVPWSBOCVXGSMXM)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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